Malaria is a major public health issue in Niger. In 2020, the Niger Malaria Control National Strategic Plan reported 5827 deaths attributable to malaria and 5,141,257 confirmed malaria cases, for an incidence of 19,200 cases per 100,000 …

A single 300 mg dose of tafenoquine (an 8-aminoquinoline), in combination with a standard 3-day course of chloroquine, is approved in several countries for the radical cure (prevention of relapse) of Plasmodium vivax malaria in patients aged ≥ 16 …

Malaria surveillance has been integrated as a core intervention in all malaria-endemic countries by the World Health Organization (WHO) since 2018 [ 1 ]. Senegal has made substantial efforts in malaria control through the National Malaria Control …

Plasmodium species cause the protozoan disease known as malaria, which is spread through the bite of infected female Anopheles mosquitoes [ 1 ]. It still poses a serious health problem, especially to pregnant women, the developing foetus, and the …

According to the 2022 World Health Organization (WHO) report, malaria still represents a global health issue. In 2021, the WHO estimated 247 million cases of malaria in 86 endemic countries [ 1 ]. However, in the Americas, malaria cases decreased …

Novel vaccines and drugs are urgently needed to alleviate the burden of disease by malaria and reverse the recent resurgence of cases [ 1 – 3 ]. Plasmodium falciparum sporozoites (SPZ), the infective form of malaria, are considered a key target for …

Malaria remains a major public health problem worldwide, with nearly half of the world’s population at risk and lives in areas where malaria transmission occurs, but with the majority of cases and deaths from sub-Saharan (SSA) [ 1 ]. In 2022, over …

Artemisinin-based combination therapy (ACT) remains a treatment of choice for uncomplicated Plasmodium falciparum malaria globally [ 1 , 2 ]. Six artemisinin-based combinations have been pre-qualified by the World Health Organization (WHO) for …

Plasmodium ovale malaria is usually considered a tropical infectious disease associated with low morbidity and mortality. However, severe disease and death have previously been reported [ 1 ]. A case of severe P. ovale malaria with a triangle …

Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be …

Pathogen genomics is revolutionizing public health by providing a rich data source for informing real-time, actionable recommendations for public health programmes [ 1 ]. Each pathogen genome is a unique record of its previous transmission history …

Malaria is still a major cause of illness in about 85 countries worldwide, with an estimated 249 million cases in 2022 [ 1 ]. Globally, malaria cases have increased by 7.39% from the baseline year of the Global Technical Strategy for malaria …

Individuals infected with Plasmodium vivax may suffer from relapses caused by dormant liver parasites (hypnozoites). Globally between 60 to 96% of P. vivax infections are due to hypnozoite reactivation [ 1 – 3 ]. These relapses can occur within …

Malaria is a disease caused by infection with Plasmodium parasites, and global cases and deaths have declined substantially since 2000 [ 1 ], with 25 countries achieving zero locally acquired cases and many more approaching this significant …

Cerebral malaria (CM) is the most common and serious neurological complication arising mostly from infection with P. falciparum [ 1 , 2 ]. Mounting evidence also confirms P. vivax as another major cause of severe malaria despite relatively …

Female Anopheles mosquitoes can carry Plasmodium protozoan parasites, some of which transmit to humans. The majority of malaria caused by Plasmodium falciparum and Plasmodium vivax occurs in Africa. Between 2010 and 2017, there was a noticeable …

Malaria continues to be a significant public health challenge in several parts of the world, where it is responsible for a high burden of morbidity and mortality [ 1 , 2 ]. Despite the impact of standard control interventions, asymptomatic …

Malaria is a disease caused by a pathogen transmitted to humans by female Anopheles mosquitoes. Despite the goal set by the World Health Organization (WHO) to reduce the global burden of malaria to 90% by 2030 [ 1 ], malaria-related morbidity and …

Malaria remains a public health problem in Uganda [ 1 ]. Transmission occurs throughout the year with peak transmission occurring between in May–June and November–December. Although the entire population remains at risk of malaria infections …