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NeuroTransmitter
Erschienen in: NeuroTransmitter 6/2019

31.05.2019 | Multiple Sklerose | Zertifizierte Fortbildung

Neurochirurgische Therapie

Therapeutische Möglichkeiten bei therapieresistentem MS-Tremor

verfasst von: Dr. med. Caspar Seitz, Dr. med. Julia Kroth, Prof. Dr. med. Sergiu Groppa

Erschienen in: NeuroTransmitter | Ausgabe 6/2019

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Zusammenfassung

Seit dem Ende des letzten Jahrhunderts wird bei therapieresistentem Multiple-Sklerose(MS)-Tremor durch läsionelle und stimulative Verfahren ein individueller Heilversuch unternommen. Oft zeigt sich eine kurz bis mittelfristig signifikante Tremorreduktion ohne eine regelhafte Verbesserung der Alltagsfunktion. Selten zeigt sich jedoch ein deutliches funktionelles sowie langfristiges Ansprechen des Tremors bei MS-Patienten.
Literatur
1.
Alusi, S.H., et al., A study of tremor in multiple sclerosis. Brain, 2001. 124(Pt 4): p. 720–30.CrossRef
2.
Pittock, S.J., et al., Prevalence of tremor in multiple sclerosis and associated disability in the Olmsted County population. Mov Disord, 2004. 19(12): p. 1482–5.CrossRef
3.
Koch, M., et al., Tremor in multiple sclerosis. J Neurol, 2007. 254(2): p. 133–45.CrossRef
4.
Hassan, A., et al., Surgical therapy for multiple sclerosis tremor: a 12-year follow-up study. 2012. 19(5): p. 764–768.
5.
Schulder, M., T.J. Sernas, and R. Karimi, Thalamic Stimulation in Patients with Multiple Sclerosis: Long-Term Follow-Up. Stereotactic and Functional Neurosurgery, 2003. 80(1–4): p. 48–55.CrossRef
6.
Torres, C.V., et al., Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus for Tremor in Patients With Multiple Sclerosis. Neurosurgery, 2010. 67(3): p. 646–651.CrossRef
7.
Oliveria, S.F., et al., Safety and efficacy of dual-lead thalamic deep brain stimulation for patients with treatment-refractory multiple sclerosis tremor: a single-centre, randomised, single-blind, pilot trial. Lancet Neurol, 2017. 16(9): p. 691–700.CrossRef
8.
Ellwardt, E. and F. Zipp, Molecular mechanisms linking neuroinflammation and neurodegeneration in MS. Exp Neurol, 2014. 262 Pt A: p. 8–17.PubMed
9.
Zipp, F., R. Gold, and H. Wiendl, Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies? JAMA Neurol, 2013. 70(12): p. 1569–74.PubMed
10.
McKay, K.A., et al., Risk factors associated with the onset of relapsing-remitting and primary progressive multiple sclerosis: a systematic review. Biomed Res Int, 2015. 2015: p. 817238.CrossRef
11.
Compston, A. and A. Coles, Multiple sclerosis. Lancet, 2008. 372(9648): p. 1502–17.CrossRef
12.
Goodin, D.S., The epidemiology of multiple sclerosis: insights to a causal cascade. Handb Clin Neurol, 2016. 138: p. 173–206.CrossRef
13.
Kearney, H., D.H. Miller, and O. Ciccarelli, Spinal cord MRI in multiple sclerosis—diagnostic, prognostic and clinical value. Nat Rev Neurol, 2015. 11(6): p. 327–38.CrossRef
14.
Riccitelli, G., et al., Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype. Hum Brain Mapp, 2011. 32(10): p. 1535–43.CrossRef
15.
Wilting, J., et al., Structural correlates for fatigue in early relapsing remitting multiple sclerosis. Eur Radiol, 2016. 26(2): p. 515–23.CrossRef
16.
Induruwa, I., C.S. Constantinescu, and B. Gran, Fatigue in multiple sclerosis — a brief review. J Neurol Sci, 2012. 323(1–2): p. 9–15.CrossRef
17.
18.
Foote, K.D., et al., Dual electrode thalamic deep brain stimulation for the treatment of posttraumatic and multiple sclerosis tremor. Neurosurgery, 2006. 58(4 Suppl 2): p. ONS-280-5; discussion ONS-285–6.
19.
Boonstra, F., et al., Tremor in multiple sclerosis is associated with cerebello-thalamic pathology. J Neural Transm (Vienna), 2017. 124(12): p. 1509–1514.CrossRef
20.
Muthuraman, M., A. Schnitzler, and S. Groppa, [Pathophysiology of tremor]. Nervenarzt, 2018. 89(4): p. 408–415.CrossRef
21.
Muthuraman, M., et al., Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors. Brain, 2018. 141(6): p. 1770–1781.CrossRef
22.
Alusi, S.H., et al., Tremor in multiple sclerosis. J Neurol Neurosurg Psychiatry, 1999. 66(2): p. 131–4.CrossRef
23.
Fahn S, T.E., Concepcion M., Parkinson’s disease and movement disorders. 2nd Edition ed. Clinical Rating Scale for Tremor. 1993. 271–280.
24.
Bain, P.G., et al., Assessing tremor severity. J Neurol Neurosurg Psychiatry, 1993. 56(8): p. 868–73.CrossRef
25.
Poewe, W.H.O.G.D.W., Parkinson-Syndrome und andere Bewegungsstörungen. 2011.
26.
McDannold, N., et al., MRI-guided focused ultrasound surgery in the brain: tests in a primate model. Magn Reson Med, 2003. 49(6): p. 1188–91.CrossRef
27.
Hynynen, K., et al., Thermal effects of focused ultrasound on the brain: determination with MR imaging. Radiology, 1997. 204(1): p. 247–53.CrossRef
28.
Alusi, S.H., et al., Stereotactic lesional surgery for the treatment of tremor in multiple sclerosis: a prospective case-controlled study. Brain, 2001. 124(Pt 8): p. 1576–89.CrossRef
29.
Alomar, S., et al., Speech and language adverse effects after thalamotomy and deep brain stimulation in patients with movement disorders: A meta-analysis. Mov Disord, 2017. 32(1): p. 53–63.CrossRef
30.
Schuurman, P.R., et al., A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med, 2000. 342(7): p. 461–8.CrossRef
31.
Bittar, R.G., et al., Thalamotomy versus thalamic stimulation for multiple sclerosis tremor. J Clin Neurosci, 2005. 12(6): p. 638–42.CrossRef
32.
Muthuraman, M., et al., Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson’s Disease. Front Neurol, 2018. 9: p. 711.CrossRef
33.
Allert, N., et al., Postoperative rehabilitation after deep brain stimulation surgery for movement disorders. Clin Neurophysiol, 2018. 129(3): p. 592–601.CrossRef
34.
Kerl, H.U., et al., The subthalamic nucleus at 3.0 Tesla: choice of optimal sequence and orientation for deep brain stimulation using a standard installation protocol: clinical article. J Neurosurg, 2012. 117(6): p. 1155–65.CrossRef
35.
Okun, M.S., et al., Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers. Arch Neurol, 2005. 62(8): p. 1250–5.CrossRef
36.
Nandi, D. and {ayT.Z. Aziz}, Deep brain stimulation in the management of neuropathic pain and multiple sclerosis tremor. J Clin Neurophysiol, 2004. 21(1): p. 31–9.CrossRef
37.
Timmermann, L., et al., [Deep brain stimulation for tremor in multiple sclerosis: consensus recommendations of the German Deep Brain Stimulation Association]. Nervenarzt, 2009. 80(6): p. 673–7.CrossRef
38.
Roy, H.A. and T.Z. Aziz, Deep brain stimulation and multiple sclerosis: Therapeutic applications. Mult Scler Relat Disord, 2014. 3(4): p. 431–9.CrossRef
39.
Groppa, S., et al., Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor. Brain, 2014. 137(Pt 1): p. 109–21.CrossRef
40.
Limousin, P., et al., Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psychiatry, 1999. 66(3): p. 289–96.CrossRef
41.
Benabid, A.L., et al., Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet, 1991. 337(8738): p. 403–6.CrossRef
42.
Schneider, S.A. and G. Deuschl, The treatment of tremor. Neurotherapeutics, 2014. 11(1): p. 128–38.CrossRef
43.
Zakaria, R., et al., Tremor reduction and quality of life after deep brain stimulation for multiple sclerosis-associated tremor. Acta Neurochir (Wien), 2013. 155(12): p. 2359–64; discussion 2364.CrossRef
44.
Abboud, H., et al., Neuromodulation in multiple sclerosis. Mult Scler, 2017. 23(13): p. 1663–1676.CrossRef
45.
Artusi, C.A., et al., Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming. J Neurol, 2018. 265(11): p. 2473–2493.CrossRef
46.
Eisinger, R.S., et al., Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor. Mov Disord Clin Pract, 2018. 5(1): p. 75–82.CrossRef
47.
Nandi, D., et al., Electrophysiological confirmation of the zona incerta as a target for surgical treatment of disabling involuntary arm movements in multiple sclerosis: use of local field potentials. J Clin Neurosci, 2002. 9(1): p. 64–8.CrossRef
48.
Blomstedt, P., et al., Deep brain stimulation of the subthalamic nucleus versus the zona incerta in the treatment of essential tremor. Acta Neurochir (Wien), 2011. 153(12): p. 2329–35.CrossRef
49.
Hamel, W., et al., Deep brain stimulation in the subthalamic area is more effective than nucleus ventralis intermedius stimulation for bilateral intention tremor. Acta Neurochir (Wien), 2007. 149(8): p. 749–58; discussion 758.CrossRef
50.
Mehanna, R., et al., Comparing two deep brain stimulation leads to one in refractory tremor. Cerebellum, 2014. 13(4): p. 425–32.CrossRef
51.
Isaacs, D.A., et al., Confined Thalamic Deep Brain Stimulation in Refractory Essential Tremor. Stereotact Funct Neurosurg, 2018. 96(5): p. 296–304.CrossRef
52.
Soh, D. and A. Fasano, Multiple sclerosis tremor: are technical advances enough? Lancet Neurol, 2017. 16(9): p. 678–679.CrossRef
Metadaten
Titel
Neurochirurgische Therapie
Therapeutische Möglichkeiten bei therapieresistentem MS-Tremor
verfasst von
Dr. med. Caspar Seitz
Dr. med. Julia Kroth
Prof. Dr. med. Sergiu Groppa
Publikationsdatum
31.05.2019
Verlag
Springer Medizin
Erschienen in
NeuroTransmitter / Ausgabe 6/2019
Print ISSN: 1436-123X
Elektronische ISSN: 2196-6397
DOI
https://doi.org/10.1007/s15016-019-6598-7

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