Skip to main content
Erschienen in: Prävention und Gesundheitsförderung 3/2014

01.08.2014 | Main Topic

Environmental and public health implications of antibiotic-resistance genes in municipal wastewaters

verfasst von: Serena Caucci, Thomas U. Berendonk

Erschienen in: Prävention und Gesundheitsförderung | Ausgabe 3/2014

Einloggen, um Zugang zu erhalten

Abstract

Aim and subject

Antibiotic resistance is a serious threat to public health in Europe leading to increasing health-care costs and deaths. Combating antibiotic resistance requires an understanding of the ecology of antibiotic-resistance genes (ARGs), their selection, and their spread in the environment. Although antibiotic resistance has involved research in clinically relevant human pathogens, environmental reservoirs and the contribution of ARGs in clinical settings have only been considered recently.

Results

In this article we discuss the links between human activities and the natural ecosystem that might influence the evolution and spread of ARGs with a special focus on wastewater treatment plants (WWTPs). Moreover, traditional and novel techniques aiming toward a better understanding of this problem are elucidated.

Conclusion

Routine monitoring programs are recommended to provide background data for mitigation activities in WWTPs based on the presence of ARGs, the abundance of antibiotics, as well as the presence of resistant bacteria in the environment.
Literatur
1.
Zurück zum Zitat Bush K, Jacoby GA, Medeiros AA (1995) A functional classification scheme for beta-lactamases and its correlation with molecular-structure. Antimicrob Agents Ch 39:1211–1233CrossRef Bush K, Jacoby GA, Medeiros AA (1995) A functional classification scheme for beta-lactamases and its correlation with molecular-structure. Antimicrob Agents Ch 39:1211–1233CrossRef
2.
Zurück zum Zitat Byappanahalli MN, Whitman RL, Shively DA et al (2006) Population structure, persistence, and seasonality of autochthonous Escherichia coli in temperate, coastal forest soil from a Great Lakes watershed. Environ Microbiol 8:504–513PubMedCrossRef Byappanahalli MN, Whitman RL, Shively DA et al (2006) Population structure, persistence, and seasonality of autochthonous Escherichia coli in temperate, coastal forest soil from a Great Lakes watershed. Environ Microbiol 8:504–513PubMedCrossRef
3.
Zurück zum Zitat Chuanchuen R (2011) Emerging drug-resistant Superbugs. Thai J Vet Med 41:7–9 Chuanchuen R (2011) Emerging drug-resistant Superbugs. Thai J Vet Med 41:7–9
4.
Zurück zum Zitat ECDPC from the European survey on carbapenemase-producing Enterobacteriaceae (EuSCAPE) project 2013. ECDPC from the European survey on carbapenemase-producing Enterobacteriaceae (EuSCAPE) project 2013.
5.
Zurück zum Zitat Fatta-Kassinos D, Vasquez MI, Kummerer K (2011) Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes—degradation, elucidation of byproducts and assessment of their biological potency. Chemosphere 85:693–709PubMedCrossRef Fatta-Kassinos D, Vasquez MI, Kummerer K (2011) Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes—degradation, elucidation of byproducts and assessment of their biological potency. Chemosphere 85:693–709PubMedCrossRef
6.
Zurück zum Zitat Gullberg E, Cao S, Berg OG et al (2011) Selection of resistant bacteria at very low antibiotic concentrations. Plos Pathog 7 Gullberg E, Cao S, Berg OG et al (2011) Selection of resistant bacteria at very low antibiotic concentrations. Plos Pathog 7
7.
Zurück zum Zitat Hijosa-Valsero M, Fink G, Schlusener MP et al (2011) Removal of antibiotics from urban wastewater by constructed wetland optimization. Chemosphere 83:713–719PubMedCrossRef Hijosa-Valsero M, Fink G, Schlusener MP et al (2011) Removal of antibiotics from urban wastewater by constructed wetland optimization. Chemosphere 83:713–719PubMedCrossRef
8.
Zurück zum Zitat Ibanez M, Gracia-Lor E, Bijlsma L et al (2013) Removal of emerging contaminants in sewage water subjected to advanced oxidation with ozone. J Hazard Mater 260:389–398PubMedCrossRef Ibanez M, Gracia-Lor E, Bijlsma L et al (2013) Removal of emerging contaminants in sewage water subjected to advanced oxidation with ozone. J Hazard Mater 260:389–398PubMedCrossRef
9.
Zurück zum Zitat Karaolia P, Michael I, García-Fernández I et al (2014) Reduction of clarithromycin and sulfamethoxazole-resistant Enterococcus by pilot-scale solar-driven Fenton oxidation. Sci Total Environ Volumes 468–469:19–27CrossRef Karaolia P, Michael I, García-Fernández I et al (2014) Reduction of clarithromycin and sulfamethoxazole-resistant Enterococcus by pilot-scale solar-driven Fenton oxidation. Sci Total Environ Volumes 468–469:19–27CrossRef
10.
Zurück zum Zitat Kummerer K (2009) Antibiotics in the aquatic environment—a review—part II. Chemosphere 75:435–441PubMedCrossRef Kummerer K (2009) Antibiotics in the aquatic environment—a review—part II. Chemosphere 75:435–441PubMedCrossRef
11.
Zurück zum Zitat Luczkiewicz A, Jankowska K, Bray R et al (2011) Antimicrobial resistance of fecal indicators in disinfected wastewater. Water Sci Technol 64:2352–2361PubMedCrossRef Luczkiewicz A, Jankowska K, Bray R et al (2011) Antimicrobial resistance of fecal indicators in disinfected wastewater. Water Sci Technol 64:2352–2361PubMedCrossRef
12.
Zurück zum Zitat Martinez JL (2009) Environmental pollution by antibiotics and by antibiotic resistance determinants. Environ Pollut 157:2893–2902PubMedCrossRef Martinez JL (2009) Environmental pollution by antibiotics and by antibiotic resistance determinants. Environ Pollut 157:2893–2902PubMedCrossRef
13.
Zurück zum Zitat Mckinney CW, Pruden A (2012) Ultraviolet disinfection of antibiotic resistant bacteria and their antibiotic resistance genes in water and wastewater. Environ Sci Technol 46:13393–13400PubMedCrossRef Mckinney CW, Pruden A (2012) Ultraviolet disinfection of antibiotic resistant bacteria and their antibiotic resistance genes in water and wastewater. Environ Sci Technol 46:13393–13400PubMedCrossRef
14.
Zurück zum Zitat Meyer E, Gastmeier P, Deja M et al (2013) Antibiotic consumption and resistance: data from Europe and Germany. Int J Med Microbiol 303:388–395PubMedCrossRef Meyer E, Gastmeier P, Deja M et al (2013) Antibiotic consumption and resistance: data from Europe and Germany. Int J Med Microbiol 303:388–395PubMedCrossRef
15.
Zurück zum Zitat Middleton JH, Salierno JD (2013) Antibiotic resistance in triclosan tolerant fecal coliforms isolated from surface waters near wastewater treatment plant outflows (Morris County, USA). Ecotox Environ Safe 88:79–88CrossRef Middleton JH, Salierno JD (2013) Antibiotic resistance in triclosan tolerant fecal coliforms isolated from surface waters near wastewater treatment plant outflows (Morris County, USA). Ecotox Environ Safe 88:79–88CrossRef
16.
Zurück zum Zitat Novo A, Manaia CM (2010) Factors influencing antibiotic resistance burden in municipal wastewater treatment plants. Appl Microbiol Biot 87:1157–1166CrossRef Novo A, Manaia CM (2010) Factors influencing antibiotic resistance burden in municipal wastewater treatment plants. Appl Microbiol Biot 87:1157–1166CrossRef
17.
Zurück zum Zitat Novo A, Andre S, Viana P et al (2013) Antibiotic resistance, antimicrobial residues and bacterial community composition in urban wastewater. Water Res 47:1875–1887PubMedCrossRef Novo A, Andre S, Viana P et al (2013) Antibiotic resistance, antimicrobial residues and bacterial community composition in urban wastewater. Water Res 47:1875–1887PubMedCrossRef
18.
Zurück zum Zitat Rizzo L, Fiorentino A, Anselmo A (2013) Advanced treatment of urban wastewater by UV radiation: effect on antibiotics and antibiotic-resistant E. coli strains. Chemosphere 92:171–176PubMedCrossRef Rizzo L, Fiorentino A, Anselmo A (2013) Advanced treatment of urban wastewater by UV radiation: effect on antibiotics and antibiotic-resistant E. coli strains. Chemosphere 92:171–176PubMedCrossRef
19.
Zurück zum Zitat Schwartz T, Kohnen W, Jansen B et al (2003) Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms. Fems Microbiol Ecol 43:325–335PubMedCrossRef Schwartz T, Kohnen W, Jansen B et al (2003) Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms. Fems Microbiol Ecol 43:325–335PubMedCrossRef
20.
Zurück zum Zitat Seiler C, Berendonk, TU (2012) Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture. Frontiers in Microbiology. (Published online) Seiler C, Berendonk, TU (2012) Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture. Frontiers in Microbiology. (Published online)
21.
Zurück zum Zitat Sidrach-Cardona R, Becares E (2013) Fecal indicator bacteria resistance to antibiotics in experimental constructed wetlands. Ecol Eng 50:107–111CrossRef Sidrach-Cardona R, Becares E (2013) Fecal indicator bacteria resistance to antibiotics in experimental constructed wetlands. Ecol Eng 50:107–111CrossRef
22.
Zurück zum Zitat Sommer MOA, Dantas G, Church GM (2009) Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325:1128–1131PubMedCrossRef Sommer MOA, Dantas G, Church GM (2009) Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325:1128–1131PubMedCrossRef
23.
Zurück zum Zitat Stepanauskas R, Glenn TC, Jagoe CH et al (2006) Coselection for microbial resistance to metals and antibiotics in freshwater microcosms. Environ Microbiol 8:1510–1514PubMedCrossRef Stepanauskas R, Glenn TC, Jagoe CH et al (2006) Coselection for microbial resistance to metals and antibiotics in freshwater microcosms. Environ Microbiol 8:1510–1514PubMedCrossRef
24.
Zurück zum Zitat Szczepanowski R, Linke B, Krahn I et al (2009) Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. Microbiol-Sgm 155:2306–2319CrossRef Szczepanowski R, Linke B, Krahn I et al (2009) Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. Microbiol-Sgm 155:2306–2319CrossRef
25.
Zurück zum Zitat Walsh F, Duffy B (2013) The culturable soil antibiotic resistome: a community of multi-drug resistant bacteria. Plos One 8 Walsh F, Duffy B (2013) The culturable soil antibiotic resistome: a community of multi-drug resistant bacteria. Plos One 8
26.
Zurück zum Zitat Zhang T, Yan QM, Ye L (2010) Autotrophic biological nitrogen removal from saline wastewater under low DO. J Chem Technol Biot 85:1340–1345CrossRef Zhang T, Yan QM, Ye L (2010) Autotrophic biological nitrogen removal from saline wastewater under low DO. J Chem Technol Biot 85:1340–1345CrossRef
Metadaten
Titel
Environmental and public health implications of antibiotic-resistance genes in municipal wastewaters
verfasst von
Serena Caucci
Thomas U. Berendonk
Publikationsdatum
01.08.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Prävention und Gesundheitsförderung / Ausgabe 3/2014
Print ISSN: 1861-6755
Elektronische ISSN: 1861-6763
DOI
https://doi.org/10.1007/s11553-014-0445-2

Weitere Artikel der Ausgabe 3/2014

Prävention und Gesundheitsförderung 3/2014 Zur Ausgabe

Leitlinien kompakt für die Allgemeinmedizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Facharzt-Training Allgemeinmedizin

Die ideale Vorbereitung zur anstehenden Prüfung mit den ersten 49 von 100 klinischen Fallbeispielen verschiedener Themenfelder

Mehr erfahren

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

Wie der Klimawandel gefährliche Pilzinfektionen begünstigt

24.05.2024 Candida-Mykosen Nachrichten

Dass sich invasive Pilzinfektionen in letzter Zeit weltweit häufen, liegt wahrscheinlich auch am Klimawandel. Ausbrüche mit dem Hefepilz Candida auris stellen eine zunehmende Gefahr für Immungeschwächte dar – auch in Deutschland.

Für erste Kopie der Patientenakte sollen Ärzte kein Geld mehr erhalten

Praxen und Kliniken müssen die erste Kopie einer Patientenakte künftig kostenlos zur Verfügung stellen. Die bisherige Regelung, die noch eine Vergütung vorsieht, wird geändert.

So wirken verschiedene Alkoholika auf den Blutdruck

23.05.2024 Störungen durch Alkohol Nachrichten

Je mehr Alkohol Menschen pro Woche trinken, desto mehr steigt ihr Blutdruck, legen Daten aus Dänemark nahe. Ob es dabei auch auf die Art des Alkohols ankommt, wurde ebenfalls untersucht.

Update Allgemeinmedizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.