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Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie 7/2014

01.07.2014 | Editorials

Dementia and sensitivity to anesthetics

verfasst von: George A. Mashour, MD, PhD, Michael S. Avidan, MBBCh

Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Ausgabe 7/2014

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Excerpt

By 2040, the population of individuals in the United States older than 65 yr of age is expected to double to more than 80 million,1 with similar trends of expansion expected in Canada.2 Increased age creates a higher risk of both dementia and the need for surgical intervention under general anesthesia. Approximately one in nine individuals ≥ 65 yr of age has Alzheimer’s disease (AD). This prevalence increases to approximately one in three for individuals ≥ 85 yr of age.3 Although murine genetic models of familial AD suggest the presence of anesthetic resistance (measured by the minimum alveolar concentration),4,5 the effects of dementia on anesthetic sensitivity in humans using an electroencephalographic index has not been reported. In the current issue of the Journal, Perez-Protto et al. explore whether surgical patients with dementia have increased sensitivity to volatile anesthetic agents.6
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Metadaten
Titel
Dementia and sensitivity to anesthetics
verfasst von
George A. Mashour, MD, PhD
Michael S. Avidan, MBBCh
Publikationsdatum
01.07.2014
Verlag
Springer US
Erschienen in
Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Ausgabe 7/2014
Print ISSN: 0832-610X
Elektronische ISSN: 1496-8975
DOI
https://doi.org/10.1007/s12630-014-0166-1

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