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2022 | OriginalPaper | Buchkapitel

2. Screening und Diagnostik von Intoxikation, riskantem, schädlichem und abhängigem Alkoholgebrauch

verfasst von : Friedrich M. Wurst, Erika Baum, Gallus Bischof, Eva Hoch, Karl Mann, Tim Neumann, Oliver Pogarell, Hans-Jürgen Rumpf, Ulrich W. Preuss, Claudia Spies, Natasha Thon, Wolfgang Weinmann, Falk Kiefer, Sabine Hoffmann

Erschienen in: S3-Leitlinie Screening, Diagnose und Behandlung alkoholbezogener Störungen

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Alkoholbezogene Störungen sind in der Bevölkerung zahlreich vorhanden und werden gleichzeitig häufig unterdiagnostiziert. Im Sinne eines frühzeitigen Screenings bzw. einer Früherkennung, exakten Diagnosestellung, Schweregradeinschätzung, Verlaufs- und Prognosebeurteilung und Therapie alkoholbezogener Störungen und um Folgeerkrankungen zu vermeiden, können sowohl Fragebögen als auch Zustandsmarker einzeln und in Kombination hilfreich sein. Auch aus der Public-Health-Perspektive sind hier verstärkte Aktivitäten und konsequente Vorgehensweisen zu empfehlen.

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Aertgeerts, B., Buntinx, F., Ansoms, S., & Fevery, J. (2001). Screening properties of questionnaires and laboratory tests for the detection of alcohol abuse or dependence in a general practice population. The British Journal of General Practice: The Journal of the Royal College of General Practitioners, 51(464), 206–217.PubMed

Allen, J. P., Litten, R. Z., Anton, R. F., & Cross, G. M. (1994). Carbohydrate-deficient transferrin as a measure of immoderate drinking: Remaining issues. Alcoholism: Clinical and Experimental Research, 18(4), 799–812.PubMedCrossRef

Allen, J. P., Wurst, F. M., Thon, N., & Litten, R. Z. (2013). Assessing the drinking status of liver transplant patients with alcoholic liver disease. Liver Transplantation, 19(4), 369–376.PubMedCrossRef

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Association Publishing.CrossRef

Anton, R. F., Stout, R. L., Roberts, J. S., & Allen, J. P. (1998). The Effect of Drinking Intensity and Frequency on Serum Carbohydrate-Deficient Transferrin and γ-Glutamyl Transferase Levels in Outpatient Alcoholics. Alcoholism: Clinical and Experimental Research, 22(7), 1456–1462.PubMedCrossRef

Appenzeller, B. M., Schuman, M., Yegles, M., & Wennig, R. (2007). Ethyl glucuronide concentration in hair is not influenced by pigmentation. Alcohol & Alcoholism, 42(4), 326–327.CrossRef

Aradottir, S., Asanovska, G., Gjerss, S., Hansson, P., & Alling, C. (2006). Phosphatidylethanol (PEth) concentrations in blood are correlated to reported alcohol intake in alcohol-dependent patients. Alcohol and Alcoholism, 41(4), 431–437.PubMedCrossRef

Arndt, T., Gierten, B., Güssregen, B., Werle, A., & Grüner, J. (2009). False-positive ethyl glucuronide immunoassay screening associated with chloral hydrate medication as confirmed by LC-MS/MS and self-medication. Forensic Science International, 184(1–3), e27–e29.PubMedCrossRef

Arndt, T., Beyreiß, R., Schröfel, S., & Stemmerich, K. (2014). Cross-reaction of propyl and butyl alcohol glucuronides with an ethyl glucuronide enzyme immunoassay. Forensic Science International, 241, 84–86.PubMedCrossRef

Babor, T. F., de la Fuente, J. R., Saunders, J., & Grant, M. (2001). The alcohol use disorders identification test: Guidelines for use in primary care. 2, 1–17.

Bager, H., Christensen, L. P., Husby, S., & Bjerregaard, L. (2017). Biomarkers for the detection of prenatal alcohol exposure: A review. Alcoholism: Clinical and Experimental Research, 41(2), 251–261.PubMedCrossRef

Bakdash, A., Burger, P., Goecke, T. W., Fasching, P. A., Reulbach, U., Bleich, S., et al. (2010). Quantification of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in meconium from newborns for detection of alcohol abuse in a maternal health evaluation study. Analytical and Bioanalytical Chemistry, 396(7), 2469–2477.PubMedCrossRef

Baranowski, S., Serr, A., Thierauf, A., Weinmann, W., Perdekamp, M. G., Wurst, F. M., & Halter, C. C. (2008). In vitro study of bacterial degradation of ethyl glucuronide and ethyl sulphate. International Journal of Legal Medicine, 122(5), 389–393.PubMedCrossRef

de Beaurepaire, R., Lukasiewicz, M., Beauverie, P., Castéra, S., Dagorne, O., Espaze, R., et al. (2007). Comparison of self-reports and biological measures for alcohol, tobacco, and illicit drugs consumption in psychiatric inpatients. European Psychiatry, 22(8), 540–548.PubMedCrossRef

Beresford, T. P., Blow, F. C., Singer, K., Hill, E., & Lucey, M. R. (1990). Comparison of CAGE questionnaire and computer-assisted laboratory profiles in screening for covert alcoholism. The Lancet, 336(8713), 482–485.CrossRef

Bergström, J. P., & Helander, A. (2008a). HPLC evaluation of clinical and pharmacological factors reported to cause false-positive carbohydrate-deficient transferrin (CDT) levels. Clinica Chimica Acta: International Journal of Clinical Chemistry, 389(1–2), 164–166.PubMedCrossRef

Bergström, J. P., & Helander, A. (2008b). Influence of alcohol use, ethnicity, age, gender, BMI and smoking on the serum transferrin glycoform pattern: implications for use of carbohydrate-deficient transferrin (CDT) as alcohol biomarker. Clinica Chimica Acta: International Journal of Clinical Chemistry, 388(1-2), 59–67.PubMedCrossRef

Bernadt, M. W., Taylor, C., Mumford, J., Smith, B., & Murray, R. M. (1982). Comparison of questionnaire and laboratory tests in the detection of excessive drinking and alcoholism. The Lancet, 319(8267), 325–328.CrossRef

Berner, M. M., Kriston, L., Bentele, M., & Härter, M. (2007). The alcohol use disorders identification test for detecting at-risk drinking: a systematic review and meta-analysis. Journal of Studies on Alcohol and Drugs, 68(3), 461–473.PubMedCrossRef

Bischof, G., Reinhardt, S., Grothues, J., Meyer, C., John, U., & Rumpf, H. J. (2007). Development and evaluation of a screening instrument for alcohol-use disorders and at-risk drinking: the brief alcohol screening instrument for medical care (BASIC). Journal of Studies on Alcohol and Drugs, 68(4), 607–614.PubMedCrossRef

Borges, G., Ye, Y., Bond, J., Cherpitel, C. J., Cremonte, M., Moskalewicz, J., et al. (2010). The dimensionality of alcohol use disorders and alcohol consumption in a cross-national perspective. Addiction, 105(2), 240–254.PubMedPubMedCentralCrossRef

Bortolotti, F., De Paoli, G., & Tagliaro, F. (2006). Carbohydrate-deficient transferrin (CDT) as a marker of alcohol abuse: a critical review of the literature 2001–2005. Journal of Chromatography B, 841(1–2), 96–109.CrossRef

Böttcher, M., Beck, O., & Helander, A. (2008). Evaluation of a new immunoassay for urinary ethyl glucuronide testing. Alcohol and Alcoholism, 43(1), 46–48.PubMedCrossRef

Breitling, L. P., Arndt, V., Drath, C., & Brenner, H. (2011). Liver enzymes: interaction analysis of smoking with alcohol consumption or BMI, comparing AST and ALT to γ-GT. PloS one, 6(11): e27951.

Brinkmann, B., Köhler, H., Banaschak, S., Berg, A., Eikelmann, B., West, A., & Heinecke, A. (2000). ROC analysis of alcoholism markers–100% specificity. International Journal of Legal Medicine, 113(5), 293–299.PubMedCrossRef

Burke, V., Puddey, I. B., Rakic, V., Swanson, N. R., Dimmitt, S. B., Beilin, L. J., et al. (1998). Carbohydrate-deficient transferrin as a marker of change in alcohol intake in men drinking 20 to 60 g of alcohol per day. Alcoholism: Clinical and Experimental Research, 22(9), 1973–1980.PubMedCrossRef

Chen, J., Conigrave, K. M., Macaskill, P., Whitfield, J. B., & Irwig, L. (2003). Combining carbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy for problem drinking. Alcohol and Alcoholism, 38(6), 574–582.PubMedCrossRef

Conigrave, K. M., Degenhardt, L. J., Whitfield, J. B., Saunders, J. B., Helander, A., Tabakoff, B., & WHO/ISBRA study group. (2002). CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project. Alcoholism: Clinical and Experimental Research, 26(3), 332–339.PubMedCrossRef

Conigrave, K. M., Davies, P., Haber, P., & Whitfield, J. B. (2003). Traditional markers of excessive alcohol use. Addiction, 98, 31–43.PubMedCrossRef

Coulton, S., Drummond, C., James, D., Godfrey, C., Bland, J. M., Parrott, S., & Peters, T. (2006). Opportunistic screening for alcohol use disorders in primary care: comparative study. BMJ, 332(7540), 511–517.PubMedPubMedCentralCrossRef

Cowan, J. M., Burris, J. M., Hughes, J. R., & Cunningham, M. P. (2010). The relationship of normal body temperature, end-expired breath temperature, and BAC/BrAC ratio in 98 physically fit human test subjects. Journal of Analytical Toxicology, 34(5), 238–242.PubMedCrossRef

Csipke, E., Touquet, R., Patel, T., Franklin, J., Brown, A., Holloway, P., et al. (2007). Use of blood alcohol concentration in resuscitation room patients. Emergency Medicine Journal, 24(8), 535–538.PubMedPubMedCentralCrossRef

Cushman, P., Jacobson, G., Barboriak, J. J., & Anderson, A. J. (1984). Biochemical markers for alcoholism: sensitivity problems. Alcoholism: Clinical and Experimental Research, 8(3), 253–257.PubMedCrossRef

Dahl, H., Stephanson, N., Beck, O., & Helander, A. (2002). Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. Journal of Analytical Toxicology, 26(4), 201–204.PubMedCrossRef

Dahl, H., Hammarberg, A., Franck, J., & Helander, A. (2011a). Urinary ethyl glucuronide and ethyl sulfate testing for recent drinking in alcohol-dependent outpatients treated with acamprosate or placebo. Alcohol and Alcoholism, 46(5), 553–557.PubMedCrossRef

Dahl, H., Voltaire Carlsson, A., Hillgren, K., & Helander, A. (2011b). Urinary ethyl glucuronide and ethyl sulfate testing for detection of recent drinking in an outpatient treatment program for alcohol and drug dependence. Alcohol and Alcoholism, 46(3), 278–282.PubMedCrossRef

Davidson, R., & Raistrick, D. (1986). The Validity of the Short Alcohol Dependence Data (SADD) Questionnaire: a short self-report questionnaire for the assessment of alcohol dependence. British Journal of Addiction, 81(2), 217–222.PubMedCrossRef

Dawson, D. A., Grant, B. F., Stinson, F. S., & Zhou, Y. (2005). Effectiveness of the derived Alcohol Use Disorders Identification Test (AUDIT-C) in screening for alcohol use disorders and risk drinking in the US general population. Alcoholism: Clinical and Experimental Research, 29(5), 844–854.PubMedCrossRef

Dilling, H., Mombour, W., Schmidt, M. H., & Schulte-Markwort, E. (Hrsg.). (1994). Internationale Klassifikation psychischer Störungen: ICD-10, Kapitel V (F); Forschungskriterien. Huber.

Dybek, I., Bischof, G., Grothues, J., Reinhardt, S., Meyer, C., Hapke, U., et al. (2006). The reliability and validity of the Alcohol Use Disorders Identification Test (AUDIT) in a German general practice population sample. Journal of Studies on Alcohol, 67(3), 473–481.PubMedCrossRef

Erim, Y., Böttcher, M., Dahmen, U., Beck, O., Broelsch, C. E., & Helander, A. (2007). Urinary ethyl glucuronide testing detects alcohol consumption in alcoholic liver disease patients awaiting liver transplantation. Liver Transplantation, 13(5), 757–761.PubMedCrossRef

Ettlinger, J., Kirchen, L., & Yegles, M. (2014). Influence of thermal hair straightening on ethyl glucuronide content in hair. Drug Testing and Analysis, 6(S1), 74–77.PubMedCrossRef

Faller, A., Richter, B., Kluge, M., Koenig, P., Seitz, H. K., Thierauf, A., et al. (2011). LC-MS/MS analysis of phosphatidylethanol in dried blood spots versus conventional blood specimens. Analytical and Bioanalytical Chemistry, 401(4), 1163–1166.

Ferreira, L. M., Binz, T., & Yegles, M. (2012). The influence of ethanol containing cosmetics on ethyl glucuronide concentration in hair. Forensic Science International, 218(1–3), 123–125.CrossRef

Gemeinsamen Bundesausschusses (G-BA). (2020). Richtlinien des Gemeinsamen Bundesausschusses über die ärztliche Betreuung während der Schwangerschaft und nach der Entbindung („Mutterschafts-Richtlinien“); veröffentlicht im Bundesanzeiger AT 27.04.2020 B3; https://www.g-ba.de/downloads/62-492-2130/Mu-RL_2020-02-20_iK_2020-04-28.pdf.

Gnann, H., Engelmann, C., Skopp, G., Winkler, M., Auwärter, V., Dresen, S., et al. (2010). Identification of 48 homologues of phosphatidylethanol in blood by LC-ESI-MS/MS. Analytical and Bioanalytical Chemistry, 396(7), 2415–2423.PubMedCrossRef

Gnann, H., Weinmann, W., & Thierauf, A. (2012). Formation of phosphatidylethanol and its subsequent elimination during an extensive drinking experiment over 5 days. Alcoholism: Clinical and Experimental Research, 36(9), 1507–1511.PubMedCrossRef

Gómez, A., Conde, A., Santana, J. M., Jorrín, A., Serrano, I. M., & Medina, R. (2006). The diagnostic usefulness of AUDIT and AUDIT-C for detecting hazardous drinkers in the elderly. Aging and Mental Health, 10(5), 558–561.PubMedCrossRef

Greenfield, T. K., & Kerr, W. C. (2008). Alcohol measurement methodology in epidemiology: recent advances and opportunities. Addiction, 103(7), 1082–1099.PubMedPubMedCentralCrossRef

Gullberg, R. G., & Polissar, N. L. (2011). Factors contributing to the variability observed in duplicate forensic breath alcohol measurement. Journal of Breath Research, 5(1), 016004.PubMedCrossRef

Haber, P., Lintzeris, N., Proude, E., & Lopatko, O. (2009). Guidelines for the treatment of alcoholproblems. Australian Guideline, Sydney.

Hackler, R., Arndt, T., Helwig-Rolig, A., Kropf, J., Steinmetz, A., & Schaefer, J. R. (2000). Investigation by isoelectric focusing of the initial carbohydrate-deficient transferrin (CDT) and non-CDT transferrin isoform fractionation step involved in determination of CDT by the ChronAlcoI. D. assay. Clinical Chemistry, 46(4), 483–492.PubMedCrossRef

Haffner, H. T., Krämer, M., & Zink, P. (1988). Veränderungen der Leberenzymwerte im Verlauf einer 36stündigen Alkoholbelastung. Blutalkohol, 25, 116–126.PubMed

Hahn, J. A., Dobkin, L. M., Mayanja, B., Emenyonu, N. I., Kigozi, I. M., Shiboski, S., et al. (2012). Phosphatidylethanol (PEth) as a biomarker of alcohol consumption in HIV-positive patients in sub-Saharan Africa. Alcoholism: Clinical and Experimental Research, 36(5), 854–862.PubMedCrossRef

Halter, C. C., Laengin, A., Al-Ahmad, A., Wurst, F. M., Weinmann, W., & Kuemmerer, K. (2009). Assessment of the stability of the ethanol metabolite ethyl sulfate in standardised degradation tests. Forensic Science International, 186(1–3), 52–55.PubMedCrossRef

Hannuksela, M. L., Liisanantti, M. K., Nissinen, A. E., & Savolainen, M. J. (2007). Biochemical markers of alcoholism. Clinical Chemical Laboratory Medicine, 45(8), 953–961.CrossRef

Hartmann, S., Aradottir, S., Graf, M., Wiesbeck, G., Lesch, O., Ramskogler, K., et al. (2007). BIOMARKER: Phosphatidylethanol as a sensitive and specific biomarker – comparison with gamma-glutamyl transpeptidase, mean corpuscular volume and carbohydrate-deficient transferrin. Addiction Biology, 12(1), 81–84.PubMedCrossRef

Hartwig, S., Auwärter, V., & Pragst, F. (2003). Effect of hair care and hair cosmetics on the concentrations of fatty acid ethyl esters in hair as markers of chronically elevated alcohol consumption. Forensic Science International, 131(2–3), 90–97.PubMedCrossRef

Helander, A. (2003). Carbohydrate-deficient transferrin (CDT): Adding sensitivity and specificity to alcohol abuse testing. Dade Behring Journal, 2003, 13–15.

Helander, A., & Hansson, T. (2013). National harmonization of the alcohol biomarker PEth. Lakartidningen, 110(39–40), 1747–1748.PubMed

Helander, A., Tabakoff, B., & CENTRES, W. I. S. (1997). Biochemical markers of alcohol use and abuse: experiences from the pilot study of the WHO/ISBRA collaborative project on state and trait markers of alcohol. Alcohol and Alcoholism, 32(2), 133–144.PubMedCrossRef

Helander, A., Eriksson, G., Stibler, H., & Jeppsson, J. O. (2001a). Interference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol abuse. Clinical Chemistry, 47(7), 1225–1233.PubMedCrossRef

Helander, A., Fors, M., & Zakrisson, B. (2001b). Study of Axis-Shield new% CDT immunoassay for quantification of carbohydrate-deficient transferrin (CDT) in serum. Alcohol and Alcoholism, 36(5), 406–412.PubMedCrossRef

Helander, A., Böttcher, M., Fehr, C., Dahmen, N., & Beck, O. (2009). Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification. Alcohol and Alcoholism, 44(1), 55–61.PubMedCrossRef

von Herbay, A., & Strohmeyer, G. (1994). Die erhöhte γ-GT (γ-Glutamyltransferase): Ursachen und Interpretationen. DMW-Deutsche Medizinische Wochenschrift, 119(30), 1041–1044.CrossRef

Hietala, J., Koivisto, H., Anttila, P., & Niemelä, O. (2006). Comparison of the combined marker GGT-CDT and the conventional laboratory markers of alcohol abuse in heavy drinkers, moderate drinkers and abstainers. Alcohol and Alcoholism, 41(5), 528–533.PubMedCrossRef

Higgins-Biddle, J. C., & Babor, T. F. (2018). A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: Past issues and future directions. The American Journal of Drug and Alcohol Abuse, 44(6), 578–586.PubMedPubMedCentralCrossRef

Hock, B., Schwarz, M., Domke, I., Grunert, V. P., Wuertemberger, M., Schiemann, U., et al. (2005). Validity of carbohydrate-deficient transferrin (% CDT), γ-glutamyltransferase (γ-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoholic and alcoholic origin. Addiction, 100(10), 1477–1486.PubMedCrossRef

Høiseth, G., Morini, L., Polettini, A., Christophersen, A. S., Johnsen, L., Karinen, R., & Mørland, J. (2009a). Serum/whole blood concentration ratio for ethylglucuronide and ethyl sulfate. Journal of Analytical Toxicology, 33(4), 208–211.PubMedCrossRef

Høiseth, G., Morini, L., Polettini, A., Christophersen, A., & Mørland, J. (2009b). Ethyl glucuronide in hair compared with traditional alcohol biomarkers – a pilot study of heavy drinkers referred to an alcohol detoxification unit. Alcoholism: Clinical and Experimental Research, 33(5), 812–816.PubMedCrossRef

Høiseth, G., Yttredal, B., Karinen, R., Gjerde, H., & Christophersen, A. (2010a). Levels of ethyl glucuronide and ethyl sulfate in oral fluid, blood, and urine after use of mouthwash and ingestion of nonalcoholic wine. Journal of Analytical Toxicology, 34(2), 84–88.PubMedCrossRef

Høiseth, G., Yttredal, B., Karinen, R., Gjerde, H., Mørland, J., & Christophersen, A. (2010b). Ethyl glucuronide concentrations in oral fluid, blood, and urine after volunteers drank 0.5 and 1.0 g/kg doses of ethanol. Journal of Analytical Toxicology, 34(6), 319–324.PubMedCrossRef

Isaksson, A., Walther, L., Hansson, T., Andersson, A., Stenton, J., & Blomgren, A. (2018). High-throughput LC-MS/Ms method for determination of the alcohol use biomarker phosphatidylethanol in clinical samples by use of a simple automated extraction procedure – preanalytical and analytical conditions. The Journal of Applied Laboratory Medicine, 2(6), 880–892.PubMedCrossRef

Jackson, R., Johnson, M., Campbell, F., Messina, J., Guillaume, L., Meier, P., et al. (2010). Screening and brief interventions for prevention and early identification of alcohol use disorders in adults and young people. University of Sheffield, School of Health and Related Research (ScHARR) Public Health Collaborating Centre.

Jeppsson, J. O., Kristensson, H., & Fimiani, C. (1993). Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol. Clinical Chemistry, 39(10), 2115–2120.PubMedCrossRef

John, U., Hapke, U., & Rumpf, H. J. (2003). A new measure of the alcohol dependence syndrome: the severity scale of alcohol dependence. European Addiction Research, 9(2), 87–93.PubMedCrossRef

Joya, X., Friguls, B., Ortigosa, S., Papaseit, E., Martínez, S. E., Manich, A., et al. (2012). Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: a review. Journal of Pharmaceutical and Biomedical Analysis, 69, 209–222.PubMedCrossRef

Kharbouche, H., Steiner, N., Morelato, M., Staub, C., Boutrel, B., Mangin, P., et al. (2010). Influence of ethanol dose and pigmentation on the incorporation of ethyl glucuronide into rat hair. Alcohol, 44(6), 507–514.PubMedCrossRef

Kilpatrick, B., Howlett, M., Sedgwick, P., & Ghodse, A. H. (2000). Drug use, self report and urinalysis. Drug and Alcohol Dependence, 58(1–2), 111–116.PubMedCrossRef

Kip, M. J., Spies, C. D., Neumann, T., Nachbar, Y., Alling, C., Aradottir, S., et al. (2008). The usefulness of direct ethanol metabolites in assessing alcohol intake in nonintoxicated male patients in an emergency room setting. Alcoholism: Clinical and Experimental Research, 32(7), 1284–1291.PubMedCrossRef

Knight, J. R., Sherritt, L., Harris, S. K., Gates, E. C., & Chang, G. (2003). Validity of brief alcohol screening tests among adolescents: a comparison of the AUDIT, POSIT, CAGE, and CRAFFT. Alcoholism: Clinical and Experimental Research, 27(1), 67–73.PubMedCrossRef

Koivisto, H., Hietala, J., Anttila, P., Parkkila, S., & Niemelä, O. (2006). Long-term ethanol consumption and macrocytosis: diagnostic and pathogenic implications. Journal of Laboratory and Clinical Medicine, 147(4), 191–196.PubMedCrossRef

Kraul, D., Hackler, R., & Althaus, H. (2004). A novel particle-enhanced assay for the immuno-nephelometric determination of carbohydrate-deficient transferrin. Alcoholism: Clinical & Experimental Research, 28(8) (Suppl): 34A.

Kwoh-Gain, I., Fletcher, L. M., Price, J., Powell, L. W., & Halliday, J. W. (1990). Desialylated transferrin and mitochondrial aspartate aminotransferase compared as laboratory markers of excessive alcohol consumption. Clinical Chemistry, 36(6), 841–845.PubMedCrossRef

Lande, R. G., Marin, B., & Chang, A. S. (2010). Clinical application of ethyl glucuronide testing in the US Army. Journal of Addictive Diseases, 30(1), 39–44.CrossRef

Lesch, O. M., Walter, H., Antal, J., Heggli, D. E., Kovacz, A., Leitner, A., et al. (1996). Carbohydrate-deficient transferrin as a marker of alcohol intake: a study with healthy subjects. Alcohol and Alcoholism, 31(3), 265–271.PubMedCrossRef

Lin, K. C., Kinnamon, D., Sankhala, D., Muthukumar, S., & Prasad, S. (2019). AWARE: A Wearable Awareness with Real-time Exposure, for monitoring alcohol consumption impact through Ethyl Glucuronide detection. Alcohol, 81, 93–99.PubMedCrossRef

Luginbühl, M., Weinmann, W., Butzke, I., & Pfeifer, P. (2019). Monitoring of direct alcohol markers in alcohol use disorder patients during withdrawal treatment and successive rehabilitation. Drug Testing and Analysis, 11(6), 859–869.PubMedCrossRef

Maenhout, T. M., De Buyzere, M. L., & Delanghe, J. R. (2013). Non-oxidative ethanol metabolites as a measure of alcohol intake. Clinica Chimica Acta, 415, 322–329.CrossRef

McDonell, M. G., Skalisky, J., Leickly, E., McPherson, S., Battalio, S., Nepom, J. R., et al. (2015). Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients. Drug and Alcohol Dependence, 157, 184–187.PubMedPubMedCentralCrossRef

Miele, G. M., Carpenter, K. M., Cockerham, M. S., Trautman, K. D., Blaine, J., & Hasin, D. S. (2000). Concurrent and predictive validity of the Substance Dependence Severity Scale (SDSS). Drug and Alcohol Dependence, 59(1), 77–88.PubMedCrossRef

Miller, P. M., Spies, C., Neumann, T., Javors, M. A., Hoyumpa, A. M., Roache, J., et al. (2006). Alcohol biomarker screening in medical and surgical settings. Alcoholism: Clinical and Experimental Research, 30(2), 185–193.PubMedCrossRef

Morgan, M. Y., Camilo, M. E., Luck, W., SHERLOCK, S., & Hoffbrand, A. V. (1981). Macrocytosis in alcohol-related liver disease: its value for screening. Clinical & Laboratory Haematology, 3(1), 35–44.CrossRef

Morini, L., Politi, L., Acito, S., Groppi, A., & Polettini, A. (2009). Comparison of ethyl glucuronide in hair with carbohydrate-deficient transferrin in serum as markers of chronic high levels of alcohol consumption. Forensic Science International, 188(1–3), 140–143.PubMedCrossRef

Morini, L., Zucchella, A., Polettini, A., Politi, L., & Groppi, A. (2010). Effect of bleaching on ethyl glucuronide in hair: an in vitro experiment. Forensic Science International, 198(1–3), 23–27.PubMedCrossRef

Musshoff, F., Albermann, E., & Madea, B. (2010). Ethyl glucuronide and ethyl sulfate in urine after consumption of various beverages and foods – misleading results? International Journal of Legal Medicine, 124(6), 623–630.PubMedCrossRef

Mutschler, J., Grosshans, M., Koopmann, A., Mann, K., Kiefer, F., & Hermann, D. (2010a). Urinary ethylglucuronide assessment in patients treated with disulfiram: a tool to improve verification of abstention and safety. Clinical Neuropharmacology, 33(6), 285–287.

National Institute for Health and Clinical Excellence NICE. (2010). Alcohol-use disorders: preventing the development of hazardous and harmful drinking. (PH 24).

National Institute for Health and Clinical Excellence NICE. (2011). Diagnosis, assessment and management of harmful drinking and alcohol dependence (CG 115).

Neumann, T., & Spies, C. (2003). Use of biomarkers for alcohol use disorders in clinical practice. Addiction, 98, 81–91.PubMedCrossRef

Neumann, T., Neuner, B., Gentilello, L. M., Weiss-Gerlach, E., Mentz, H., Rettig, J. S., et al. (2004). Gender differences in the performance of a computerized version of the alcohol use disorders identification test in subcritically injured patients who are admitted to the emergency department. Alcoholism: Clinical and Experimental Research, 28(11), 1693–1701.PubMedCrossRef

Neumann, T., Gentilello, L. M., Neuner, B., Weiß-Gerlach, E., Schürmann, H., Schröder, T., et al. (2009). Screening trauma patients with the alcohol use disorders identification test and biomarkers of alcohol use. Alcoholism: Clinical and Experimental Research, 33(6), 970–976.PubMedCrossRef

Niemelä, O. (2002). Serum diagnosis of alcoholic liver disease and markers of ethanol intake. In D. I. N. Shermann, V. Preedy, & R. R. Watson (Hrsg.), Ethanol and the liver (1. Aufl., S. 411–449). Taylor and Francis.

Niemelä, O. (2007). Biomarkers in alcoholism. Clinica chimica acta, 377(1–2), 39–49.CrossRef

Niemelä, O. (2016). Biomarker-based approaches for assessing alcohol use disorders. International Journal of Environmental Research and Public Health, 13(2), 166.PubMedPubMedCentralCrossRef

Niemelä, O., & Alatalo, P. (2010). Biomarkers of alcohol consumption and related liver disease. Scandinavian Journal of Clinical and Laboratory Investigation, 70(5), 305–312.PubMedCrossRef

O’Connor, E. A., Perdue, L. A., Senger, C. A., Rushkin, M., Patnode, C. D., Bean, S. I., & Jonas, D. E. (2018). Screening and behavioral counseling interventions to reduce unhealthy alcohol use in adolescents and adults: updated evidence report and systematic review for the US Preventive Services Task Force. Jama, 320(18), 1910–1928.PubMedCrossRef

OCEBM Levels of Evidence Working Group. (2011). The Oxford 2011 Levels of Evidence. Oxford Centre for Evidence-Based Medicine. https://www.cebm.net/wp-content/uploads/2014/06/CEBM-Levels-of-Evidence-2.1.pdf.

Oslin, D. W., Pettinati, H. M., Luck, G., Semwanga, A., Cnaan, A., & O'Brien, C. P. (1998). Clinical correlations with carbohydrate-deficient transferrin levels in women with alcoholism. Alcoholism: Clinical and Experimental Research, 22(9), 1981–1985.PubMedCrossRef

Pichini, S., Marchei, E., Vagnarelli, F., Tarani, L., Raimondi, F., Maffucci, R., et al. (2012). Assessment of prenatal exposure to ethanol by meconium analysis: results of an Italian multicenter study. Alcoholism: Clinical and Experimental Research, 36(3), 417–424.PubMedCrossRef

Politi, L., Morini, L., Leone, F., & Polettini, A. (2006). Ethyl glucuronide in hair: is it a reliable marker of chronic high levels of alcohol consumption? Addiction, 101(10), 1408–1412.PubMedCrossRef

Puukka, K., Hietala, J., Koivisto, H., Anttila, P., Bloigu, R., & Niemelä, O. (2006). Additive effects of moderate drinking and obesity on serum γ-glutamyl transferase activity. The American Journal of Clinical Nutrition, 83(6), 1351–1354.PubMedCrossRef

Redondo, A. H., Körber, C., König, S., Längin, A., Al-Ahmad, A., & Weinmann, W. (2012). Inhibition of bacterial degradation of EtG by collection as dried urine spots (DUS). Analytical and Bioanalytical Chemistry, 402(7), 2417–2424.PubMedCrossRef

Reif, A., Fallgatter, A. J., & Schmidtke, A. (2005). Carbohydrate-deficient transferrin parallels disease severity in anorexia nervosa. Psychiatry Research, 137(1-2), 143–146.PubMedCrossRef

Reinert, D. F., & Allen, J. P. (2002). The alcohol use disorders identification test (AUDIT): a review of recent research. Alcoholism: Clinical and Experimental Research, 26(2), 272–279.PubMedCrossRef

Reinert, D. F., & Allen, J. P. (2007). The alcohol use disorders identification test: an update of research findings. Alcoholism: Clinical and Experimental Research, 31(2), 185–199.PubMedCrossRef

Reisfield, G. M., Goldberger, B. A., Pesce, A. J., Crews, B. O., Wilson, G. R., Teitelbaum, S. A., & Bertholf, R. L. (2011). Ethyl glucuronide, ethyl sulfate, and ethanol in urine after intensive exposure to high ethanol content mouthwash. Journal of Analytical Toxicology, 35(5), 264–268.PubMedCrossRef

Rentenversicherung, D. (2010). Leitlinien zur Sozialmedizinischen Beurteilung bei Abhängigkeitserkrankungen. Stand 24.

Rinck, D., Frieling, H., Freitag, A., Hillemacher, T., Bayerlein, K., Kornhuber, J., & Bleich, S. (2007). Combinations of carbohydrate-deficient transferrin, mean corpuscular erythrocyte volume, gamma-glutamyltransferase, homocysteine and folate increase the significance of biological markers in alcohol dependent patients. Drug and Alcohol Dependence, 89(1), 60–65.PubMedCrossRef

Rosman, A. S., & Lieber, C. S. (1994). Diagnostic utility of laboratory tests in alcoholic liver disease. Clinical Chemistry, 40(8), 1641–1651.PubMedCrossRef

Ruhl, C. E., & Everhart, J. E. (2005). Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population. Clinical Gastroenterology and Hepatology, 3(12), 1260–1268.PubMedCrossRef

Rumpf, H. J., Hapke, U., Meyer, C., & John, U. (2002). Screening for alcohol use disorders and at-risk drinking in the general population: Psychometric performance of three questionnaires. Alcohol and Alcoholism, 37(3), 261–268.PubMedCrossRef

Rumpf, H. J., Wohlert, T., Freyer-Adam, J., Grothues, J., & Bischof, G. (2013). Screening questionnaires for problem drinking in adolescents: performance of AUDIT, AUDIT-C, CRAFFT and POSIT. European Addiction Research, 19(3), 121–127.PubMedCrossRef

Salaspuro, M. (1999). Carbohydrate-deficient transferrin as compared to other markers of alcoholism: a systematic review. Alcohol, 19(3), 261–271.PubMedCrossRef

Salmela, K. S., Laitinen, K., Nyström, M., & Salaspuro, M. (1994). Carbohydrate-deficient transferrin during 3 weeks' heavy alcohol consumption. Alcoholism: Clinical and Experimental Research, 18(2), 228–230.PubMedCrossRef

Schmiemann, G., Biesewig-Siebenmorgen, J., Gebhardt, K., & Egidi, G. (2014). The Bremen periodic health exam-feasibility of a new concept. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, 108(4), 196–202.PubMedCrossRef

Schröck, A., Pfäffli, M., König, S., & Weinmann, W. (2016). Application of phosphatidylethanol (PEth) in whole blood in comparison to ethyl glucuronide in hair (hEtG) in driving aptitude assessment (DAA). International Journal of Legal Medicine, 130(6), 1527–1533.PubMedCrossRef

Schröck, A., Thierauf-Emberger, A., Schürch, S., & Weinmann, W. (2017). Phosphatidylethanol (PEth) detected in blood for 3 to 12 days after single consumption of alcohol – A drinking study with 16 volunteers. International Journal of Legal Medicine, 131(1), 153–160.PubMedCrossRef

Schröck, A., Wurst, F. M., Thon, N., & Weinmann, W. (2017). Assessing phosphatidylethanol (PEth) levels reflecting different drinking habits in comparison to the alcohol use disorders identification test-C (AUDIT-C). Drug and Alcohol Dependence, 178, 80–86.PubMedCrossRef

Schröck, A., Henzi, A., Bütikofer, P., König, S., & Weinmann, W. (2018). Determination of the formation rate of phosphatidylethanol by phospholipase D (PLD) in blood and test of two selective PLD inhibitors. Alcohol, 73, 1–7.PubMedCrossRef

Scouller, K. A. Y., Conigrave, K. M., MacAskill, P., Irwig, L., & Whitfield, J. B. (2000). Should we use carbohydrate-deficient transferrin instead of γ-glutamyltransferase for detecting problem drinkers? A systematic review and metaanalysis. Clinical Chemistry, 46(12), 1894–1902.PubMedCrossRef

Sillanaukee, P., & Olsson, U. (2001). Improved diagnostic classification of alcohol abusers by combining carbohydrate-deficient transferrin and γ-glutamyltransferase. Clinical Chemistry, 47(4), 681–685.PubMedCrossRef

Sillanaukee, P., Van der Gaag, M. S., Sierksma, A., Hendriks, H. F. J., Strid, N., Pönniö, M., & Nikkari, S. T. (2003). Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes. Alcoholism: Clinical and Experimental Research, 27(1), 57–60.PubMedCrossRef

Skipper, G. E., Thon, N., DuPont, R. L., Campbell, M. D., Weinmann, W., & Wurst, F. M. (2014). Cellular photo digital breathalyzer for monitoring alcohol use: a pilot study. European Addiction Research, 20(3), 137–142.PubMedCrossRef

Sobell, L. C., & Sobell, M. B. (1995). Alcohol timeline followback users’ manual. Addiction Research Foundation.

Sobell, L. C., & Sobell, M. B. (2003). Assessment of Drinking Behavior. In J. P. Allen & M. Columbus (Hrsg.), Assessing alcohol problems: A guide for clinicians and researchers. Diane Publishing.

Society of Hair Testing (SOHT). (2009). Consensus of the Society of Hair Testing on hair testing for chronic excessive alcohol consumption. http://soht.org/pdf/Consensus_EtG_2009.pdf. Zugegriffen am 22.07.2013.

Society of Hair Testing (SOHT). (2019). Consensus for the use of alcohol markers in hair for supporting the assessment of abstinence and chronic alcohol consumption. https://soht.org/images/pdf/Revision_2019_Alcoholmarkers.pdf. Zugegriffen am 19.08.2020.

Sporkert, F., Kharbouche, H., Augsburger, M. P., Klemm, C., & Baumgartner, M. R. (2012). Positive EtG findings in hair as a result of a cosmetic treatment. Forensic Science International, 218(1–3), 97–100.PubMedCrossRef

Staufer, K., Andresen, H., Vettorazzi, E., Tobias, N., Nashan, B., & Sterneck, M. (2011). Urinary ethyl glucuronide as a novel screening tool in patients pre-and post-liver transplantation improves detection of alcohol consumption. Hepatology, 54(5), 1640–1649.PubMedCrossRef

Staufer, K., Roedl, K., Kivaranovic, D., Drolz, A., Horvatits, T., Rasoul-Rockenschaub, S., et al. (2017). Renal replacement therapy in critically ill liver cirrhotic patients – Outcome and clinical implications. Liver International, 37(6), 843–850.PubMedCrossRef

Stewart, S. H., Reuben, A., Brzezinski, W. A., Koch, D. G., Basile, J., Randall, P. K., & Miller, P. M. (2009). Preliminary evaluation of phosphatidylethanol and alcohol consumption in patients with liver disease and hypertension. Alcohol and Alcoholism, 44(5), 464–467.PubMedPubMedCentralCrossRef

Stewart, S. H., Koch, D. G., Burgess, D. M., Willner, I. R., & Reuben, A. (2013). Sensitivity and specificity of urinary ethyl glucuronide and ethyl sulfate in liver disease patients. Alcoholism: Clinical and Experimental Research, 37(1), 150–155.PubMedCrossRef

Stibler, H. (1991). Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clinical Chemistry, 37(12), 2029–2037.PubMedCrossRef

Stibler, H., & Kjellin, K. G. (1976). Isoelectric focusing and electrophoresis of the CSF proteins in tremor of different origins: A study of 38 cases with the cerebellar syndrome of chronic alcoholism, Parkinson's disease and essential tremor. Journal of the Neurological Sciences, 30(2–3), 269–285.PubMedCrossRef

Stibler, H., Borg, S., & Joustra, M. (1986). Micro anion exchange chromatography of carbohydrate-deficient transferrin in serum in relation to alcohol consumption (Swedish Patent8400587–5). Alcoholism: Clinical and Experimental Research, 10(5), 535–544.PubMedCrossRef

Stockwell, T., Murphy, D., & Hodgson, R. (1983). The severity of alcohol dependence questionnaire: its use, reliability and validity. British Journal of Addiction, 78(2), 145–155.PubMedCrossRef

Stowell, L. I., Fawcett, J. P., Brooke, M., Robinson, G. M., & Stanton, W. R. (1997). Comparison of two commercial test kits for quantification of serum carbohydrate-deficient transferrin. Alcohol and Alcoholism, 32(4), 507–516.PubMedCrossRef

Strano-Rossi, S. (1999). Methods used to detect drug abuse in pregnancy: a brief review. Drug and alcohol dependence, 53(3), 257–271.PubMedCrossRef

Thierauf, A., Halter, C. C., Rana, S., Auwaerter, V., Wohlfarth, A., Wurst, F. M., & Weinmann, W. (2009). Urine tested positive for ethyl glucuronide after trace amounts of ethanol. Addiction, 104(12), 2007–2012.PubMedCrossRef

Thiesen, H., & Hesse, M. (2010). Biological markers of problem drinking in homeless patients. Addictive Behaviors, 35(3), 260–262.PubMedCrossRef

Thon, N., Weinmann, W., Yegles, M., Preuss, U., & Wurst, F. M. (2013). Direkte Ethanolmetaboliten als Biomarker für Alkoholkonsum: Grundlagen und Anwendungen. Fortschritte der Neurologie· Psychiatrie, 81(09), 493–502.PubMedCrossRef

Topic, A., & Djukic, M. (2013). Diagnostic characteristics and application of alcohol biomarkers. Clinical Laboratory, 59(3–4), 233–245.PubMed

U.S. Preventive Services Task Force (USPSTF). (2018, November 13). Unhealthy Alcohol Use in Adolescents and Adults: Screening and Behavioral Counseling Interventions. https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/unhealthy-alcohol-use-in-adolescents-and-adults-screening-and-behavioral-counseling-interventions.

Ulwelling, W., & Smith, K. (2018). The PEth blood test in the security environment: What it is; why it is important; and interpretative guidelines. Journal of forensic sciences, 63(6), 1634–1640.PubMedCrossRef

Vaswani, M., & Rao, R. V. (2005). Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis. Indian Journal of Medical Sciences, 59(10), 423–430.PubMedCrossRef

Viel, G., Boscolo-Berto, R., Cecchetto, G., Fais, P., Nalesso, A., & Ferrara, S. D. (2012). Phosphatidylethanol in blood as a marker of chronic alcohol use: a systematic review and meta-analysis. International Journal of Molecular Sciences, 13(11), 14788–14812.PubMedPubMedCentralCrossRef

Walther, L., de Bejczy, A., Löf, E., Hansson, T., Andersson, A., Guterstam, J., et al. (2015). Phosphatidylethanol is superior to carbohydrate-deficient transferrin and γ-glutamyltransferase as an alcohol marker and is a reliable estimate of alcohol consumption level. Alcoholism: Clinical and Experimental Research, 39(11), 2200–2208.PubMedCrossRef

Wang, Y., Chen, X., Hahn, J. A., Brumback, B., Zhou, Z., Miguez, M. J., & Cook, R. L. (2018). Phosphatidylethanol in comparison to self-reported alcohol consumption among HIV-infected women in a randomized controlled trial of naltrexone for reducing hazardous drinking. Alcoholism: Clinical and Experimental Research, 42(1), 128–134.PubMedCrossRef

Whitfield, J. B., Fletcher, L. M., Murphy, T. L., Powell, L. W., Halliday, J., Heath, A. C., & Martin, N. G. (1998). Smoking, obesity, and hypertension alter the dose-response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake. Clinical Chemistry, 44(12), 2480–2489.PubMedCrossRef

Wittchen, H. U., Beloch, E., Garczynski, E., Holly, A., Lachner, G., Perkonigg, A., et al. (1995). Münchener Composite International Diagnostic Interview (M-CIDI). Paper-pencil, 2(2), 2/95.

Wittchen, H. U., Wunderlich, U., Gruschwitz, S., & Zaudig, M. (1997). SKID-I. Strukturiertes Klinisches Interview für DSM-IV. Achse I: Psychische Störungen. Hogrefe.

Wurst, F. M., Kempter, C., Seidl, S., & Alt, A. (1999). Ethyl glucuronide – a marker of alcohol consumption and a relapse marker with clinical and forensic implications. Alcohol and Alcoholism (Oxford, Oxfordshire), 34(1), 71–77.PubMedCrossRef

Wurst, F. M., Vogel, R., Jachau, K., Varga, A., Alling, C., Alt, A., & Skipper, G. E. (2003). Ethyl glucuronide discloses recent covert alcohol use not detected by standard testing in forensic psychiatric inpatients. Alcoholism: Clinical and Experimental Research, 27(3), 471–476.PubMedCrossRef

Wurst, F. M., Wiesbeck, G. A., Metzger, J. W., Weinmann, W., Graf, M., & WHO/ISBRA Study on Biological State and Trait Markers of Alcohol Use and Dependence. (2004). On sensitivity, specificity, and the influence of various parameters on ethyl glucuronide levels in urine – results from the WHO/ISBRA study. Alcoholism: Clinical and Experimental Research, 28(8), 1220–1228.PubMedCrossRef

Wurst, F. M., Kelso, E., Weinmann, W., Pragst, F., Yegles, M., & Poromaa, I. S. (2008). Measurement of direct ethanol metabolites suggests higher rate of alcohol use among pregnant women than found with the AUDIT – a pilot study in a population-based sample of Swedish women. American Journal of Obstetrics and Gynecology, 198(4), 407–4e1.CrossRef

Wurst, F. M., Thon, N., Aradottir, S., Hartmann, S., Wiesbeck, G. A., Lesch, O., et al. (2010). Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports. Addiction Biology, 15(1), 88–95.

Wurst, F. M., Thon, N., Yegles, M., Halter, C., Weinmann, W., Laskowska, B., et al. (2011). Optimizing heroin-assisted treatment (HAT): assessment of the contribution of direct ethanol metabolites in identifying hazardous and harmful alcohol use. Drug and Alcohol Dependence, 115(1–2), 57–61.PubMedCrossRef

Wurst, F. M., Thon, N., Yegles, M., Schrück, A., Preuss, U. W., & Weinmann, W. (2015). Ethanol metabolites: their role in the assessment of alcohol intake. Alcoholism: Clinical and Experimental Research, 39(11), 2060–2072.PubMedCrossRef

Wymer, A., & Becker, D. M. (1990). Recognition and evaluation of red blood cell macrocytosis in the primary care setting. Journal of General Internal Medicine, 5(3), 192–197.PubMedCrossRef

Yegles, M., Labarthe, A., Auwärter, V., Hartwig, S., Vater, H., Wennig, R., & Pragst, F. (2004). Comparison of ethyl glucuronide and fatty acid ethyl ester concentrations in hair of alcoholics, social drinkers and teetotallers. Forensic Science International, 145(2–3), 167–173.PubMedCrossRef

Zhang, D. X., Li, S. T. S., Lee, Q. K.Y., Chan, K. H. S., Kim, J. H., Yip, B. H. K., ... & Wong, M. C. S. (2017). Systematic review of guidelines on managing patients with harmful use of alcohol in primary healthcare settings. Alcohol and alcoholism, 52(5), 595–609.

Titel: Screening und Diagnostik von Intoxikation, riskantem, schädlichem und abhängigem Alkoholgebrauch
verfasst von: Friedrich M. Wurst
Erika Baum
Gallus Bischof
Eva Hoch
Karl Mann
Tim Neumann
Oliver Pogarell
Hans-Jürgen Rumpf
Ulrich W. Preuss
Claudia Spies
Natasha Thon
Wolfgang Weinmann
Falk Kiefer
Sabine Hoffmann
Verlag: Springer Berlin Heidelberg
Buch: S3-Leitlinie Screening, Diagnose und Behandlung alkoholbezogener Störungen
Print ISBN: 978-3-662-63676-3

Electronic ISBN: 978-3-662-63677-0

Copyright-Jahr: 2022
DOI: https://doi.org/10.1007/978-3-662-63677-0_2

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