Erschienen in:
01.05.2020 | ASO Author Reflections
ASO Author Reflections: The Sequential Radiographic Effects of Preoperative Chemotherapy and (Chemo)Radiation on Tumor Anatomy in Patients with Localized Pancreatic Cancer
verfasst von:
Giampaolo Perri, MD, Matthew H. G. Katz, MD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 10/2020
Einloggen, um Zugang zu erhalten
Excerpt
Radiographic downstaging of localized pancreatic adenocarcinoma has historically been an uncommon event following preoperative therapy. We previously identified only one patient among 122 who had a borderline resectable tumor that was downstaged to resectable after preoperative gemcitabine-based chemotherapy with or without chemoradiation.
1 Many have assumed that higher response rates associated with FOLFIRINOX and gemcitabine plus nab-paclitaxel relative to gemcitabine alone in metastatic patients indicates higher rates of local downstaging after preoperative therapy. Thus, these two systemic regimens, with or without subsequent (chemo)radiation, continue to be administered to “shrink” the size and/or anatomic extent of borderline or locally advanced cancers to facilitate pancreatectomy. …