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European Journal of Pediatrics

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16.03.2020 | Editorial

“How can a drug to treat claudication in adults save preterm newborns?”

verfasst von: Serife Kurul, Karel Allegaert, Robert B. Flint, H. Rob Taal

Erschienen in: European Journal of Pediatrics | Ausgabe 8/2020

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Pentoxifylline (Trental®) (PTX) is a vasoactive drug, registered in 1972 to treat intermittent claudication in adults. More recently, this drug has been of growing interest in different conditions such as renal, vascular, inflammatory, and infectious diseases. Particularly, it has been suggested that PTX could be beneficial for sepsis in preterm neonates. A recent Cochrane review including 6 relatively small studies showed that PTX improves survival in neonatal sepsis [1]. How can PTX, initially developed for a completely different population and indication, save premature newborns with sepsis? …

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Titel: “How can a drug to treat claudication in adults save preterm newborns?”
verfasst von: Serife Kurul
Karel Allegaert
Robert B. Flint
H. Rob Taal
Publikationsdatum: 16.03.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 8/2020
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-020-03631-6

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