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04.11.2020 | Original Article

Photosensitizers attenuate LPS-induced inflammation: implications in dentistry and general health

verfasst von: Ana Carolina Fernandes Couto, Renan Villanova Homem de Carvalho, Guilherme Thomaz Pereira Brancini, Fernando Grine Martins, Carlos Arterio Sorgi, Raquel Assed Bezerra da Silva, Paulo Nelson-Filho, Francisco Wanderley Garcia Paula-Silva, Maria Cristina Borsatto, Gilberto Úbida Leite Braga, Arthur Belém Novaes Júnior

Erschienen in: Lasers in Medical Science | Ausgabe 4/2021

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Abstract

Antimicrobial photodynamic therapy (aPDT) is a complementary therapeutic modality for periodontal and endodontic diseases, in which Gram-negative bacteria are directly involved. Currently, there are few evidences regarding the effects of aPDT on bacterial components such as lipopolysaccharide (LPS) and it would represent a major step forward in the clinical use of this therapy. In this context, this study aimed to evaluate the efficacy of different photosensitizers (PSs) used in aPDT in LPS inhibition. Four PSs were used in this study: methylene blue (MB), toluidine blue (TBO), new methylene blue (NMB), and curcumin (CUR). Different approaches to evaluate LPS interaction with PSs were used, such as spectrophotometry, Limulus amebocyte lysate (LAL) test, functional assays using mouse macrophages, and an in vivo model of LPS injection. Spectrophotometry showed that LPS decreased the absorbance of all PSs used, indicating interactions between the two species. LAL assay revealed significant differences in LPS concentrations upon pre-incubation with the different PSs. Interestingly, the inflammatory potential of LPS decreased after previous treatment with the four PSs, resulting in decreased secretion of inflammatory cytokines by macrophages. In vivo, pre-incubating curcumin with LPS prevented animals from undergoing septic shock within the established time. Using relevant models to study the inflammatory activity of LPS, we found that all PSs used in this work decreased LPS-induced inflammation, with a more striking effect observed for NMB and curcumin. These data advance the understanding of the mechanisms of LPS inhibition by PSs.

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Titel: Photosensitizers attenuate LPS-induced inflammation: implications in dentistry and general health
verfasst von: Ana Carolina Fernandes Couto
Renan Villanova Homem de Carvalho
Guilherme Thomaz Pereira Brancini
Fernando Grine Martins
Carlos Arterio Sorgi
Raquel Assed Bezerra da Silva
Paulo Nelson-Filho
Francisco Wanderley Garcia Paula-Silva
Maria Cristina Borsatto
Gilberto Úbida Leite Braga
Arthur Belém Novaes Júnior
Publikationsdatum: 04.11.2020
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 4/2021
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03180-2

Springer Medizin

Abstract

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