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01.04.2012 | Original Article

Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study

verfasst von: Richard D. Semba, Anne R. Cappola, Kai Sun, Stefania Bandinelli, Mansi Dalal, Candace Crasto, Jack M. Guralnik, Luigi Ferrucci

Erschienen in: European Journal of Applied Physiology | Ausgabe 4/2012

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Abstract

Handgrip strength is a strong indicator of total body muscle strength and is a predictor of poor outcomes in older adults. The aging suppressor gene klotho encodes a single-pass transmembrane protein that is secreted as a circulating hormone. In mice, disruption of klotho expression results in a syndrome that includes sarcopenia, atherosclerosis, osteoporosis, and shortened lifespan, and conversely, overexpression of klotho leads to a greater longevity. The objective was to determine whether plasma klotho levels are related to skeletal muscle strength in humans. We measured plasma klotho in 804 adults, ≥65 years, in the InCHIANTI study, a longitudinal population-based study of aging in Tuscany, Italy. Grip strength was positively correlated with plasma klotho at threshold <681 pg/mL. After adjusting for age, sex, education, smoking, physical activity, cognition, and chronic diseases, plasma klotho (per 1 standard deviation increase) was associated with grip strength (beta = 1.20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength.

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Titel: Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study
verfasst von: Richard D. Semba
Anne R. Cappola
Kai Sun
Stefania Bandinelli
Mansi Dalal
Candace Crasto
Jack M. Guralnik
Luigi Ferrucci
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 4/2012
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-011-2072-3

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