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16.06.2023 | Original Article

Delayed cartilage oligomeric matrix protein response to loading is associated with femoral cartilage composition post-ACLR

verfasst von: Caroline Lisee, Alyssa Evans-Pickett, Hope Davis-Wilson, Amanda E. Munsch, Lara Longobardi, Todd A. Schwartz, David Lalush, Jason R. Franz, Brian Pietrosimone

Erschienen in: European Journal of Applied Physiology | Ausgabe 11/2023

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Abstract

Purpose

To determine associations between immediate and delayed response of serum cartilage oligomeric matrix protein (sCOMP) to loading (i.e., 3000 walking steps) and femoral cartilage interlimb T1ρ relaxation times in individual’s post-anterior cruciate ligament reconstruction (ACLR).

Methods

This cross-sectional study included 20 individuals 6–12 months following primary ACLR (65% female, 20.5 ± 4.0 years old, 24.9 ± 3.0 kg/m², 7.3 ± 1.5 months post-ACLR). Serum samples were collected prior to, immediately following, and 3.5 h following walking 3000 steps on a treadmill at habitual walking speed. sCOMP concentrations were processed using enzyme-linked immunosorbent assays. Immediate and delayed absolute sCOMP responses to loading were evaluated immediately and 3.5 h post-walking, respectively. Participants underwent bilateral magnetic resonance imaging with T1ρ sequences to calculate resting femoral cartilage interlimb T1ρ relaxation time ratios between limbs (i.e., ACLR/Uninjured limb). Linear regression models were fitted to determine associations between sCOMP response to loading and femoral cartilage T1ρ outcomes controlling for pre-loading sCOMP concentrations.

Results

Greater increases in delayed sCOMP response to loading were associated with greater lateral (∆R² = 0.29, p = 0.02) but not medial (∆R² < 0.01, p = 0.99) femoral cartilage interlimb T1ρ ratios. Associations between immediate sCOMP response to loading with femoral cartilage interlimb T1ρ ratios were weak and non-significant (∆R² range = 0.02–0.09, p range = 0.21–0.58).

Conclusion

Greater delayed sCOMP response to loading, a biomarker of cartilage breakdown, is associated with worse lateral femoral cartilage composition in the ACLR limb compared to the uninjured limb. Delayed sCOMP response to loading may be a more indicative metabolic indicator linked to deleterious changes in composition than immediate sCOMP response.

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Titel: Delayed cartilage oligomeric matrix protein response to loading is associated with femoral cartilage composition post-ACLR
verfasst von: Caroline Lisee
Alyssa Evans-Pickett
Hope Davis-Wilson
Amanda E. Munsch
Lara Longobardi
Todd A. Schwartz
David Lalush
Jason R. Franz
Brian Pietrosimone
Publikationsdatum: 16.06.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 11/2023
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-023-05253-w

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