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European Archives of Oto-Rhino-Laryngology

Erschienen in:

18.03.2024 | Head and Neck

Correlation between MRI (DWI and DCE) and cellularity of parotid gland pleomorphic adenomas

verfasst von: Laura Monestier, Jean Del Grande, Ralph Haddad, Laure Santini, Justin Michel, Arthur Varoquaux, Nicolas Fakhry

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2024

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Abstract

Purpose

Parotid pleomorphic adenomas present a risk of recurrence, higher when the tumour is a hypocellular subtype. The aim of the study was to determine whether it is possible to characterize this histological subtype with diffusion and perfusion sequences of the preoperative MRI.

Methods

This retrospective study included 97 patients operated between 2010 and 2020. Histologic slides review was performed to classify tumours into three histologic subtypes: hypocellular, classical and hypercellular. Univariate and multivariate analyses studied the correlation between histology and diffusion and perfusion MRI parameters obtained with OleaSphere® software.

Results

The hypocellular subtype had higher apparent diffusion coefficient values than the other two subtypes: 2.13 ± 0.23, 1.83 ± 0.42, and 1.61 ± 0.4 × 10^–3 mm²/s for hypocellular, classical and hypercellular subtype respectively (p < 0.0001). Multivariate analysis showed that an ADC_mean > 1.88 × 10^–3 mm²/s was suggestive of a hypocellular pleomorphic adenoma in 79% of the cases, with a specificity and PPV of 94 and 96% (p < 0.001), respectively.

Conclusion

The histological subtype of a pleomorphic adenoma can be predicted preoperatively with ADC values. A prospective and multicentric study on a larger cohort is needed to confirm our results.

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Titel: Correlation between MRI (DWI and DCE) and cellularity of parotid gland pleomorphic adenomas
verfasst von: Laura Monestier
Jean Del Grande
Ralph Haddad
Laure Santini
Justin Michel
Arthur Varoquaux
Nicolas Fakhry
Publikationsdatum: 18.03.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2024
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-024-08562-8

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Correlation between MRI (DWI and DCE) and cellularity of parotid gland pleomorphic adenomas