Erschienen in:
01.07.2014 | Editorials
Dementia and sensitivity to anesthetics
verfasst von:
George A. Mashour, MD, PhD, Michael S. Avidan, MBBCh
Erschienen in:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
|
Ausgabe 7/2014
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Excerpt
By 2040, the population of individuals in the United States older than 65 yr of age is expected to double to more than 80 million,
1 with similar trends of expansion expected in Canada.
2 Increased age creates a higher risk of both dementia and the need for surgical intervention under general anesthesia. Approximately one in nine individuals ≥ 65 yr of age has Alzheimer’s disease (AD). This prevalence increases to approximately one in three for individuals ≥ 85 yr of age.
3 Although murine genetic models of familial AD suggest the presence of anesthetic resistance (measured by the minimum alveolar concentration),
4,
5 the effects of dementia on anesthetic sensitivity in humans using an electroencephalographic index has not been reported. In the current issue of the
Journal, Perez-Protto
et al. explore whether surgical patients with dementia have increased sensitivity to volatile anesthetic agents.
6 …