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Current Anesthesiology Reports
Erschienen in: Current Anesthesiology Reports 1/2024

16.12.2023 | Anesthesia, Pain Management and Long-term Outcomes (VNR Gottumukkala and ER Mariano, Section Editors)

Anesthetic Exposure During Early Childhood and Neurodevelopmental Outcomes: Our Current Understanding

verfasst von: Tanvee Singh, Amy Pitts, Caleb Miles, Caleb Ing

Erschienen in: Current Anesthesiology Reports | Ausgabe 1/2024

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Abstract

Purpose of Review

The question of anesthetic neurotoxicity emerged two decades ago, but controversy about whether anesthetics cause neurodevelopmental problems in children remains. Interpretation of the published literature is complicated by a paucity of randomized controlled trials and heterogeneity of the published studies. This review summarizes our current understanding and discusses potential sources of study bias and methods to better understand and address issues contributing to bias.

Recent Findings

Recent clinical studies of anesthetic neurotoxicity and meta-analyses of the published studies have reported that children exposed to anesthesia have worse neurodevelopmental outcome scores than unexposed children, particularly in domains of executive function and behavior.

Summary

While anesthetic-exposed children report worse neurodevelopmental outcomes, whether these differences are caused by the anesthesia, or other factors such baseline disease, surgical inflammation, or physiologic disturbances, remains a subject of intense debate. To answer this question, further well-designed studies will be required.
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Metadaten
Titel
Anesthetic Exposure During Early Childhood and Neurodevelopmental Outcomes: Our Current Understanding
verfasst von
Tanvee Singh
Amy Pitts
Caleb Miles
Caleb Ing
Publikationsdatum
16.12.2023
Verlag
Springer US
Erschienen in
Current Anesthesiology Reports / Ausgabe 1/2024
Elektronische ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-023-00592-y

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