Skip to main content
Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie 9/2017

05.07.2017 | Reports of Original Investigations

A retrospective assessment of prognostication in 456,685 patients undergoing elective major non-cardiac surgery

verfasst von: Daniel McIsaac, MD, MPH, Luke T. Lavallée, MD, MSc, Carl van Walraven, MD, MSc

Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Ausgabe 9/2017

Einloggen, um Zugang zu erhalten

Abstract

Background

The accuracy of patient prognostication varies extensively in studies of select populations. Prognostication is an important component of patient selection for elective surgery. This retrospective study assessed patient prognostication prior to elective surgery by comparing the observed with the expected number of deaths in such patients.

Study design

We used population-based administrative data to identify all adults undergoing one of 13 most common elective major non-cardiac gender-neutral surgeries in Ontario, Canada from 2002–2014. Survival status within one year of surgery was determined by linking to vital statistics. Expected death risk was determined with health administrative data and a previously derived and externally validated index.

Results

We identified 456,685 patients of which 17,266 (3.8%) died within one year of surgery. Patients whose expected one-year death risk was > 25% accounted for 5.3% of the entire cohort (n = 24,178) but 51.7% of all deaths (n = 8,927). The overall observed death risk was significantly lower than expected (standardized mortality ratio [SMR], 0.72; 95% confidence interval, 0.71 to 0.73; P < 0.0001). The SMRs were significantly < 1 (values ranged from 0.54 [partial liver resection] to 0.93 [total knee replacement]) in 11/13 (85%) surgery types. Improved outcomes were especially notable in patients with a higher expected death risk. Only 35/5,539 (0.6%) surgeons had one-year patient death risks that exceeded the population average.

Conclusions

The observed number of deaths within one year of elective surgery is significantly lower than expected, with minimal inter-surgeon variation. These results suggest that patient selection for major elective non-cardiac surgery identified individuals with better than expected survival and whose survival was not adversely influenced by their surgery.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
2.
Zurück zum Zitat Vigano A, Dorgan M, Buckingham J, Bruera E, Suarez-Almazor ME. Survival prediction in terminal cancer patients: a systematic review of the medical literature. PalliatMed 2000; 14: 363-74.CrossRef Vigano A, Dorgan M, Buckingham J, Bruera E, Suarez-Almazor ME. Survival prediction in terminal cancer patients: a systematic review of the medical literature. PalliatMed 2000; 14: 363-74.CrossRef
3.
Zurück zum Zitat Cheon S, Agarwal A, Popovic M, et al. The accuracy of clinicians’ predictions of survival in advanced cancer: a review. Ann Palliat Med 2016; 5: 22-9.PubMed Cheon S, Agarwal A, Popovic M, et al. The accuracy of clinicians’ predictions of survival in advanced cancer: a review. Ann Palliat Med 2016; 5: 22-9.PubMed
4.
Zurück zum Zitat Chow E, Harth T, Hruby G, Finkelstein J, Wu J, Danjoux C. How accurate are physicians’ clinical predictions of survival and the available prognostic tools in estimating survival times in terminally ill cancer patients? A systematic review. Clin Oncol (R Coll Radiol) 2001; 13: 209-18. Chow E, Harth T, Hruby G, Finkelstein J, Wu J, Danjoux C. How accurate are physicians’ clinical predictions of survival and the available prognostic tools in estimating survival times in terminally ill cancer patients? A systematic review. Clin Oncol (R Coll Radiol) 2001; 13: 209-18.
5.
Zurück zum Zitat Knaus WA, Wagner DP, Lynn J. Short-term mortality predictions for critically ill hospitalized adults: science and ethics. Science 1991; 254: 389-94.CrossRefPubMed Knaus WA, Wagner DP, Lynn J. Short-term mortality predictions for critically ill hospitalized adults: science and ethics. Science 1991; 254: 389-94.CrossRefPubMed
6.
Zurück zum Zitat Rocker G, Cook D, Sjokvist P, et al. Clinician predictions of intensive care unit mortality. Crit Care Med 2004; 32: 1149-54.CrossRefPubMed Rocker G, Cook D, Sjokvist P, et al. Clinician predictions of intensive care unit mortality. Crit Care Med 2004; 32: 1149-54.CrossRefPubMed
7.
Zurück zum Zitat Sinuff T, Adhikari NK, Cook DJ, et al. Mortality predictions in the intensive care unit: comparing physicians with scoring systems. Crit Care Med 2006; 34: 878-85.CrossRefPubMed Sinuff T, Adhikari NK, Cook DJ, et al. Mortality predictions in the intensive care unit: comparing physicians with scoring systems. Crit Care Med 2006; 34: 878-85.CrossRefPubMed
8.
Zurück zum Zitat Bilimoria KY, Liu Y, Paruch JL, et al. Development and evaluation of the universal ACS NSQIP surgical risk calculator: a decision aid and informed consent tool for patients and surgeons. J Am Coll Surg 2013; 217: 833-42..e1-3 Bilimoria KY, Liu Y, Paruch JL, et al. Development and evaluation of the universal ACS NSQIP surgical risk calculator: a decision aid and informed consent tool for patients and surgeons. J Am Coll Surg 2013; 217: 833-42..e1-3
10.
Zurück zum Zitat Bourne R, DeBoer DP, Hawker G, Kreder H, Mahomed M, Paterson J. Total hip and knee replacement. In: Tu JV, Pinfold SP, McColgan P, Laupacis A, editors. Access to Health Services in Ontario: An ICES Atlas. Toronto: Institute for Clincal Evaluative Sciences; 2005. p. 156-71. Bourne R, DeBoer DP, Hawker G, Kreder H, Mahomed M, Paterson J. Total hip and knee replacement. In: Tu JV, Pinfold SP, McColgan P, Laupacis A, editors. Access to Health Services in Ontario: An ICES Atlas. Toronto: Institute for Clincal Evaluative Sciences; 2005. p. 156-71.
11.
Zurück zum Zitat Wijeysundera DN, Austin PC, Beattie WS, Hux JE, Laupacis A. Variation in the practice of preoperative medical consultation for major elective noncardiac surgery: a population-based study. Anesthesiology 2012; 116: 25-34.CrossRefPubMed Wijeysundera DN, Austin PC, Beattie WS, Hux JE, Laupacis A. Variation in the practice of preoperative medical consultation for major elective noncardiac surgery: a population-based study. Anesthesiology 2012; 116: 25-34.CrossRefPubMed
12.
Zurück zum Zitat Wijeysundera DN, Wijeysundera HC, Yun L, et al. Risk of elective major noncardiac surgery after coronary stent insertion: a population-based study. Circulation 2012; 126: 1355-62.CrossRefPubMed Wijeysundera DN, Wijeysundera HC, Yun L, et al. Risk of elective major noncardiac surgery after coronary stent insertion: a population-based study. Circulation 2012; 126: 1355-62.CrossRefPubMed
13.
Zurück zum Zitat Wijeysundera DN, Beattie WS, Karkouti K, Neuman MD, Austin PC, Laupacis A. Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study. Br Med J 2011; 342: d3695.CrossRef Wijeysundera DN, Beattie WS, Karkouti K, Neuman MD, Austin PC, Laupacis A. Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study. Br Med J 2011; 342: d3695.CrossRef
14.
Zurück zum Zitat Wijeysundera DN, Austin PC, Beattie WS, Hux JE, Laupacis A. A population-based study of anesthesia consultation before major noncardiac surgery. Arch Intern Med 2009; 169: 595-602.CrossRefPubMed Wijeysundera DN, Austin PC, Beattie WS, Hux JE, Laupacis A. A population-based study of anesthesia consultation before major noncardiac surgery. Arch Intern Med 2009; 169: 595-602.CrossRefPubMed
15.
Zurück zum Zitat McIsaac I, Bryson GL, van Walraven C. Elective, major noncardiac surgery on the weekend: a population-based cohort study of 30-day mortality. Med Care 2014; 52: 557-64.CrossRefPubMed McIsaac I, Bryson GL, van Walraven C. Elective, major noncardiac surgery on the weekend: a population-based cohort study of 30-day mortality. Med Care 2014; 52: 557-64.CrossRefPubMed
16.
Zurück zum Zitat McIsaac DI, Bryson GL, van Walraven C. Association of frailty and 1-year postoperative mortality following major elective noncardiac surgery: a population-based cohort study. JAMA Surg 2016; 151: 538-45.CrossRefPubMed McIsaac DI, Bryson GL, van Walraven C. Association of frailty and 1-year postoperative mortality following major elective noncardiac surgery: a population-based cohort study. JAMA Surg 2016; 151: 538-45.CrossRefPubMed
17.
Zurück zum Zitat van Walraven C. The hospital-patient one-year mortality risk score accurately predicted long-term death risk in hospitalized patients. J Clin Epidemiol 2014; 67: 1025-34.CrossRefPubMed van Walraven C. The hospital-patient one-year mortality risk score accurately predicted long-term death risk in hospitalized patients. J Clin Epidemiol 2014; 67: 1025-34.CrossRefPubMed
18.
Zurück zum Zitat Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-83.CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-83.CrossRefPubMed
19.
Zurück zum Zitat van Walraven C, McAlister FA, Bakal JA, Hawken S, Donze J. External validation of the Hospital-patient One-year Mortality Risk (HOMR) model for predicting death within 1 year after hospital admission. CMAJ 2015; 187: 725-33.CrossRefPubMedPubMedCentral van Walraven C, McAlister FA, Bakal JA, Hawken S, Donze J. External validation of the Hospital-patient One-year Mortality Risk (HOMR) model for predicting death within 1 year after hospital admission. CMAJ 2015; 187: 725-33.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Casey G, van Walraven C. Using the the Hospitalized patient One-year Mortality Risk (HOMR) score for prognostication using information from the medical record. J Am Geriatr Soc 2017 (in press). Casey G, van Walraven C. Using the the Hospitalized patient One-year Mortality Risk (HOMR) score for prognostication using information from the medical record. J Am Geriatr Soc 2017 (in press).
21.
Zurück zum Zitat van Walraven C, Forster AJ. HOMR-now! A modification of the HOMR score that predicts 1-year death risk for hospitalized patients using data immediately available at patient admission. Am J Med 2017 (in press). van Walraven C, Forster AJ. HOMR-now! A modification of the HOMR score that predicts 1-year death risk for hospitalized patients using data immediately available at patient admission. Am J Med 2017 (in press).
22.
Zurück zum Zitat Greenland S, Rothman KJ. Introduction to categorical statistics. In: Rothman KJ, Greenland S, editors. Modern Epidemiology -. 2nd ed. Philadelphia: Lippincott-Raven Publishers; 1998. p. 253-80. Greenland S, Rothman KJ. Introduction to categorical statistics. In: Rothman KJ, Greenland S, editors. Modern Epidemiology -. 2nd ed. Philadelphia: Lippincott-Raven Publishers; 1998. p. 253-80.
23.
Zurück zum Zitat Pearse RM, Harrison DA, James P, et al. Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care 2006; 10: R81.CrossRefPubMedPubMedCentral Pearse RM, Harrison DA, James P, et al. Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care 2006; 10: R81.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Glance LG, Li Y, Dick AW. Quality of quality measurement: impact of risk adjustment, hospital volume, and hospital performance. Anesthesiology 2016; 125: 1092-102.CrossRefPubMed Glance LG, Li Y, Dick AW. Quality of quality measurement: impact of risk adjustment, hospital volume, and hospital performance. Anesthesiology 2016; 125: 1092-102.CrossRefPubMed
Metadaten
Titel
A retrospective assessment of prognostication in 456,685 patients undergoing elective major non-cardiac surgery
verfasst von
Daniel McIsaac, MD, MPH
Luke T. Lavallée, MD, MSc
Carl van Walraven, MD, MSc
Publikationsdatum
05.07.2017
Verlag
Springer US
Erschienen in
Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Ausgabe 9/2017
Print ISSN: 0832-610X
Elektronische ISSN: 1496-8975
DOI
https://doi.org/10.1007/s12630-017-0909-x

Weitere Artikel der Ausgabe 9/2017

Canadian Journal of Anesthesia/Journal canadien d'anesthésie 9/2017 Zur Ausgabe

Book and New Media Reviews

Ultrasound Guided Regional Anesthesia

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

Delir bei kritisch Kranken – Antipsychotika versus Placebo

16.05.2024 Delir Nachrichten

Um die Langzeitfolgen eines Delirs bei kritisch Kranken zu mildern, wird vielerorts auf eine Akuttherapie mit Antipsychotika gesetzt. Eine US-amerikanische Forschungsgruppe äußert jetzt erhebliche Vorbehalte gegen dieses Vorgehen. Denn es gibt neue Daten zum Langzeiteffekt von Haloperidol bzw. Ziprasidon versus Placebo.

Eingreifen von Umstehenden rettet vor Erstickungstod

15.05.2024 Fremdkörperaspiration Nachrichten

Wer sich an einem Essensrest verschluckt und um Luft ringt, benötigt vor allem rasche Hilfe. Dass Umstehende nur in jedem zweiten Erstickungsnotfall bereit waren, diese zu leisten, ist das ernüchternde Ergebnis einer Beobachtungsstudie aus Japan. Doch es gibt auch eine gute Nachricht.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.