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Clinical Oral Investigations

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19.05.2022 | Original Article

Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study

verfasst von: Şivge Kurgan, Canan Önder, Nur Balcı, Nihan Akdoğan, S. Merve Altıngöz, Muhittin A. Serdar, Meral Günhan

Erschienen in: Clinical Oral Investigations | Ausgabe 9/2022

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Abstract

Objectives

Kynurenine pathway (KP) is the primary way of degrading tryptophan (TRP) and generates several bioactive metabolites (such as kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3OHKYN)) to regulate biological processes that include host-microbiome signaling and immune cell response. This study is aimed to determine the relationship between periodontal inflammation and tryptophan-kynurenine metabolism and identify their association with periodontal clinical parameters.

Materials and methods

Saliva and serum samples were collected from 20 stage III, grade B generalized periodontitis patients, and 20 periodontally healthy control individuals. Samples were analyzed for IL-6, KYN, TRP, KYN/TRP ratio, KYNA, 3OHKYN, picolinic acid (PA), and quinolinic acid (QA) by liquid chromatography–mass spectrometry. Clinical periodontal parameters (plaque index (PI), probing pocket depth (PPD), gingival recession (GR), clinical attachment loss (CAL), and bleeding on probing (BOP)) were recorded.

Results

Clinical parameters were significantly higher in the periodontitis group (p < 0.001). Salivary IL-6, TRP, KYN, KYNA, PA, and QA levels were significantly higher and KYN/TRP ratio was significantly lower in periodontitis group than control group (p < 0.05). Serum KYN, KYN/TRP ratio and PA levels were significantly higher in periodontitis group than control group (p < 0.05). PPD, BOP, PI, and CAL had significantly positive correlations with salivary IL-6, TRP, PA, QA, and serum KYN and significantly negative correlations with salivary KYN/TRP ratio.

Conclusions

Our results suggest that periodontal inflammation plays a role in local and systemic tryptophan-kynurenine metabolism.

Clinical relevance

Due to their effects on the immune and inflammatory systems, kynurenines may be potential agents for diagnosis and treatment of periodontal diseases.

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Titel: Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study
verfasst von: Şivge Kurgan
Canan Önder
Nur Balcı
Nihan Akdoğan
S. Merve Altıngöz
Muhittin A. Serdar
Meral Günhan
Publikationsdatum: 19.05.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 9/2022
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-022-04528-4

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Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study