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Erschienen in: InFo Hämatologie + Onkologie 3/2024

20.03.2024 | Brachytherapie | Schwerpunkt

Schwerpunkt Zervixkarzinom

Radiochemotherapie des Zervixkarzinoms*

verfasst von: Dr. Alina Sturdza, Dr. Johannes Knoth

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 3/2024

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Das lokal fortgeschrittene Zervixkarzinom ist eine schwerwiegende Erkrankung, bei der eine interdisziplinäre Therapie das Optimum darstellt. Die Behandlung besteht ab dem Stadium cT1b2/T2a2 N0 bzw. bei Vorliegen von Lymphknotenmetastasen aus einer primären Radiochemotherapie. Über Vorgehen und aktuellen Forschungsstand informiert Sie dieser Beitrag. …
Literatur
2.
Zurück zum Zitat Bhatla N et al. Cancer of the cervix uteri. Int J Gynaecol Obstet. 2018;143(2):22-36 Bhatla N et al. Cancer of the cervix uteri. Int J Gynaecol Obstet. 2018;143(2):22-36
3.
Zurück zum Zitat Knoth J et al. Clinical and imaging findings in cervical cancer and their impact on FIGO and TNM staging—An analysis from the EMBRACE study. Gynecol Oncol. 2020;159(1):136-41 Knoth J et al. Clinical and imaging findings in cervical cancer and their impact on FIGO and TNM staging—An analysis from the EMBRACE study. Gynecol Oncol. 2020;159(1):136-41
4.
Zurück zum Zitat Lucia F et al. Multicentric development and evaluation of (18)F-FDG PET/CT and MRI radiomics models to predict para-aortic lymph node involvement in locally advanced cervical cancer. Eur J Nucl Med Mol Imaging. 2023;50(8):2514-28 Lucia F et al. Multicentric development and evaluation of (18)F-FDG PET/CT and MRI radiomics models to predict para-aortic lymph node involvement in locally advanced cervical cancer. Eur J Nucl Med Mol Imaging. 2023;50(8):2514-28
5.
Zurück zum Zitat Su CH et al. Survival effect of pre-RT PET-CT on cervical cancer: Image-guided intensity-modulated radiation therapy era. Front Oncol. 2023;13:1012491 Su CH et al. Survival effect of pre-RT PET-CT on cervical cancer: Image-guided intensity-modulated radiation therapy era. Front Oncol. 2023;13:1012491
6.
Zurück zum Zitat Weyl A et al. PET-MRI for evaluation of response to radiochemotherapy in patients with locally advanced cervical cancer. Int J Gynecol Cancer. 2023;33(5):676-82 Weyl A et al. PET-MRI for evaluation of response to radiochemotherapy in patients with locally advanced cervical cancer. Int J Gynecol Cancer. 2023;33(5):676-82
7.
Zurück zum Zitat Cibula D et al. ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer - Update 2023. Radiother Oncol. 2023:184:109682 Cibula D et al. ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer - Update 2023. Radiother Oncol. 2023:184:109682
8.
Zurück zum Zitat Rose PG et al. Nomograms predicting progression-free survival, overall survival, and pelvic recurrence in locally advanced cervical cancer developed from an analysis of identifiable prognostic factors in patients from NRG oncology/gynecologic oncology group randomized trials of Chemoradiotherapy. J Clin Oncol. 2015;33(19):2136-42 Rose PG et al. Nomograms predicting progression-free survival, overall survival, and pelvic recurrence in locally advanced cervical cancer developed from an analysis of identifiable prognostic factors in patients from NRG oncology/gynecologic oncology group randomized trials of Chemoradiotherapy. J Clin Oncol. 2015;33(19):2136-42
9.
Zurück zum Zitat Xue R et al. The efficacy of concurrent weekly carboplatin with radiotherapy in the treatment of cervical cancer: a meta-analysis. Gynecol Oncol. 2018;150(3):412-19 Xue R et al. The efficacy of concurrent weekly carboplatin with radiotherapy in the treatment of cervical cancer: a meta-analysis. Gynecol Oncol. 2018;150(3):412-19
10.
Zurück zum Zitat Lorvidhaya V et al. Concurrent mitomycin C, 5-fluorouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: a randomized trial. Int J Radiat Oncol Biol Phys. 2003;55(5):1226-32 Lorvidhaya V et al. Concurrent mitomycin C, 5-fluorouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: a randomized trial. Int J Radiat Oncol Biol Phys. 2003;55(5):1226-32
11.
Zurück zum Zitat Tanderup K et al. Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer. Radiother Oncol. 2016;120(3):441-46 Tanderup K et al. Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer. Radiother Oncol. 2016;120(3):441-46
12.
Zurück zum Zitat Pötter R et al. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study. Lancet Oncol. 2021;22(4):538-47 Pötter R et al. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study. Lancet Oncol. 2021;22(4):538-47
13.
Zurück zum Zitat Sturdza A et al. Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study. Radiother Oncol. 2016;120(3):428-33 Sturdza A et al. Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study. Radiother Oncol. 2016;120(3):428-33
14.
Zurück zum Zitat Petric P et al. Results of image guided brachytherapy for stage IB cervical cancer in the RetroEMBRACE study. Radiother Oncol. 2021;157:24-31 Petric P et al. Results of image guided brachytherapy for stage IB cervical cancer in the RetroEMBRACE study. Radiother Oncol. 2021;157:24-31
15.
Zurück zum Zitat Schmid MP et al. Risk factors for local failure following Chemoradiation and magnetic resonance image-guided Brachytherapy in locally advanced cervical cancer: results from the EMBRACE-I study. J Clin Oncol. 2023;41(10):1933-42 Schmid MP et al. Risk factors for local failure following Chemoradiation and magnetic resonance image-guided Brachytherapy in locally advanced cervical cancer: results from the EMBRACE-I study. J Clin Oncol. 2023;41(10):1933-42
16.
Zurück zum Zitat Sturdza AE et al. Nomogram predicting overall survival in patients with locally advanced cervical cancer treated with Radiochemotherapy including image-guided Brachytherapy: a retro-EMBRACE study. Int J Radiat Oncol Biol Phys. 2021;111(1):168-77 Sturdza AE et al. Nomogram predicting overall survival in patients with locally advanced cervical cancer treated with Radiochemotherapy including image-guided Brachytherapy: a retro-EMBRACE study. Int J Radiat Oncol Biol Phys. 2021;111(1):168-77
17.
Zurück zum Zitat Fokdal L et al. Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: analysis from the retroEMBRACE study. Radiother Oncol. 2016;120(3):434-40 Fokdal L et al. Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: analysis from the retroEMBRACE study. Radiother Oncol. 2016;120(3):434-40
18.
Zurück zum Zitat Jensen NB et al. Dose-volume effects and risk factors for late diarrhea in cervix cancer patients after Radiochemotherapy with image guided adaptive Brachytherapy in the EMBRACE I study. Int J Radiat Oncol Biol Phys. 2021;109(3):688-700 Jensen NB et al. Dose-volume effects and risk factors for late diarrhea in cervix cancer patients after Radiochemotherapy with image guided adaptive Brachytherapy in the EMBRACE I study. Int J Radiat Oncol Biol Phys. 2021;109(3):688-700
19.
Zurück zum Zitat Spampinato S et al. Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021;158:312-20 Spampinato S et al. Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021;158:312-20
20.
Zurück zum Zitat Spampinato S et al. Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021;158:300-8 Spampinato S et al. Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021;158:300-8
21.
Zurück zum Zitat Vittrup AS et al. Persistence of late substantial patient-reported symptoms (LAPERS) after Radiochemotherapy including image guided adaptive Brachytherapy for locally advanced cervical cancer: a report from the EMBRACE study. Int J Radiat Oncol Biol Phys. 2021;109(1):161-73 Vittrup AS et al. Persistence of late substantial patient-reported symptoms (LAPERS) after Radiochemotherapy including image guided adaptive Brachytherapy for locally advanced cervical cancer: a report from the EMBRACE study. Int J Radiat Oncol Biol Phys. 2021;109(1):161-73
Metadaten
Titel
Schwerpunkt Zervixkarzinom
Radiochemotherapie des Zervixkarzinoms*
verfasst von
Dr. Alina Sturdza
Dr. Johannes Knoth
Publikationsdatum
20.03.2024
Verlag
Springer Medizin
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 3/2024
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-024-0496-2

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