Skip to main content
Erschienen in: Current Allergy and Asthma Reports 4/2021

01.04.2021 | Occupational Allergies (JA Poole, Section Editor)

Nutritional Factors in Occupational Lung Disease

verfasst von: Mia Isaak, Arzu Ulu, Abigail Osunde, Tara M. Nordgren, Corrine Hanson

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Lung diseases such as asthma and COPD are major public health issues and related to occupational exposures. While therapies to limit the development and progression of these diseases are limited, nutrition interventions could offer potential alternatives to mediate the inflammation associated with these diseases. This is a narrative review of the current state of relevant nutrients on inflammation and respiratory outcomes associated with occupational exposures.

Recent Findings

Relevant nutrients that have been investigated in recent years include omega-3 polyunsaturated fatty acids, zinc, vitamin D, dairy products, and antioxidants. These nutrients have demonstrated the potential to prevent or modify the adverse outcomes associated with occupational exposures, primarily in preclinical studies.

Summary

Current therapies for respiratory consequences associated with occupational exposures are limited; therefore, addressing strategies for reducing inflammation is important in improving quality of life and limiting health care costs. More human studies are warranted to determine the effectiveness of nutrition as an intervention.
Literatur
1.
Zurück zum Zitat Wells AD, Poole JA, Romberger DJ. Influence of farming exposure on the development of asthma and asthma-like symptoms. Int Immunopharmacol. 2014;23(1):356–63.PubMedPubMedCentralCrossRef Wells AD, Poole JA, Romberger DJ. Influence of farming exposure on the development of asthma and asthma-like symptoms. Int Immunopharmacol. 2014;23(1):356–63.PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Eduard W, Pearce N, Douwes J. Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest. 2009;136(3):716–25.PubMedCrossRef Eduard W, Pearce N, Douwes J. Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest. 2009;136(3):716–25.PubMedCrossRef
3.
Zurück zum Zitat Foster TS, Miller JD, Marton JP, Caloyeras JP, Russell MW, Menzin J. Assessment of the economic burden of COPD in the U.S.: a review and synthesis of the literature. COPD. 2006;3(4):211–8.PubMedCrossRef Foster TS, Miller JD, Marton JP, Caloyeras JP, Russell MW, Menzin J. Assessment of the economic burden of COPD in the U.S.: a review and synthesis of the literature. COPD. 2006;3(4):211–8.PubMedCrossRef
4.
Zurück zum Zitat Mannino DM. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest. 2002;121(5 Suppl):121S–6S.PubMedCrossRef Mannino DM. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest. 2002;121(5 Suppl):121S–6S.PubMedCrossRef
5.
Zurück zum Zitat Menzin J, Boulanger L, Marton J, Guadagno L, Dastani H, Dirani R, et al. The economic burden of chronic obstructive pulmonary disease (COPD) in a U.S. Medicare population. Respir Med. 2008;102(9):1248–56.PubMedCrossRef Menzin J, Boulanger L, Marton J, Guadagno L, Dastani H, Dirani R, et al. The economic burden of chronic obstructive pulmonary disease (COPD) in a U.S. Medicare population. Respir Med. 2008;102(9):1248–56.PubMedCrossRef
6.
Zurück zum Zitat Barnett SB, Nurmagambetov TA. Costs of asthma in the United States: 2002-2007. J Allergy Clin Immunol. 2011;127(1):145–52.PubMedCrossRef Barnett SB, Nurmagambetov TA. Costs of asthma in the United States: 2002-2007. J Allergy Clin Immunol. 2011;127(1):145–52.PubMedCrossRef
7.
Zurück zum Zitat Weiss KB, Gergen PJ, Hodgson TA. An economic evaluation of asthma in the United States. N Engl J Med. 1992;326(13):862–6.PubMedCrossRef Weiss KB, Gergen PJ, Hodgson TA. An economic evaluation of asthma in the United States. N Engl J Med. 1992;326(13):862–6.PubMedCrossRef
8.
Zurück zum Zitat Mannino DM, et al. Surveillance for asthma--United States, 1980-1999. MMWR Surveill Summ. 2002;51(1):1–13.PubMed Mannino DM, et al. Surveillance for asthma--United States, 1980-1999. MMWR Surveill Summ. 2002;51(1):1–13.PubMed
9.
Zurück zum Zitat Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46(5):1308–21.PubMedCrossRef Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46(5):1308–21.PubMedCrossRef
10.
Zurück zum Zitat Scoditti E, et al. Role of diet in chronic obstructive pulmonary disease prevention and treatment. Nutrients. 2019;11(6). Scoditti E, et al. Role of diet in chronic obstructive pulmonary disease prevention and treatment. Nutrients. 2019;11(6).
11.
Zurück zum Zitat Calder PC. 3 PUFA and inflammation: from membrane to nucleus and from bench to bedside. Proc Nutr Soc. 2020:1–13. Calder PC. 3 PUFA and inflammation: from membrane to nucleus and from bench to bedside. Proc Nutr Soc. 2020:1–13.
12.
Zurück zum Zitat Watson H, Stackhouse C. Omega-3 fatty acid supplementation for cystic fibrosis. Cochrane Database Syst Rev. 2020;4:CD002201.PubMed Watson H, Stackhouse C. Omega-3 fatty acid supplementation for cystic fibrosis. Cochrane Database Syst Rev. 2020;4:CD002201.PubMed
13.
Zurück zum Zitat •• Brigham EP, Woo H, McCormack M, Rice J, Koehler K, Vulcain T, et al. Omega-3 and omega-6 intake modifies asthma severity and response to indoor air pollution in children. Am J Respir Crit Care Med. 2019;199(12):1478–86. This paper showed that Omega-3 and omega-6 intake are associated with pediatric asthma morbidity and may modify the asthmatic response to indoor particulate matter exposure. •• Brigham EP, Woo H, McCormack M, Rice J, Koehler K, Vulcain T, et al. Omega-3 and omega-6 intake modifies asthma severity and response to indoor air pollution in children. Am J Respir Crit Care Med. 2019;199(12):1478–86. This paper showed that Omega-3 and omega-6 intake are associated with pediatric asthma morbidity and may modify the asthmatic response to indoor particulate matter exposure.
14.
Zurück zum Zitat Gutiérrez S, Svahn SL, Johansson ME. Effects of omega-3 fatty acids on immune cells. Int J Mol Sci. 2019;20(20). Gutiérrez S, Svahn SL, Johansson ME. Effects of omega-3 fatty acids on immune cells. Int J Mol Sci. 2019;20(20).
15.
Zurück zum Zitat Miyata J, Arita M. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergol Int. 2015;64(1):27–34.PubMedCrossRef Miyata J, Arita M. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergol Int. 2015;64(1):27–34.PubMedCrossRef
16.
Zurück zum Zitat Muley P, Shah M, Muley A. Omega-3 fatty acids supplementation in children to prevent asthma: is it worthy?-a systematic review and meta-analysis. J Allergy (Cairo). 2015;2015:312052. Muley P, Shah M, Muley A. Omega-3 fatty acids supplementation in children to prevent asthma: is it worthy?-a systematic review and meta-analysis. J Allergy (Cairo). 2015;2015:312052.
17.
Zurück zum Zitat •• Li XY, Hao L, Liu YH, Chen CY, Pai VJ, Kang JX. Protection against fine particle-induced pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids. Biochim Biophys Acta Gen Subj. 2017;1861(3):577–84. This paper demonstrates that elevating tissue omega-3 levels can prevent and treat fine particle-induced health problems. •• Li XY, Hao L, Liu YH, Chen CY, Pai VJ, Kang JX. Protection against fine particle-induced pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids. Biochim Biophys Acta Gen Subj. 2017;1861(3):577–84. This paper demonstrates that elevating tissue omega-3 levels can prevent and treat fine particle-induced health problems.
19.
Zurück zum Zitat Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta. 2010;1801(12):1260–73.PubMedPubMedCentralCrossRef Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta. 2010;1801(12):1260–73.PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Serhan CN, et al. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014;7(2):a016311.PubMedCrossRef Serhan CN, et al. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014;7(2):a016311.PubMedCrossRef
21.
Zurück zum Zitat Levy BD, Serhan CN. Resolution of acute inflammation in the lung. Annu Rev Physiol. 2014;76:467–92.PubMedCrossRef Levy BD, Serhan CN. Resolution of acute inflammation in the lung. Annu Rev Physiol. 2014;76:467–92.PubMedCrossRef
23.
Zurück zum Zitat Duvall MG, Levy BD. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. Eur J Pharmacol. 2016;785:144–55.PubMedCrossRef Duvall MG, Levy BD. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. Eur J Pharmacol. 2016;785:144–55.PubMedCrossRef
24.
Zurück zum Zitat Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol. 2001;2(7):612–9.PubMedCrossRef Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol. 2001;2(7):612–9.PubMedCrossRef
25.
Zurück zum Zitat •• Nordgren TM, et al. The omega-3 fatty acid docosahexaenoic acid attenuates organic dust-induced airway inflammation. Nutrients. 2014;6(12):5434–52. This paper demonstrates mechanisms through which dietary supplementation with DHA may be an effective therapeutic strategy to reduce the airway inflammatory consequences in individuals exposed to agriculture dust environments. •• Nordgren TM, et al. The omega-3 fatty acid docosahexaenoic acid attenuates organic dust-induced airway inflammation. Nutrients. 2014;6(12):5434–52. This paper demonstrates mechanisms through which dietary supplementation with DHA may be an effective therapeutic strategy to reduce the airway inflammatory consequences in individuals exposed to agriculture dust environments.
26.
27.
Zurück zum Zitat •• Nordgren TM, Heires AJ, Bailey KL, Katafiasz DM, Toews ML, Wichman CS, et al. Docosahexaenoic acid enhances amphiregulin-mediated bronchial epithelial cell repair processes following organic dust exposure. Am J Physiol Lung Cell Mol Physiol. 2018;314(3):L421–31. These data indicate a role for AREG in the process of tissue repair after inflammatory lung injury caused by environmental dust exposure and implicate a role for DHA in regulating AREG-mediated repair signaling in human bronchial epithelial cells. •• Nordgren TM, Heires AJ, Bailey KL, Katafiasz DM, Toews ML, Wichman CS, et al. Docosahexaenoic acid enhances amphiregulin-mediated bronchial epithelial cell repair processes following organic dust exposure. Am J Physiol Lung Cell Mol Physiol. 2018;314(3):L421–31. These data indicate a role for AREG in the process of tissue repair after inflammatory lung injury caused by environmental dust exposure and implicate a role for DHA in regulating AREG-mediated repair signaling in human bronchial epithelial cells.
28.
Zurück zum Zitat •• Nogradi N, Couetil LL, Messick J, Stochelski MA, Burgess JR. Omega-3 fatty acid supplementation provides an additional benefit to a low-dust diet in the management of horses with chronic lower airway inflammatory disease. J Vet Intern Med. 2015;29(1):299–306. A group of horses that received PUFA had greater improvement in cough, lung function, and neutrophils when compared to placebo. •• Nogradi N, Couetil LL, Messick J, Stochelski MA, Burgess JR. Omega-3 fatty acid supplementation provides an additional benefit to a low-dust diet in the management of horses with chronic lower airway inflammatory disease. J Vet Intern Med. 2015;29(1):299–306. A group of horses that received PUFA had greater improvement in cough, lung function, and neutrophils when compared to placebo.
29.
Zurück zum Zitat •• Dominguez EC, et al. A High docosahexaenoic acid diet alters the lung inflammatory response to acute dust exposure. Nutrients. 2020;12(8):2334. These data indicate that consuming a DHA-rich diet leads to the enhanced production of inflammation-reducing mediatros during an acute inflammatory challenge to dust. •• Dominguez EC, et al. A High docosahexaenoic acid diet alters the lung inflammatory response to acute dust exposure. Nutrients. 2020;12(8):2334. These data indicate that consuming a DHA-rich diet leads to the enhanced production of inflammation-reducing mediatros during an acute inflammatory challenge to dust. 
30.
31.
Zurück zum Zitat •• Nordgren TM, Heires AJ, Wyatt TA, Poole JA, LeVan TD, Cerutis D, et al. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. Respir Res. 2013;14:51. This paper highlights a role for inflammation resolving mediators in attenuating the pro-inflammatory responses of bronchial epithelial cells to organic dust extract. •• Nordgren TM, Heires AJ, Wyatt TA, Poole JA, LeVan TD, Cerutis D, et al. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. Respir Res. 2013;14:51. This paper highlights a role for inflammation resolving mediators  in attenuating the pro-inflammatory responses of bronchial epithelial cells to organic dust extract.
32.
Zurück zum Zitat •• Nordgren TM, Bauer CD, Heires AJ, Poole JA, Wyatt TA, West WW, et al. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. Transl Res. 2015;166(1):57–69. In both single and repetitive dust exposure studies, lipid-derived pro-resolving mediators significantly decreased bronchoalveolar lavage neutrophil infiltration, interleukin 6, and tumor necrosis factor. •• Nordgren TM, Bauer CD, Heires AJ, Poole JA, Wyatt TA, West WW, et al. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. Transl Res. 2015;166(1):57–69. In both single and repetitive dust exposure studies, lipid-derived pro-resolving mediators significantly decreased bronchoalveolar lavage neutrophil infiltration, interleukin 6, and tumor necrosis factor.
33.
Zurück zum Zitat •• Antonini JM, Kodali V, Shoeb M, Kashon M, Roach KA, Boyce G, et al. Effect of a high-fat diet and occupational exposure in different rat strains on lung and systemic responses: examination of the exposome in an animal model. Toxicol Sci. 2020;174(1):100–11. This study examined an experimental model integrating multiple aspects of the exposome, including diet, by collecting biological samples during critical life stages of an exposed animal that are applicable to worker populations. •• Antonini JM, Kodali V, Shoeb M, Kashon M, Roach KA, Boyce G, et al. Effect of a high-fat diet and occupational exposure in different rat strains on lung and systemic responses: examination of the exposome in an animal model. Toxicol Sci. 2020;174(1):100–11. This study examined an experimental model integrating multiple aspects of the exposome, including diet, by collecting biological samples during critical life stages of an exposed animal that are applicable to worker populations.
34.
Zurück zum Zitat •• Gilley KN, Wierenga KA, Chauhuan PS, Wagner JG, Lewandowski RP, Ross EA, et al. Influence of total Western diet on docosahexaenoic acid suppression of silica-triggered lupus flaring in NZBWF1 mice. PLoS One. 2020;15(5):e0233183. This paper demonstrated DHA supplementation at a translationally relevant dose was highly effective in preventing cSiO2-triggered lupus flaring in NZBWF1 mice, even against the background of a typical Western diet. •• Gilley KN, Wierenga KA, Chauhuan PS, Wagner JG, Lewandowski RP, Ross EA, et al. Influence of total Western diet on docosahexaenoic acid suppression of silica-triggered lupus flaring in NZBWF1 mice. PLoS One. 2020;15(5):e0233183. This paper demonstrated DHA supplementation at a translationally relevant dose was highly effective in preventing cSiO2-triggered lupus flaring in NZBWF1 mice, even against the background of a typical Western diet.
35.
Zurück zum Zitat •• Wierenga KA, Wee J, Gilley KN, Rajasinghe LD, Bates MA, Gavrilin MA, et al. Docosahexaenoic acid suppresses silica-induced inflammasome activation and IL-1 cytokine release by interfering with priming signal. Front Immunol. 2019;10:2130. This paper showed DHA suppressed cSiO2-induced inflammasome activation and IL-1 cytokine release in macrophages by acting at the level of priming. •• Wierenga KA, Wee J, Gilley KN, Rajasinghe LD, Bates MA, Gavrilin MA, et al. Docosahexaenoic acid suppresses silica-induced inflammasome activation and IL-1 cytokine release by interfering with priming signal. Front Immunol. 2019;10:2130. This paper showed DHA suppressed cSiO2-induced inflammasome activation and IL-1 cytokine release in macrophages by acting at the level of priming.
36.
Zurück zum Zitat •• Hanson C, Lyden E, Rennard S, Mannino DM, Rutten EPA, Hopkins R, et al. The relationship between dietary fiber intake and lung function in the National Health and Nutrition Examination Surveys. Ann Am Thorac Soc. 2016;13(5):643–50. This paper showed increased fiber intake was associated with improved lung function in a United States population. •• Hanson C, Lyden E, Rennard S, Mannino DM, Rutten EPA, Hopkins R, et al. The relationship between dietary fiber intake and lung function in the National Health and Nutrition Examination Surveys. Ann Am Thorac Soc. 2016;13(5):643–50. This paper showed increased fiber intake was associated with improved lung function in a United States population.
37.
Zurück zum Zitat Biltagi MA, Baset AA, Bassiouny M, Kasrawi MA, Attia M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatr. 2009;98(4):737–42.PubMedCrossRef Biltagi MA, Baset AA, Bassiouny M, Kasrawi MA, Attia M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatr. 2009;98(4):737–42.PubMedCrossRef
38.
Zurück zum Zitat Reisman J, Schachter HM, Dales RE, Tran K, Kourad K, Barnes D, et al. Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review. BMC Complement Altern Med. 2006;6:26.PubMedPubMedCentralCrossRef Reisman J, Schachter HM, Dales RE, Tran K, Kourad K, Barnes D, et al. Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review. BMC Complement Altern Med. 2006;6:26.PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey. Chest. 2005;128(6):3792–8.PubMedCrossRef Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey. Chest. 2005;128(6):3792–8.PubMedCrossRef
40.
Zurück zum Zitat Janssens W, Bouillon R, Claes B, Carremans C, Lehouck A, Buysschaert I, et al. Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax. 2010;65(3):215–20.PubMedCrossRef Janssens W, Bouillon R, Claes B, Carremans C, Lehouck A, Buysschaert I, et al. Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax. 2010;65(3):215–20.PubMedCrossRef
41.
Zurück zum Zitat Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006;83(4):754–9.PubMedCrossRef Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006;83(4):754–9.PubMedCrossRef
42.
Zurück zum Zitat •• Lange NE, Sparrow D, Vokonas P, Litonjua AA. Vitamin D deficiency, smoking, and lung function in the Normative Aging Study. Am J Respir Crit Care Med. 2012;186(7):616–21. This paper reported vitamin D sufficiency may have a protective effect against the damaging effects of smoking on lung function. •• Lange NE, Sparrow D, Vokonas P, Litonjua AA. Vitamin D deficiency, smoking, and lung function in the Normative Aging Study. Am J Respir Crit Care Med. 2012;186(7):616–21. This paper reported vitamin D sufficiency may have a protective effect against the damaging effects of smoking on lung function.
43.
Zurück zum Zitat •• Golden GA, Wyatt TA, Romberger DJ, Reiff D, McCaskill M, Bauer C, et al. Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences. J Biochem Mol Toxicol. 2013;27(1):77–86. This paper demonstrated a mechanism for vitamin D’s role in modulating organic dust–induced airway inflammatory outcomes. •• Golden GA, Wyatt TA, Romberger DJ, Reiff D, McCaskill M, Bauer C, et al. Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences. J Biochem Mol Toxicol. 2013;27(1):77–86. This paper demonstrated a mechanism for vitamin D’s role in modulating organic dust–induced airway inflammatory outcomes.
44.
Zurück zum Zitat •• Dusad A, Thiele GM, Klassen LW, Wang D, Duryee MJ, Mikuls TR, et al. Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice. Immunol Res. 2015;62(1):46–59. In this paper, high-concentration vitamin D was protective against systemic bone loss, resulting from ODE- or LPS-induced airway injury. •• Dusad A, Thiele GM, Klassen LW, Wang D, Duryee MJ, Mikuls TR, et al. Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice. Immunol Res. 2015;62(1):46–59. In this paper, high-concentration vitamin D was protective against systemic bone loss,  resulting from ODE- or LPS-induced airway injury.
45.
Zurück zum Zitat Sze MA, Hogg JC, Sin DD. Bacterial microbiome of lungs in COPD. Int J Chron Obstruct Pulmon Dis. 2014;9:229–38.PubMedPubMedCentral Sze MA, Hogg JC, Sin DD. Bacterial microbiome of lungs in COPD. Int J Chron Obstruct Pulmon Dis. 2014;9:229–38.PubMedPubMedCentral
46.
Zurück zum Zitat Haldar K, George L, Wang Z, Mistry V, Ramsheh MY, Free RC, et al. The sputum microbiome is distinct between COPD and health, independent of smoking history. Respir Res. 2020;21(1):183.PubMedPubMedCentralCrossRef Haldar K, George L, Wang Z, Mistry V, Ramsheh MY, Free RC, et al. The sputum microbiome is distinct between COPD and health, independent of smoking history. Respir Res. 2020;21(1):183.PubMedPubMedCentralCrossRef
47.
Zurück zum Zitat Roggenbuck M, Anderson D, Barfod KK, Feelisch M, Geldenhuys S, Sørensen SJ, et al. Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner. Respir Res. 2016;17(1):116.PubMedPubMedCentralCrossRef Roggenbuck M, Anderson D, Barfod KK, Feelisch M, Geldenhuys S, Sørensen SJ, et al. Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner. Respir Res. 2016;17(1):116.PubMedPubMedCentralCrossRef
49.
Zurück zum Zitat Abrahamsson TR, Jakobsson HE, Andersson AF, Björkstén B, Engstrand L, Jenmalm MC. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014;44(6):842–50.PubMedCrossRef Abrahamsson TR, Jakobsson HE, Andersson AF, Björkstén B, Engstrand L, Jenmalm MC. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014;44(6):842–50.PubMedCrossRef
50.
Zurück zum Zitat Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016;22(10):1187–91.PubMedPubMedCentralCrossRef Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016;22(10):1187–91.PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, et al. ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Rep. 2013;3(2):386–400.PubMedPubMedCentralCrossRef Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, et al. ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Rep. 2013;3(2):386–400.PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Pyle CJ, Akhter S, Bao SY, Dodd CE, Schlesinger LS, Knoell DL. Zinc modulates endotoxin-induced human macrophage inflammation through ZIP8 induction and C/EBPβ inhibition. PLoS One. 2017;12(1):e0169531.PubMedPubMedCentralCrossRef Pyle CJ, Akhter S, Bao SY, Dodd CE, Schlesinger LS, Knoell DL. Zinc modulates endotoxin-induced human macrophage inflammation through ZIP8 induction and C/EBPβ inhibition. PLoS One. 2017;12(1):e0169531.PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat von Bülow V, Rink L, Haase H. Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-alpha and IL-1 beta production in monocytes by elevation of guanosine 3’,5’-cyclic monophosphate. J Immunol. 2005;175(7):4697–705.CrossRef von Bülow V, Rink L, Haase H. Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-alpha and IL-1 beta production in monocytes by elevation of guanosine 3’,5’-cyclic monophosphate. J Immunol. 2005;175(7):4697–705.CrossRef
54.
Zurück zum Zitat Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol. 2006;20(1):3–18.PubMedCrossRef Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol. 2006;20(1):3–18.PubMedCrossRef
55.
Zurück zum Zitat Ervin RB, Kennedy-Stephenson J. Mineral intakes of elderly adult supplement and non-supplement users in the third National Health And Nutrition Examination Survey. J Nutr. 2002;132(11):3422–7.PubMedCrossRef Ervin RB, Kennedy-Stephenson J. Mineral intakes of elderly adult supplement and non-supplement users in the third National Health And Nutrition Examination Survey. J Nutr. 2002;132(11):3422–7.PubMedCrossRef
56.
Zurück zum Zitat •• Knoell DL, Smith DA, Sapkota M, Heires AJ, Hanson CK, Smith LM, et al. Insufficient zinc intake enhances lung inflammation in response to agricultural organic dust exposure. J Nutr Biochem. 2019;70:56–64. This study showed a high prevalence of zinc deficiency in a cohort of veterans, and also demonstrated airway inflammation was most pronounced in zinc deficient mice treated with repetitive dust exposure. •• Knoell DL, Smith DA, Sapkota M, Heires AJ, Hanson CK, Smith LM, et al. Insufficient zinc intake enhances lung inflammation in response to agricultural organic dust exposure. J Nutr Biochem. 2019;70:56–64. This study showed a high prevalence of zinc deficiency in a cohort of veterans, and also demonstrated airway inflammation was most pronounced in zinc deficient mice treated with repetitive dust exposure.
57.
Zurück zum Zitat •• Knoell DL, Smith D, Bao S, Sapkota M, Wyatt TA, Zweier JL, et al. Imbalance in zinc homeostasis enhances lung Tissue Loss following cigarette smoke exposure. J Trace Elem Med Biol. 2020;60:126483. This paper showed an imbalance in zinc homeostasis increased susceptibility to permanent lung injury following prolonged cigarette smoke exposure. •• Knoell DL, Smith D, Bao S, Sapkota M, Wyatt TA, Zweier JL, et al. Imbalance in zinc homeostasis enhances lung Tissue Loss following cigarette smoke exposure. J Trace Elem Med Biol. 2020;60:126483. This paper showed  an imbalance in zinc homeostasis increased susceptibility to permanent lung injury following prolonged cigarette smoke exposure.
58.
Zurück zum Zitat von Mutius E, Vercelli D. Farm living: effects on childhood asthma and allergy. Nat Rev Immunol. 2010;10(12):861–8.CrossRef von Mutius E, Vercelli D. Farm living: effects on childhood asthma and allergy. Nat Rev Immunol. 2010;10(12):861–8.CrossRef
59.
Zurück zum Zitat •• Wyss AB, House JS, Hoppin JA, Richards M, Hankinson JL, Long S, et al. Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study. Thorax. 2018;73(3):279–82. This study reports a novel association between raw milk consumption and higher pulmonary function that lasts into older adulthood. •• Wyss AB, House JS, Hoppin JA, Richards M, Hankinson JL, Long S, et al. Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study. Thorax. 2018;73(3):279–82. This study reports a novel association between raw milk consumption and higher pulmonary function that lasts into older adulthood.
60.
Zurück zum Zitat Braun-Fahrländer C, von Mutius E. Can farm milk consumption prevent allergic diseases? Clin Exp Allergy. 2011;41(1):29–35.PubMedCrossRef Braun-Fahrländer C, von Mutius E. Can farm milk consumption prevent allergic diseases? Clin Exp Allergy. 2011;41(1):29–35.PubMedCrossRef
61.
Zurück zum Zitat •• Nordgren TM, Heires AJ, Zempleni J, Swanson BJ, Wichman C, Romberger DJ. Bovine milk-derived extracellular vesicles enhance inflammation and promote M1 polarization following agricultural dust exposure in mice. J Nutr Biochem. 2019;64:110–20. The results of this study suggest a role for diet-derived extracellular vesicles in the modulation of lung inflammation in response to organic dust. •• Nordgren TM, Heires AJ, Zempleni J, Swanson BJ, Wichman C, Romberger DJ. Bovine milk-derived extracellular vesicles enhance inflammation and promote M1 polarization following agricultural dust exposure in mice. J Nutr Biochem. 2019;64:110–20. The results of this study suggest a role for diet-derived extracellular vesicles in the modulation of lung inflammation in response to organic dust.
62.
Zurück zum Zitat Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, et al. A switch in regulatory T cells through farm exposure during immune maturation in childhood. Allergy. 2017;72(4):604–15.PubMedCrossRef Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, et al. A switch in regulatory T cells through farm exposure during immune maturation in childhood. Allergy. 2017;72(4):604–15.PubMedCrossRef
63.
Zurück zum Zitat Kääriö H, Huttunen K, Karvonen AM, Schaub B, von Mutius E, Pekkanen J, et al. Exposure to a farm environment is associated with T helper 1 and regulatory cytokines at age 4.5 years. Clin Exp Allergy. 2016;46(1):71–7.PubMedCrossRef Kääriö H, Huttunen K, Karvonen AM, Schaub B, von Mutius E, Pekkanen J, et al. Exposure to a farm environment is associated with T helper 1 and regulatory cytokines at age 4.5 years. Clin Exp Allergy. 2016;46(1):71–7.PubMedCrossRef
64.
Zurück zum Zitat Lluis A, Depner M, Gaugler B, Saas P, Casaca VI, Raedler D, et al. Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood. J Allergy Clin Immunol. 2014;133(2):551–9.PubMedCrossRef Lluis A, Depner M, Gaugler B, Saas P, Casaca VI, Raedler D, et al. Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood. J Allergy Clin Immunol. 2014;133(2):551–9.PubMedCrossRef
65.
Zurück zum Zitat Loss G, et al. The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study. J Allergy Clin Immunol. 2011;128(4):766–773.e4.PubMedCrossRef Loss G, et al. The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study. J Allergy Clin Immunol. 2011;128(4):766–773.e4.PubMedCrossRef
66.
Zurück zum Zitat Brick T, et al. The beneficial effect of farm milk consumption on asthma, allergies, and infections: from meta-analysis of evidence to clinical trial. J Allergy Clin Immunol Pract. 2020;8(3):878–889.e3.PubMedCrossRef Brick T, et al. The beneficial effect of farm milk consumption on asthma, allergies, and infections: from meta-analysis of evidence to clinical trial. J Allergy Clin Immunol Pract. 2020;8(3):878–889.e3.PubMedCrossRef
67.
Zurück zum Zitat Iddir M, et al. Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis. Nutrients. 2020;12(6). Iddir M, et al. Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis. Nutrients. 2020;12(6).
68.
Zurück zum Zitat Hanson C, et al. A comparison of nutritional antioxidant content in breast milk, donor milk, and infant formulas. Nutrients. 2016;8(11). Hanson C, et al. A comparison of nutritional antioxidant content in breast milk, donor milk, and infant formulas. Nutrients. 2016;8(11).
69.
Zurück zum Zitat Zhai T, et al. Potential micronutrients and phytochemicals against the pathogenesis of chronic obstructive pulmonary disease and lung cancer. Nutrients. 2018;10(7). Zhai T, et al. Potential micronutrients and phytochemicals against the pathogenesis of chronic obstructive pulmonary disease and lung cancer. Nutrients. 2018;10(7).
70.
Zurück zum Zitat Bobrowska-Korzeniowska M, Jerzyńska J, Polańska K, Gromadzińska J, Hanke W, Wasowicz W, et al. The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children - Polish Mother and Child Cohort Study. Allergy Asthma Proc. 2020;41(1):e19–25.PubMedCrossRef Bobrowska-Korzeniowska M, Jerzyńska J, Polańska K, Gromadzińska J, Hanke W, Wasowicz W, et al. The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children - Polish Mother and Child Cohort Study. Allergy Asthma Proc. 2020;41(1):e19–25.PubMedCrossRef
71.
Zurück zum Zitat Garcia-Larsen V, del Giacco SR, Moreira A, Bonini M, Charles D, Reeves T, et al. Asthma and dietary intake: an overview of systematic reviews. Allergy. 2016;71(4):433–42.PubMedCrossRef Garcia-Larsen V, del Giacco SR, Moreira A, Bonini M, Charles D, Reeves T, et al. Asthma and dietary intake: an overview of systematic reviews. Allergy. 2016;71(4):433–42.PubMedCrossRef
72.
Zurück zum Zitat •• Gerald CL, et al. Sorrel extract reduces oxidant production in airway epithelial cells exposed to swine barn dust extract in vitro. Mediators Inflamm. 2019;2019:7420468. The results of this study suggest a possible role for sorrel in preventing oxidant-mediated stress responses in bronchial epithelial cells exposed to hog barn dust. •• Gerald CL, et al. Sorrel extract reduces oxidant production in airway epithelial cells exposed to swine barn dust extract in vitro. Mediators Inflamm. 2019;2019:7420468. The results of this study suggest a possible role for sorrel in preventing oxidant-mediated stress responses in bronchial epithelial cells exposed to hog barn dust.
73.
Zurück zum Zitat Warren KJ, et al. Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice. Safety (Basel). 2017;3(1). Warren KJ, et al. Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice. Safety (Basel). 2017;3(1).
74.
Zurück zum Zitat Romberger DJ, Heires AJ, Nordgren TM, Souder CP, West W, Liu XD, et al. Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activation. Am J Physiol Lung Cell Mol Physiol. 2015;309(4):L388–99.PubMedPubMedCentralCrossRef Romberger DJ, Heires AJ, Nordgren TM, Souder CP, West W, Liu XD, et al. Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activation. Am J Physiol Lung Cell Mol Physiol. 2015;309(4):L388–99.PubMedPubMedCentralCrossRef
75.
Zurück zum Zitat Wyatt TA, Nemecek M, Chandra D, DeVasure JM, Nelson AJ, Romberger DJ, et al. Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10. J Immunotoxicol. 2020;17(1):153–62.PubMedCrossRef Wyatt TA, Nemecek M, Chandra D, DeVasure JM, Nelson AJ, Romberger DJ, et al. Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10. J Immunotoxicol. 2020;17(1):153–62.PubMedCrossRef
76.
Zurück zum Zitat Poole JA, Wyatt TA, Kielian T, Oldenburg P, Gleason AM, Bauer A, et al. Toll-like receptor 2 regulates organic dust-induced airway inflammation. Am J Respir Cell Mol Biol. 2011;45(4):711–9.PubMedPubMedCentralCrossRef Poole JA, Wyatt TA, Kielian T, Oldenburg P, Gleason AM, Bauer A, et al. Toll-like receptor 2 regulates organic dust-induced airway inflammation. Am J Respir Cell Mol Biol. 2011;45(4):711–9.PubMedPubMedCentralCrossRef
78.
Zurück zum Zitat Havet A, et al. Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study. Eur Respir J. 2018;51(4). Havet A, et al. Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study. Eur Respir J. 2018;51(4).
Metadaten
Titel
Nutritional Factors in Occupational Lung Disease
verfasst von
Mia Isaak
Arzu Ulu
Abigail Osunde
Tara M. Nordgren
Corrine Hanson
Publikationsdatum
01.04.2021
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 4/2021
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-021-01003-0

Weitere Artikel der Ausgabe 4/2021

Current Allergy and Asthma Reports 4/2021 Zur Ausgabe

Rhinosinusitis (J Mullol, Section Editor)

The COVID-19 Pandemic—an Epidemiological Perspective

Autoimmunity (TK Tarrant, Section Editor)

Fatal Anaphylaxis: Epidemiology and Risk Factors

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

30.04.2024 Künstliche Intelligenz Nachrichten

Krebserkrankungen unbekannten Ursprungs (CUP) sind eine diagnostische Herausforderung. KI-Systeme können Pathologen dabei unterstützen, zytologische Bilder zu interpretieren, um den Primärtumor zu lokalisieren.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.