Over the past few decades, surgery for Hirschsprung’s disease (HD) has evolved into a minimally invasive, single-stage procedure with excellent outcomes. Intraoperative frozen section biopsy is critical for this procedure to avoid the potential risk of leaving a retained aganglionic segment. However, this facility is not available in most low-income countries. Therefore, a two-stage procedure with an initial colostomy is still practiced in the developing world. We aimed to evaluate the outcome of single-stage transanal pullthrough performed in a facility without frozen section biopsy.
Methods
A retrospective review of all patients who underwent transanal pullthrough in two teaching hospitals over a 6-year period (2015–2020).
Results
Forty-seven children underwent transanal endorectal pullthrough (TERPT). Age at surgery ranged from 2 months to 6 years and mean weight was 8.7 kg. Barium enema did not show transition zone in 6 patients (12.8%) while others demonstrated short segment HD. Intraoperatively, the transition zone was visualized in 40 patients (85%). TERPT alone was performed in 35 (74.5%), TERPT with laparotomy to visualize transition zone in 9 (26.7%) and TERPT with transabdominal mobilization was required in 3 (6.4%). Definitive histopathologic examination revealed aganglionic segment pullthrough in 4 (8.5%) and transitional zone pullthrough in another 4 (8.5%). However, with long term follow up all eight children remained asymptomatic and no intervention was required.
Conclusions
Transanal pullthrough offers reduced number of surgeries and faster recovery. We have also observed a good functional outcome despite a discrepancy with pathology results. Overall, our data suggests it is a safe and viable option for the treatment of short segment HD in facilities where frozen section is not available.
Hinweise
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Abkürzungen
HD
Hirschsprung’s disease
LMIC
Low-income and Middle-income countries
TERPT
Transanal endorectal pullthrough
PT
Pullthrough
Introduction
Hirschsprung’s disease is one of the most common causes of intestinal obstruction in children [1, 2]. Short segment HD accounts for 80% of the cases [3]. Traditionally, this condition use to be managed with a 2-stage surgery. Initially a proximal diverting colostomy was done followed by transabdominal pull-through after a couple of months [4]. In 1998, there was a significant shift in the approach with the discovery of the single stage transanal pull-through procedure [5, 6].
Many surgeons abandoned the routine use of a colostomy in favor of this procedure [7]. Subsequently, studies have shown it to be safe, even in newborns, and it has become the standard of practice in many centers [8, 9]. This procedure became popular because of the simplified nature and potential for cost savings [10]. It is also a minimally invasive technique that offers faster recovery with fewer complications [11, 12]. All these qualities are extremely attractive for low income countries where there are few pediatric surgery centers with limited resources [13].
Anzeige
However, the procedure has one drawback. It is dependent on frozen section for identification of the normally innervated bowel [6]. Frozen section is described as a critical part of the procedure because barium enema may be inaccurate in 10% of the cases [14, 15]. Without frozen section confirmation, there is a potential risk of leaving aganglionic bowel behind in these patients [15].
Frozen section facility is not available in most LMIC such as ours, thus mandating colostomy for all children with this condition. Nonetheless, we recently started performing single stage pullthrough in selected patients despite the lack of this facility. We aim to report our initial experience and to determine whether this is a possible alternative for other resource-limited countries.
Methodology
We conducted a retrospective hospital-based study at Tikur Anbessa Hospital and Menelik Hospital. These are the largest centers affiliated with Addis Ababa University, Ethiopia. They have a high burden of pediatric surgical cases, with more than 2000 procedures being performed yearly.
We included all children less than 15 years of age who underwent one stage transanal pullthrough over the past 6 years (January 2015–December 2020). Data was obtained from medical records using a structured questionnaire. Variables included demography, symptoms, operative details, post-op complications and histopathology result. Telephone interviews were also conducted for follow-up data on July 2021. Data was then entered, coded and analyzed using SPSS version 23. Ethical approval was obtained from the institutional review board of the college of health sciences, Addis Ababa University.
Anzeige
The single-stage transanal pullthrough procedure was offered to selected patients with HD in our institution. The considerations for selecting these patients were
1.
Hirschsprung disease confirmed with full thickness rectal biopsy
2.
Short segment disease without significant dilatation of the descending colon (diagnosed on barium enema)
3.
No severe enterocolitis or severe malnutrition
4.
Respond to rectal irrigation until the age of 3 months or weight of 5 kg (surgery delayed in order to avoid anesthesia-related complications.)
The soave pullthrough technique was used in all cases. Extent of resection was determined by barium enema and intraoperative visualization of transition zone by the surgeon. Dilated bowel above transition zone was resected as much as possible until normal caliber bowel was reached. Biopsy (for permanent section) was taken from proximal pulled down segment.
Results
Over a period of 6 years, 47 children underwent transanal soave pullthrough. There were 39 boys (83%) and 8 girls (17%). Half of the children were from Addis Ababa (51.1%) while others came from different regions in the country. Mean follow up time was 11.5 months.
Thirty-eight children (80.9%) had symptoms since birth. Presenting complaints were chronic constipation in 39 children (83%), acute obstruction in 5 (10.6%) and 3 children (6.4%) had pseudo-incontinence. Only one child had malnutrition and anemia which was corrected before the surgery.
Age at surgery ranged from 2 months to 6 years (median 6 months) and mean weight was 8.7 Kg. Barium enema did not show transition zone in 6 patients (12.8%) while others demonstrated short segment HD (Fig. 1). Intraoperatively, transition zone was visualized in 40 patients (85%). Transition zone was in rectum in 2 (4.3%), rectosigmoid in 26 (55.3%) and sigmoid in 12 (25.5%).
Fig. 1
Barium enema of one of the participants showing classic features of HD with narrow rectum (R), dilated sigmoid (S) and funnel shaped transition zone (T)
×
TERPT alone was performed in 35 patients (74.5%) (Fig. 2). In 9 patients (26.7%) a small left lower quadrant incision was made to visualize the transition zone before starting TERPT. Laparotomy for transabdominal mobilization was required in 3 patients (5.4%).
Fig. 2
Intraoperative picture of one of our cases of TERPT demonstrating rectum (R), dilated sigmoid (S) and transition zone (T). Note that resection has proceeded proximal to the dilated sigmoid until normal caliber bowel is reached
×
The mean operating time was 118.9 minutes. There were no intraoperative anesthetic complications. Intraoperative transfusion was required in 2 children (4.3%). Post-operative hospital stays ranged from 2 days to 1 month (median 4 days). Resumption of oral feeding ranged from 1 to 6 days (mean 2 days).
Definitive histopathologic examination (permanent section) revealed aganglionic segment pullthrough in 4 (8.5%) and transitional zone pullthrough in another 4 (8.5%). All eight children remained asymptomatic and no intervention was undertaken. The children also did not require laxatives or enemas. In 2 of the children (4.2%) the bowel status is unknown because biopsy sample was lost. (Fig. 3)
Fig. 3
Definitive histopathology results after pullthrough performed without frozen section confirmation
×
Anzeige
Post op complications occurred in 25 children (53.2%). The most common complication was perineal excoriation which occurred in 13 children (27.7%). Other complications are outlined in Table 1. Two of the children with abdominal incision had wound infection. One resolved with antibiotics but the other developed wound dehiscence that required secondary closure.
Table 1
Postoperative complications
Post-op complications
N (%)
Perianal excoriation
13 (27.7%)
Wound infection
2 (4.3%)
Enterocolitis
5 (10.6%)
- Death
1
Obstructive symptoms
4 (8.5%)
- Twisted pullthrough
1
- Acquired aganglionosis
1
- Suspected internal sphincter achalasia
2
Constipation
3 (6.3%)
Anastomotic leak
1 (2.1%)
There was one late death 10 days after discharge due to enterocolitis. The child died during transportation before the parents could get back to our hospital.
Three children required redo pull thorough (6.4%). All three children had ganglionated pullthrough. The indications for redo operation in the three children were twisted pullthrough, acquired aganglionosis and anastomotic leak. All children underwent a colostomy before the redo-pullthrough.
Continence was assessed in those over the age of 3 years which were 28 (59.6%). Of these, 5 (17.8%) report streaking on underpants and 2 (7.1%) report occasional soiling. Both children who had postoperative soiling accidents, were the children who had soiling pre-operatively and have noted improvement. There were no children with overt incontinence.
Anzeige
Discussion
It is proven that TERPT has several advantages over the two stage pullthrough procedure as it offers reduced number of surgeries, faster recovery and overall reduced cost [10, 12]. Our data also substantiates this finding as we found less operating time (118 min), early resumption of oral feeding (2 days) and early hospital discharge (5 days) comparable to other literatures on TERPT [16, 17]. These factors are especially important low income settings as there are limited resources. Moreover, this procedure avoids a colostomy which has a high psychosocial burden in the developing world [18, 19].
Intraoperative frozen section is considered a standard part of the procedure [6, 15] and we faced ethical concern in performing one stage TERPT without this facility. However, studies on the pathology of HD have shown that even intraoperative frozen section can have a discrepancy with permanent section in 3–15% [20‐22]. We also considered frozen section may be less reliable in developing nations as it is dependent on availability of experienced pathologist [20].
Additionally, our practice was supported by other studies that reported contrast enema and/or intraoperative naked eye visualization are sufficient for the identification of transition zone [1, 3, 7, 10, 16, 23] (Table 2). Some of these authors also recommend resecting normal appearing bowel more proximal to transition zone to ensure pullthrough of ganglionated bowel [7, 16]. This was the practice in our setting as well.
Table 2
Comparison of studies on single stage pullthorugh performed without frozen section
Retained aganglionosis occurred in 3 of the 7 studies who performed single stage transanal pullthrough without frozen section. The study by Shrestha [3] reported 1 out of 20 cases which is an acceptable rate. They performed redo pullthrough because of the biopsy result. Significant rate of retained aganglionosis occurred in the study by Sookpotarom (14.8%) [1] followed by our current study (8.5%). In both studies however, the patients did not have symptoms and did not undergo intervention. We deferred redo-surgery because we chose to make decisions based on clinical symptoms rather than relying on pathology results.
Anzeige
Although uncommon, late diagnosed Hirschsprung can present with soiling preoperatively [24]. We had two such patients who persisted to have some soiling after the procedure. Otherwise, good continence was reported from a majority of the patients which is expected [25]. Other complications encountered in our study include wound infection, enterocolitis, anastomotic leak, twisted pullthrough, which have comparable rates to other studies [15, 26, 27]. These complications are also not specific to one stage TERPT and can occur in the two stage pullthrough procedure [28].
Conclusion
Our experience, as well as literature reviewed, has demonstrated the feasibility of performing transanal pullthrough in the absence of frozen section facility. It had acceptable short term and long-term outcomes with none of the complications being attributed to remnant aganglionic segment. This procedure should serve as an alternative in the treatment of HD in children from LMIC.
Acknowledgements
We would like to express our gratitude to all the teams involved in the management of these patients. Special mention goes to the unit of pediatric surgery: Prof. Miliard Derbew, Dr. Fisseha Temesgen, Dr. Belachew Dejene, Dr. Woubedel Kiflu and Prof. Amezene Tadesse.
Declarations
Competing interests
The authors declare no competing interests.
Ethics approval and consent to participate
This article does not contain any studies with human participants or animals performed by any of the authors. All methods were performed in accordance with the declaration of Helsinki and approved by the Addis Ababa University, college of health sciences IRB (reference number 097/18/surg). Written informed consent was obtained from all legal guardians / parents of participants included in the study.
Consent for publication
Not required because no identifying images or clinical details of participants that compromise anonymity are included.
Competing interest
All authors declare that we have no conflict of interest to disclose.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.
Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.
Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.
Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.
Update Chirurgie
Bestellen Sie unseren Fach-Newsletterund bleiben Sie gut informiert.
Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
