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Current Allergy and Asthma Reports

Erschienen in:

01.05.2017 | Pediatric Allergy and Immunology (W Dolen, Section Editor)

Chronic Candidiasis in Children

verfasst von: Laura Green, William K. Dolen

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 5/2017

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Abstract

Purpose of Review

Healthy children may develop candidal infections as the result of exposure to antibiotics or corticosteroids, but chronic candidiasis in children after the newborn period is unusual. Chronic mucocutaneous candidiasis (CMC) refers to a group of conditions characterized by recurrent or persistent infections with Candida species, particularly Candida albicans. CMC is a phenotype observed in a spectrum of immunologic disorders, some with endocrinologic and autoimmune features.

Recent Findings

CMC can arise secondary to inherited or acquired T cell deficiencies, but in children is largely due to inborn errors impairing the dectin pathway and IL-17 immunity. We review the current understanding of the pathogenesis of chronic mucocutaneous candidiasis and discuss the immunologic pathways by which the immune system handles Candida. We highlight the historical and recent knowledge of CMC in children, emphasizing recent insights into basic science aspects of the dectin pathway, IL-17 signaling, consequences of AIRE gene defects, and clinical aspects of inheritance, and features that distinguish the different syndromes.

Summary

The clinical phenotype of CMC has many underlying genetic causes. Genetic testing is required for definitive diagnosis.

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Titel: Chronic Candidiasis in Children
verfasst von: Laura Green
William K. Dolen
Publikationsdatum: 01.05.2017
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 5/2017
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-017-0699-9

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Springer Medizin

Chronic Candidiasis in Children

Abstract

Purpose of Review

Recent Findings

Summary

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