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Erschienen in: InFo Hämatologie + Onkologie 7-8/2021

27.07.2021 | Lymphome | Zertifizierte Fortbildung

PZNSL

Diagnostik und Therapie des primären ZNS-Lymphoms

verfasst von: Dr. med. Jens Blobner, Nico Teske, Dr. med. Philipp Karschnia, Prof. Dr. med. Martin Dreyling, PD. Dr. med Louisa von Baumgarten

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 7-8/2021

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Primäre ZNS-Lymphome sind hämatologische Neoplasien, die ausschließlich das zentrale Nervensystem befallen und aggressiv verlaufen. Ihre Seltenheit erschwert die systematische Bewertung und die Etablierung einheitlicher Behandlungsstandards. Trotz ihrer niedrigen Inzidenz befinden sich neuere Therapieansätze aktuell in der Erprobung. Lesen Sie in dieser Übersicht, worin diese neueren Konzepte bestehen - und wie PZNSL derzeit lege artis diagnostiziert und behandelt werden.
Literatur
1.
Zurück zum Zitat Louis DN et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803-20 Louis DN et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803-20
2.
Zurück zum Zitat Ostrom QT et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015. Neuro Oncol. 2018;20(suppl_4):iv1-iv86 Ostrom QT et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015. Neuro Oncol. 2018;20(suppl_4):iv1-iv86
3.
Zurück zum Zitat Matinella A et al. Neurological complications of HIV infection in pre-HAART and HAART era: a retrospective study. J Neurol. 2015;262(5):1317-27 Matinella A et al. Neurological complications of HIV infection in pre-HAART and HAART era: a retrospective study. J Neurol. 2015;262(5):1317-27
4.
Zurück zum Zitat Küker W et al. Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. J Neurooncol. 2005;72(2):169-77 Küker W et al. Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. J Neurooncol. 2005;72(2):169-77
5.
Zurück zum Zitat Hoang-Xuan K et al. Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology. Lancet Oncol. 2015;16(7):e322-32 Hoang-Xuan K et al. Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology. Lancet Oncol. 2015;16(7):e322-32
6.
Zurück zum Zitat Coulon A et al. Radiographic findings in 37 cases of primary CNS lymphoma in immunocompetent patients. Eur Radiol. 2002;12(2):329-40 Coulon A et al. Radiographic findings in 37 cases of primary CNS lymphoma in immunocompetent patients. Eur Radiol. 2002;12(2):329-40
7.
Zurück zum Zitat Bühring U et al. MRI features of primary central nervous system lymphomas at presentation. Neurology. 2001;57(3):393-6 Bühring U et al. MRI features of primary central nervous system lymphomas at presentation. Neurology. 2001;57(3):393-6
8.
Zurück zum Zitat Deckert M et al. Primary lymphoma of the central nervous system--a diagnostic challenge. Hematol Oncol. 2014;32(2):57-67 Deckert M et al. Primary lymphoma of the central nervous system--a diagnostic challenge. Hematol Oncol. 2014;32(2):57-67
9.
Zurück zum Zitat Grommes C et al. Comprehensive Approach to Diagnosis and Treatment of Newly Diagnosed Primary CNS Lymphoma. Neuro Oncol. 2019;21(3):296-305 Grommes C et al. Comprehensive Approach to Diagnosis and Treatment of Newly Diagnosed Primary CNS Lymphoma. Neuro Oncol. 2019;21(3):296-305
10.
Zurück zum Zitat Weller M. Glucocorticoid treatment of primary CNS lymphoma. J Neurooncol. 1999;43(3):237-9 Weller M. Glucocorticoid treatment of primary CNS lymphoma. J Neurooncol. 1999;43(3):237-9
11.
Zurück zum Zitat Brück W et al. [Differential diagnosis of lymphoid infiltrates in the central nervous system: experience of the Network Lymphomas and Lymphomatoid Lesions in the Nervous System]. Pathologe. 2013;34(3):186-97 Brück W et al. [Differential diagnosis of lymphoid infiltrates in the central nervous system: experience of the Network Lymphomas and Lymphomatoid Lesions in the Nervous System]. Pathologe. 2013;34(3):186-97
12.
Zurück zum Zitat Porter AB et al. Primary Central Nervous System Lymphoma Can Be Histologically Diagnosed after Previous Corticosteroid Use: A Pilot Study to Determine Whether Corticosteroids Prevent the Diagnosis of Primary Central Nervous System Lymphoma. Ann Neurol. 2008;63(5):662-7 Porter AB et al. Primary Central Nervous System Lymphoma Can Be Histologically Diagnosed after Previous Corticosteroid Use: A Pilot Study to Determine Whether Corticosteroids Prevent the Diagnosis of Primary Central Nervous System Lymphoma. Ann Neurol. 2008;63(5):662-7
13.
Zurück zum Zitat Ferreri AJM et al. How I Treat Primary CNS Lymphoma. Blood. 2011;118(3):510-22 Ferreri AJM et al. How I Treat Primary CNS Lymphoma. Blood. 2011;118(3):510-22
14.
Zurück zum Zitat Jahnke K et al. Detection of Subclinical Systemic Disease in Primary CNS Lymphoma by Polymerase Chain Reaction of the Rearranged Immunoglobulin Heavy-Chain Genes. J Clin Oncol. 2006;24(29):4754-7 Jahnke K et al. Detection of Subclinical Systemic Disease in Primary CNS Lymphoma by Polymerase Chain Reaction of the Rearranged Immunoglobulin Heavy-Chain Genes. J Clin Oncol. 2006;24(29):4754-7
15.
Zurück zum Zitat Margold M et al. The Value of Bone Marrow Biopsy for Staging of Patients with Primary CNS Lymphoma. Neuro Oncol. 2021; https://doi.org/10.1093/neuonc/noab109 Margold M et al. The Value of Bone Marrow Biopsy for Staging of Patients with Primary CNS Lymphoma. Neuro Oncol. 2021; https://​doi.​org/​10.​1093/​neuonc/​noab109
16.
Zurück zum Zitat Abrey LE et al. Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol. 2005;23(22):5034-43 Abrey LE et al. Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol. 2005;23(22):5034-43
17.
Zurück zum Zitat Mendez JS et al. The elderly left behind-changes in survival trends of primary central nervous system lymphoma over the past 4 decades. Neuro Oncol. 2018;20(5):687-94 Mendez JS et al. The elderly left behind-changes in survival trends of primary central nervous system lymphoma over the past 4 decades. Neuro Oncol. 2018;20(5):687-94
18.
Zurück zum Zitat Weller M et al. Surgery for Primary CNS Lymphoma? Challenging a Paradigm. Neuro Oncol. 2012;14(12):1481-4 Weller M et al. Surgery for Primary CNS Lymphoma? Challenging a Paradigm. Neuro Oncol. 2012;14(12):1481-4
19.
Zurück zum Zitat Herrlinger U et al. Neuro-Oncology Working Group of the German Society NOA-03 Trial of High-Dose Methotrexate in Primary Central Nervous System Lymphoma: Final Report. Ann Neurol. 2005;57(6):843-7 Herrlinger U et al. Neuro-Oncology Working Group of the German Society NOA-03 Trial of High-Dose Methotrexate in Primary Central Nervous System Lymphoma: Final Report. Ann Neurol. 2005;57(6):843-7
20.
Zurück zum Zitat Bergner N et al. Role of Chemotherapy Additional to High-Dose Methotrexate for Primary Central Nervous System Lymphoma (PCNSL). Cochrane Database Syst Rev. 2012;11:CD009355 Bergner N et al. Role of Chemotherapy Additional to High-Dose Methotrexate for Primary Central Nervous System Lymphoma (PCNSL). Cochrane Database Syst Rev. 2012;11:CD009355
21.
Zurück zum Zitat Ferreri AJM et al. High-Dose Cytarabine plus High-Dose Methotrexate versus High-Dose Methotrexate Alone in Patients with Primary CNS Lymphoma: A Randomised Phase 2 Trial. Lancet. 2009;374(9700):1512-20 Ferreri AJM et al. High-Dose Cytarabine plus High-Dose Methotrexate versus High-Dose Methotrexate Alone in Patients with Primary CNS Lymphoma: A Randomised Phase 2 Trial. Lancet. 2009;374(9700):1512-20
22.
Zurück zum Zitat Pels H et al. Primary central nervous system lymphoma: results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol. 2003;21(24):4489-95. Pels H et al. Primary central nervous system lymphoma: results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol. 2003;21(24):4489-95.
23.
Zurück zum Zitat Juergens A et al. Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma. Ann Neurol. 2010;67(2):182-9 Juergens A et al. Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma. Ann Neurol. 2010;67(2):182-9
24.
Zurück zum Zitat Pels H et al. Early Relapses in Primary CNS Lymphoma after Response to Polychemotherapy without Intraventricular Treatment: Results of a Phase II Study. J Neurooncol. 2009;91(3):299-305 Pels H et al. Early Relapses in Primary CNS Lymphoma after Response to Polychemotherapy without Intraventricular Treatment: Results of a Phase II Study. J Neurooncol. 2009;91(3):299-305
25.
Zurück zum Zitat Bromberg JEC et al. Rituximab in patients with primary CNS lymphoma (HOVON 105/ALLG NHL 24): a randomised, open-label, phase 3 intergroup study. Lancet Oncol. 2019;20(2):216-228 Bromberg JEC et al. Rituximab in patients with primary CNS lymphoma (HOVON 105/ALLG NHL 24): a randomised, open-label, phase 3 intergroup study. Lancet Oncol. 2019;20(2):216-228
26.
Zurück zum Zitat Ferreri AJM et al. Chemoimmunotherapy with Methotrexate, Cytarabine, Thiotepa, and Rituximab (MATRix Regimen) in Patients with Primary CNS Lymphoma: Results of the First Randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) Phase 2 Trial. Lancet Haematol. 2016;3(5):e217-27 Ferreri AJM et al. Chemoimmunotherapy with Methotrexate, Cytarabine, Thiotepa, and Rituximab (MATRix Regimen) in Patients with Primary CNS Lymphoma: Results of the First Randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) Phase 2 Trial. Lancet Haematol. 2016;3(5):e217-27
27.
Zurück zum Zitat Seidel S et al. Twenty-Year Follow-up of a Pilot/Phase II Trial on the Bonn Protocol for Primary CNS Lymphoma. Neurology. 2020;95(23):e3138-e3144 Seidel S et al. Twenty-Year Follow-up of a Pilot/Phase II Trial on the Bonn Protocol for Primary CNS Lymphoma. Neurology. 2020;95(23):e3138-e3144
28.
Zurück zum Zitat Rubenstein JL et al. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol. 2013;31(25):3061-8 Rubenstein JL et al. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol. 2013;31(25):3061-8
29.
Zurück zum Zitat Pulczynski EJ et al. Successful Change of Treatment Strategy in Elderly Patients with Primary Central Nervous System Lymphoma by De-Escalating Induction and Introducing Temozolomide Maintenance: Results from a Phase II Study by the Nordic Lymphoma Group. Haematologica. 2015;100(4):534-40 Pulczynski EJ et al. Successful Change of Treatment Strategy in Elderly Patients with Primary Central Nervous System Lymphoma by De-Escalating Induction and Introducing Temozolomide Maintenance: Results from a Phase II Study by the Nordic Lymphoma Group. Haematologica. 2015;100(4):534-40
30.
Zurück zum Zitat Hoang-Xuan K et al. Chemotherapy Alone as Initial Treatment for Primary CNS Lymphoma in Patients Older than 60 Years: A Multicenter Phase II Study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group. J Clin Oncol. 2003;21(14):2726-31 Hoang-Xuan K et al. Chemotherapy Alone as Initial Treatment for Primary CNS Lymphoma in Patients Older than 60 Years: A Multicenter Phase II Study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group. J Clin Oncol. 2003;21(14):2726-31
31.
Zurück zum Zitat Omuro A et al. Methotrexate and Temozolomide versus Methotrexate, Procarbazine, Vincristine, and Cytarabine for Primary CNS Lymphoma in an Elderly Population: An Intergroup ANOCEF-GOELAMS Randomised Phase 2 Trial. Lancet Haematol. 2015;2(6):e251-9 Omuro A et al. Methotrexate and Temozolomide versus Methotrexate, Procarbazine, Vincristine, and Cytarabine for Primary CNS Lymphoma in an Elderly Population: An Intergroup ANOCEF-GOELAMS Randomised Phase 2 Trial. Lancet Haematol. 2015;2(6):e251-9
32.
Zurück zum Zitat Fritsch K et al. High-Dose Methotrexate-Based Immuno-Chemotherapy for Elderly Primary CNS Lymphoma Patients (PRIMAIN Study). Leukemia. 2017;31(4):846-52 Fritsch K et al. High-Dose Methotrexate-Based Immuno-Chemotherapy for Elderly Primary CNS Lymphoma Patients (PRIMAIN Study). Leukemia. 2017;31(4):846-52
33.
Zurück zum Zitat DeAngelis LM et al. Radiation Therapy Oncology Group Study 93-10 Combination Chemotherapy and Radiotherapy for Primary Central Nervous System Lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol. 2002;20(24):4643-8 DeAngelis LM et al. Radiation Therapy Oncology Group Study 93-10 Combination Chemotherapy and Radiotherapy for Primary Central Nervous System Lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol. 2002;20(24):4643-8
34.
Zurück zum Zitat Poortmans PMP et al. High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962. J Clin Oncol. 2003;21(24):4483-8 Poortmans PMP et al. High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962. J Clin Oncol. 2003;21(24):4483-8
35.
Zurück zum Zitat Korfel A et al. Response to Chemotherapy and Treating Institution Predict Survival in Primary Central Nervous System Lymphoma. Br J Haematol. 2005;128(2):177-83 Korfel A et al. Response to Chemotherapy and Treating Institution Predict Survival in Primary Central Nervous System Lymphoma. Br J Haematol. 2005;128(2):177-83
36.
Zurück zum Zitat Thiel E et al. High-Dose Methotrexate with or without Whole Brain Radiotherapy for Primary CNS Lymphoma (G-PCNSL-SG-1): A Phase 3, Randomised, Non-Inferiority Trial. Lancet Oncol. 2010;11(11):1036-47 Thiel E et al. High-Dose Methotrexate with or without Whole Brain Radiotherapy for Primary CNS Lymphoma (G-PCNSL-SG-1): A Phase 3, Randomised, Non-Inferiority Trial. Lancet Oncol. 2010;11(11):1036-47
37.
Zurück zum Zitat Morris PG et al. Rituximab, methotrexate, procarbazine, and vincristine followed by consolidation reduced-dose whole-brain radiotherapy and cytarabine in newly diagnosed primary CNS lymphoma: final results and long-term outcome. J Clin Oncol. 2013;31(31):3971-9 Morris PG et al. Rituximab, methotrexate, procarbazine, and vincristine followed by consolidation reduced-dose whole-brain radiotherapy and cytarabine in newly diagnosed primary CNS lymphoma: final results and long-term outcome. J Clin Oncol. 2013;31(31):3971-9
38.
Zurück zum Zitat Glass J et al. Phase I and II Study of Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide for Primary CNS Lymphoma: NRG Oncology RTOG 0227. J Clin Oncol. 2016;34(14):1620-5 Glass J et al. Phase I and II Study of Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide for Primary CNS Lymphoma: NRG Oncology RTOG 0227. J Clin Oncol. 2016;34(14):1620-5
39.
Zurück zum Zitat Illerhaus G et al. High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma. J Clin Oncol. 2006;24(24):3865-70 Illerhaus G et al. High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma. J Clin Oncol. 2006;24(24):3865-70
40.
Zurück zum Zitat Kasenda B et al. Prognosis after high-dose chemotherapy followed by autologous stem-cell transplantation as first-line treatment in primary CNS lymphoma--a long-term follow-up study. Ann Oncol. 2012;23(10):2670-5 Kasenda B et al. Prognosis after high-dose chemotherapy followed by autologous stem-cell transplantation as first-line treatment in primary CNS lymphoma--a long-term follow-up study. Ann Oncol. 2012;23(10):2670-5
41.
Zurück zum Zitat Omuro A et al. R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma. Blood. 2015;125(9):1403-10 Omuro A et al. R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma. Blood. 2015;125(9):1403-10
42.
Zurück zum Zitat Illerhaus G et al. High-Dose Chemotherapy with Autologous Haemopoietic Stem Cell Transplantation for Newly Diagnosed Primary CNS Lymphoma: A Prospective, Single-Arm, Phase 2 Trial. Lancet Haematol. 2016;3(8):e388-97 Illerhaus G et al. High-Dose Chemotherapy with Autologous Haemopoietic Stem Cell Transplantation for Newly Diagnosed Primary CNS Lymphoma: A Prospective, Single-Arm, Phase 2 Trial. Lancet Haematol. 2016;3(8):e388-97
43.
Zurück zum Zitat Ferreri AJM et al. Whole-Brain Radiotherapy or Autologous Stem-Cell Transplantation as Consolidation Strategies after High-Dose Methotrexate-Based Chemoimmunotherapy in Patients with Primary CNS Lymphoma: Results of the Second Randomisation of the International Extranodal Lymphoma Study Group-32 Phase 2 Trial. Lancet Haematol. 2017;4(11):e510-e523 Ferreri AJM et al. Whole-Brain Radiotherapy or Autologous Stem-Cell Transplantation as Consolidation Strategies after High-Dose Methotrexate-Based Chemoimmunotherapy in Patients with Primary CNS Lymphoma: Results of the Second Randomisation of the International Extranodal Lymphoma Study Group-32 Phase 2 Trial. Lancet Haematol. 2017;4(11):e510-e523
44.
Zurück zum Zitat Houillier C et al. Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients 60 Years of Age and Younger: Results of the Intergroup ANOCEF-GOELAMS Randomized Phase II PRECIS Study. J Clin Oncol. 2019;37(10):823-33 Houillier C et al. Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients 60 Years of Age and Younger: Results of the Intergroup ANOCEF-GOELAMS Randomized Phase II PRECIS Study. J Clin Oncol. 2019;37(10):823-33
45.
Zurück zum Zitat von Baumgarten L et al. The Diagnosis and Treatment of Primary CNS Lymphoma. Dtsch Arztebl Int. 2018;115(25):419-26 von Baumgarten L et al. The Diagnosis and Treatment of Primary CNS Lymphoma. Dtsch Arztebl Int. 2018;115(25):419-26
46.
Zurück zum Zitat Löw S et al. Primary Central Nervous System Lymphoma. Ther Adv Neurol Disord. 2018;11:1756286418793562 Löw S et al. Primary Central Nervous System Lymphoma. Ther Adv Neurol Disord. 2018;11:1756286418793562
47.
Zurück zum Zitat Nelson DF et al. Radiotherapy in the Treatment of Primary Central Nervous System Lymphoma (PCNSL). J Neurooncol. 1999;43(3):241-7 Nelson DF et al. Radiotherapy in the Treatment of Primary Central Nervous System Lymphoma (PCNSL). J Neurooncol. 1999;43(3):241-7
48.
Zurück zum Zitat DeAngelis LM et al. Primary CNS lymphoma: treatment with combined chemotherapy and radiotherapy. J Neurooncol. 1999;43(3):249-57 DeAngelis LM et al. Primary CNS lymphoma: treatment with combined chemotherapy and radiotherapy. J Neurooncol. 1999;43(3):249-57
49.
Zurück zum Zitat DeAngelis LM et al. Combined Modality Therapy for Primary CNS Lymphoma. J Clin Oncol. 1992;10(4):635-43 DeAngelis LM et al. Combined Modality Therapy for Primary CNS Lymphoma. J Clin Oncol. 1992;10(4):635-43
50.
Zurück zum Zitat Glass J et al. Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome. J Neurosurg. 1994;81(2):188-95 Glass J et al. Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome. J Neurosurg. 1994;81(2):188-95
51.
Zurück zum Zitat O'Brien P et al. Phase II Multicenter Study of Brief Single-Agent Methotrexate Followed by Irradiation in Primary CNS Lymphoma. J Clin Oncol. 2000;18(3):519-26 O'Brien P et al. Phase II Multicenter Study of Brief Single-Agent Methotrexate Followed by Irradiation in Primary CNS Lymphoma. J Clin Oncol. 2000;18(3):519-26
52.
Zurück zum Zitat Abrey LE et al. Treatment for Primary CNS Lymphoma: The next Step. J Clin Oncol. 2000;18(17):3144-50 Abrey LE et al. Treatment for Primary CNS Lymphoma: The next Step. J Clin Oncol. 2000;18(17):3144-50
53.
Zurück zum Zitat Ferreri AJ et al. Combined Treatment with High-Dose Methotrexate, Vincristine and Procarbazine, without Intrathecal Chemotherapy, Followed by Consolidation Radiotherapy for Primary Central Nervous System Lymphoma in Immunocompetent Patients. Oncology. 2001;60(2):134-40 Ferreri AJ et al. Combined Treatment with High-Dose Methotrexate, Vincristine and Procarbazine, without Intrathecal Chemotherapy, Followed by Consolidation Radiotherapy for Primary Central Nervous System Lymphoma in Immunocompetent Patients. Oncology. 2001;60(2):134-40
54.
Zurück zum Zitat Correa DD et al. Cognitive Functions in Primary CNS Lymphoma after Single or Combined Modality Regimens. Neuro Oncol. 2012;14(1):101-8 Correa DD et al. Cognitive Functions in Primary CNS Lymphoma after Single or Combined Modality Regimens. Neuro Oncol. 2012;14(1):101-8
55.
Zurück zum Zitat Doolittle ND et al. Long-Term Cognitive Function, Neuroimaging, and Quality of Life in Primary CNS Lymphoma. Neurology. 2013;81(1):84-92 Doolittle ND et al. Long-Term Cognitive Function, Neuroimaging, and Quality of Life in Primary CNS Lymphoma. Neurology. 2013;81(1):84-92
56.
Zurück zum Zitat Grommes C, DeAngelis LM. Primary CNS Lymphoma. J Clin Oncol. 2017;35(21):2410-8 Grommes C, DeAngelis LM. Primary CNS Lymphoma. J Clin Oncol. 2017;35(21):2410-8
57.
Zurück zum Zitat Schorb E et al. High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma--a randomized phase III trial (MATRix). BMC Cancer. 2016;16:282 Schorb E et al. High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma--a randomized phase III trial (MATRix). BMC Cancer. 2016;16:282
58.
Zurück zum Zitat Langner-Lemercier S et al. Primary CNS Lymphoma at First Relapse/Progression: Characteristics, Management, and Outcome of 256 Patients from the French LOC Network. Neuro Oncol. 2016;18(9):1297-303 Langner-Lemercier S et al. Primary CNS Lymphoma at First Relapse/Progression: Characteristics, Management, and Outcome of 256 Patients from the French LOC Network. Neuro Oncol. 2016;18(9):1297-303
59.
Zurück zum Zitat Pentsova E et al. Methotrexate re-challenge for recurrent primary central nervous system lymphoma. J Neurooncol. 2014;117(1):161-5 Pentsova E et al. Methotrexate re-challenge for recurrent primary central nervous system lymphoma. J Neurooncol. 2014;117(1):161-5
60.
Zurück zum Zitat Plotkin SR et al. Treatment of relapsed central nervous system lymphoma with high-dose methotrexate. Clin Cancer Res. 2004;10(17):5643-6 Plotkin SR et al. Treatment of relapsed central nervous system lymphoma with high-dose methotrexate. Clin Cancer Res. 2004;10(17):5643-6
61.
Zurück zum Zitat Hottinger AF et al. Salvage Whole Brain Radiotherapy for Recurrent or Refractory Primary CNS Lymphoma. Neurology. 2007;69(11):1178-82 Hottinger AF et al. Salvage Whole Brain Radiotherapy for Recurrent or Refractory Primary CNS Lymphoma. Neurology. 2007;69(11):1178-82
62.
Zurück zum Zitat Nguyen PL et al. Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma. J Clin Oncol. 2005;23(7):1507-13 Nguyen PL et al. Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma. J Clin Oncol. 2005;23(7):1507-13
63.
Zurück zum Zitat Kasenda B et al. High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group. Leukemia. 2017;31(12):2623-9 Kasenda B et al. High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group. Leukemia. 2017;31(12):2623-9
64.
Zurück zum Zitat Raizer JJ et al. Pemetrexed in the treatment of relapsed/refractory primary central nervous system lymphoma. Cancer. 2012;118(15):3743-8 Raizer JJ et al. Pemetrexed in the treatment of relapsed/refractory primary central nervous system lymphoma. Cancer. 2012;118(15):3743-8
65.
Zurück zum Zitat Fischer L et al. Prospective trial on topotecan salvage therapy in primary CNS lymphoma. Ann Oncol. 2006;17(7):1141-5 Fischer L et al. Prospective trial on topotecan salvage therapy in primary CNS lymphoma. Ann Oncol. 2006;17(7):1141-5
66.
Zurück zum Zitat Soussain C et al. Ibrutinib Monotherapy for Relapse or Refractory Primary CNS Lymphoma and Primary Vitreoretinal Lymphoma: Final Analysis of the Phase II "proof-of-Concept" ILOC Study by the Lymphoma Study Association (LYSA) and the French Oculo-Cerebral Lymphoma (LOC) Network. Eur J Cancer. 2019;117:121-30 Soussain C et al. Ibrutinib Monotherapy for Relapse or Refractory Primary CNS Lymphoma and Primary Vitreoretinal Lymphoma: Final Analysis of the Phase II "proof-of-Concept" ILOC Study by the Lymphoma Study Association (LYSA) and the French Oculo-Cerebral Lymphoma (LOC) Network. Eur J Cancer. 2019;117:121-30
67.
Zurück zum Zitat Korfel A et al. Phase II Trial of Temsirolimus for Relapsed/Refractory Primary CNS Lymphoma. J Clin Oncol. 2016;34(15):1757-63 Korfel A et al. Phase II Trial of Temsirolimus for Relapsed/Refractory Primary CNS Lymphoma. J Clin Oncol. 2016;34(15):1757-63
68.
Zurück zum Zitat Rubenstein JL et al. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018;2(13):1595-607 Rubenstein JL et al. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018;2(13):1595-607
69.
Zurück zum Zitat Tun HW et al. Phase 1 Study of Pomalidomide and Dexamethasone for Relapsed/Refractory Primary CNS or Vitreoretinal Lymphoma. Blood. 2018;132(21):2240-8 Tun HW et al. Phase 1 Study of Pomalidomide and Dexamethasone for Relapsed/Refractory Primary CNS or Vitreoretinal Lymphoma. Blood. 2018;132(21):2240-8
70.
Zurück zum Zitat Ambady P et al. Combination Immunotherapy as a Non-Chemotherapy Alternative for Refractory or Recurrent CNS Lymphoma. Leuk Lymphoma. 2019;60(2):515-8 Ambady P et al. Combination Immunotherapy as a Non-Chemotherapy Alternative for Refractory or Recurrent CNS Lymphoma. Leuk Lymphoma. 2019;60(2):515-8
71.
Zurück zum Zitat Nayak L et al. PD-1 Blockade with Nivolumab in Relapsed/Refractory Primary Central Nervous System and Testicular Lymphoma. Blood. 2017;129(23):3071-3 Nayak L et al. PD-1 Blockade with Nivolumab in Relapsed/Refractory Primary Central Nervous System and Testicular Lymphoma. Blood. 2017;129(23):3071-3
72.
Zurück zum Zitat Abramson JS et al. Anti-CD19 CAR T Cells in CNS Diffuse Large-B-Cell Lymphoma. N Engl J Med. 2017;377(8):783-4 Abramson JS et al. Anti-CD19 CAR T Cells in CNS Diffuse Large-B-Cell Lymphoma. N Engl J Med. 2017;377(8):783-4
73.
Zurück zum Zitat Ghesquieres H et al. Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†. Ann Oncol. 2019;30(4):621-8 Ghesquieres H et al. Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†. Ann Oncol. 2019;30(4):621-8
74.
Zurück zum Zitat Abrey LE et al. Long-Term Survival in Primary CNS Lymphoma. J Clin Oncol. 1998;16(3):859-63 Abrey LE et al. Long-Term Survival in Primary CNS Lymphoma. J Clin Oncol. 1998;16(3):859-63
75.
Zurück zum Zitat Kurzwelly D et al. Primary CNS Lymphoma in the Elderly: Temozolomide Therapy and MGMT Status. J Neurooncol. 2010;97(3):389-92 Kurzwelly D et al. Primary CNS Lymphoma in the Elderly: Temozolomide Therapy and MGMT Status. J Neurooncol. 2010;97(3):389-92
76.
Zurück zum Zitat Brandsma D et al. Primary CNS lymphoma in HIV infection. Handb Clin Neurol. 2018;152:177-186 Brandsma D et al. Primary CNS lymphoma in HIV infection. Handb Clin Neurol. 2018;152:177-186
77.
Zurück zum Zitat Wieters I et al. Autologous stem cell transplantation in HIV-related lymphoma in the rituximab era - a feasibility study in a monocentric cohort. J Int AIDS Soc. 2014;17(4 Suppl 3):19648 Wieters I et al. Autologous stem cell transplantation in HIV-related lymphoma in the rituximab era - a feasibility study in a monocentric cohort. J Int AIDS Soc. 2014;17(4 Suppl 3):19648
78.
Zurück zum Zitat Cavaliere R et al. International Primary Central Nervous System Lymphoma Collaborative Group Primary Central Nervous System Post-Transplantation Lymphoproliferative Disorder: An International Primary Central Nervous System Lymphoma Collaborative Group Report. Cancer. 2010;116(4):863-70 Cavaliere R et al. International Primary Central Nervous System Lymphoma Collaborative Group Primary Central Nervous System Post-Transplantation Lymphoproliferative Disorder: An International Primary Central Nervous System Lymphoma Collaborative Group Report. Cancer. 2010;116(4):863-70
Metadaten
Titel
PZNSL
Diagnostik und Therapie des primären ZNS-Lymphoms
verfasst von
Dr. med. Jens Blobner
Nico Teske
Dr. med. Philipp Karschnia
Prof. Dr. med. Martin Dreyling
PD. Dr. med Louisa von Baumgarten
Publikationsdatum
27.07.2021
Verlag
Springer Medizin
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 7-8/2021
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-021-8750-3

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