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Erschienen in:

01.10.2022 | Original Paper

Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression

verfasst von: Beatriz G. S. Rocha, Caroline C. Picoli, Bryan O. P. Gonçalves, Walison N. Silva, Alinne C. Costa, Michele M. Moraes, Pedro A. C. Costa, Gabryella S. P. Santos, Milla R. Almeida, Luciana M. Silva, Youvika Singh, Marcelo Falchetti, Gabriela D. A. Guardia, Pedro P. G. Guimarães, Remo C. Russo, Rodrigo R. Resende, Mauro C. X. Pinto, Jaime H. Amorim, Vasco A. C. Azevedo, Alexandre Kanashiro, Helder I. Nakaya, Edroaldo L. Rocha, Pedro A. F. Galante, Akiva Mintz, Paul S. Frenette, Alexander Birbrair

Erschienen in: Angiogenesis | Ausgabe 1/2023

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Abstract

Cancer cells are embedded within the tissue and interact dynamically with its components during cancer progression. Understanding the contribution of cellular components within the tumor microenvironment is crucial for the success of therapeutic applications. Here, we reveal the presence of perivascular GFAP+/Plp1+ cells within the tumor microenvironment. Using in vivo inducible Cre/loxP mediated systems, we demonstrated that these cells derive from tissue-resident Schwann cells. Genetic ablation of endogenous Schwann cells slowed down tumor growth and angiogenesis. Schwann cell-specific depletion also induced a boost in the immune surveillance by increasing tumor-infiltrating anti-tumor lymphocytes, while reducing immune-suppressor cells. In humans, a retrospective in silico analysis of tumor biopsies revealed that increased expression of Schwann cell-related genes within melanoma was associated with improved survival. Collectively, our study suggests that Schwann cells regulate tumor progression, indicating that manipulation of Schwann cells may provide a valuable tool to improve cancer patients’ outcomes.

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Titel: Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
verfasst von: Beatriz G. S. Rocha
Caroline C. Picoli
Bryan O. P. Gonçalves
Walison N. Silva
Alinne C. Costa
Michele M. Moraes
Pedro A. C. Costa
Gabryella S. P. Santos
Milla R. Almeida
Luciana M. Silva
Youvika Singh
Marcelo Falchetti
Gabriela D. A. Guardia
Pedro P. G. Guimarães
Remo C. Russo
Rodrigo R. Resende
Mauro C. X. Pinto
Jaime H. Amorim
Vasco A. C. Azevedo
Alexandre Kanashiro
Helder I. Nakaya
Edroaldo L. Rocha
Pedro A. F. Galante
Akiva Mintz
Paul S. Frenette
Alexander Birbrair
Publikationsdatum: 01.10.2022
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 1/2023
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-022-09858-1

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Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression

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