Cannabidiol use and perceptions in France: a national survey

Cannabis contains a variety of cannabinoids, with Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) being the most studied. The former is responsible for the ‘high’ provoked by cannabis use and is associated with a risk of dependence. In contrast, CBD does not have a high affinity for brain cannabinoid receptor 1 and is ‘non-intoxicating’ [1]. Although CBD may have anxiolytic properties [2] a World Health Organization review concluded that CBD “exhibits no effects indicative of any abuse or dependence potential”, has a good safety profile, and that “there is no evidence of recreational use of CBD or any public health-related problems associated with the use of pure CBD” [3]. A meta-analysis recently confirmed CBD’s safety profile [4].

Consequently, CBD-based products are proliferating worldwide. However, legislation on the use of cannabis-based products differs from country to country, even in Europe [5]. In France, CBD as a prescription drug (Epidyolex) is only available for ‘compassionate use’. CBD as a food supplement, such as THC-deprived dried cannabis flowers, or used as an ingredient is legal if THC levels remain below 0.3%. Most CBD products can be purchased in specialized shops, pharmacies, and supermarkets (dried cannabis flowers cannot currently be purchased in pharmacies and supermarkets). However, this legal framework is probably confusing for most French citizens (as shown in a UK-based sample [6]). Indeed, cannabis use, including for therapeutic purposes, is criminalized in France. Previous governments have restricted access to CBD products based on a 1990 Ministerial Order prohibiting cannabis use. In December 2021, the government banned the sale of CBD-rich THC-deprived cannabis flowers to consumers, but this ban was provisionally suspended in January 2022 by the Council of State, deeming it disproportionate to the product’s harmfulness [7].

CBD has a wide potential therapeutic spectrum [2]. There is evidence supporting its usefulness to treat epilepsy, as illustrated by the approval of Epidyolex. However, for other conditions including anxiety, pain/inflammation, schizophrenia, substance use disorders, and post-traumatic stress disorder, evidence from human studies is mixed. For most of these conditions, there is a lack of well-powered randomized, placebo-controlled studies to draw definitive conclusions [8]. In terms of real-world data, studies have highlighted potential benefits of CBD for overall quality of health and/or wellbeing, pain, depression, anxiety, and symptom improvement, especially in patients experiencing moderate to severe symptoms [9, 10].

CBD products are often marketed as complementary health products rather than medicines. There are concerns over the labelling of these products and their quality (i.e., THC levels, presence of contaminants) in terms of consumer safety and public health [11, 12, 13, 14]. 

Well-being has been highlighted as a major reason to use CBD in France and the UK [17, 18]. However, some consumers also use it to relieve disease symptoms [17]. Cannabis is generally perceived as less harmful than other psychoactive substances [19], and there is a decreasing trend in its perceived harmfulness [20, 21, 22]. As a cannabis-derived compound, CBD is likely to benefit from this change in perception. Moreover, CBD is increasingly seen as a ‘natural product’ [6]. In Canada and the US, a study has found that CBD users are more likely to perceive CBD as good for health than non-users [23]. Although CBD is commonly perceived as safe in Europe [6], few studies on the subject have been published to date. Moreover, to the best of our knowledge, data on the prevalence of CBD use at the national level in European countries are only available in Germany, where 4.3% of individuals have ever used CBD [24]. Studies conducted in non-representative samples of populations have reported a prevalence of CBD use ranging from 10.9% [6] to 14% [25] in Europe, 26.1% in the US and 16.2% in Canada [23].

Finally, as the harms caused by CBD may vary according to one’s health status and pattern of use, it is important to characterize the profile of CBD users. In Germany, lifetime CBD use was greater among educated, urban, tobacco (ex-)users [24] and similar results have been found in other settings [23]. These studies must be reproduced in other contexts and where CBD is legal, within sub-groups of CBD users. For instance, cannabis-CBD co-users may have different demographic characteristics compared to CBD only users [26]. It is therefore key to assess the extent of CBD use in EU countries, evaluate its perceived harmfulness, and characterize the profile of CBD users.

We aimed to assess the prevalence of CBD use in France, characterize the profile of users, and highlight factors associated with its perceived harmfulness from a large web-based national survey of French adults.

In a national sample of adults in France, the prevalence of CBD use was 10%, while 30% had never heard of it. CBD use was associated with younger age, tobacco use, cannabis use, poor self-reported general health status, and a perception that alternative medicines provide better solutions to health problems than conventional medicines. Cluster analysis revealed four different user profiles based on socio-demographics and behavioural characteristics. Those who perceived CBD as harmless were more likely to use it.

To our knowledge, the present study is the first to assess the national prevalence of CBD use in France. The prevalence of CBD use in France is higher than in Germany (lifetime use of non-prescribed CBD was estimated at 4.3%, and current use at 1.1% [24]) but lower than in the US and Canada ( 26.1 and 16.2%, respectively [23]). These higher prevalences are partly explained by the fact that cannabis is more accessible in the US and Canada than in France. The survey in the US and Canada also found a positive association between cannabis use and CBD use. Similarly to other studies, our results confirm that a substantial proportion of those aware of CBD-based products did not have an opinion with regards to their harmfulness, and few perceived them as harmful [6, 23].

We did not find any association between CBD use and gender, educational level, and the difficulty to pay bills. However, we found an association with socio-professional category.

The CBD market is relatively new. Thirty percent of our adult population in France had never heard of CBD. In contrast, half the population was aware of CBD products in Germany [24]. As the recent increased visibility and popularity of CBD is likely to continue in adults—and especially in persons with health conditions—we can expect that consumption prevalence will also increase in the coming years.

To our knowledge, our study is the first to describe the profile of CBD users in the French general population. Clusters differed in terms of age, gender, city size, tobacco and cannabis use, health characteristics and their view on the alternative medicines statement (Table 3). Our cluster analysis confirmed the relationship between cannabis and CBD use, suggesting that cannabis co-users constitute a distinct category of CBD users [26, 30, 31]. Given results from human studies and observational data, we can hypothesise that some people use CBD in an attempt to reduce their cannabis consumption [31, 32]. We also found that poor self-reported general health status was associated with a higher likelihood of using CBD, and that health characteristics differ between clusters, suggesting CBD is used for therapeutic reasons [17]. Therapeutic use was frequently reported in a self-selected convenience sample of CBD users mainly from the US [16], and in a Swiss study [33]. Nevertheless, we cannot draw definitive conclusions about CBD’s impact on various health conditions—including anxiety, sleeping disorders and chronic pain [8]—which are often cited as reasons for its use [6, 16, 17, 18, 34], and which are often described as beneficial on internet sites, often for marketing purposes [35, 36]. The frequency of CBD use did not differ between clusters (daily use between 10 and 28%). However, since we did not collect information on CBD routes of administration and dosages, we are unable to determine whether or not there is a difference in CBD intake between clusters. Further studies are needed to explore such differences between users, as well as possible related stigma (e.g. using CBD-rich cannabis to smoke vs. sublingual drops).

Given the association we found between CBD use and agreeing with the alternative medicines statement, it would seem that CBD was perceived as a safe alternative to conventional medicine to maintain health and prevent disease [6], a perception probably driven by its plant-based origin. However, answers from Clusters 1 and 2 highlighted that not all CBD users considered alternatives medicines superior.

The sizeable proportion (30.8%) of our study sample who had not heard of CBD highlights that a substantial part of the French population is still unaware of it, and its potential properties. In respondents who had heard of it, 57.4% perceived it to be not at all or slightly harmful. This reflects a generally positive attitude toward CBD and its safety profile, and is consistent with previous findings [6, 37] and scientific data [3, 4]. In Goodman et al.’s study, approximately 30% of responders perceived CBD as ‘good’ or ‘very good’ for health, and 25% as ‘neither good nor bad’. Furthermore, in that study, 30% replied ‘do not know’ to the question on CBD harmfulness, which is very close to the 29.3% in our study who had no opinion.

As expected, we found a negative correlation between perceived harmfulness of CBD and CBD use [23]. This relationship has already been highlighted for cannabis [20, 38] and for psychoactive substances more generally [39]. Importantly, we found that both cannabis and regular alcohol use were associated with positive and negative perceptions of CBD safety. It would therefore seem that compared to non-substance users, substance users more often had enough information and/or felt concerned enough about CBD to be able to form their own opinion about its safety.

Our results from this first assessment of CBD use prevalence in France have several implications. First, the fact that 10% of the study population declared using CBD makes the regulation of CBD-based products in France—and EU in general—an urgent issue, especially in light of reports of adulteration and mislabelling [12, 14, 40], as well as misinformation [1, 36] and drug-testing issues [41]. Second, we identified different profiles of users so creating segmented markets may help consumers find the most suitable CBD-based products for their specific needs. Third, the relatively high prevalence of CBD use in our study highlights the need for reliable information on CBD’s properties, and the importance of raising people’s and physicians’ awareness of possible adverse events (e.g., CBD hepatotoxicity at very high doses [15]) and drug–drug interactions with CBD [42]. Finally, as CBD is already used by French cannabis users, and given that it may lower harms related to illegal cannabis use (i.e., THC-rich cannabis from the black market) [31, 43], the incorporation of CBD-based products into harm reduction approaches for cannabis users could be considered.

The main strengths of the present study are the sampling methodology used based on quotas, the fact that older adults were included unlike in previous CBD use studies, and that willingness to participate was not related to CBD use (as it was not presented as a primary objective). Another strength is that we simultaneously assessed awareness, use, and perception of CBD, and highlighted the relationships between them. Finally, profiling CBD users shed more light on specific sub-groups of users, and emphasized that factors associated with CBD use are differentially distributed across sub-groups.

The study also has limitations. While online surveys may reduce desirability bias (as compared to face-to-face interview), there may have been sampling bias (excluding people without internet or using it marginally). Moreover, since our study was cross-sectional, we were not able to explore the relationship between perceived harmfulness and CBD use. Further studies are needed to test whether perceived absence of harmfulness is prior or subsequent to CBD use. As the survey did not primarily focus on CBD use, only a few questions were asked about it. Therefore, data regarding the patterns of use (doses, route of administration, duration of use) and reasons for using CBD were not collected. These would have been valuable to better cluster users. Finally, as the sample size was based on the quota method, the number of CBD users was small, which limited the power of our analyses.

To conclude, 10% of the adult population in our French sample reported using CBD, and several user profiles emerged. Further research in the general population on the knowledge, the perceived effectiveness and the motivation for CBD consumption, as well as on its real-life toxicity are required. Our results indirectly advocate clearer European regulations on CBD to ensure that people have access to safe and high-quality products. Moreover, more accurate and accessible information about CBD’s effects and possible interactions with other drugs is needed. Finally, repeated surveys on CBD use in the general population are needed to monitor its use and clarify the reasons for using it.