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29.10.2023 | Review Article

Xenogeneic collagen matrix vs. connective tissue graft for the treatment of multiple gingival recession: a systematic review and meta-analysis

verfasst von: Lorena Zegarra-Caceres, Ariana Orellano-Merluzzi, Francisco Wilker Mustafa Gomes Muniz, Sérgio Luis Scombatti de Souza, Marcelo Faveri, Jonathan Meza-Mauricio

Erschienen in: Odontology | Ausgabe 2/2024

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Abstract

The aim of this systematic review (SR) compared the effect of xenogeneic collagen matrix (XCM) vs. connective tissue graft (CTG) for the treatment of multiple gingival recession (MGR) Miller Class I and II or Cairo type I. Five databases were searched up to August 2022 for randomized clinical trials (RCTs) comparing the clinical effects of XCM vs. CTG in the treatment of MGR. The random effects model of mean differences was used to determine reduction of gingival recession (GR), gain in keratinized tissue width (KTW), gain in gingival thickness (GT) and gain in clinical attachment level (CAL). The risk ratio was used to complete root coverage (CRC) at 6 and 12 months. 10 RCTs, representing 1095 and 649 GR at 6 and 12 months, respectively, were included in this SR. The meta-analysis showed no statistically significant difference in GR reduction, KTW gain GT gain or CAL gain between groups at 6 months. However, at 12 months of follow-up, differences favoring the control group were observed (p < 0.05). CRC was significantly higher in the CTG group at 6 and 12 months. Regarding dentine hypersensitivity (DH), no statistically significant differences were found between groups at 6 and 12 months of follow-up (p < 0.05). At 12 months, CTG showed significantly superior clinical results in the treatment of MGR: however, this difference was not observed in the decrease of DH.

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Chambrone L, Ortega MAS, Sukekava F, Rotundo R, Kalemaj Z, Buti J, et al. Root coverage procedures for treating single and multiple recession-type defects: an updated cochrane systematic review. J Periodontol. 2019;90:1399–422. https://doi.org/10.1002/JPER.19-0079.CrossRefPubMed

Tonetti MS, Jepsen S. Clinical efficacy of periodontal plastic surgery procedures: consensus report of group 2 of the 10th european workshop on periodontology. J Clin Periodontol. 2014;41:S36-43. https://doi.org/10.1111/jcpe.12219.CrossRefPubMed

Cairo F, Rotundo R, Miller PD, Pini Prato GP. Root coverage esthetic score: a system to evaluate the esthetic outcome of the treatment of gingival recession through evaluation of clinical cases. J Periodontol. 2009;80:705–10. https://doi.org/10.1902/JOP.2009.080565.CrossRefPubMed

Zucchelli G, Tavelli L, McGuire MK, Rasperini G, Feinberg SE, Wang HL, et al. Autogenous soft tissue grafting for periodontal and peri-implant plastic surgical reconstruction. J Periodontol. 2020;91:9–16. https://doi.org/10.1002/JPER.19-0350.CrossRefPubMed

McGuire MK, Nunn M. Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part 1: comparison of clinical parameters. J Periodontol. 2003;74:1110–25. https://doi.org/10.1902/jop.2003.74.8.1110.CrossRefPubMed

Zucchelli G, Cesari C, Amore C, Montebugnoli L, De Sanctis M. Laterally moved, coronally advanced flap: a modified surgical approach for isolated recession-type defects. J Periodontol. 2004;75:1734–41. https://doi.org/10.1902/jop.2004.75.12.1734.CrossRefPubMed

Cieślik-Wegemund M, Wierucka-Młynarczyk B, Tanasiewicz M, Gilowski L. Tunnel technique with collagen matrix compared with connective tissue graft for treatment of periodontal recession: a randomized clinical trial. J Periodontol. 2016;87:1436–43. https://doi.org/10.1902/jop.2016.150676.CrossRefPubMed

Bertl K, Spineli LM, Mohandis K, Stavropoulos A. Root coverage stability: a systematic overview of controlled clinical trials with at least 5 years of follow-up. Clin Exp Dent Res. 2021;7:692–710. https://doi.org/10.1002/cre2.395.CrossRefPubMedPubMedCentral

Chambrone L, Botelho J, Machado V, Mascarenhas P, Mendes JJ, Avila-Ortiz G. Does the subepithelial connective tissue graft in conjunction with a coronally advanced flap remain as the gold standard therapy for the treatment of single gingival recession defects? A systematic review and network meta-analysis. J Periodontol. 2022;93:1336–52. https://doi.org/10.1002/JPER.22-0167.CrossRefPubMed

10.

Dadlani S. Porcine acellular dermal matrix: an alternative to connective tissue graft - a narrative review. Int J Dent. 2021. https://doi.org/10.1155/2021/1652032.CrossRefPubMedPubMedCentral

11.

Wessel JR, Tatakis DN. Patient outcomes following subepithelial connective tissue graft and free gingival graft procedures. J Periodontol. 2008;79:425–30. https://doi.org/10.1902/JOP.2008.070325.CrossRefPubMed

12.

Buff LR, Bürklin T, Eickholz P, Mönting JS, Ratka-Krüger P. Does harvesting connective tissue grafts from the palate cause persistent sensory dysfunction? A pilot study Quintessence Int. 2009;40:479–89.PubMed

13.

Reiser GM, Bruno JF, Mahan PE, Larkin LH. The subepithelial connective tissue graft palatal donor site: anatomic considerations for surgeons. Int J Periodontics Restorative Dent. 1996;16:130–7.PubMed

14.

Moraschini V, Calasans-Maia MD, Dias AT, de Carvalho FM, Sartoretto SC, Sculean A, et al. Effectiveness of connective tissue graft substitutes for the treatment of gingival recessions compared with coronally advanced flap: a network meta-analysis. Clin Oral Investig. 2020;24:3395–406. https://doi.org/10.1007/S00784-020-03547-3.CrossRefPubMed

15.

Santamaria MP, Rossato A, Miguel MMV, Fonseca MB, Bautista CRG, de Marco AC, et al. Comparison of two types of xenogeneic matrices to treat single gingival recessions: a randomized clinical trial. J Periodontol. 2022;93:709–20. https://doi.org/10.1002/JPER.21-0212.CrossRefPubMed

16.

Rotundo R, Genzano L, Patel D, D’Aiuto F, Nieri M. Adjunctive benefit of a xenogenic collagen matrix associated with coronally advanced flap for the treatment of multiple gingival recessions: a superiority, assessor-blind, randomized clinical trial. J Clin Periodontol. 2019;46:1013–23. https://doi.org/10.1111/jcpe.13168.CrossRefPubMed

17.

Meza-Mauricio J, Cortez-Gianezzi J, Duarte PM, Tavelli L, Rasperini G, de Faveri M. Comparison between a xenogeneic dermal matrix and connective tissue graft for the treatment of multiple adjacent gingival recessions: a randomized controlled clinical trial. Clin Oral Investig. 2021;25:6919–29. https://doi.org/10.1007/S00784-021-03982-W.CrossRefPubMed

18.

Galli M, Yao Y, Giannobile WV, Wang HL. Current and future trends in periodontal tissue engineering and bone regeneration. Plast Aesthet Res. 2021;8:3. https://doi.org/10.20517/2347-9264.2020.176.CrossRefPubMedPubMedCentral

19.

Bianchi S, Bernardi S, Simeone D, Torge D, Macchiarelli G, Marchetti E. Proliferation and morphological assessment of human periodontal ligament fibroblast towards bovine pericardium membranes: an in vitro study. Materials (Basel). 2022;15:8284. https://doi.org/10.3390/ma15238284.ADSCrossRefPubMed

20.

Liang C, Liao L, Tian W. Advances focusing on the application of decellularized extracellular matrix in periodontal regeneration. Biomolecules. 2023;13:673. https://doi.org/10.3390/biom13040673.CrossRefPubMedPubMedCentral

21.

Tavelli L, Barootchi S, Rodriguez MV, Mancini L, Majzoub J, Travan S, Sugai J, Chan HL, Kripfgans O, Wang HL, Giannobile WV. Recombinant human platelet-derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: a triple-blinded, randomized, placebo-controlled trial. J Clin Periodontol. 2022;49:1169–84. https://doi.org/10.1111/jcpe.13706.CrossRefPubMedPubMedCentral

22.

Sanz M, Lorenzo R, Aranda JJ, Martin C, Orsini M. Clinical evaluation of a new collagen matrix (Mucograft® prototype) to enhance the width of keratinized tissue in patients with fixed prosthetic restorations: a randomized prospective clinical trial. J Clin Periodontol. 2009;36:868–76. https://doi.org/10.1111/j.1600-051X.2009.01460.x.CrossRefPubMed

23.

Huang JP, Liu JM, Wu YM, Chen LL, Ding PH. Efficacy of xenogeneic collagen matrix in the treatment of gingival recessions: a systematic review and meta-analysis. Oral Dis. 2019;25:996–1008. https://doi.org/10.1111/ODI.12949.CrossRefPubMed

24.

Tonetti MS, Cortellini P, Pellegrini G, Nieri M, Bonaccini D, Allegri M, et al. Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: randomized trial assessing non-inferiority in root coverage and superiority in oral health-related quality of life. J Clin Periodontol. 2018;45:78–88. https://doi.org/10.1111/jcpe.12834.CrossRefPubMed

25.

Barakat H, Dayoub S, Alarkan R. A porcine collagen matrix (Mucograft®) vs connective tissue graft in the treatment of multiple gingival recessions: a comparative clinical study. World J Dent. 2018;9:275–9.CrossRef

26.

Schmitt CM, Schlegel KA, Gammel L, Moest T. Gingiva thickening with a porcine collagen matrix in a preclinical dog model: histological outcomes. J Clin Periodontol. 2019;46:1273–81. https://doi.org/10.1111/JCPE.13196.CrossRefPubMed

27.

Gürlek Ö, Gümüş P, Nizam N, Buduneli N. Coronally advanced flap with connective tissue graft or xenogeneic acellular dermal matrix in the treatment of multiple gingival recessions: a split-mouth randomized clinical trial. J Esthet Restor Dent. 2020;32:380–8. https://doi.org/10.1111/JERD.12547.CrossRefPubMed

28.

Nahas R, Gondim V, Carvalho CV, Calderero LM, Rosa EF, Sakiyama T, et al. Treatment of multiple recessions with collagen matrix versus connective tissue: a randomized clinical trial. Braz Oral Res. 2019;33:1–12. https://doi.org/10.1590/1807-3107BOR-2019.VOL33.0123.CrossRef

29.

Rakasevic DL, Milinkovic IZ, Jankovic SM, Soldatovic IA, Aleksic ZM, Nikolic-Jakoba NS. The use of collagen porcine dermal matrix and connective tissue graft with modified coronally advanced tunnel technique in the treatment of multiple adjacent type I gingival recessions: a randomized, controlled clinical trial. J Esthet Restor Dent. 2020;32:681–90. https://doi.org/10.1111/JERD.12624.CrossRefPubMed

30.

Maluta R, Monteiro MF, Peruzzo DC, Joly JC. Root coverage of multiple gingival recessions treated with coronally advanced flap associated with xenogeneic acellular dermal matrix or connective tissue graft: a 6-month split-mouth controlled and randomized clinical trial. Clin Oral Investig. 2021;25:5765–73. https://doi.org/10.1007/S00784-021-03879-8.CrossRefPubMed

31.

Vincent-Bugnas S, Laurent J, Naman E, Charbit M, Borie G. Treatment of multiple gingival recessions with xenogeneic acellular dermal matrix compared to connective tissue graft: a randomized split-mouth clinical trial. J Periodontal Implant Sci. 2021;51:77–88. https://doi.org/10.5051/JPIS.2002400120.CrossRefPubMed

32.

Pietruska M, Skurska A, Podlewski L, Milewski R, Podlewski L, Pietruski J. Clinical evaluation of Miller class I and II recessions treatment with the use of modified coronally advanced tunnel technique with either collagen matrix or subepithelial connective tissue graft: a randomized clinical study. J Clin Periodontol. 2019;46:86–95. https://doi.org/10.1111/jcpe.13031.CrossRefPubMed

33.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. The BMJ. 2021;372:1–9. https://doi.org/10.1136/BMJ.N71.CrossRef

34.

Schardt C, Adams MB, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007;7:16–22. https://doi.org/10.1186/1472-6947-7-16.CrossRefPubMedPubMedCentral

35.

Miller PD. A classification of marginal tissue recession. Int J Periodontics Restorative Dent. 1985;5:8–13.PubMed

36.

Cairo F, Nieri M, Cincinelli S, Mervelt J, Pagliaro U. The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: an explorative and reliability study. J Clin Periodontol. 2011;38:661–6. https://doi.org/10.1111/j.1600-051X.2011.01732.x.CrossRefPubMed

37.

Greenhalgh T, Peacock R. Effectiveness and efficiency of search methods in systematic reviews of complex evidence: audit of primary sources. BMJ. 2005;331:1064–5. https://doi.org/10.1136/bmj.38636.593461.68.CrossRefPubMedPubMedCentral

38.

De Raadt A, Warrens MJ, Bosker RJ, Kiers HAL. Kappa coefficients for missing data. Educ Psychol Meas. 2019;79:558–76. https://doi.org/10.1177/0013164418823249.CrossRefPubMedPubMedCentral

39.

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. The BMJ. 2019;366:1–8. https://doi.org/10.1136/bmj.l4898.CrossRef

40.

Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64:383–94. https://doi.org/10.1016/j.jclinepi.2010.04.026.CrossRefPubMed

41.

Guyatt GH, Thorlund K, Oxman AD, Walter SD, Patrick D, Furukawa TA, et al. GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles - continuous outcomes. J Clin Epidemiol. 2013;66:173–83. https://doi.org/10.1016/J.JCLINEPI.2012.08.001.CrossRefPubMed

42.

Paolantonio M, Dolci M, Esposito P, D’Archivio D, Lisanti L, Di LA, et al. Subpedicle acellular dermal matrix graft and autogenous connective tissue graft in the treatment of gingival recessions: a comparative 1-year clinical study. J Periodontol. 2002;73:1299–307. https://doi.org/10.1902/jop.2002.73.11.1299.CrossRefPubMed

43.

Tonetti MS, Cortellini P, Bonaccini D, Deng K, Cairo F, Allegri M, et al. Autologous connective tissue graft or xenogenic collagen matrix with coronally advanced flaps for coverage of multiple adjacent gingival recession. 36-month follow-up of a randomized multicentre trial. J Clin Periodontol. 2021;48:962–9. https://doi.org/10.1902/JOP.2002.73.11.1299.CrossRefPubMed

44.

Aroca S, Molnár B, Windisch P, Gera I, Salvi GE, Nikolidakis D, et al. Treatment of multiple adjacent Miller class I and II gingival recessions with a modified coronally advanced tunnel (MCAT) technique and a collagen matrix or palatal connective tissue graft: a randomized, controlled clinical trial. J Clin Periodontol. 2013;40:713–20. https://doi.org/10.1111/jcpe.12112.CrossRefPubMed

45.

AlSarhan MA, Al Jasser R, Tarish MA, AlHuzaimi AI, Alzoman H. Xenogeneic collagen matrix versus connective tissue graft for the treatment of multiple gingival recessions: a systematic review and meta-analysis. Clin Exp Dent Res. 2019;5:566–79. https://doi.org/10.1002/CRE2.210.CrossRefPubMedPubMedCentral

46.

Tavelli L, Barootchi S, Nguyen TVN, Tattan M, Ravidà A, Wang HL. Efficacy of tunnel technique in the treatment of localized and multiple gingival recessions: a systematic review and meta-analysis. J Periodontol. 2018;89:1075–90. https://doi.org/10.1002/JPER.18-0066.CrossRefPubMed

47.

Moraschini V, de Almeida DCF, Sartoretto S, Bailly Guimarães H, Chaves Cavalcante I, Diuana C-M. Clinical efficacy of xenogeneic collagen matrix in the treatment of gingival recession: a systematic review and meta-analysis. Acta Odontol Scand. 2019;77:457–67. https://doi.org/10.1080/00016357.2019.1588372.CrossRefPubMed

48.

Cairo F, Cortellini P, Pilloni A, Nieri M, Cincinelli S, Amunni F, et al. Clinical efficacy of coronally advanced flap with or without connective tissue graft for the treatment of multiple adjacent gingival recessions in the aesthetic area: a randomized controlled clinical trial. J Clin Periodontol. 2016;43:849–56. https://doi.org/10.1111/jcpe.12590.CrossRefPubMed

49.

Pini Prato G, Rotundo R, Franceschi D, Cairo F, Cortellini P, Nieri M. Fourteen-year outcomes of coronally advanced flap for root coverage: follow-up from a randomized trial. J Clin Periodontol. 2011;38:715–20. https://doi.org/10.1111/J.1600-051X.2011.01744.X.CrossRefPubMed

50.

Tavelli L, Barootchi S, Di Gianfilippo R, Modarressi M, Cairo F, Rasperini G, et al. Acellular dermal matrix and coronally advanced flap or tunnel technique in the treatment of multiple adjacent gingival recessions. A 12-year follow-up from a randomized clinical trial. J Clin Periodontol. 2019;46:937–48. https://doi.org/10.1111/jcpe.13163.CrossRefPubMed

51.

Barootchi S, Tavelli L, Di Gianfilippo R, Byun HY, Oh TJ, Barbato L, et al. Long term assessment of root coverage stability using connective tissue graft with or without an epithelial collar for gingival recession treatment. A 12-year follow-up from a randomized clinical trial. J Clin Periodontol. 2019;46:1124–33. https://doi.org/10.1111/jcpe.13187.CrossRefPubMed

52.

Barootchi S, Tavelli L, Di Gianfilippo R, Shedden K, Oh TJ, Rasperini G, et al. Soft tissue phenotype modification predicts gingival margin long-term (10-year) stability: longitudinal analysis of six randomized clinical trials. J Clin Periodontol. 2022;49:672–83. https://doi.org/10.1111/JCPE.13641.CrossRefPubMedPubMedCentral

53.

Tatakis DN, Chambrone L, Allen EP, Langer B, McGuire MK, Richardson CR, et al. Periodontal soft tissue root coverage procedures: a consensus report from the AAP regeneration workshop. J Periodontol. 2015;86:S52–5. https://doi.org/10.1902/jop.2015.140376.CrossRefPubMed

54.

Stefanini M, Jepsen K, de Sanctis M, Baldini N, Greven B, Heinz B, et al. Patient-reported outcomes and aesthetic evaluation of root coverage procedures: a 12-month follow-up of a randomized controlled clinical trial. J Clin Periodontol. 2016;43:1132–41. https://doi.org/10.1111/jcpe.12626.CrossRefPubMed

55.

Zucchelli G, Sharma P, Mounssif I. Esthetics in periodontics and implantology. Periodontol. 2000;2018(77):7–18. https://doi.org/10.1111/PRD.12207.CrossRef

56.

Kim SM, Choi YH, Kim YG, Park JW, Lee JM, Suh JY. Analysis of the esthetic outcome after root coverage procedures using a comprehensive approach. J Esthet Restor Dent. 2014;26:107–18. https://doi.org/10.1111/JERD.12085.CrossRefPubMed

57.

Cairo F, Barootchi S, Tavelli L, Barbato L, Wang HL, Rasperini G, et al. Aesthetic-and patient-related outcomes following root coverage procedures: a systematic review and network meta-analysis. J Clin Periodontol. 2020;47:1403–15. https://doi.org/10.1111/jcpe.13346.CrossRefPubMed

58.

Rossmann JA, Rees TD. A comparative evaluation of hemostatic agents in the management of soft tissue graft donor site bleeding. J Periodontol. 1999;70:1369–75. https://doi.org/10.1902/JOP.1999.70.11.1369.CrossRefPubMed

59.

Guralnick WC, Berg L. Gelfoam in oral surgery; a report of 250 cases. Oral Surg Oral Med Oral Pathol. 1948;1:632–9. https://doi.org/10.1016/0030-4220(48)90337-5.CrossRefPubMed

60.

Schinini G, Sales D, Gómez MV, Romanelli HJ, Chambrone L. Healing of donor sites of connective tissue grafts harvested by the single incision technique: a randomized clinical trial evaluating the use of collagen hemostatic sponge with or without sutures. J Periodontol. 2021;92:629–36. https://doi.org/10.1002/JPER.20-0645.CrossRefPubMed

61.

Wennström JL. Mucogingival therapy. Ann Periodontol. 1996;1:671–701. https://doi.org/10.1902/ANNALS.1996.1.1.671.CrossRefPubMed

62.

Cairo F, Pagliaro U, Buti J, Baccini M, Graziani F, Tonelli P, et al. Root coverage procedures improve patient aesthetics. A systematic review and Bayesian network meta-analysis. J Clin Periodontol. 2016;43:965–75. https://doi.org/10.1111/jcpe.12603.CrossRefPubMed

63.

Clauser C, Nieri M, Franceschi D, Pagliaro U, Pini-Prato G. Evidence-based mucogingival therapy. Part 2: ordinary and individual patient data meta-analyses of surgical treatment of recession using complete root coverage as the outcome variable. J Periodontol. 2003;74:741–56. https://doi.org/10.1902/jop.2003.74.5.741.CrossRefPubMed

64.

Krauser JT. Hypersensitive teeth. Part I: etiology. J Prosthet Dent. 1986;56:153–6. https://doi.org/10.1016/0022-3913(86)90462-2.CrossRefPubMed

65.

Castellini G, Bruschettini M, Gianola S, Gluud C, Moja L. Assessing imprecision in cochrane systematic reviews: a comparison of GRADE and trial sequential analysis. Syst Rev. 2018;7:1–10. https://doi.org/10.1186/s13643-018-0770-1.CrossRef

Titel: Xenogeneic collagen matrix vs. connective tissue graft for the treatment of multiple gingival recession: a systematic review and meta-analysis
verfasst von: Lorena Zegarra-Caceres
Ariana Orellano-Merluzzi
Francisco Wilker Mustafa Gomes Muniz
Sérgio Luis Scombatti de Souza
Marcelo Faveri
Jonathan Meza-Mauricio
Publikationsdatum: 29.10.2023
Verlag: Springer Nature Singapore
Erschienen in: Odontology / Ausgabe 2/2024
Print ISSN: 1618-1247
Elektronische ISSN: 1618-1255
DOI: https://doi.org/10.1007/s10266-023-00863-4

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Xenogeneic collagen matrix vs. connective tissue graft for the treatment of multiple gingival recession: a systematic review and meta-analysis

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