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Clinical & Translational Metabolism
Erschienen in: Clinical Reviews in Bone and Mineral Metabolism 3/2016

22.08.2016 | Bone quality

Bone Quality Assessment Techniques: Geometric, Compositional, and Mechanical Characterization from Macroscale to Nanoscale

verfasst von: Heather B. Hunt, Eve Donnelly

Erschienen in: Clinical & Translational Metabolism | Ausgabe 3/2016

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Abstract

This review presents an overview of the characterization techniques available to experimentally evaluate bone quality, defined as the geometric and material factors that contribute to fracture resistance independently of areal bone mineral density (aBMD) assessed by dual-energy X-ray absorptiometry. The methods available for characterization of the geometric, compositional, and mechanical properties of bone across multiple length scales are summarized, along with their outcomes and their advantages and disadvantages. Examples of how each technique is used are discussed, as well as practical concerns such as sample preparation and whether or not each testing method is destructive. Techniques that can be used in vivo and those that have been recently improved or developed are emphasized, including high-resolution peripheral quantitative computed tomography to evaluate geometric properties and reference point indentation to evaluate material properties. Because no single method can completely characterize bone quality, we provide a framework for how multiple characterization methods can be used together to generate a more comprehensive analysis of bone quality to complement aBMD in fracture risk assessment.
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Metadaten
Titel
Bone Quality Assessment Techniques: Geometric, Compositional, and Mechanical Characterization from Macroscale to Nanoscale
verfasst von
Heather B. Hunt
Eve Donnelly
Publikationsdatum
22.08.2016
Verlag
Springer US
Erschienen in
Clinical & Translational Metabolism / Ausgabe 3/2016
Print ISSN: 1534-8644
Elektronische ISSN: 2948-2445
DOI
https://doi.org/10.1007/s12018-016-9222-4

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