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Erschienen in: European Journal of Plastic Surgery 1/2024

01.12.2024 | Review

A review: recent advances in the application of 3D printing biomaterials in breast reconstruction research

verfasst von: Xiong Lv, Chun Xiang, Yan Zheng, Shu-Feng Xu, Wan-Xuan Zhou, Xu-Ling Lv

Erschienen in: European Journal of Plastic Surgery | Ausgabe 1/2024

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Abstract

Breast reconstruction is an indispensable component of surgical treatment for breast cancer. Currently, implant-based breast reconstruction (IBBR) has become a primary method, utilizing prosthetic implants. The advantages of implantation, such as fewer complications, safety, and convenience, have made it a research hotspot in recent years. Among implant materials, high-polymer materials stand out due to their lightweight, cost-effectiveness, high plasticity, and good biocompatibility, making them the most promising choice. Simultaneously, with the advancement of 3D printing technology, some 3D-printed prosthetic scaffolds have gradually emerged in breast reconstruction research and even in clinical applications. Therefore, this review briefly discusses the historical development of high-polymer biomaterials and related technologies in breast reconstruction. It also primarily explores the progress in the application of newly developed artificial implants, especially those based on emerging technologies like 3D printing. The purpose of this review is to provide a comprehensive summary of the past and present developments in breast reconstruction, aiming to contribute to the synthesis of clinical advancements and future research directions in this field.
Level of evidence: Not ratable 
Literatur
1.
Zurück zum Zitat Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249CrossRefPubMed Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249CrossRefPubMed
2.
Zurück zum Zitat Zhou CM, Xue Q, Wang Y, Tong J, Ji M, Yang JJ (2021) Machine learning to predict the cancer-specific mortality of patients with primary non-metastatic invasive breast cancer. Surg Today 51(5):756–763PubMedCrossRef Zhou CM, Xue Q, Wang Y, Tong J, Ji M, Yang JJ (2021) Machine learning to predict the cancer-specific mortality of patients with primary non-metastatic invasive breast cancer. Surg Today 51(5):756–763PubMedCrossRef
3.
Zurück zum Zitat Kolak A, Kamińska M, Sygit K, Budny A, Surdyka D, Kukiełka-Budny B, Burdan F (2017) Primary and secondary prevention of breast cancer. Ann Agric Environ Med 24(4):549–553PubMedCrossRef Kolak A, Kamińska M, Sygit K, Budny A, Surdyka D, Kukiełka-Budny B, Burdan F (2017) Primary and secondary prevention of breast cancer. Ann Agric Environ Med 24(4):549–553PubMedCrossRef
4.
Zurück zum Zitat Peart O (2015) Breast intervention and breast cancer treatment options. RadiolTechnol 86(5):535M-558M; quiz 559–62 Peart O (2015) Breast intervention and breast cancer treatment options. RadiolTechnol 86(5):535M-558M; quiz 559–62
5.
Zurück zum Zitat Maughan KL, Lutterbie MA, Ham PS (2010) Treatment of breast cancer. Am Fam Physician 81(11):1339–1346PubMed Maughan KL, Lutterbie MA, Ham PS (2010) Treatment of breast cancer. Am Fam Physician 81(11):1339–1346PubMed
6.
Zurück zum Zitat Rossi L, Mazzara C, Pagani O (2019) Diagnosis and treatment of breast cancer in young women. Curr Treat Options Oncol 20(12):86PubMedCrossRef Rossi L, Mazzara C, Pagani O (2019) Diagnosis and treatment of breast cancer in young women. Curr Treat Options Oncol 20(12):86PubMedCrossRef
7.
Zurück zum Zitat Yan J, Liu Z, Du S, Li J, Ma L, Li L (2020) Diagnosis and treatment of breast cancer in the precision medicine era. Methods Mol Biol 2204:53–61PubMedCrossRef Yan J, Liu Z, Du S, Li J, Ma L, Li L (2020) Diagnosis and treatment of breast cancer in the precision medicine era. Methods Mol Biol 2204:53–61PubMedCrossRef
8.
Zurück zum Zitat Fisher B, Jeong JH, Anderson S, Bryant J, Fisher ER, Wolmark N (2002) Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med 347(8):567–575PubMedCrossRef Fisher B, Jeong JH, Anderson S, Bryant J, Fisher ER, Wolmark N (2002) Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med 347(8):567–575PubMedCrossRef
9.
Zurück zum Zitat Zehra S, Doyle F, Barry M, Walsh S, Kell MR (2020) Health-related quality of life following breast reconstruction compared to total mastectomy and breast-conserving surgery among breast cancer survivors: a systematic review and meta-analysis. Breast Cancer 27(4):534–566PubMedCrossRef Zehra S, Doyle F, Barry M, Walsh S, Kell MR (2020) Health-related quality of life following breast reconstruction compared to total mastectomy and breast-conserving surgery among breast cancer survivors: a systematic review and meta-analysis. Breast Cancer 27(4):534–566PubMedCrossRef
10.
Zurück zum Zitat Zhang C, Hu G, Biskup E, Qiu X, Zhang H, Zhang H (2018) Depression induced by total mastectomy, breast conserving surgery and breast reconstruction: a systematic review and meta-analysis. World J Surg 42(7):2076–2085PubMedCrossRef Zhang C, Hu G, Biskup E, Qiu X, Zhang H, Zhang H (2018) Depression induced by total mastectomy, breast conserving surgery and breast reconstruction: a systematic review and meta-analysis. World J Surg 42(7):2076–2085PubMedCrossRef
11.
Zurück zum Zitat Plesca M, Bordea C, El Houcheimi B, Ichim E, Blidaru A (2016) Evolution of radical mastectomy for breast cancer. J Med Life 9(2):183–186PubMedPubMedCentral Plesca M, Bordea C, El Houcheimi B, Ichim E, Blidaru A (2016) Evolution of radical mastectomy for breast cancer. J Med Life 9(2):183–186PubMedPubMedCentral
12.
Zurück zum Zitat Kim MK, Kim T, Moon HG, Jin US, Kim K, Kim J, Lee JW, Kim J, Lee E, Yoo TK, Noh DY, Minn KW, Han W (2015) Effect of cosmetic outcome on quality of life after breast cancer surgery. Eur J Surg Oncol 41(3):426–432PubMedCrossRef Kim MK, Kim T, Moon HG, Jin US, Kim K, Kim J, Lee JW, Kim J, Lee E, Yoo TK, Noh DY, Minn KW, Han W (2015) Effect of cosmetic outcome on quality of life after breast cancer surgery. Eur J Surg Oncol 41(3):426–432PubMedCrossRef
13.
Zurück zum Zitat Padmalatha S, Tsai YT, Ku HC, Wu YL, Yu T, Fang SY, Ko NY (2021) Higher risk of depression after total mastectomy versus breast reconstruction among adult women with breast cancer: a systematic review and metaregression. Clin Breast Cancer 21(5):e526–e538PubMedCrossRef Padmalatha S, Tsai YT, Ku HC, Wu YL, Yu T, Fang SY, Ko NY (2021) Higher risk of depression after total mastectomy versus breast reconstruction among adult women with breast cancer: a systematic review and metaregression. Clin Breast Cancer 21(5):e526–e538PubMedCrossRef
14.
Zurück zum Zitat Fanakidou I, Zyga S, Alikari V, Tsironi M, Stathoulis J, Theofilou P (2018) Mental health, loneliness, and illness perception outcomes in quality of life among young breast cancer patients after mastectomy: the role of breast reconstruction. Qual Life Res 27(2):539–543PubMedCrossRef Fanakidou I, Zyga S, Alikari V, Tsironi M, Stathoulis J, Theofilou P (2018) Mental health, loneliness, and illness perception outcomes in quality of life among young breast cancer patients after mastectomy: the role of breast reconstruction. Qual Life Res 27(2):539–543PubMedCrossRef
15.
Zurück zum Zitat Guliyeva G, Torres RA, Avila FR, Kaplan JL, Lu X, Forte AJ (2022) The impact of implant-based reconstruction on persistent pain after breast cancer surgery: a systematic review. J Plast Reconstr Aesthet Surg 75(2):519–527PubMedCrossRef Guliyeva G, Torres RA, Avila FR, Kaplan JL, Lu X, Forte AJ (2022) The impact of implant-based reconstruction on persistent pain after breast cancer surgery: a systematic review. J Plast Reconstr Aesthet Surg 75(2):519–527PubMedCrossRef
16.
Zurück zum Zitat Popowich B, Kostaras X, Temple-Oberle C (2020) Breast reconstruction after therapeutic or prophylactic mastectomy for breast cancer: a comparison of guideline recommendations. Eur J Surg Oncol 46(6):1046–1051PubMedCrossRef Popowich B, Kostaras X, Temple-Oberle C (2020) Breast reconstruction after therapeutic or prophylactic mastectomy for breast cancer: a comparison of guideline recommendations. Eur J Surg Oncol 46(6):1046–1051PubMedCrossRef
17.
Zurück zum Zitat de Kerckhove M, Matsunaga N, Tomita S, Fujii M, Terao Y (2023) Tertiary autologous breast reconstruction after implant-based reconstruction: safety and patient-related outcomes. J Plast Reconstr Aesthet Surg 79:47–54PubMedCrossRef de Kerckhove M, Matsunaga N, Tomita S, Fujii M, Terao Y (2023) Tertiary autologous breast reconstruction after implant-based reconstruction: safety and patient-related outcomes. J Plast Reconstr Aesthet Surg 79:47–54PubMedCrossRef
18.
Zurück zum Zitat Murphy SV, Atala A (2014) 3D bioprinting of tissues and organs. Nat Biotechnol 32(8):773–785PubMedCrossRef Murphy SV, Atala A (2014) 3D bioprinting of tissues and organs. Nat Biotechnol 32(8):773–785PubMedCrossRef
19.
Zurück zum Zitat Mandrycky C, Wang Z, Kim K, Kim DH (2016) 3D bioprinting for engineering complex tissues. Biotechnol Adv 34(4):422–434PubMedCrossRef Mandrycky C, Wang Z, Kim K, Kim DH (2016) 3D bioprinting for engineering complex tissues. Biotechnol Adv 34(4):422–434PubMedCrossRef
20.
Zurück zum Zitat Vijayavenkataraman S, Yan WC, Lu WF, Wang CH, Fuh JYH (2018) 3D bioprinting of tissues and organs for regenerative medicine. Adv Drug Deliv Rev 132:296–332PubMedCrossRef Vijayavenkataraman S, Yan WC, Lu WF, Wang CH, Fuh JYH (2018) 3D bioprinting of tissues and organs for regenerative medicine. Adv Drug Deliv Rev 132:296–332PubMedCrossRef
21.
22.
Zurück zum Zitat Rozen WM, Ashton MW, Taylor GI (2008) Defining the role for autologous breast reconstruction after mastectomy: social and oncologic implications. Clin Breast Cancer 8(2):134–142PubMedCrossRef Rozen WM, Ashton MW, Taylor GI (2008) Defining the role for autologous breast reconstruction after mastectomy: social and oncologic implications. Clin Breast Cancer 8(2):134–142PubMedCrossRef
23.
Zurück zum Zitat Teo I, Reece GP, Christie IC, Guindani M, Markey MK, Heinberg LJ, Crosby MA, Fingeret MC (2016) Body image and quality of life of breast cancer patients: influence of timing and stage of breast reconstruction. Psychooncology 25(9):1106–1112PubMedCrossRef Teo I, Reece GP, Christie IC, Guindani M, Markey MK, Heinberg LJ, Crosby MA, Fingeret MC (2016) Body image and quality of life of breast cancer patients: influence of timing and stage of breast reconstruction. Psychooncology 25(9):1106–1112PubMedCrossRef
24.
Zurück zum Zitat Stefura T, Rusinek J, Wątor J, Zagórski A, Zając M, Libondi G, Wysocki WM, Koziej M (2023) Implant vs. autologous tissue-based breast reconstruction: A systematic review and meta-analysis of the studies comparing surgical approaches in 55,455 patients. J Plast Reconstr Aesthet Surg 77:346–358PubMedCrossRef Stefura T, Rusinek J, Wątor J, Zagórski A, Zając M, Libondi G, Wysocki WM, Koziej M (2023) Implant vs. autologous tissue-based breast reconstruction: A systematic review and meta-analysis of the studies comparing surgical approaches in 55,455 patients. J Plast Reconstr Aesthet Surg 77:346–358PubMedCrossRef
25.
Zurück zum Zitat Panchal H, Matros E (2017) Current trends in postmastectomy breast reconstruction. Plast Reconstr Surg 140(5S Advances in Breast Reconstruction):7s-13s Panchal H, Matros E (2017) Current trends in postmastectomy breast reconstruction. Plast Reconstr Surg 140(5S Advances in Breast Reconstruction):7s-13s
26.
Zurück zum Zitat von Glinski M, Holler N, Kümmel S, Wallner C, Wagner JM, Sogorski A, Reinkemeier F, Reinisch M, Lehnhardt M, Behr B (2023) The partner perspective on autologous and implant-based breast reconstruction. Aesthetic Plast Surg 47(4):1324–1331CrossRef von Glinski M, Holler N, Kümmel S, Wallner C, Wagner JM, Sogorski A, Reinkemeier F, Reinisch M, Lehnhardt M, Behr B (2023) The partner perspective on autologous and implant-based breast reconstruction. Aesthetic Plast Surg 47(4):1324–1331CrossRef
27.
Zurück zum Zitat Chu MW, Samra F, Kanchwala SK, Momeni A (2017) Treatment options for bilateral autologous breast reconstruction in patients with inadequate donor-site volume. J Reconstr Microsurg 33(5):305–311PubMedCrossRef Chu MW, Samra F, Kanchwala SK, Momeni A (2017) Treatment options for bilateral autologous breast reconstruction in patients with inadequate donor-site volume. J Reconstr Microsurg 33(5):305–311PubMedCrossRef
28.
Zurück zum Zitat Escandón JM, Escandón L, Ahmed A, Weiss A, Nazerali R, Ciudad P, Langstein HN, Manrique OJ (2022) Breast reconstruction using the Latissimus Dorsi Flap and Immediate Fat Transfer (LIFT): a systematic review and meta-analysis. J Plast Reconstr Aesthet Surg 75(11):4106–4116PubMedCrossRef Escandón JM, Escandón L, Ahmed A, Weiss A, Nazerali R, Ciudad P, Langstein HN, Manrique OJ (2022) Breast reconstruction using the Latissimus Dorsi Flap and Immediate Fat Transfer (LIFT): a systematic review and meta-analysis. J Plast Reconstr Aesthet Surg 75(11):4106–4116PubMedCrossRef
29.
Zurück zum Zitat Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW (2015) Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Biomaterials 52:551–560PubMedCrossRef Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW (2015) Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Biomaterials 52:551–560PubMedCrossRef
30.
Zurück zum Zitat O’Halloran NA, Dolan EB, Kerin MJ, Lowery AJ, Duffy GP (2018) Hydrogels in adipose tissue engineering-potential application in post-mastectomy breast regeneration. J Tissue Eng Regen Med 12(12):2234–2247PubMedCrossRef O’Halloran NA, Dolan EB, Kerin MJ, Lowery AJ, Duffy GP (2018) Hydrogels in adipose tissue engineering-potential application in post-mastectomy breast regeneration. J Tissue Eng Regen Med 12(12):2234–2247PubMedCrossRef
31.
Zurück zum Zitat Banani MA, Rahmatullah M, Farhan N, Hancox Z, Yousaf S, Arabpour Z, Moghaddam ZS, Mozafari M, Sefat F (2021) Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration. Regen Med 16(1):47–70PubMedCrossRef Banani MA, Rahmatullah M, Farhan N, Hancox Z, Yousaf S, Arabpour Z, Moghaddam ZS, Mozafari M, Sefat F (2021) Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration. Regen Med 16(1):47–70PubMedCrossRef
32.
Zurück zum Zitat Li L, Su Y, Xiu B, Huang X, Chi W, Hou J, Zhang Y, Tian J, Wang J, Wu J (2019) Comparison of prepectoral and subpectoral breast reconstruction after mastectomies: a systematic review and meta analysis. Eur J Surg Oncol 45(9):1542–1550PubMedCrossRef Li L, Su Y, Xiu B, Huang X, Chi W, Hou J, Zhang Y, Tian J, Wang J, Wu J (2019) Comparison of prepectoral and subpectoral breast reconstruction after mastectomies: a systematic review and meta analysis. Eur J Surg Oncol 45(9):1542–1550PubMedCrossRef
33.
Zurück zum Zitat Liu J, Zheng X, Lin S, Han H, Xu C (2022) A systematic review and meta-analysis on the prepectoral single-stage breast reconstruction. Support Care Cancer 30(7):5659–5668PubMedCrossRef Liu J, Zheng X, Lin S, Han H, Xu C (2022) A systematic review and meta-analysis on the prepectoral single-stage breast reconstruction. Support Care Cancer 30(7):5659–5668PubMedCrossRef
35.
Zurück zum Zitat Potter S, Conroy EJ, Cutress RI, Williamson PR, Whisker L, Thrush S, Skillman J, Barnes NLP, Mylvaganam S, Teasdale E, Jain A, Gardiner MD, Blazeby JM, Holcombe C (2019) Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study. Lancet Oncol 20(2):254–266PubMedPubMedCentralCrossRef Potter S, Conroy EJ, Cutress RI, Williamson PR, Whisker L, Thrush S, Skillman J, Barnes NLP, Mylvaganam S, Teasdale E, Jain A, Gardiner MD, Blazeby JM, Holcombe C (2019) Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study. Lancet Oncol 20(2):254–266PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Freeman MD, Vemula R, Rao R, Matatov TS, Strong AL, Tandon R, Chaffin AE, Jansen DA (2016) Refinements in the techniques of 2-stage breast reconstruction. Ann Plast Surg 76(Suppl 4):S304–S311PubMedCrossRef Freeman MD, Vemula R, Rao R, Matatov TS, Strong AL, Tandon R, Chaffin AE, Jansen DA (2016) Refinements in the techniques of 2-stage breast reconstruction. Ann Plast Surg 76(Suppl 4):S304–S311PubMedCrossRef
37.
Zurück zum Zitat Qureshi AA, Broderick KP, Belz J, Funk S, Reaven N, Brandt KE, Tenenbaum MM, Margenthaler JA, Aft RL, Myckatyn TM (2016) Uneventful versus successful reconstruction and outcome pathways in implant-based breast reconstruction with acellular dermal matrices. Plast Reconstr Surg 138(2):173e–183ePubMedCrossRef Qureshi AA, Broderick KP, Belz J, Funk S, Reaven N, Brandt KE, Tenenbaum MM, Margenthaler JA, Aft RL, Myckatyn TM (2016) Uneventful versus successful reconstruction and outcome pathways in implant-based breast reconstruction with acellular dermal matrices. Plast Reconstr Surg 138(2):173e–183ePubMedCrossRef
38.
Zurück zum Zitat Remington AC, Gurtner GC, Wan DC, Nguyen D, Momeni A (2019) Identifying risk factors for postoperative major complications in staged implant-based breast reconstruction with AlloDerm. Breast J 25(4):597–603PubMedCrossRef Remington AC, Gurtner GC, Wan DC, Nguyen D, Momeni A (2019) Identifying risk factors for postoperative major complications in staged implant-based breast reconstruction with AlloDerm. Breast J 25(4):597–603PubMedCrossRef
39.
Zurück zum Zitat Qian B, Xiong L, Guo K, Wang R, Yang J, Wang Z, Tong J, Sun J (2020) Comprehensive management of breast augmentation with polyacrylamide hydrogel injection based on 15 years of experience: a report on 325 cases. Ann Transl Med 8(7):475PubMedPubMedCentralCrossRef Qian B, Xiong L, Guo K, Wang R, Yang J, Wang Z, Tong J, Sun J (2020) Comprehensive management of breast augmentation with polyacrylamide hydrogel injection based on 15 years of experience: a report on 325 cases. Ann Transl Med 8(7):475PubMedPubMedCentralCrossRef
40.
Zurück zum Zitat Bielli A, Scioli MG, Gentile P, Cervelli V, Orlandi A (2015) Adipose tissue-derived stem cell therapy for post-surgical breast reconstruction-more light than shadows. Adv Clin Exp Med 24(3):545–548PubMedCrossRef Bielli A, Scioli MG, Gentile P, Cervelli V, Orlandi A (2015) Adipose tissue-derived stem cell therapy for post-surgical breast reconstruction-more light than shadows. Adv Clin Exp Med 24(3):545–548PubMedCrossRef
41.
Zurück zum Zitat Shamoun F, Asaad M, Hanson SE (2021) Oncologic safety of autologous fat grafting in breast reconstruction. Clin Breast Cancer 21(4):271–277PubMedCrossRef Shamoun F, Asaad M, Hanson SE (2021) Oncologic safety of autologous fat grafting in breast reconstruction. Clin Breast Cancer 21(4):271–277PubMedCrossRef
42.
Zurück zum Zitat Kosowski TR, Rigotti G, Khouri RK (2015) Tissue-engineered autologous breast regeneration with brava®-assisted fat grafting. Clin Plast Surg 42(3):325–37, viii Kosowski TR, Rigotti G, Khouri RK (2015) Tissue-engineered autologous breast regeneration with brava®-assisted fat grafting. Clin Plast Surg 42(3):325–37, viii
43.
Zurück zum Zitat Gampper TJ, Khoury H, Gottlieb W, Morgan RF (2007) Silicone gel implants in breast augmentation and reconstruction. Ann Plast Surg 59(5):581–590PubMedCrossRef Gampper TJ, Khoury H, Gottlieb W, Morgan RF (2007) Silicone gel implants in breast augmentation and reconstruction. Ann Plast Surg 59(5):581–590PubMedCrossRef
44.
Zurück zum Zitat Asplund O (1984) Capsular contracture in silicone gel and saline-filled breast implants after reconstruction. Plast Reconstr Surg 73(2):270–275PubMedCrossRef Asplund O (1984) Capsular contracture in silicone gel and saline-filled breast implants after reconstruction. Plast Reconstr Surg 73(2):270–275PubMedCrossRef
45.
Zurück zum Zitat Vandeweyer E, Hertens D, Nogaret JM, Deraemaecker R (2001) Immediate breast reconstruction with saline-filled implants: no interference with the oncologic outcome? Plast Reconstr Surg 107(6):1409–1412PubMedCrossRef Vandeweyer E, Hertens D, Nogaret JM, Deraemaecker R (2001) Immediate breast reconstruction with saline-filled implants: no interference with the oncologic outcome? Plast Reconstr Surg 107(6):1409–1412PubMedCrossRef
46.
Zurück zum Zitat Piza-Katzer H, Pülzl P, Balogh B, Wechselberger G (2002) Long-term results of MISTI gold breast implants: a retrospective study, Plast Reconstr Surg 110(6):1455–9; discussion 1460–2 Piza-Katzer H, Pülzl P, Balogh B, Wechselberger G (2002) Long-term results of MISTI gold breast implants: a retrospective study, Plast Reconstr Surg 110(6):1455–9; discussion 1460–2
47.
Zurück zum Zitat Garcia-Tutor E, Alonso-Burgos A, Marre D, Adrian CA (2011) Radiotransparency of polyvinylpyrrolidone-hydrogel and hydrogel breast implants: a quantitative analysis with mastectomy specimens. Aesthetic Plast Surg 35(2):203–210PubMedCrossRef Garcia-Tutor E, Alonso-Burgos A, Marre D, Adrian CA (2011) Radiotransparency of polyvinylpyrrolidone-hydrogel and hydrogel breast implants: a quantitative analysis with mastectomy specimens. Aesthetic Plast Surg 35(2):203–210PubMedCrossRef
48.
Zurück zum Zitat Kirkpatrick WN, Jones BM (2002) The history of trilucent implants, and a chemical analysis of the triglyceride filler in 51 consecutively removed trilucent breast prostheses. Br J Plast Surg 55(6):479–489PubMedCrossRef Kirkpatrick WN, Jones BM (2002) The history of trilucent implants, and a chemical analysis of the triglyceride filler in 51 consecutively removed trilucent breast prostheses. Br J Plast Surg 55(6):479–489PubMedCrossRef
49.
Zurück zum Zitat Inglefield C (2011) Early clinical experience of hyaluronic acid gel for breast enhancement. J Plast Reconstr Aesthet Surg 64(6):722–729PubMedCrossRef Inglefield C (2011) Early clinical experience of hyaluronic acid gel for breast enhancement. J Plast Reconstr Aesthet Surg 64(6):722–729PubMedCrossRef
50.
Zurück zum Zitat Zou H, Mo R, Wang S, Yan X, Lin Y, Tan Q (2023) Analysis of breast follow-up results in patients after polyacrylamide hydrogel (PAAG) or silicone prosthesis removal. J Plast Reconstr Aesthet Surg 77:219–227PubMedCrossRef Zou H, Mo R, Wang S, Yan X, Lin Y, Tan Q (2023) Analysis of breast follow-up results in patients after polyacrylamide hydrogel (PAAG) or silicone prosthesis removal. J Plast Reconstr Aesthet Surg 77:219–227PubMedCrossRef
51.
Zurück zum Zitat Coleman SR (2006) Structural fat grafting: more than a permanent filler. Plast Reconstr Surg 118(3 Suppl):108s–120sPubMedCrossRef Coleman SR (2006) Structural fat grafting: more than a permanent filler. Plast Reconstr Surg 118(3 Suppl):108s–120sPubMedCrossRef
52.
Zurück zum Zitat Qin Z, Yu Z, Song B (2022) Efficacy and safety of External Volume Expansion (EVE) on fat grafting: a systematic review and single-arm meta-analysis. J Plast Reconstr Aesthet Surg 75(3):1073–1082PubMedCrossRef Qin Z, Yu Z, Song B (2022) Efficacy and safety of External Volume Expansion (EVE) on fat grafting: a systematic review and single-arm meta-analysis. J Plast Reconstr Aesthet Surg 75(3):1073–1082PubMedCrossRef
53.
Zurück zum Zitat Herly M, Ørholt M, Larsen A, Pipper CB, Bredgaard R, Gramkow CS, Katz AJ, Drzewiecki KT, Vester-Glowinski PV (2018) Efficacy of breast reconstruction with fat grafting: a systematic review and meta-analysis. J Plast Reconstr Aesthet Surg 71(12):1740–1750PubMedCrossRef Herly M, Ørholt M, Larsen A, Pipper CB, Bredgaard R, Gramkow CS, Katz AJ, Drzewiecki KT, Vester-Glowinski PV (2018) Efficacy of breast reconstruction with fat grafting: a systematic review and meta-analysis. J Plast Reconstr Aesthet Surg 71(12):1740–1750PubMedCrossRef
54.
Zurück zum Zitat Major GS, Simcock JW, Woodfield TBF, Lim KS (2022) Overcoming functional challenges in autologous and engineered fat grafting trends. Trends Biotechnol 40(1):77–92PubMedCrossRef Major GS, Simcock JW, Woodfield TBF, Lim KS (2022) Overcoming functional challenges in autologous and engineered fat grafting trends. Trends Biotechnol 40(1):77–92PubMedCrossRef
55.
Zurück zum Zitat Jin S, Li F (2019) Fate of free fat grafts with or without adipogenic adjuncts to enhance graft outcomes. Plast Reconstr Surg 144(3):511e–512ePubMedCrossRef Jin S, Li F (2019) Fate of free fat grafts with or without adipogenic adjuncts to enhance graft outcomes. Plast Reconstr Surg 144(3):511e–512ePubMedCrossRef
56.
Zurück zum Zitat Cai J, Feng J, Liu K, Zhou S, Lu F (2018) Early macrophage infiltration improves fat graft survival by inducing angiogenesis and hematopoietic stem cell recruitment. Plast Reconstr Surg 141(2):376–386PubMedCrossRef Cai J, Feng J, Liu K, Zhou S, Lu F (2018) Early macrophage infiltration improves fat graft survival by inducing angiogenesis and hematopoietic stem cell recruitment. Plast Reconstr Surg 141(2):376–386PubMedCrossRef
57.
Zurück zum Zitat Cronin TD, Greenberg RL (1970) Our experiences with the silastic gel breast prosthesis. Plast Reconstr Surg 46(1):1–7PubMedCrossRef Cronin TD, Greenberg RL (1970) Our experiences with the silastic gel breast prosthesis. Plast Reconstr Surg 46(1):1–7PubMedCrossRef
58.
Zurück zum Zitat Guidoin R, Rolland C, Fleury D, Charara J, Marceau D, Bronskill M, Cardou A, King M, Lessard R (1994) Physical characterization of unimplanted gel filled breast implants. Should old standards be revisited? Asaio J 40(4):943–58 Guidoin R, Rolland C, Fleury D, Charara J, Marceau D, Bronskill M, Cardou A, King M, Lessard R (1994) Physical characterization of unimplanted gel filled breast implants. Should old standards be revisited? Asaio J 40(4):943–58
59.
Zurück zum Zitat Benediktsson K, Perbeck L (2006) Capsular contracture around saline-filled and textured subcutaneously-placed implants in irradiated and non-irradiated breast cancer patients: five years of monitoring of a prospective trial. J Plast Reconstr Aesthet Surg 59(1):27–34PubMedCrossRef Benediktsson K, Perbeck L (2006) Capsular contracture around saline-filled and textured subcutaneously-placed implants in irradiated and non-irradiated breast cancer patients: five years of monitoring of a prospective trial. J Plast Reconstr Aesthet Surg 59(1):27–34PubMedCrossRef
60.
Zurück zum Zitat Ersek RA, Salisbury AV (1997) Textured surface, nonsilicone gel breast implants: four years’ clinical outcome. Plast Reconstr Surg 100(7):1729–1739PubMedCrossRef Ersek RA, Salisbury AV (1997) Textured surface, nonsilicone gel breast implants: four years’ clinical outcome. Plast Reconstr Surg 100(7):1729–1739PubMedCrossRef
61.
Zurück zum Zitat Papanastasiou S, Odili J, Newman P, Evans J (2000) Are triglyceride breast implants really biocompatible? Ann Plast Surg 45(2):172–3; discussion 174–6 Papanastasiou S, Odili J, Newman P, Evans J (2000) Are triglyceride breast implants really biocompatible? Ann Plast Surg 45(2):172–3; discussion 174–6
62.
Zurück zum Zitat Rohrich RJ, Beran SJ, Ingram Jr. AE, Young VL (1996) Development of alternative breast implant filler material: criteria and horizons. Plast Reconstr Surg 98(3):552–60; discussion 561–2 Rohrich RJ, Beran SJ, Ingram Jr. AE, Young VL (1996) Development of alternative breast implant filler material: criteria and horizons. Plast Reconstr Surg 98(3):552–60; discussion 561–2
63.
Zurück zum Zitat Münker R, Zörner C, McKiernan D, Opitz J (2001) Prospective study of clinical findings and changes in 56 trilucent implant explantations. Aesthetic Plast Surg 25(6):421–426PubMedCrossRef Münker R, Zörner C, McKiernan D, Opitz J (2001) Prospective study of clinical findings and changes in 56 trilucent implant explantations. Aesthetic Plast Surg 25(6):421–426PubMedCrossRef
64.
Zurück zum Zitat Hedén P, Sellman G, von Wachenfeldt M, Olenius M, Fagrell D (2020) Body shaping and volume restoration: the role of hyaluronic acid. Aesthetic Plast Surg 44(4):1286–1294PubMedCrossRef Hedén P, Sellman G, von Wachenfeldt M, Olenius M, Fagrell D (2020) Body shaping and volume restoration: the role of hyaluronic acid. Aesthetic Plast Surg 44(4):1286–1294PubMedCrossRef
65.
Zurück zum Zitat Lin K, Bartlett SP, Matsuo K, LiVolsi VA, Parry C, Hass B, Whitaker LA (1994) Hyaluronic acid-filled mammary implants: an experimental study. Plast Reconstr Surg 94(2):306–15; discussion 316–7 Lin K, Bartlett SP, Matsuo K, LiVolsi VA, Parry C, Hass B, Whitaker LA (1994) Hyaluronic acid-filled mammary implants: an experimental study. Plast Reconstr Surg 94(2):306–15; discussion 316–7
66.
Zurück zum Zitat Hummelink S, Verhulst AC, Maal TJJ, Ulrich DJO (2018) Applications and limitations of using patient-specific 3D printed molds in autologous breast reconstruction. Eur J Plast Surg 41(5):571–576PubMedPubMedCentralCrossRef Hummelink S, Verhulst AC, Maal TJJ, Ulrich DJO (2018) Applications and limitations of using patient-specific 3D printed molds in autologous breast reconstruction. Eur J Plast Surg 41(5):571–576PubMedPubMedCentralCrossRef
67.
Zurück zum Zitat Luo Y, Wei X, Wan Y, Lin X, Wang Z, Huang P (2019) 3D printing of hydrogel scaffolds for future application in photothermal therapy of breast cancer and tissue repair. Acta Biomater 92:37–47PubMedCrossRef Luo Y, Wei X, Wan Y, Lin X, Wang Z, Huang P (2019) 3D printing of hydrogel scaffolds for future application in photothermal therapy of breast cancer and tissue repair. Acta Biomater 92:37–47PubMedCrossRef
68.
Zurück zum Zitat Zhou M, Hou J, Zhang G, Luo C, Zeng Y, Mou S, Xiao P, Zhong A, Yuan Q, Yang J, Wang Z, Sun J (2019) Tuning the mechanics of 3D-printed scaffolds by crystal lattice-like structural design for breast tissue engineering. Biofabrication 12(1):015023PubMedCrossRef Zhou M, Hou J, Zhang G, Luo C, Zeng Y, Mou S, Xiao P, Zhong A, Yuan Q, Yang J, Wang Z, Sun J (2019) Tuning the mechanics of 3D-printed scaffolds by crystal lattice-like structural design for breast tissue engineering. Biofabrication 12(1):015023PubMedCrossRef
69.
Zurück zum Zitat Ni R, Luo C, Ci H, Sun D, An R, Wang Z, Yang J, Li Y, Sun J (2023) Construction of vascularized tissue-engineered breast with dual angiogenic and adipogenic micro-tissues. Mater Today Bio 18:100539PubMedCrossRef Ni R, Luo C, Ci H, Sun D, An R, Wang Z, Yang J, Li Y, Sun J (2023) Construction of vascularized tissue-engineered breast with dual angiogenic and adipogenic micro-tissues. Mater Today Bio 18:100539PubMedCrossRef
70.
Zurück zum Zitat Zhao P, Wang B, Wang L, Fu Z, Hu J, Liu Y, Wang J, He Y (2023) Rapid printing of 3D porous scaffolds for breast reconstruction. Bio-Des Manuf 6(6):691–703CrossRef Zhao P, Wang B, Wang L, Fu Z, Hu J, Liu Y, Wang J, He Y (2023) Rapid printing of 3D porous scaffolds for breast reconstruction. Bio-Des Manuf 6(6):691–703CrossRef
71.
72.
Zurück zum Zitat Dong X, Premaratne ID, Sariibrahimoglu K, Limem S, Scott J, Gadjiko M, Berri N, Ginter P, Spector JA (2022) 3D-printed poly-4-hydroxybutyrate bioabsorbable scaffolds for nipple reconstruction. Acta Biomater 143:333–343PubMedCrossRef Dong X, Premaratne ID, Sariibrahimoglu K, Limem S, Scott J, Gadjiko M, Berri N, Ginter P, Spector JA (2022) 3D-printed poly-4-hydroxybutyrate bioabsorbable scaffolds for nipple reconstruction. Acta Biomater 143:333–343PubMedCrossRef
73.
Zurück zum Zitat Dong X, Shih S, Premaratne ID, Sariibrahimoglu K, Ginter P, Scott J, Limem S, Spector JA (2023) Long-term maintenance of projection of nipples reconstructed using three-dimensionally printed Poly-4-hydroxybutyrate bioabsorbable scaffolds. Plast Reconstr Surg 152(4):646e–654ePubMedCrossRef Dong X, Shih S, Premaratne ID, Sariibrahimoglu K, Ginter P, Scott J, Limem S, Spector JA (2023) Long-term maintenance of projection of nipples reconstructed using three-dimensionally printed Poly-4-hydroxybutyrate bioabsorbable scaffolds. Plast Reconstr Surg 152(4):646e–654ePubMedCrossRef
74.
Zurück zum Zitat Van Belleghem S, Mahadik B, Snodderly K, Mote Z, Jiang B, Yu JR, McLoughlin S, He X, Nam AJ, Fisher JP (2021) Dual extrusion patterning drives tissue development aesthetics and shape retention in 3D printed nipple-areola constructs. Adv Healthc Mater 10(23):e2101249PubMedPubMedCentralCrossRef Van Belleghem S, Mahadik B, Snodderly K, Mote Z, Jiang B, Yu JR, McLoughlin S, He X, Nam AJ, Fisher JP (2021) Dual extrusion patterning drives tissue development aesthetics and shape retention in 3D printed nipple-areola constructs. Adv Healthc Mater 10(23):e2101249PubMedPubMedCentralCrossRef
75.
Zurück zum Zitat Tervaert JWC, Mohazab N, Redmond D, van Eeden C, Osman M (2022) Breast implant illness: scientific evidence of its existence. Expert Rev Clin Immunol 18(1):15–29CrossRef Tervaert JWC, Mohazab N, Redmond D, van Eeden C, Osman M (2022) Breast implant illness: scientific evidence of its existence. Expert Rev Clin Immunol 18(1):15–29CrossRef
76.
Zurück zum Zitat Georgieva M, Kammerer S, Prantl L, Jung F, Stroszczynski C, Jung EM (2020) Imaging of breast implant and implant-associated complications: capsular contracture and intra- or extracapsular rupture. Clin Hemorheol Microcirc 76(2):221–231PubMedCrossRef Georgieva M, Kammerer S, Prantl L, Jung F, Stroszczynski C, Jung EM (2020) Imaging of breast implant and implant-associated complications: capsular contracture and intra- or extracapsular rupture. Clin Hemorheol Microcirc 76(2):221–231PubMedCrossRef
77.
Zurück zum Zitat Chopra K, Buckingham B, Matthews J, Sabino J, Tadisina KK, Silverman RP, Goldberg NH, Slezak S, Singh DP (2017) Acellular dermal matrix reduces capsule formation in two-stage breast reconstruction. Int Wound J 14(2):414–419PubMedCrossRef Chopra K, Buckingham B, Matthews J, Sabino J, Tadisina KK, Silverman RP, Goldberg NH, Slezak S, Singh DP (2017) Acellular dermal matrix reduces capsule formation in two-stage breast reconstruction. Int Wound J 14(2):414–419PubMedCrossRef
78.
Zurück zum Zitat Whaley RD, Aldrees R, Dougherty RE, Granada CP, Badve SS, Al Diffalha S (2022) Breast Implant Capsule-Associated Squamous Cell Carcinoma: Report of 2 Patients. Int J Surg Pathol 30(8):900–907 Whaley RD, Aldrees R, Dougherty RE, Granada CP, Badve SS, Al Diffalha S (2022) Breast Implant Capsule-Associated Squamous Cell Carcinoma: Report of 2 Patients. Int J Surg Pathol 30(8):900–907
79.
Zurück zum Zitat Hong KY, Kim IK, Sakong Y, Park BY, Jin US (2023) Effects of an antiadhesive agent on capsule formation in implant-based breast reconstruction: a randomized controlled trial. Plast Reconstr Surg 151(4):717–726PubMedCrossRef Hong KY, Kim IK, Sakong Y, Park BY, Jin US (2023) Effects of an antiadhesive agent on capsule formation in implant-based breast reconstruction: a randomized controlled trial. Plast Reconstr Surg 151(4):717–726PubMedCrossRef
80.
Zurück zum Zitat Wright MA, Miller AJ, Dong X, Karinja SJ, Samadi A, Lara DO, Mukherjee S, Veiseh O, Spector JA (2023) Reducing peri-implant capsule thickness in submuscular rodent model of breast reconstruction with delayed radiotherapy. J Surg Res 291:158–166PubMedCrossRef Wright MA, Miller AJ, Dong X, Karinja SJ, Samadi A, Lara DO, Mukherjee S, Veiseh O, Spector JA (2023) Reducing peri-implant capsule thickness in submuscular rodent model of breast reconstruction with delayed radiotherapy. J Surg Res 291:158–166PubMedCrossRef
81.
Zurück zum Zitat Behranwala KA, Dua RS, Ross GM, Ward A, A’Hern R, Gui GP (2006) The influence of radiotherapy on capsule formation and aesthetic outcome after immediate breast reconstruction using biodimensional anatomical expander implants. J Plast Reconstr Aesthet Surg 59(10):1043–1051PubMedCrossRef Behranwala KA, Dua RS, Ross GM, Ward A, A’Hern R, Gui GP (2006) The influence of radiotherapy on capsule formation and aesthetic outcome after immediate breast reconstruction using biodimensional anatomical expander implants. J Plast Reconstr Aesthet Surg 59(10):1043–1051PubMedCrossRef
82.
Zurück zum Zitat Persichetti P, Segreto F, Pendolino AL, Del Buono R, Marangi GF (2014) Breast implant capsule flaps and grafts: a review of the literature. Aesthetic Plast Surg 38(3):540–548PubMedCrossRef Persichetti P, Segreto F, Pendolino AL, Del Buono R, Marangi GF (2014) Breast implant capsule flaps and grafts: a review of the literature. Aesthetic Plast Surg 38(3):540–548PubMedCrossRef
83.
Zurück zum Zitat Handel N, Garcia ME, Wixtrom R (2013) Breast implant rupture: causes, incidence, clinical impact, and management. Plast Reconstr Surg 132(5):1128–1137PubMedCrossRef Handel N, Garcia ME, Wixtrom R (2013) Breast implant rupture: causes, incidence, clinical impact, and management. Plast Reconstr Surg 132(5):1128–1137PubMedCrossRef
84.
Zurück zum Zitat Badri D, Copertino N (2023) Breast implant capsule-associated squamous cell carcinoma: a systematic review and case presentation. Aesthetic Plast Surg Badri D, Copertino N (2023) Breast implant capsule-associated squamous cell carcinoma: a systematic review and case presentation. Aesthetic Plast Surg
85.
Zurück zum Zitat de Faria Castro Fleury E, D'Alessandro GS, Wludarski SCL (2018) Silicone-Induced Granuloma of Breast Implant Capsule (SIGBIC): histopathology and radiological correlation. J Immunol Res 2018:6784971 de Faria Castro Fleury E, D'Alessandro GS, Wludarski SCL (2018) Silicone-Induced Granuloma of Breast Implant Capsule (SIGBIC): histopathology and radiological correlation. J Immunol Res 2018:6784971
86.
Zurück zum Zitat Baker JE, Seitz AP, Boudreau RM, Skinner MJ, Beydoun A, Kaval N, Caldwell CC, Gulbins E, Edwards MJ, Gobble RM (2020) Doxycycline-coated silicone breast implants reduce acute surgical-site infection and inflammation. Plast Reconstr Surg 146(5):1029–1041PubMedCrossRef Baker JE, Seitz AP, Boudreau RM, Skinner MJ, Beydoun A, Kaval N, Caldwell CC, Gulbins E, Edwards MJ, Gobble RM (2020) Doxycycline-coated silicone breast implants reduce acute surgical-site infection and inflammation. Plast Reconstr Surg 146(5):1029–1041PubMedCrossRef
87.
Zurück zum Zitat van Heerden J, Turner M, Hoffmann D, Moolman J (2009) Antimicrobial coating agents: can biofilm formation on a breast implant be prevented? J Plast Reconstr Aesthet Surg 62(5):610–617PubMedCrossRef van Heerden J, Turner M, Hoffmann D, Moolman J (2009) Antimicrobial coating agents: can biofilm formation on a breast implant be prevented? J Plast Reconstr Aesthet Surg 62(5):610–617PubMedCrossRef
Metadaten
Titel
A review: recent advances in the application of 3D printing biomaterials in breast reconstruction research
verfasst von
Xiong Lv
Chun Xiang
Yan Zheng
Shu-Feng Xu
Wan-Xuan Zhou
Xu-Ling Lv
Publikationsdatum
01.12.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Plastic Surgery / Ausgabe 1/2024
Print ISSN: 0930-343X
Elektronische ISSN: 1435-0130
DOI
https://doi.org/10.1007/s00238-024-02171-8

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