Erschienen in:
01.09.2013 | Originalien
Lack of association between the haplotype GCC/ATA polymorphism in the IL-10 promoter and SLE risk
Evidence from a meta-analysis
verfasst von:
B. Wang, Y.-G. Fan, D.-Q. Ye
Erschienen in:
Zeitschrift für Rheumatologie
|
Ausgabe 7/2013
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Abstract
Numerous studies have investigated the association between the interleukin (IL)-10 promoter haplotype GCC/ATA (at the − 1082, − 819 and − 592 positions of the IL-10 gene) polymorphism and systemic lupus erythematosus (SLE) risk, but the results were inconsistent. We performed the current meta-analysis to assess precisely the association by comparing the GCC haplotype with the ATA haplotype. A literature search was conducted using Pubmed and Web of Science databases. Twelve studies including 1765 cases and 2444 controls were included in this meta-analysis. The overall odds ratios (total and stratified by ethnicity: Asian or Caucasian) were 1.042 (95 % confidence interval [CI] 0.893–1.216; p = 0.599), 0.790 (95 % CI 0.528–1.182; p = 0.251), and 1.093 (95 % CI 0.919–1.300; p = 0.317), respectively. The results indicated that the GCC haplotype revealed no statistically significant association with SLE risk; thus, the haplotype GCC/ATA polymorphism of the IL-10 promoter is not likely to be involved in SLE susceptibility.