Background
Metabolic syndrome (MetS) is defined as a cluster of cardiometabolic risk factors (CMRFs), including central obesity, high blood pressure (BP), dyslipidaemia, and high fasting glucose [
1]. Compelling evidence suggests that early onset of MetS has become more common and childhood MetS can track into adulthood, thereby increasing the risk of future cardiovascular disease. In 2020, about 3% of children aged 6–12 years, and 5% of adolescents aged 13–18 years had MetS globally [
2]. Notably, several definitions have been used to define pediatric MetS but no consensus on the MetS definition has been established. The existing widely used pediatric MetS definitions such as the International Diabetes Federation (IDF) definition and the modified National Cholesterol Education Program (NCEP) definition involve different definitions and heterogenous cut-offs for MetS components [
3,
4], impeding pediatricians to quickly assess MetS risk and CMRFs clustering in clinical practice. For example, age- and sex- specific waist circumference (WC) percentile cut-offs are used for defining central obesity in both IDF and NCEP definitions. Likewise, age-, sex- and height- specific systolic/diastolic blood pressure (SBP/DBP) percentile cut-offs are used to define elevated BP in NCEP definition. Thus, development of an easy-to-apply and standardized definition to facilitate the clinical diagnosis of pediatric MetS is imperative.
Emerging evidence has showed the potential of using simplified static cut-offs for defining central obesity and elevated BP in children and adolescents. For instance, several systematic reviews showed that waist-to-height ratio (WHtR) is a useful alternative for WC to predict pediatric MetS and identify youths with CMRFs clustering [
5,
6]. Indeed, WHtR has already been proposed for assessing central obesity as a component of pediatric MetS definition [
7‐
9]. Furthermore, a recent pooled analysis of 34,224 children and adolescent aged 6–18 years from multiple countries reported that simplified WHtR cut-offs (i.e., 0.50 for European and US youths, and 0.46 for Asian, South American and African youths) were robust for identifying central obesity in children and adolescents [
10]. In addition, the simplified static cut-offs of SBP/DBP (i.e., 120/80 mm Hg for children aged 6–12 years and 130/80 mm Hg for adolescents aged 13–17 years) have also been widely validated and recommended to define elevated BP in the pediatric population [
11‐
14]. By incorporating these simple static cut-offs, we proposed a new simplified definition of pediatric MetS and validated its performance in 10 pediatric populations from 9 countries worldwide.
Discussion
To our knowledge, we proposed the first simplified and easy-to-apply definition for assessing MetS in pediatric population. The simplified definition also demonstrated good performance in identifying youths with MetS risk when compared with two widely used pediatric MetS definitions (i.e., the IDF definition, the NCEP definition) in 10 diverse pediatric populations globally.
Due to discrepant cut-offs are used for defining MetS components, the prevalence estimations of MetS varied greatly between the IDF and NCEP definitions. The variability of MetS prevalence across the populations may be mainly influenced by the nutritional status of the populations, with the prevalence of overweight&obesity ranging from 10.1% in China to 39.8% in Greece across the 10 populations according to BMI categories using Cole’s cut-off points [
25] (Table S
1). Additionally, other factors such as demographic characteristics, geographic location, and socioeconomic status may also influence the variability of MetS prevalence across the populations. The IDF definition tends to estimate lower prevalence of MetS than that of the NCEP definition. However, the MetS prevalence estimated by the simplified definition was within the prevalence estimations defined by IDF and NCEP definitions, which seemed to support the validity of the simplified definition. Moreover, the simplified definition also has several advantages over the existing MetS definitions. The utilization of simple and static cut-offs in lieu of complex age- and sex-specific cut-offs for defining each MetS component could facilitate easy application in clinical practice. The ROC curve analyses showed that the simplified definition was highly consistent with both IDF and NCEP definitions for estimating MetS prevalence with AUC ranging from 0.79 to 0.91. Whether using the IDF or NCEP definition as the gold standard, the simplified definition showed high specificity and NPV, which means its high ability in identifying non-MetS children. However, the sensitivity and PPV seemed a little lower, which suggests that potential MetS children can be identified by the simplified definition but they may require further diagnosis. It is encouraging that replacing complex cut-offs (i.e., age- and sex- specific WC percentile values for defining central obesity, and additional height- specific BP percentile values for defining high BP) with simple static cut-offs did not appear to sacrifice the performance or accuracy in identifying pediatric MetS risk.
The existing widely used pediatric MetS definitions are intended for use among children aged 10 years or older. For instance, the IDF and NCEP definitions were designed for use in youths aged 10–17 years and 12–19 years, respectively. It is well-documented that metabolic abnormalities such as insulin resistance and dyslipidaemia are already prevalent in prepubertal children aged 10 years and under [
26,
27]. A recent prospective cohort study showed that childhood CMRFs were positively associated with adulthood cardiovascular events [
28]. Another longitudinal study showed that controlling obesity and related CMRFs during the prepubertal stage appeared to be critical in preventing pubertal MetS effectively [
27]. Additionally, a recent systematic review suggested the importance of initiating the prevention of atherosclerosis in early life [
29]. Considering the increasing prevalence of MetS and CMRFs clustering in prepubertal children and its far-reaching health implications [
2,
30], early diagnosis of the MetS among prepubertal children is also warranted [
31]. The proposed simplified definition addresses this gap by enabling MetS risk assessment for both prepubertal and pubertal children from ages 6 to 17 years. However, the performance of the simplified definition can not be validated for children aged 6–11 years in current study because of unavailability of gold standard in this specific age group. In addition, our proposed simplified definition used static cut-offs for defining central obesity and elevated BP, which is very convenient and easy-to-apply for rapid screening in clinical practice compared with two widely used existing definitions (e.g., IDF or NCEP definition).
Apart from developing simplified ‘monitoring level’ definition for MetS risk monitoring at conservative population level, we also proposed a ‘action level’ definition with more stringent cut-offs to guide pediatric clinical practice to identify severely affected youths who require an immediate intervention. The ‘action level’ definition also includes meeting at least 3 of the same 5 components, but the cut-offs for defining the 5 components are set more stringently. In our pooled population, the total MetS prevalence estimates at ‘monitoring level’ and ‘action level’ were 6.2% and 1.2% in adolescents aged 12–17 years, respectively. The development of both monitoring and action level definitions may be better to guide clinical practice for identifying severity of MetS risk [
32]. The monitoring level definition identifies at-risk youths who requires close monitoring and observation whereas the action level identifies severely at-risk youths who require a timely intervention to ameliorate the risk profile. It is potentially useful for applications of simplified pediatric MetS definition in clinical practice for early detection of MetS, risk stratification, and targeted interventions.
A recent review commented that developing a consistent global definition of pediatric MetS currently faced several challenges, including the variations in child anthropometric and metabolic characteristics by race/ethnicity or geographic regions or pubertal stages, and a single definition can not differentiate the severity of MetS risk [
3]. In the process of developing the simplified definition, we attempted to overcome these challenges by incorporating specific WHtR cut-offs for different racial/ethnic groups and geographic areas), and different cut-offs of BP or TG for younger children and older adolescents accounting for pubertal stages. Furthermore, we developed two level definitions (monitoring and action levels) to assess severity of MetS, as recommended by the American Heart Association [
33].
Limitations
First, although we conducted a large-scale validation for the simplified definition in a diverse mixed sample of adolescents aged 12–17 years from 9 countries, further validation in more geographically representative and multi-racial/ethnic samples is warranted to ensure its applicability across diverse populations. Second, we defined central obesity using international WC 90th percentile values rather than individual population-specific 90th WC references (in consideration of the variation of WC across countries/races). We did this just for the direct comparison between countries using a unified international WC reference. However, the validation should be conducted based on population-specific WC references in future when individual population-specific WC references are available. Third, we just assessed the application of pediatric MetS in adolescents aged 12–17 years, as the IDF or NCEP definition was only recommended to be applied in adolescents aged ≥ 10 years or ≥ 12 years, and there is no “gold standard” for children aged < 10 years which we can use for the validation. Future research also should assess the performance of simplified definition in children aged 6–11 years, and subclinical vascular damage may be the optimal outcome to assess the impact of MetS in younger children. Fourth, our study was cross-sectionally designed and causality inference should not be made. Further rigorous epidemiological studies including prospective follow-up study and even clinical implementation are warranted to assess the utility and long-term prognostic value of MetS risk estimated by the proposed simplified definition in predicting future cardiovascular outcomes later in life. Fifth, the practicality of assessing multiple components in routine pediatric care settings is still insufficient, as the current definition of pediatric MetS requests at least three of five components according to the IDF or NCEP definition. Future studies should consider this challenge.
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