Introduction
Methods
Study design, setting and participants
Baseline measures
Exposures
Follow-up and outcome
Statistical methods
Results
Sex-specific tertiles of total physical activity (METh/day)
| Low | Medium | High |
P value |
---|---|---|---|---|
Male
| 21.8–34.5 | > 34.5–45.8 | > 45.8–140.7 | |
Female
| 22.0–31.7 | > 31.7–38.2 | > 38.2–128.9 | |
Overall population
| ||||
Number of participants | 10,527 | 10,527 | 10,527 | |
Age (years), mean (SD) | 50.7 (16.0) | 48.9 (15.0) | 47.6 (16.2) | 0.00 |
BMI (kg/m2), mean (SD) | 24.8 (3.7) | 24.4 (3.4) | 24.2 (3.3) | 0.00 |
Normal, < 25 kg/m2 (%) | 57.5 | 62.4 | 65.4 | 0.00 |
Overweight, 25–29.9 kg/m2 (%) | 33.7 | 31.6 | 29.3 | |
Obese, ≥ 30 kg/m2 (%) | 8.8 | 6.0 | 5.4 | |
Waist circumference (cm), mean (SD) | 85.7 (12.0) | 84.0 (11.6) | 82.8 (11.4) | 0.00 |
Normal < 94 cm | 75.4 | 80.1 | 82.5 | |
Central obesity, ≥ 94 cm—< 102 cm (%) | 15.3 | 13.1 | 12.0 | |
Severe central obesity, ≥ 102 cm (%) | 9.4 | 6.8 | 5.5 | |
Smoking (%) | 0.00 | |||
Never | 63.8 | 64.5 | 66.7 | |
Former | 27.7 | 27.8 | 25.4 | |
Current | 8.6 | 7.7 | 7.9 | |
Alcohol consumption (%) | 0.00 | |||
≤ 3 times/month | 47.1 | 45.6 | 46.3 | |
1–6 times/week | 50.7 | 52.7 | 52.0 | |
> 1 time/day | 2.3 | 1.8 | 1.7 | |
Level of education, ≥ 13 years (%) | 31.7 | 34.6 | 25.3 | 0.00 |
Diabetes, yes (%) | 2.1 | 1.8 | 1.9 | 0.38 |
Lipid disturbance, yes (%) | 2.8 | 2.0 | 2.2 | 0.00 |
Hypertension, yes (%) | 11.4 | 8.9 | 8.4 | 0.00 |
Daily aspirin use, yes (%) | 20.0 | 18.5 | 17.1 | 0.00 |
Leisure time physical activity, METh/day (%) | ||||
Low, ≤ 1.6 METh/day | 49.3 | 30.5 | 21.6 | 0.00 |
Medium, > 1,6–3.6 METh/day | 34.9 | 36.5 | 28.8 | |
High, > 3.6 METh/day | 15.8 | 33.1 | 49.6 | |
Sitting time, ≥ 6 h/day (%) | 41.3 | 47.0 | 17.3 | 0.00 |
Male
| ||||
Number of participants | 3,575 | 3,575 | 3,575 | |
Age (years), mean (SD) | 50.9 (16.6) | 50.9 (16.2) | 48.9 (18.1) | 0.00 |
BMI (kg/m2), mean (SD) | 25.1 (3.3) | 24.9 (2.8) | 24.8 (2.9) | 0.00 |
Normal, < 25 kg/m2 (%) | 52.2 | 55.8 | 57.3 | |
Overweight, 25–29.9 kg/m2 (%) | 40.8 | 39.7 | 37.9 | |
Obese, ≥ 30 kg/m2 (%) | 7.1 | 4.5 | 4.7 | |
Waist circumference (cm), mean (SD) | 94.0 (10.9) | 92.3 (10.1) | 91.4 (10.8) | 0.00 |
Normal < 94 cm | 48.6 | 56.6 | 58.6 | |
Central obesity, ≥ 94 cm—< 102 cm (%) | 30.4 | 28.1 | 27.6 | |
Severe central obesity, ≥ 102 cm (%) | 21.0 | 15.3 | 13.7 | |
Smoking (%) | 0.00 | |||
Never | 60.8 | 63.0 | 65.7 | |
Former | 31.2 | 30.7 | 28.0 | |
Current | 8.0 | 6.4 | 6.3 | |
Alcohol consumption (%) | 0.21 | |||
≤ 3 times/month | 29.5 | 31.0 | 30.9 | |
1–6 times/week | 66.7 | 65.5 | 66.2 | |
> 1 time/day | 3.8 | 3.5 | 3.0 | |
Level of education, ≥ 13 years (%) | 33.5 | 30.4 | 14.5 | 0.00 |
Diabetes, yes (%) | 2.8 | 2.5 | 2.5 | 0.71 |
Lipid disturbance, yes (%) | 2.7 | 2.3 | 2.4 | 0.59 |
Hypertension, yes (%) | 10.6 | 9.4 | 9.2 | 0.10 |
Daily aspirin use, yes (%) | 16.3 | 15.3 | 14.4 | 0.09 |
Leisure time physical activity, METh/day (%) | ||||
Low, ≤ 1.6 METh/day | 49.3 | 27.7 | 25.3 | 0.00 |
Medium, > 1,6–3.6 METh/day | 35.6 | 35.9 | 28.2 | |
High, > 3.6 METh/day | 15.1 | 36.4 | 46.5 | |
Sitting time, ≥ 6 h/day (%) | 49.8 | 41.5 | 9.9 | 0.00 |
Female
| ||||
Number of participants | 6,952 | 6,952 | 6,951 | |
Age (years), mean (SD) | 50.5 (15.7) | 47.9 (14.2) | 46.9 (15.1) | 0.00 |
BMI (kg/m2), mean (SD) | 24.7 (3.9) | 24.2 (3.6) | 23.9 (3.4) | 0.00 |
Normal, < 25 kg/m2 (%) | 60.3 | 65.8 | 69.5 | |
Overweight, 25–29.9 kg/m2 (%) | 30.0 | 27.4 | 24.8 | |
Obese, ≥ 30 kg/m2 (%) | 9.7 | 6.8 | 5.7 | |
Waist circumference (cm), mean (SD) | 81.9 (10.5) | 80.3 (10.2) | 79.1 (9.6) | 0.00 |
Normal < 80 cm (%) | 43.9 | 51.4 | 56.7 | |
Central obesity, ≥ 80 cm – < 88 cm (%) | 30.3 | 29.0 | 26.4 | |
Severe central obesity, ≥ 88 cm (%) | 25.8 | 19.6 | 16.9 | |
Smoking (%) | 0.03 | |||
Never | 65.2 | 65.2 | 67.1 | |
Former | 25.9 | 26.4 | 24.1 | |
Current | 8.9 | 8.4 | 8.8 | |
Alcohol consumption (%) | 0.00 | |||
≤ 3 times/month | 56.2 | 53.1 | 54.2 | |
1–6 times/week | 42.4 | 46.0 | 44.8 | |
> 1 time/day | 1.5 | 0.92 | 1.0 | |
Level of education, ≥ 13 years (%) | 30.8 | 36.8 | 30.8 | 0.00 |
Diabetes, yes (%) | 1.7 | 1.5 | 1.6 | 0.54 |
Lipid disturbance, yes (%) | 2.8 | 1.8 | 2.1 | 0.00 |
Hypertension, yes (%) | 11.9 | 8.6 | 8.0 | 0.00 |
Daily aspirin use, yes (%) | 21.9 | 20.1 | 18.4 | 0.00 |
Use of contraceptive pills, yes (%) | 65.1 | 71.0 | 68.6 | 0.00 |
Use of hormone replacement therapy, yes (%) | 29.8 | 25.5 | 22.9 | 0.00 |
Leisure time physical activity, METh/day (%) | 0.00 | |||
Low, ≤ 1.5 METh/day | 49.3 | 31.8 | 19.8 | |
Medium, > 1,5–3,1 METh/day | 34.5 | 36.7 | 29.1 | |
High > 3,1 METh/day | 16.2 | 31.5 | 51.1 | |
Sitting time, ≥ 6 h/day (%) | 37.0 | 49.8 | 21.2 | 0.00 |
Total physical activity
Sex-specific tertiles of total physical activity (METh/day)
| Continuous (per 1METh/day increase) | Low | Medium | High |
P for linear trend |
---|---|---|---|---|---|
Male
| 21.8–34.5 | > 34.5–45.8 | > 45.8–140.7 | ||
Female
| 22.0–31.7 | > 31.7–38.2 | > 38.2–128.9 | ||
Total
| |||||
Myocardial infarction | |||||
Number of events | 599 | 523 | 499 | ||
Person-years (py) | 186,508 | 189,339 | 189,636 | ||
Event rate per 100,000 pya
| 321.2 | 276.2 | 263.1 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.98 (0.87–1.10) | 0.96 (0.85–1.08) | 0.51 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.03 (0.91–1.17) | 0.95 (0.83–1.08) | 0.34 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.04 (0.91–1.18) | 0.96 (0.84–1.10) | 0.48 |
Male
| |||||
Myocardial infarction | |||||
Number of events | 302 | 297 | 315 | ||
Person-years | 61,118 | 61,686 | 61,840 | ||
Event rate per 100,000 pya
| 494.1 | 481.5 | 509.4 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.97 (0.83–1.14) | 1.08 (0.92–1.26) | 0.26 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.99 (0.84–1.18) | 1.06 (0.89–1.26) | 0.48 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.05 (0.88–1.25) | 1.12 (0.93–1.34) | 0.24 |
Female
| |||||
Myocardial infarction | |||||
Number of events | 297 | 226 | 184 | ||
Person-years | 125,391 | 127,653 | 127,797 | ||
Event rate per 100,000 pya
| 236.9 | 177.0 | 144.0 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.01 (0.85–1.20) | 0.82 (0.68–0.98) | 0.02 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.11 (0.92–1.34) | 0.82 (0.67–1.00) | 0.03 |
HR (95% CI)c
| 0.99 (0.98–0.99) | 1.00 (reference) | 1.07 (0.88–1.31) | 0.78 (0.63–0.97) | 0.02 |
Sex-specific tertiles of total physical activity (METh/day)
| Continuous (per1METh/day increase) | Low | Medium | High |
P value for trend |
---|---|---|---|---|---|
Male
| 21.8–34.5 | > 34.5–45.8 | > 45.8–140.7 | ||
Female
| 22.0–31.7 | > 31.7–38.2 | > 38.2–128.9 | ||
Total
| |||||
Stroke, ischemic and hemorrhagic | |||||
Number of events | 680 | 621 | 578 | ||
Person-years (py) | 186,105 | 188,926 | 189,091 | ||
Event rate per 100,000 pya
| 365.3 | 328.7 | 305.7 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.05 (0.94–1.17) | 1.00 (0.89–1.12) | 0.84 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.04 (0.92–1.17) | 0.99 (0.88–1.12) | 0.76 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.09 (0.96–1.23) | 1.04 (0.92–1.19) | 0.66 |
Stroke, ischemic | |||||
Number of events | 468 | 397 | 408 | ||
Person-years | 186,105 | 188,926 | 189,091 | ||
Event rate per 100,000 pya
| 251.5 | 210.1 | 215.8 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.99 (0.86–1.13) | 1.03 (0.90–1.18) | 0.58 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.97 (0.84–1.12) | 1.02 (0.88–1.18) | 0.73 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.02 (0.87–1.19) | 1.07 (0.92–1.25) | 0.34 |
Stroke, hemorrhagic | |||||
Number of events | 114 | 114 | 84 | ||
Person-years | 186,105 | 188,926 | 189,091 | ||
Event rate per 100,000 pya
| 61.3 | 60.3 | 44.4 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.11 (0.85–1.44) | 0.83 (0.63–1.11) | 0.13 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.08 (0.81–1.42) | 0.85 (0.63–1.14) | 0.20 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.15 (0.86–1.54) | 0.93 (0.68–1.27) | 0.48 |
Male
| |||||
Stroke, ischemic and hemorrhagic | |||||
Number of events | 254 | 289 | 285 | ||
Person-years | 61,492 | 61,944 | 62,055 | ||
Event rate per 100,000 pya
| 413.1 | 466.6 | 459.3 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.13 (0.95–1.34) | 1.15 (0.97–1.37) | 0.15 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.10 (0.92–1.32) | 1.12 (0.93–1.35) | 0.29 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.13 (0.94–1.37) | 1.14 (0.94–1.39) | 0.25 |
Stroke, ischemic | |||||
Number of events | 178 | 194 | 205 | ||
Person-years | 61,492 | 61,944 | 62,055 | ||
Event rate per 100,000 pya
| 289.5 | 313.2 | 330.4 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.08 (0.88–1.33) | 1.18 (0.97–1.48) | 0.10 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.07 (0.86–1.34) | 1.18 (0.94–1.47) | 0.16 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.13 (0.90–1.42) | 1.21 (0.96–1.52) | 0.14 |
Stroke, hemorrhagic | |||||
Number of events | 45 | 44 | 37 | ||
Person-years | 61,492 | 61,944 | 62,055 | ||
Event rate per 100,000 pya
| 73.2 | 71.0 | 9.6 | ||
HR (95% CI)a
| 1.00 (0.98–1.00) | 1.00 (reference) | 0.97 (0.64–1.47) | 0.85 (0.55–1.31) | 0.44 |
HR (95% CI)b
| 0.99 (0.98–1.00) | 1.00 (reference) | 0.82 (0.52–1.27) | 0.78 (0.49–1.23) | 0.34 |
HR (95% CI)c
| 0.99 (0.98–1.00) | 1.00 (reference) | 0.82 (0.51–1.30) | 0.83 (0.51–1.33) | 0.51 |
Female
| |||||
Stroke, ischemic and hemorrhagic | |||||
Number of events | 426 | 332 | 293 | ||
Person-years | 124,613 | 126,982 | 127,036 | ||
Event rate per 100,000 pya
| 341.9 | 261.5 | 230.6 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.00 (0.87–1.16) | 0.89 (0.77–1.04) | 0.12 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.00 (0.86–1.18) | 0.91 (0.77–1.07) | 0.21 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 1.07 (0.91–1.26) | 0.98 (0.83–1.17) | 0.74 |
Stroke, ischemic | |||||
Number of events | 290 | 203 | 203 | ||
Person-years | 124,612 | 126,982 | 127,036 | ||
Event rate per 100,000 pya
| 232.7 | 159.9 | 159.8 | ||
HR (95% CI)a
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.92 (0.77–1.10) | 0.93 (0.77–1.11) | 0.46 |
HR (95% CI)b
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.91 (0.75–1.11) | 0.92 (0.76–1.12) | 0.45 |
HR (95% CI)c
| 1.00 (0.99–1.00) | 1.00 (reference) | 0.96 (078–1.17) | 1.00 (0.82–1.23) | 0.94 |
Stroke, hemorrhagic | |||||
Number of events | 69 | 70 | 47 | ||
Person-years | 124,613 | 126,982 | 127,036 | ||
Event rate per 100,000 pya
| 55.4 | 55.1 | 37.0 | ||
HR (95% CI)a
| 0.99 (0.98–1.00) | 1.00 (reference) | 1.21 (0.86–1.69) | 0.82 (0.56–1.19) | 0.19 |
HR (95% CI)b
| 0.99 (0.97–1.00) | 1.00 (reference) | 1.30 (0.91–1.86) | 0.90 (0.61–1.34) | 0.40 |
HR (95% CI)c
| 0.99 (0.98–1.00) | 1.00 (reference) | 1.45 (0.99–2.11) | 1.01 (0.67–1.53) | 0.73 |
Leisure time physical activity
Sex-specific tertiles of leisure
time physical activity (METh/day)
| Continuous (per 1METh/day increase) | Low | Medium | High |
P for linear trend |
---|---|---|---|---|---|
Male
| 0–1.6 | > 1.6–3.6 | > 3.6–16.3 | ||
Female
| 0–1.5 | > 1.5–3.1 | > 3.1–16.3 | ||
Total
| |||||
Myocardial infarction | |||||
Number of events | 428 | 404 | 250 | ||
Person-years (py) | 148,444 | 145,680 | 147,299 | ||
Event rate per 100,000 pya
| 288.3 | 277.3 | 169.7 | ||
HR (95% CI)a
| 0.96 (0.94–0.99) | 1.00 (reference) | 0.88 (0.77–1.01) | 0.75 (0.64–0.87) | 0.00 |
HR (95% CI)b
| 0.98 (0.95–1.01) | 1.00 (reference) | 0.92 (0.79–1.06) | 0.81 (0.68–0.95) | 0.01 |
HR (95% CI)c
| 0.97 (0.94–1.01) | 1.00 (reference) | 0.89 (0.76–1.03) | 0.79 (0.66–0.94) | 0.01 |
Male
| |||||
Myocardial infarction | |||||
Number of events | 234 | 239 | 143 | ||
Person-years | 47,753 | 46,096 | 47,342 | ||
Event rate per 100,000 pya
| 490.0 | 518.5 | 302.1 | ||
HR (95% CI)a
| 0.98 (0.95–1.01) | 1.00 (reference) | 0.92 (0.77–1.11) | 0.76 (0.61–0.93) | 0.01 |
HR (95% CI)b
| 0.99 (0.96–1.03) | 1.00 (reference) | 0.96 (0.79–1.17) | 0.80 (0.64–1.00) | 0.04 |
HR (95% CI)c
| 0.99 (0.96–1.03) | 1.00 (reference) | 0.96 (0.78–1.17) | 0.78 (0.62–0.98) | 0.03 |
Female
| |||||
Myocardial infarction | |||||
Number of events | 194 | 165 | 107 | ||
Person-years | 100,691 | 99,584 | 99,957 | ||
Event rate per 100,000 pya
| 192.7 | 165.7 | 107.0 | ||
HR (95% CI)a
| 0.92 (0.87–0.97) | 1.00 (reference) | 0.83 (0.67–1.02) | 0.74 (0.58–0.93) | 0.01 |
HR (95% CI)b
| 0.93 (0.88–0.99) | 1.00 (reference) | 0.86 (0.68–1.07) | 0.82 (0.64–1.06) | 0.14 |
HR (95% CI)c
| 0.92 (0.87–0.98) | 1.00 (reference) | 0.80 (0.63–1.01) | 0.80 (0.61–1.04) | 0.10 |
Sex-specific tertiles of leisure time physical activity (METh/day)
| Continuous (per 1METh/day increase) | Low | Medium | High |
P for linear trend |
---|---|---|---|---|---|
Male
| 0–1.6 | > 1.6–3.6 | > 3.6–16.3 | ||
Female
| 0–1.5 | > 1.5–3.1 | > 3.1–16.3 | ||
Total
| |||||
Stroke, ischemic and hemorrhagic | |||||
Number of events | 490 | 461 | 307 | ||
Person-years (py) | 148,334 | 145,194 | 147,037 | ||
Event rate per 100,000 pya
| 330.3 | 317.5 | 208.8 | ||
HR (95% CI)a
| 0.96 (0.94–0.99) | 1.00 (reference) | 0.88 (0.77–1.00) | 0.79 (0.69–0.91) | 0.01 |
HR (95% CI)b
| 0.97 (0.94–0.99) | 1.00 (reference) | 0.92 (0.80–1.05) | 0.83 (0.71–0.97) | 0.02 |
HR (95% CI)c
| 0.97 (0.94–1.00) | 1.00 (reference) | 0.93 (0.81–1.07) | 0.86 (0.73–1.00) | 0.06 |
Stroke, ischemic | |||||
Number of events | 332 | 313 | 213 | ||
Person-years | 148,334 | 145,194 | 147,037 | ||
Event rate per 100,000 pya
| 223.8 | 215.6 | 144.9 | ||
HR (95% CI)a
| 0.97 (0.94–1.01) | 1.00 (reference) | 0.87 (0.75–1.02) | 0.81 (0.69–0.97) | 0.02 |
HR (95% CI)b
| 0.99 (0.95–1.02) | 1.00 (reference) | 0.93 (0.79–1.10) | 0.87 (0.72–1.04) | 0.14 |
HR (95% CI)c
| 0.99 (0.96–1.02) | 1.00 (reference) | 0.93 (0.78–1.10) | 0.90 (0.74–1.09) | 0.31 |
Stroke, hemorrhagic | |||||
Number of events | 96 | 75 | 58 | ||
Person-years | 148,334 | 145,194 | 147,037 | ||
Event rate per 100,000 pya
| 64.7 | 51.7 | 39.4 | ||
HR (95% CI)a
| 0.93 (0.87–0.99) | 1.00 (reference) | 0.74 (0.55–1.01) | 0.75 (0.54–1.04) | 0.09 |
HR (95% CI)b
| 0.93 (0.86–0.99) | 1.00 (reference) | 0.76 (0.55–1.04) | 0.74 (0.53–1.05) | 0.11 |
HR (95% CI)c
| 0.93 (0.86–0.99) | 1.00 (reference) | 0.76 (0.55–1.06) | 0.75 (0.52–1.08) | 0.14 |
Male
| |||||
Stroke, ischemic and hemorrhagic | |||||
Number of events | 203 | 221 | 127 | ||
Person-years | 48,129 | 46,193 | 47,516 | ||
Event rate per 100,000 pya
| 421.8 | 478.4 | 267.3 | ||
HR (95% CI)a
| 0.97 (0.93–1.00) | 1.00 (reference) | 0.96 (0.79–1.16) | 0.75 (0.60–0.94) | 0.01 |
HR (95% CI)b
| 0.97 (0.94–1.01) | 1.00 (reference) | 0.95 (0.77–1.16) | 0.78 (0.61–0.98) | 0.03 |
HR (95% CI)c
| 0.97 (0.93–1.01) | 1.00 (reference) | 0.94 (0.76–1.16) | 0.78 (0.61–0.99) | 0.04 |
Stroke, ischemic | |||||
Number of events | 147 | 146 | 95 | ||
Person-years | 48,129 | 46,193 | 47,516 | ||
Event rate per 100,000 pya
| 305.4 | 316.1 | 199.9 | ||
HR (95% CI)a
| 0.98 (0.94–1.03) | 1.00 (reference) | 0.87 (0.69–1.09) | 0.77 (0.60–1.00) | 0.06 |
HR (95% CI)b
| 0.99 (0.95–1.03) | 1.00 (reference) | 0.84 (0.66–1.08) | 0.77 (0.58–1.01) | 0.07 |
HR (95% CI)c
| 0.98 (0.94–1.03) | 1.00 (reference) | 0.82 (0.64–1.06) | 0.75 (0.56–1.00) | 0.06 |
Stroke, hemorrhagic | |||||
Number of events | 35 | 41 | 20 | ||
Person-years | 48,129 | 46,193 | 47,516 | ||
Event rate per 100,000 pya
| 72.7 | 88.8 | 42.1 | ||
HR (95% CI)a
| 0.93 (0.85–1.02) | 1.00 (reference) | 1.08 (0.69–1.70) | 0.70 (0.40–1.21) | 0.18 |
HR (95% CI)b
| 0.96 (0.87–1.05) | 1.00 (reference) | 1.14 (0.70–1.86) | 0.83 (0.47–1.48) | 0.49 |
HR (95% CI)c
| 0.96 (0.87–1.06) | 1.00 (reference) | 1.16 (0.69–1.93) | 0.87 (0.48–1.58) | 0.59 |
Female
| |||||
Stroke, ischemic and hemorrhagic | |||||
Number of events | 287 | 240 | 180 | ||
Person-years | 100,205 | 99,001 | 99,522 | ||
Event rate per 100,000 pya
| 286.4 | 242.4 | 180.9 | ||
HR (95% CI)a
| 0.95 (0.92–0.99) | 1.00 (reference) | 0.82 (0.69–0.97) | 0.82 (0.68–0.99) | 0.05 |
HR (95% CI)b
| 0.96 (0.92–1.00) | 1.00 (reference) | 0.89 (0.74–1.07) | 0.88 (0.72–1.07) | 0.23 |
HR (95% CI)c
| 0.97 (0.93–1.02) | 1.00 (reference) | 0.92 (0.76–1.11) | 0.91 (0.74–1.13) | 0.43 |
Stroke, ischemic | |||||
Number of events | 185 | 167 | 118 | ||
Person-years | 100,205 | 99,0001 | 99,522 | ||
Event rate per 100,000 pya
| 184.6 | 168.7 | 118.6 | ||
HR (95% CI)a
| 0.96 (0.92–1.01) | 1.00 (reference) | 0.88 (0.72–1.09) | 0.85 (0.67–1.07) | 0.17 |
HR (95% CI)b
| 0.98 (0.93–1.03) | 1.00 (reference) | 1.00 (0.80–1.25) | 0.95 (0.74–1.23) | 0.70 |
HR (95% CI)c
| 0.99 (0.94–1.05) | 1.00 (reference) | 1.02 (0.80–1.28) | 1.03 (0.79–1.33) | 0.84 |
Stroke, hemorrhagic | |||||
Number of events | 61 | 34 | 38 | ||
Person-years | 100,205 | 99,001 | 99,521 | ||
Event rate per 100,000 pya
| 60.9 | 34.4 | 38.2 | ||
HR (95% CI)a
| 0.92 (0.84–1.02) | 1.00 (reference) | 0.55 (0.36–0.83) | 0.78 (0.52–1.18) | 0.30 |
HR (95% CI)b
| 0.89 (0.80–0.99) | 1.00 (reference) | 0.53 (0.35–0.84) | 0.69 (0.45–1.08) | 0.14 |
HR (95% CI)c
| 0.89 (0.80–0.99) | 1.00 (reference) | 0.56 (0.36–0.88) | 0.70 (0.44–1.09) | 0.15 |