Skip to main content
Erschienen in: Der Nervenarzt 9/2023

06.09.2023 | Psychopharmakotherapie | CME

Gewichtszunahme unter Therapie mit Psychopharmaka

Hintergründe und Management

verfasst von: J. Eder, M. S. Simon, Dr. med. C. Glocker, R. Musil

Erschienen in: Der Nervenarzt | Ausgabe 9/2023

zum CME-Kurs Einloggen, um Zugang zu erhalten

Zusammenfassung

Psychopharmakaassoziierte Gewichtszunahme (PAGZ) ist eine bekannte, häufige und für die Prognose der Patienten relevante Nebenwirkung. Die einzelnen Medikamente haben unterschiedlich hohe Risiken für das Auftreten der PAGZ, gleichzeitig gibt es individuelle Risikofaktoren seitens der Patienten wie Alter, Geschlecht, metabolische und genetische Faktoren. Da die metabolischen Veränderungen im Rahmen einer PAGZ langfristig eine erhöhte Mortalität zur Folge haben, gilt es, durch eine entsprechende Prävention vorzubeugen und im Fall einer bereits eingetretenen PAGZ gezielt zu intervenieren. Ein entsprechendes Monitoring ist deshalb unerlässlich. Dieser Artikel gibt einen Überblick über zugrunde liegende Mechanismen, Risikokonstellationen und mögliche Gegenmaßnahmen.
Literatur
1.
Zurück zum Zitat Walker ER, McGee RE, Druss BG (2015) Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry 72(4):334–341PubMedPubMedCentral Walker ER, McGee RE, Druss BG (2015) Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry 72(4):334–341PubMedPubMedCentral
2.
Zurück zum Zitat Manu P, Dima L, Shulman M, Vancampfort D, De Hert M, Correll CU (2015) Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management. Acta Psychiatr Scand 132(2):97–108PubMed Manu P, Dima L, Shulman M, Vancampfort D, De Hert M, Correll CU (2015) Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management. Acta Psychiatr Scand 132(2):97–108PubMed
3.
Zurück zum Zitat Tiihonen J, Lönnqvist J, Wahlbeck K, Klaukka T, Niskanen L, Tanskanen A et al (2009) 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 374(9690):620–627PubMed Tiihonen J, Lönnqvist J, Wahlbeck K, Klaukka T, Niskanen L, Tanskanen A et al (2009) 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 374(9690):620–627PubMed
4.
Zurück zum Zitat Verhaeghe N, De Maeseneer J, Maes L, Van Heeringen C, Annemans L (2011) Effectiveness and cost-effectiveness of lifestyle interventions on physical activity and eating habits in persons with severe mental disorders: a systematic review. Int J Behav Nutr Phys Act 8(1):28PubMedPubMedCentral Verhaeghe N, De Maeseneer J, Maes L, Van Heeringen C, Annemans L (2011) Effectiveness and cost-effectiveness of lifestyle interventions on physical activity and eating habits in persons with severe mental disorders: a systematic review. Int J Behav Nutr Phys Act 8(1):28PubMedPubMedCentral
5.
Zurück zum Zitat Vandenberghe F, Gholam-Rezaee M, Saigí-Morgui N, Delacrétaz A, Choong E, Solida-Tozzi A et al (2015) Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment. J Clin Psychiatry 76(11):e1417–e1423PubMed Vandenberghe F, Gholam-Rezaee M, Saigí-Morgui N, Delacrétaz A, Choong E, Solida-Tozzi A et al (2015) Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment. J Clin Psychiatry 76(11):e1417–e1423PubMed
7.
Zurück zum Zitat Barton B, Simon M, Glocker C, Musil R (2020) Was tun, wenn das Körpergewicht unter Psychopharmaka ansteigt? InFo Neurologie 22(12):30–39 Barton B, Simon M, Glocker C, Musil R (2020) Was tun, wenn das Körpergewicht unter Psychopharmaka ansteigt? InFo Neurologie 22(12):30–39
8.
Zurück zum Zitat Barton BB, Segger F, Fischer K, Obermeier M, Musil R (2020) Update on weight-gain caused by antipsychotics: a systematic review and meta-analysis. Expert Opin Drug Saf 19(3):295–314PubMed Barton BB, Segger F, Fischer K, Obermeier M, Musil R (2020) Update on weight-gain caused by antipsychotics: a systematic review and meta-analysis. Expert Opin Drug Saf 19(3):295–314PubMed
9.
Zurück zum Zitat Musil R, Obermeier M, Russ P, Hamerle M (2015) Weight gain and antipsychotics: a drug safety review. Expert Opin Drug Saf 14(1):73–96PubMed Musil R, Obermeier M, Russ P, Hamerle M (2015) Weight gain and antipsychotics: a drug safety review. Expert Opin Drug Saf 14(1):73–96PubMed
10.
Zurück zum Zitat Bak M, Fransen A, Janssen J, van Os J, Drukker M (2014) Almost all antipsychotics result in weight gain: a meta-analysis. PLoS ONE 9(4):e94112PubMedPubMedCentral Bak M, Fransen A, Janssen J, van Os J, Drukker M (2014) Almost all antipsychotics result in weight gain: a meta-analysis. PLoS ONE 9(4):e94112PubMedPubMedCentral
11.
Zurück zum Zitat Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G et al (2020) Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry 7(1):64–77PubMedPubMedCentral Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G et al (2020) Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry 7(1):64–77PubMedPubMedCentral
12.
Zurück zum Zitat Rognoni C, Bertolani A, Jommi C (2021) Second-generation antipsychotic drugs for patients with schizophrenia: systematic literature review and meta-analysis of metabolic and cardiovascular side effects. Clin Drug Investig 41(4):303–319PubMedPubMedCentral Rognoni C, Bertolani A, Jommi C (2021) Second-generation antipsychotic drugs for patients with schizophrenia: systematic literature review and meta-analysis of metabolic and cardiovascular side effects. Clin Drug Investig 41(4):303–319PubMedPubMedCentral
13.
Zurück zum Zitat Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A et al (2012) Changes in body weight and psychotropic drugs: a systematic synthesis of the literature. PLoS ONE 7(6):e36889PubMedPubMedCentral Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A et al (2012) Changes in body weight and psychotropic drugs: a systematic synthesis of the literature. PLoS ONE 7(6):e36889PubMedPubMedCentral
14.
Zurück zum Zitat Gill H, Gill B, El-Halabi S, Chen-Li D, Lipsitz O, Rosenblat JD et al (2020) Antidepressant medications and weight change: a narrative review. Obesity 28(11):2064–2072PubMed Gill H, Gill B, El-Halabi S, Chen-Li D, Lipsitz O, Rosenblat JD et al (2020) Antidepressant medications and weight change: a narrative review. Obesity 28(11):2064–2072PubMed
15.
Zurück zum Zitat Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N et al (2019) Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet 394(10202):939–951PubMedPubMedCentral Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N et al (2019) Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet 394(10202):939–951PubMedPubMedCentral
16.
Zurück zum Zitat Wharton S, Raiber L, Serodio KJ, Lee J, Christensen RAG (2018) Medications that cause weight gain and alternatives in Canada: a narrative review. DMSO 11:427–438 Wharton S, Raiber L, Serodio KJ, Lee J, Christensen RAG (2018) Medications that cause weight gain and alternatives in Canada: a narrative review. DMSO 11:427–438
17.
Zurück zum Zitat Grootens KP, Meijer A, Hartong EG, Doornbos B, Bakker PR, Al Hadithy A et al (2018) Weight changes associated with antiepileptic mood stabilizers in the treatment of bipolar disorder. Eur J Clin Pharmacol 74(11):1485–1489PubMed Grootens KP, Meijer A, Hartong EG, Doornbos B, Bakker PR, Al Hadithy A et al (2018) Weight changes associated with antiepileptic mood stabilizers in the treatment of bipolar disorder. Eur J Clin Pharmacol 74(11):1485–1489PubMed
18.
Zurück zum Zitat Grohmann R, Engel RR, Rüther E, Hippius H (2004) The AMSP drug safety program: methods and global results. Pharmacopsychiatry 37(Suppl 1):S4–11PubMed Grohmann R, Engel RR, Rüther E, Hippius H (2004) The AMSP drug safety program: methods and global results. Pharmacopsychiatry 37(Suppl 1):S4–11PubMed
19.
Zurück zum Zitat Schneider M, Pauwels P, Toto S, Bleich S, Grohmann R, Heinze M et al (2020) Severe weight gain as an adverse drug reaction of psychotropics: data from the AMSP project between 2001 and 2016. Eur Neuropsychopharmacol 36:60–71PubMed Schneider M, Pauwels P, Toto S, Bleich S, Grohmann R, Heinze M et al (2020) Severe weight gain as an adverse drug reaction of psychotropics: data from the AMSP project between 2001 and 2016. Eur Neuropsychopharmacol 36:60–71PubMed
20.
21.
Zurück zum Zitat Ishikawa S, Yamamura R, Hashimoto N, Okubo R, Sawagashira R, Ito YM et al (2022) The type rather than the daily dose or number of antipsychotics affects the incidence of hyperglycemic progression. Prog Neuropsychopharmacol Biol Psychiatry 113:110453PubMed Ishikawa S, Yamamura R, Hashimoto N, Okubo R, Sawagashira R, Ito YM et al (2022) The type rather than the daily dose or number of antipsychotics affects the incidence of hyperglycemic progression. Prog Neuropsychopharmacol Biol Psychiatry 113:110453PubMed
22.
Zurück zum Zitat Teasdale SB, Ward PB, Samaras K, Firth J, Stubbs B, Tripodi E et al (2019) Dietary intake of people with severe mental illness: systematic review and meta-analysis. Br J Psychiatry 214(5):251–259PubMed Teasdale SB, Ward PB, Samaras K, Firth J, Stubbs B, Tripodi E et al (2019) Dietary intake of people with severe mental illness: systematic review and meta-analysis. Br J Psychiatry 214(5):251–259PubMed
23.
Zurück zum Zitat Vancampfort D, Firth J, Schuch FB, Rosenbaum S, Mugisha J, Hallgren M et al (2017) Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. World Psychiatry 16(3):308–315PubMedPubMedCentral Vancampfort D, Firth J, Schuch FB, Rosenbaum S, Mugisha J, Hallgren M et al (2017) Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. World Psychiatry 16(3):308–315PubMedPubMedCentral
24.
Zurück zum Zitat Mutwalli H, Keeler JL, Bektas S, Dhopatkar N, Treasure J, Himmerich H (2023) Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: a systematic review and meta-analysis. J Psychiatr Res 160:137–162PubMed Mutwalli H, Keeler JL, Bektas S, Dhopatkar N, Treasure J, Himmerich H (2023) Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: a systematic review and meta-analysis. J Psychiatr Res 160:137–162PubMed
25.
Zurück zum Zitat Smith E, Singh R, Lee J, Colucci L, Graff-Guerrero A, Remington G et al (2021) Adiposity in schizophrenia: a systematic review and meta-analysis. Acta Psychiatr Scand 144(6):524–536PubMed Smith E, Singh R, Lee J, Colucci L, Graff-Guerrero A, Remington G et al (2021) Adiposity in schizophrenia: a systematic review and meta-analysis. Acta Psychiatr Scand 144(6):524–536PubMed
26.
Zurück zum Zitat Kucera J, Horska K, Hruska P, Kuruczova D, Micale V, Ruda-Kucerova J et al (2021) Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: untargeted proteomics approach in adipose tissue. Prog Neuropsychopharmacol Biol Psychiatry 108:110165PubMed Kucera J, Horska K, Hruska P, Kuruczova D, Micale V, Ruda-Kucerova J et al (2021) Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: untargeted proteomics approach in adipose tissue. Prog Neuropsychopharmacol Biol Psychiatry 108:110165PubMed
28.
Zurück zum Zitat Kishi T, Elmquist JK (2005) Body weight is regulated by the brain: a link between feeding and emotion. Mol Psychiatry 10(2):132–146PubMed Kishi T, Elmquist JK (2005) Body weight is regulated by the brain: a link between feeding and emotion. Mol Psychiatry 10(2):132–146PubMed
29.
Zurück zum Zitat Zhang JP, Lencz T, Zhang RX, Nitta M, Maayan L, John M et al (2016) Pharmacogenetic associations of antipsychotic drug-related weight gain: a systematic review and meta-analysis. Schizophr Bull 42(6):1418–1437PubMedPubMedCentral Zhang JP, Lencz T, Zhang RX, Nitta M, Maayan L, John M et al (2016) Pharmacogenetic associations of antipsychotic drug-related weight gain: a systematic review and meta-analysis. Schizophr Bull 42(6):1418–1437PubMedPubMedCentral
30.
Zurück zum Zitat Muntané G, Vázquez-Bourgon J, Sada E, Martorell L, Papiol S, Bosch E et al (2023) Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis. Eur Psychiatry 66(1):1–28 Muntané G, Vázquez-Bourgon J, Sada E, Martorell L, Papiol S, Bosch E et al (2023) Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis. Eur Psychiatry 66(1):1–28
31.
Zurück zum Zitat Gebhardt S, Haberhausen M, Heinzel-Gutenbrunner M, Gebhardt N, Remschmidt H, Krieg JC et al (2009) Antipsychotic-induced body weight gain: predictors and a systematic categorization of the long-term weight course. J Psychiatr Res 43(6):620–626PubMed Gebhardt S, Haberhausen M, Heinzel-Gutenbrunner M, Gebhardt N, Remschmidt H, Krieg JC et al (2009) Antipsychotic-induced body weight gain: predictors and a systematic categorization of the long-term weight course. J Psychiatr Res 43(6):620–626PubMed
32.
Zurück zum Zitat Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT et al (2006) Risperidone-related weight gain: genetic and nongenetic predictors. J Clin Psychopharmacol 26(2):128–134PubMed Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT et al (2006) Risperidone-related weight gain: genetic and nongenetic predictors. J Clin Psychopharmacol 26(2):128–134PubMed
33.
Zurück zum Zitat Basson BR, Kinon BJ, Taylor CC, Szymanski KA, Gilmore JA, Tollefson GD (2001) Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone. J Clin Psychiatry 62(4):231–238PubMed Basson BR, Kinon BJ, Taylor CC, Szymanski KA, Gilmore JA, Tollefson GD (2001) Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone. J Clin Psychiatry 62(4):231–238PubMed
35.
Zurück zum Zitat Brandl EJ, Frydrychowicz C, Tiwari AK, Lett TA, Kitzrow W, Büttner S et al (2012) Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. Prog Neuropsychopharmacol Biol Psychiatry 38(2):134–141PubMed Brandl EJ, Frydrychowicz C, Tiwari AK, Lett TA, Kitzrow W, Büttner S et al (2012) Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. Prog Neuropsychopharmacol Biol Psychiatry 38(2):134–141PubMed
36.
Zurück zum Zitat Hinney A, Körner A, Fischer-Posovszky P (2022) The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits. Nat Rev Endocrinol 18(10):623–637PubMedPubMedCentral Hinney A, Körner A, Fischer-Posovszky P (2022) The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits. Nat Rev Endocrinol 18(10):623–637PubMedPubMedCentral
37.
Zurück zum Zitat Dobrodeeva VS, Shnayder NA, Novitsky MA, Asadullin AR, Vaiman EE, Petrova MM et al (2022) Association of a single-nucleotide variant rs11100494 of the NPY5R gene with antipsychotic-induced metabolic disorders. Pharmaceutics 14(2):222PubMedPubMedCentral Dobrodeeva VS, Shnayder NA, Novitsky MA, Asadullin AR, Vaiman EE, Petrova MM et al (2022) Association of a single-nucleotide variant rs11100494 of the NPY5R gene with antipsychotic-induced metabolic disorders. Pharmaceutics 14(2):222PubMedPubMedCentral
38.
Zurück zum Zitat De Hert M, Dekker JM, Wood D, Kahl KG, Holt RIG, Möller HJ (2009) Cardiovascular disease and diabetes in people with severe mental illness position statement from the European PsychiatricAssociation (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur Psychiatry 24(6):412–424PubMed De Hert M, Dekker JM, Wood D, Kahl KG, Holt RIG, Möller HJ (2009) Cardiovascular disease and diabetes in people with severe mental illness position statement from the European PsychiatricAssociation (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur Psychiatry 24(6):412–424PubMed
39.
Zurück zum Zitat DGBS e. V., DGPPN e. V. (2019) S3-Leitlinie zur Diagnostik und Therapie Bipolarer Störungen Langversion DGBS e. V., DGPPN e. V. (2019) S3-Leitlinie zur Diagnostik und Therapie Bipolarer Störungen Langversion
42.
Zurück zum Zitat Bartels S, Desilets R (2012) Health promotion programs for people with serious mental illness. SAMHSA-HRSA Center for Integrated Health Solutions, Washington Bartels S, Desilets R (2012) Health promotion programs for people with serious mental illness. SAMHSA-HRSA Center for Integrated Health Solutions, Washington
44.
Zurück zum Zitat Stubbs B, Vancampfort D, Hallgren M, Firth J, Veronese N, Solmi M et al (2018) EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and position statement from the European psychiatric association (EPA), supported by the international organization of physical therapists in mental. Eur Psychiatry 54:124–144PubMed Stubbs B, Vancampfort D, Hallgren M, Firth J, Veronese N, Solmi M et al (2018) EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and position statement from the European psychiatric association (EPA), supported by the international organization of physical therapists in mental. Eur Psychiatry 54:124–144PubMed
46.
Zurück zum Zitat Lee K, Abraham S, Cleaver R (2022) A systematic review of licensed weight-loss medications in treating antipsychotic-induced weight gain and obesity in schizophrenia and psychosis. Gen Hosp Psychiatry 78:58–67PubMed Lee K, Abraham S, Cleaver R (2022) A systematic review of licensed weight-loss medications in treating antipsychotic-induced weight gain and obesity in schizophrenia and psychosis. Gen Hosp Psychiatry 78:58–67PubMed
47.
Zurück zum Zitat Hakami AY, Felemban R, Ahmad RG, Al-Samadani AH, Salamatullah HK, Baljoon JM et al (2022) The association between antipsychotics and weight gain and the potential role of metformin concomitant use: a retrospective cohort study. Front Psychiatry 13:914165PubMedPubMedCentral Hakami AY, Felemban R, Ahmad RG, Al-Samadani AH, Salamatullah HK, Baljoon JM et al (2022) The association between antipsychotics and weight gain and the potential role of metformin concomitant use: a retrospective cohort study. Front Psychiatry 13:914165PubMedPubMedCentral
48.
Zurück zum Zitat Fitzgerald I, O’Connell J, Keating D, Hynes C, McWilliams S, Crowley EK (2022) Metformin in the management of antipsychotic-induced weight gain in adults with psychosis: development of the first evidence-based guideline using GRADE methodology. Evid Based Ment Health 25(1):15–22PubMed Fitzgerald I, O’Connell J, Keating D, Hynes C, McWilliams S, Crowley EK (2022) Metformin in the management of antipsychotic-induced weight gain in adults with psychosis: development of the first evidence-based guideline using GRADE methodology. Evid Based Ment Health 25(1):15–22PubMed
49.
Zurück zum Zitat Zheng W, Zhang QE, Cai DB, Yang XH, Ungvari GS, Ng CH et al (2019) Combination of metformin and lifestyle intervention for antipsychotic-related weight gain: a meta-analysis of randomized controlled trials. Pharmacopsychiatry 52(1):24–31PubMed Zheng W, Zhang QE, Cai DB, Yang XH, Ungvari GS, Ng CH et al (2019) Combination of metformin and lifestyle intervention for antipsychotic-related weight gain: a meta-analysis of randomized controlled trials. Pharmacopsychiatry 52(1):24–31PubMed
50.
Zurück zum Zitat McIntyre RS, Paron E, Burrows M, Blavignac J, Gould E, Camacho F et al (2021) Psychiatric safety and weight loss efficacy of naltrexone/bupropion as add-on to antidepressant therapy in patients with obesity or overweight. J Affect Disord 289:167–176PubMed McIntyre RS, Paron E, Burrows M, Blavignac J, Gould E, Camacho F et al (2021) Psychiatric safety and weight loss efficacy of naltrexone/bupropion as add-on to antidepressant therapy in patients with obesity or overweight. J Affect Disord 289:167–176PubMed
51.
Zurück zum Zitat Lyu X, Du J, Zhan G, Wu Y, Su H, Zhu Y et al (2018) Naltrexone and bupropion combination treatment for smoking cessation and weight loss in patients with schizophrenia. Front Pharmacol 9:181PubMedPubMedCentral Lyu X, Du J, Zhan G, Wu Y, Su H, Zhu Y et al (2018) Naltrexone and bupropion combination treatment for smoking cessation and weight loss in patients with schizophrenia. Front Pharmacol 9:181PubMedPubMedCentral
52.
Zurück zum Zitat Shi Q, Wang Y, Hao Q, Vandvik PO, Guyatt G, Li J et al (2022) Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials. Lancet 399(10321):259–269PubMed Shi Q, Wang Y, Hao Q, Vandvik PO, Guyatt G, Li J et al (2022) Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials. Lancet 399(10321):259–269PubMed
53.
Zurück zum Zitat UK NCGC (2014) Obesity: identification, assessment and management of overweight and obesity in children, young people and adults UK NCGC (2014) Obesity: identification, assessment and management of overweight and obesity in children, young people and adults
54.
Zurück zum Zitat UK NCGC (2023) Semaglutide for managing overweight and obesity UK NCGC (2023) Semaglutide for managing overweight and obesity
55.
Zurück zum Zitat Siskind D, Hahn M, Correll CU, Fink-Jensen A, Russell AW, Bak N et al (2019) Glucagon-like peptide‑1 receptor agonists for antipsychotic-associated cardio-metabolic risk factors: a systematic review and individual participant data meta-analysis. Diabetes Obes Metab 21(2):293–302PubMed Siskind D, Hahn M, Correll CU, Fink-Jensen A, Russell AW, Bak N et al (2019) Glucagon-like peptide‑1 receptor agonists for antipsychotic-associated cardio-metabolic risk factors: a systematic review and individual participant data meta-analysis. Diabetes Obes Metab 21(2):293–302PubMed
56.
Zurück zum Zitat Paik J (2021) Olanzapine/Samidorphan: first approval. Drugs 81(12):1431–1436PubMed Paik J (2021) Olanzapine/Samidorphan: first approval. Drugs 81(12):1431–1436PubMed
57.
Zurück zum Zitat Jawad MY, Alnefeesi Y, Lui LMW, Ceban F, Chen-Li DCJ, Teopiz K et al (2022) Olanzapine and samidorphan combination treatment: a systematic review. J Affect Disord 301:99–106PubMed Jawad MY, Alnefeesi Y, Lui LMW, Ceban F, Chen-Li DCJ, Teopiz K et al (2022) Olanzapine and samidorphan combination treatment: a systematic review. J Affect Disord 301:99–106PubMed
58.
Zurück zum Zitat Pressanto C, Scholtz S, Ali N (2023) Obesity and bariatric surgery in adults living with severe mental illness: perceptions and clinical challenges. BJPsych Bull 47(3):165–171PubMedPubMedCentral Pressanto C, Scholtz S, Ali N (2023) Obesity and bariatric surgery in adults living with severe mental illness: perceptions and clinical challenges. BJPsych Bull 47(3):165–171PubMedPubMedCentral
Metadaten
Titel
Gewichtszunahme unter Therapie mit Psychopharmaka
Hintergründe und Management
verfasst von
J. Eder
M. S. Simon
Dr. med. C. Glocker
R. Musil
Publikationsdatum
06.09.2023
Verlag
Springer Medizin
Erschienen in
Der Nervenarzt / Ausgabe 9/2023
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-023-01534-z

Weitere Artikel der Ausgabe 9/2023

Der Nervenarzt 9/2023 Zur Ausgabe