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European Journal of Applied Physiology

Erschienen in:

01.03.2020 | Original Article

Biological variation of arginine vasopressin

verfasst von: Kurt J. Sollanek, Jeffery S. Staab, Robert W. Kenefick, Samuel N. Cheuvront

Erschienen in: European Journal of Applied Physiology | Ausgabe 3/2020

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Abstract

Purpose

There is growing interest in the measurement of plasma levels of arginine vasopressin (AVP) for the assessment of mild dehydration. However, the principles of biological variation have not been applied to the study of AVP and understanding biological variation of AVP may provide insights regarding measurement thresholds. The purpose of this investigation was to determine the biological variation of AVP in healthy euhydrated individuals to understand the potential for establishing both static and/or change thresholds of importance.

Methods

We studied 29 healthy volunteers (24 men and 5 women) while controlling for hydration and pre-analytical factors. All subjects completed between 2–8 trials where biological variation was determined using widely published methods. We determined the intraindividual, interindividual, and analytical coefficients of variation (CV_I, CV_G, and CV_A, respectively) and subsequently the index of individuality and heterogeneity (II and IH, respectively).

Results

AVP did not reach the IH threshold required to be considered useful in the dynamic assessment of physiological deviations from normal. AVP levels approached the II threshold required to be considered useful in the static assessment of physiological deviations from normal.

Conclusions

This analysis demonstrates that AVP assessment is unlikely to yield useful information about hydration status.

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Titel: Biological variation of arginine vasopressin
verfasst von: Kurt J. Sollanek
Jeffery S. Staab
Robert W. Kenefick
Samuel N. Cheuvront
Publikationsdatum: 01.03.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 3/2020
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-020-04303-x

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Abstract

Purpose

Methods

Results

Conclusions

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