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International Urology and Nephrology

Erschienen in:

26.06.2023 | Nephrology - Original Paper

Immunological features of ESRD patients undergoing hemodialysis of various ages

verfasst von: XiaoHong Chen, FangFang Xiang, XueSen Cao, WenLv Lv, Bo Shen, JianZhou Zou, XiaoQiang Ding

Erschienen in: International Urology and Nephrology | Ausgabe 1/2024

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Abstract

Aims

To investigate the immunological characteristics of hemodialysis (HD) patients with end-stage renal disease (ESRD) of various ages, and the impact of age-related immune alterations on these patients, with a focus on peripheral T cells.

Methods

From September 2016 to September 2019, HD patients were enrolled and followed prospectively for 3 years. Patients were divided into three groups based on their ages: < 45, 45 to 64, and ≥ 65. The distribution of T cell subsets in different age groups was investigated and compared. The effects of altered T cell subsets on overall survival were also investigated.

Results

A total of 371 HD patients were enrolled. The reduced number of naive CD8+ T cells (P < 0.001) and increased number of EMRA CD8+ T cells (P = 0.024) were independently associated with the advanced age among all T cell subsets studied. Patient survival may be affected by numerical changes in naive CD8+ T cells. However, when HD patients were < 45 or ≥ 65 years, the reduction had no significant impact on survival. Only in HD patients aged 45 to 64 years, the number of naïve CD8+ T cells found to be insufficient but not deficient, identified as an independent predictor of poor survival.

Conclusions

The most significant age-related immune change in HD patients was a decrease in peripheral naive CD8+ T cells, which was an independent predictor of 3-year overall survival in HD patients aged 45 ~ 64 years.

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Titel: Immunological features of ESRD patients undergoing hemodialysis of various ages
verfasst von: XiaoHong Chen
FangFang Xiang
XueSen Cao
WenLv Lv
Bo Shen
JianZhou Zou
XiaoQiang Ding
Publikationsdatum: 26.06.2023
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 1/2024
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-023-03683-1

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