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Clinical & Translational Metabolism
Erschienen in: Clinical Reviews in Bone and Mineral Metabolism 1/2019

10.01.2019 | Review Paper

Fourier Transform Infrared Spectroscopy of Bone Tissue: Bone Quality Assessment in Preclinical and Clinical Applications of Osteoporosis and Fragility Fracture

verfasst von: Nikolaos Kourkoumelis, Xianzuo Zhang, Zeming Lin, Jian Wang

Erschienen in: Clinical & Translational Metabolism | Ausgabe 1/2019

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Abstract

The pathogenesis of bone fragility is of utmost importance especially to modern societies with aging populations. Increased skeletal fragility due to aging and disease motivates researchers to investigate the contributing biological mechanisms and to find ways to inhibit them. Bone quality is a set of structural and compositional variables that contribute to bone strength and influence its ability to resist fracture. They originate from multiple bone hierarchical levels and include the morphology (mass distribution), the chemical composition, and the biomechanical properties of bone tissue such as stiffness, fatigue strength, and fracture toughness. Qualitative and quantitative measurements of bone material properties reflect the underlying health or disease status. Fourier transform infrared (FTIR) spectroscopy and imaging are able to evaluate spatially inhomogeneous structures like bone in the form of sections or homogenized powder, providing simultaneous quantitative and qualitative information from both organic and inorganic tissue components. These techniques give a snapshot of structural and material properties that essentially depend on bone turnover while they are also sensitive to tissue alterations due to metabolic and nonmetabolic diseases, and external factors like administration of drugs. In this review, we discuss the application of FTIR spectroscopy and imaging to preclinical and clinical studies. The interpretation of results emphasizes the potential of infrared spectroscopic techniques to associate bone heterogeneity with fracture risk, assess the compositional and structural properties of osteoporotic bone, and investigate bisphosphonates’ antiresorptive action and side effects.
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Metadaten
Titel
Fourier Transform Infrared Spectroscopy of Bone Tissue: Bone Quality Assessment in Preclinical and Clinical Applications of Osteoporosis and Fragility Fracture
verfasst von
Nikolaos Kourkoumelis
Xianzuo Zhang
Zeming Lin
Jian Wang
Publikationsdatum
10.01.2019
Verlag
Springer US
Erschienen in
Clinical & Translational Metabolism / Ausgabe 1/2019
Print ISSN: 1534-8644
Elektronische ISSN: 2948-2445
DOI
https://doi.org/10.1007/s12018-018-9255-y

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ACKNOWLEDGEMENT TO REFEREES

Acknowledgement to Referees 2018

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