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Der Schmerz
Erschienen in: Der Schmerz 4/2018

23.05.2018 | Epilepsie | CME

Schmerz und Epilepsie

Eine klinisch-neuroanatomisch-pathophysiologische Übersicht

verfasst von: Prof. Dr. med. P. Martin

Erschienen in: Der Schmerz | Ausgabe 4/2018

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Zusammenfassung

Schmerzen im Rahmen von Epilepsien kommen als Kopfschmerzen nach Anfällen häufig vor, sind aber insgesamt selten. Sie verdienen Beachtung als klinische Phänomene, die zu erkennen, zu diagnostizieren und differenzialdiagnostisch abzugrenzen sind, sowie als Symptomatik, deren anatomische und physiologische Grundlagen Aufschluss über Schmerzphänomene im Allgemeinen geben können. Epilepsiebezogene Schmerzen werden einerseits nach Lokalisation als somatosensorische (unilaterale), abdominelle oder die Kopfregion betreffende Schmerzen und andererseits nach zeitlicher Beziehung zur epileptischen Erregungssteigerung als iktale, periiktale und interiktale Schmerzen eingeteilt. Dieser Systematik folgend wird eine Übersicht über Schmerzphänomene im Zusammenhang mit epileptischen Anfällen gegeben. In Bezug auf iktale somatosensorische Anfälle werden funktionell neuroanatomische Aspekte, in Zusammenhang mit abdominellen Epilepsien die Differenzialdiagnostik betrachtet. Bei epilepsiebezogenen Kopfschmerzen werden Nomenklatur und v.a. genetisch-epidemiologische und pathophysiologische Beziehungen zwischen Migräne und Epilepsien dargestellt.
Literatur
1.
Scholz J, Vieregge P, Moser A (1999) Central pain as a manifestation of partial epileptic seizures. Pain 80:445–450PubMedCrossRef
2.
Cai S, Hamiwka LD, Wirrell EC (2008) Peri-ictal headache in children: prevalence and character. Pediatr Neurol 39:91–96PubMedCrossRef
3.
Asadi-Pooya AA, Asadollahi M, Sperling MR (2016) Ictal pain: occurrence, clinical features, and underlying etiologies. Epilepsy Behav 61:54–62CrossRef
4.
Binswanger O (1913) Symptomatologie. In: Die Epilepsie. Alfred Hölder, Wien, Leipzig, S 184–313
5.
6.
Gowers WR (1901) Epilepsy and other convulsive disorders: their causes, symptoms and treatment. Chapter II: Symptoms. Churchill, London., S 35–70
7.
Jackson H (1875) Case illustrating the relation betwixt certain cases of migraine and epilepsy. Lancet 14:244–245CrossRef
8.
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang Y‑H, Zuberi SM (2017) ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology. Epilepsia 58:512–521PubMedPubMedCentralCrossRef
9.
Fisher R, Cross H, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Perez ER, Scheffer IE, Zuberi SM (2017) Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia 58:522–530PubMedCrossRef
10.
11.
Bodfish JW, Harper V, Deacon JM, Deacon JR, Symons FJ (2006) Issues in pain assessment for adults with severe to profound mental retardation. In: Oberlander TF, Symons FJ (Hrsg) Pain in Children and adults with developmental disabilities, S 173–192
12.
Breau LM (2003) Non-communicating children’s pain checklist: better pain assessment for severely disabled children. Expert Rev Pharmacoecon Outcomes Res 3:327–339PubMedCrossRef
13.
Blumberg J, Fernández IS, Vendrame M, Oehl B, Tatum WO, Schuele S, Alexopoulos AV, Poduri A, Kellinghaus C, Schulze-Bonhage A, Loddenkemper T (2012) Dacrystic seizures: demographic, semiologic, and etiologic insights from a multicenter study in long-term video-EEG monitoring units. Epilepsia 53:1810–1819PubMedCrossRefPubMedCentral
14.
15.
Avbersek A, Sisodiya S (2010) Does the primary literature provide support for clinical signs used to distinguish psychogenic nonepileptic seizures from epileptic seizures? J Neurol Neurosurg Psychiatr 81:719–725CrossRef
16.
Siegel AM, Williamson PD, Roberts DW, Thadani VM, Darcey TM (1999) Localized pain associated with seizures originating in the parietal lobe. Epilepsia 40:845–855PubMedCrossRef
17.
Montavont A, Mauguière F, Mazzola L, Garcia-Larrea L, Ryvlin P, Isnard J (2015) On the origin of painful somatosensory seizures. Neurology 84:594–601PubMedCrossRef
18.
Mauguière F, Courjon J (1978) Somatosensory epilepsy, a review of 127 cases. Brain 101:307–332PubMedCrossRef
19.
Salanova V, Andermann F, Rasmussen T, Olivier A, Quesney LF (1995) Parietal lobe epilepsy. Clinical manifestations and outcome in 82 patients treated surgically between 1929 and 1988. Brain 118:607–627PubMedCrossRef
20.
Wilkinson HA (1973) Epileptic pain: an uncommon manifestation with localizing value. Neurology 23:518–520PubMedCrossRef
21.
Pazarcı NK, Bebek N, Baykan B, Gürses C, Gökyiğit A (2016) Reappraisal of epileptic pain as a rare symptom of seizures. Epilepsy Behav 55:101–107CrossRef
22.
23.
Head H, Holmes G (1911) Sensory disturbances from cerebral lesions. Brain 34:102–154CrossRef
24.
Mazzola L, Isnard J, Peyron R, Mauguière F (2012) Stimulation of the human cortex and the experience of pain: Wilder Penfield’s observations revisited. Brain 135:631–640PubMedCrossRef
25.
Penfield W, Jasper H (1954) Epilepsy and the functional anatomy of the human brain. J&A Churchill, London, S 773
26.
Penfield W, Boldrey E (1937) Somatic motor and sensory representations in the cerebral cortex of man as studied by electrical stimulation. Brain 60:389–443CrossRef
27.
Andersson JL, Lilja A, Hartvig P, Långström B, Gordh T, Handwerker H, Torebjörk E (1997) Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography. Exp Brain Res 117:192–199PubMedCrossRef
28.
Apkarian AV, Bushnell MC, Treede RD, Zubieta JK (2005) Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9:463–484PubMedCrossRef
29.
Baumgärtner U, Vogel H, Ohara S, Treede RD, Lenz F (2011) Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex. J Neurophysiol 106:722–730PubMedPubMedCentralCrossRef
30.
Coghill RC, Sang CN, Maisog JM, Iadarola MJ (1999) Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol 82:1934–1943PubMedCrossRef
31.
Ferretti A, Babiloni C, Del Gratta C, Caulo M, Tartaro A, Bonomo L, Rossini PM, Romani GL (2003) Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli. Neuroimage 20:1625–1638PubMedCrossRef
32.
Frot M, Mauguière F (2003) Dual representation of pain in the operculo-insular cortex in humans. Brain 126:438–450PubMedCrossRef
33.
Fujiwara N, Imai M, Nagamine T, Mima T, Oga T, Takeshita K, Toma K, Shibasaki H (2002) Second somatosensory area (SII) plays a significant role in selective somatosensory attention. Cogn Brain Res 14:389–397CrossRef
34.
Peltz E, Seifert F, DeCol R, Dörfler A, Schwab S, Maihöfner C (2011) Functional connectivity of the human insular cortex during noxious and innocuous thermal stimulation. Neuroimage 54:1324–1335PubMedCrossRef
35.
Segerdahl A, Mezue M, Okell TW, Farrar JT, Tracey I (2015) The dorsal posterior insula subserves a fundamental role in human pain. Nat Neurosci 18:499–500PubMedCrossRefPubMedCentral
36.
Tarkka IM, Treede RD (1993) Equivalent electrical source analysis of pain-related somatosensory evoked potentials elicited by a CO2 laser. J Clin Neurophysiol 10:513–519PubMedCrossRef
37.
Li K, Guo L, Nie J, Li G, Liu T (2009) Review of methods for functional brain connectivity detection using fMRI. Comput Med Imaging Graph 33:131–139PubMedCrossRef
38.
Apkarian AV, Shi T (1994) Squirrel monkey lateral thalamus. I. Somatic nociresponsive neurons and their relation to spinothalamic terminals. J Neurosci 14:6779–6795PubMedCrossRefPubMedCentral
39.
Craig AD, Bushnell MC, Zhang ET, Blomqvist A (1994) A thalamic nucleus specific for pain and temperature sensation. Nature 372:770–773PubMedCrossRef
40.
Friedman DP, Murray EA, O’Neill JB, Mishkin M (1986) Cortical connections of the somatosensory fields of the lateral sulcus of macaques: evidence for a corticolimbic pathway for touch. J Comp Neurol 252:323–347PubMedCrossRef
41.
Gingold SI, Greenspan JD, Apkarian AV (1991) Anatomic evidence of nociceptive inputs to primary somatosensory cortex: relationship between spinothalamic terminals and thalamocortical cells in squirrel monkeys. J Comp Neurol 308:467–490PubMedCrossRef
42.
Bastuji H, Mazza S, Pechet C, Frot M, Mauguière F, Magnin M, Garcia-Larrea L (2012) Filtering the reality: functional dissociation of lateral and medial pain systems during sleep in humans. Hum Brain Mapp 33:2638–2649PubMedCrossRef
43.
Iannetti GD, Mouraux A (2010) From the neuromatrix to the pain matrix (and back). Exp Brain Res 205:1–12PubMedCrossRef
44.
45.
Melzack R (1999) From the gate to the neuromatrix. Pain Suppl 6:S121–S126CrossRef
46.
Albe-Fessard D, Berkley KJ, Kruger L, Ralston HJ 3rd, Willis WD Jr (1985) Diencephalic mechanisms of pain sensation. Brain Res 356:217–296PubMedCrossRef
47.
Frot M, Mauguière F, Magnin M, Garcia-Larrea L (2008) Parallel processing of nociceptive A‑δ inputs in SII and midcingulate cortex in humans. J Neurosci 28:944–952PubMedCrossRefPubMedCentral
48.
Xie YF, Huo FQ, Tang JS (2009) Cerebral cortex modulation of pain. Acta Pharmacol Sin 30:31–41PubMedCrossRef
49.
Frot M, Magnin M, Mauguière F, Garcia-Larrea L (2013) Cortical representation of pain in primary sensory-motor areas (SI/MI) – a study using intracortical recordings in humans. Hum Brain Mapp 34:2655–2668PubMedCrossRef
50.
Schnitzler A, Ploner M (2000) Neurophysiology and functional neuroanatomy of pain perception. J Clin Neurophysiol 17:592–603PubMedCrossRef
51.
Dong WK, Chudler EH, Sugiyama K, Roberts VJ, Hayashi T (1994) Somatosensory, multisensory, and task-related neurons in cortical area 7b(PF) of unanesthetized monkeys. J Neurophysiol 72:542–564PubMedCrossRef
52.
Castejon C, Barros-Zulaica N, Nuñez A (2016) Control of somatosensory cortical processing by thalamic posterior medial nucleus: a new role of thalamus in cortical function. PLOSone 11:e148169CrossRef
53.
Dum RP, Levinthal DJ, Strick PL (2009) The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. J Neurosci 29:14223–14235PubMedPubMedCentralCrossRef
54.
Porro CA, Cettolo V, Francescato MP, Baraldi P (1998) Temporal and intensity coding of pain in human cortex. J Neurophysiol 80:3312–3320PubMedCrossRef
55.
Kim JS (2007) Patterns of sensory abnormality in cortical stroke: evidence for a dichotomized sensory system. Neurology 68:174–180PubMedCrossRef
56.
Knecht S, Kunesch E, Schnitzler A (1996) Parallel and serial processing of haptic information in man: effects of parietal lesions on sensorimotor hand function. Neuropsychologia 34:669–687PubMedCrossRef
57.
Greenspan JD, Lee RR, Lenz FA (1999) Pain sensitivity alterations as a function of lesion location in the parasylvian cortex. Pain 81:273–282PubMedCrossRef
58.
59.
Burton H, Carlson M (1986) Second somatic sensory cortical area (SII) in a prosimian primate, Galago crassicaudatus. J Comp Neurol 247:200–220PubMedCrossRef
60.
Dong WK, Salonen LD, Kawakami Y, Shiwaku T, Kaukoranta EM, Martin RF (1989) Nociceptive responses of trigeminal neurons in SII-7b cortex of awake monkeys. Brain Res 484:314–324PubMedCrossRef
61.
Lu C, Yang T, Zhao H, Zhang M, Meng F, Fu H, Xie Y, Xu H (2016) Insular cortex is critical for the perception, modulation , and chronification of pain. Neurosci Bull 32:191–201PubMedPubMedCentralCrossRef
62.
Hanamori T, Kunitake T, Kato K, Kannan H (1998) Responses of neurons in the insular cortex to gustatory, visceral, and nociceptive stimuli in rats. J Neurophysiol 79:2535–2545PubMedCrossRef
63.
Zhang ZH, Dougherty PM, Oppenheimer SM (1999) Monkey insular cortex neurons respond to baroreceptive and somatosensory convergent inputs. Neuroscience 94:351–360PubMedCrossRef
64.
Berthier M, Starkstein S, Leiguarda R (1988) Asymbolia for pain: a sensory-limbic disconnection syndrome. Ann Neurol 24:41–49PubMedCrossRef
65.
Garcia-Larrea L, Perchet C, Creac’h C, Convers P, Peyron R, Laurent B, Mauguière F, Magnin M (2010) Operculo-insular pain (perisylvian pain): a distinct central pain syndrome. Brain 133:2528–2539PubMedCrossRef
66.
Vogt BA, Finch DM, Olson CR (1992) Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex 2:435–443PubMed
67.
Stevensson P, Minoshima S, Beydoun A, Morrow TJ, Casey KL (1997) Cerebral processing of acute skin and muscle pain in humans. J Neurophysiol 78:450–460CrossRef
68.
Vogt BA, Sikes RW (2000) The medial pain system, cingulate cortex, and parallel processing of nociceptive information. Prog Brain Res 122:223–235PubMedCrossRef
69.
Sikes RW, Vogt BA (1992) Nociceptive neurons in area 24 of rabbit cingulate cortex. J Neurophysiol 68:1720–1732PubMedCrossRef
70.
Yamamura H, Iwata K, Tsuboi Y, Toda K, Kitajima K, Shimizu N, Nomura H, Hibiya J, Fujita S, Sumino R (1996) Morphological and electrophysiological properties of ACCx nociceptive neurons in rat. Brain Res 735:83–92PubMedCrossRef
71.
Yang JW, Shih HC, Shyu BC (2006) Intracortical circuits in rat anterior cingulate cortex are activated by nociceptive inputs mediated by medial thalamus. J Neurophysiol 96:3409–3422PubMedCrossRef
72.
Sikes RW, Vogt LJ, Vogt BA (2008) Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex. Pain 135:164–170CrossRef
73.
Rainville P, Duncan GH, Price DD, Carrier B, Sushnell MC (1997) Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277:968–971PubMedCrossRef
74.
Iwata K, Kamo H, Ogawa A, Tsuboi Y, Noma N, Mitsubishi Y, Taira M, Koshikawa N, Kitagawa J (2005) Anterior cingulate cortical neuronal activity during perception of noxious thermal stimuli in monkeys. J Neurophysiol 94:1980–1991PubMedCrossRef
75.
Koyama T, Tanaka YZ, Mikami A (1998) Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain. Neuroreport 9:2663–2667PubMedCrossRef
76.
Ostrowsky K, Magnin M, Ryvlin P, Isnard J, Guenot M, Mauguière F (2002) Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation. Cereb Cortex 12:376–385PubMedCrossRef
77.
Ostrowsky K, Isnard J, Ryvlin P, Guénot M, Fischer C, Mauguière F (2000) Functional mapping of the insular cortex: clinical implication in temporal lobe epilepsy. Epilepsia 41:681–686PubMedCrossRef
78.
Peyron R, Laurent B, Garcia-Larrea L (2000) Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin 30:263–288PubMedCrossRef
79.
Biemond A (1956) The conduction of pain above the level of the thalamus opticus. Arch Neurol Psychiatry 75:231–244CrossRef
80.
Isnard J, Guénot M, Magnin M, Derambure P, Catenoix H, Mauguière F, Garcia-Larrea L (2008) Stereo-electroencephalographic (SEEG) study of the insulo-operculo-cingulo nociceptive network in painful epilepsy. Epilepsia 49(Suppl 7):6–7
81.
Isnard J, Guénot M, Sindou M, Mauguière F (2004) Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study. Epilepsia 45:1079–1090PubMedCrossRef
82.
Weimer K, Gulewitsch MD, Schlarb AA, Schwille-Kiuntke J, Klosterhalfen S, Enck P (2013) Placebo effects in children: a review. Pediatr Res 74:96–102PubMedCrossRef
83.
84.
Moore MT (1945) Paroxysmal abdominal pain; a form of focal symptomatic epilepsy. JAMA 129:1233–1240CrossRef
85.
Bonaventura CT, Mpondo CT, Mwasada G, Nyundo AA (2016) Abdominal epilepsy, an uncommon cause of chronic and recurrent abdominal pain: a case report. Clin Case Rep 4:1117–1119CrossRef
86.
87.
Dutta SR, Hazarika I, Chakravarty BP (2006) Abdominal epilepsy, an uncommon cause of recurrent abdominal pain: a brief report. Gut 56:439–441CrossRef
88.
Harshe DG, Harshe SD, Harshe GR, Harshe GG (2016) Abdominal epilepsy in an adult: a diagnosis often missed. J Clin Diagn Res 10(10):VD1–VD2PubMedPubMedCentral
89.
90.
Mpomdo BCT, Mwasada G, Nyundo AA (2016) Abdominal epilepsy, an uncommon cause of chronic and recurrent abdominal pain: a case report. Clin Case Rep 4(12):1117–1119CrossRef
91.
de Lope SJ, Alarcón Fernández O, Aguilar Mendoza J, Beltrán Coronel J, Barinagarrementeria F, Pérez Manauta J (1994) Abdominal epilepsy. Rev Gastroenterol Mex 59:297–300
92.
Zinkin NT, Peppercorn MA (2005) Abdominal epilepsy. Best Pract Res Clin Gastroenterol 19:263–274PubMedCrossRef
93.
Van Buren JM (1963) The abdominal aura. A study of abdominal sensations occurring in epilepsy and produced by depth stimulation. Electroencephalogr Clin Neurophysiol 15:1–19CrossRef
94.
Franzon RC, Lopes CF, Schmutzler KM, Morais MI, Guerreiro MM (2002) Recurrent abdominal pain: when should an epileptic seizure be suspected? Arq Neuropsiquiatr 60:628–630PubMedCrossRef
95.
Kshirsagar VY, Nagarsenkar S, Ahmed M, Colaco S, Wingkar KC (2012) Abdominal epilepsy in chronic recurrent abdominal pain. J Pediatr Neurosci 7:163–166PubMedPubMedCentralCrossRef
96.
Peppercorn MA, Herzog AG (1989) The spectrum of abdominal epilepsy in adults. Am J Gastroenterol 84:1294–1296PubMed
97.
Niedermeyer E (1993) Abnormal EEG patterns: epileptic and paroxysmal. In: Niedermeyer E, Lopes da Silva F (Hrsg) Electroencephalography. Williams & Wilkins, Baltimore, S 217–240
98.
99.
Headache Classification Committee of the International Headache Society (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808CrossRef
100.
101.
102.
Beger HG, Apitzsch D, Meves M (1976) Die Arteria coeliaca-Kompression. Langenbecks Arch Chir 341:253–269PubMedCrossRef
103.
Grotemeyer D, Duran M, Iskandar F, Blondin D, Nguyen K, Sandmann W (2009) Median arcuate ligament syndrome: vascular surgical therapy and follow-up of 18 patients. Langenbecks Arch Surg 394:1085–1092PubMedCrossRef
104.
Marcoccia A, Di Tola M, Paris F, Donato G, Libanori V, Picarelli A (2010) A 41-year-old woman with paroxysmal abdominal pain, weight loss and epigastric bruit. Intern Emerg Med 5:49–52PubMedCrossRef
105.
Martin P, Stockmann J (2014) Das aortomesenteriale Kompressionssyndrom (Wilkie-Syndrom) – eine Differenzialdiagnose bei Personen mit Entwicklungsstörungen und Wirbelsäulendeformitäten. Med Mensch Geist Mehrf Beh 11:32–39
106.
Chen XL, Tian H, Li JZ, Tao J, Tang H, Li Y, Wu B (2012) Paroxysmal drastic abdominal pain with tardive cutaneous lesions presenting in Henoch-Schönlein purpura. World J Gastroenterol 18:1991–1995PubMedPubMedCentralCrossRef
107.
Bergmann C, de Charry C, Karkowski L, de Charry F, Hajek V, Debourdeau P, Pavic M, Pasquet F (2012) Abdominal pain of unusual cause. Rev Med Interne 33:593–594PubMedCrossRef
108.
de Latour RP, Mary JY, Salanoubat C, Terriou L, Etienne G, Mohty M, Roth S, de Guibert S, Maury S, Cahn JY, Socié G, French Society of Hematology, French Association of Young Hematologists (2008) Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories. Blood 112:3099–3106PubMedCrossRef
109.
110.
Kuemmerle-Deschner JB, Dembi Samba S, Tyrrell PN, Koné-Paut I, Marie I, Deschner N, Benseler SM (2014) Challenges in diagnosing Muckle-Wells syndrome: identifying two distinct phenotypes. Arthritis Care Res 66:765–772CrossRef
111.
Mumenthaler M, Mattle H (1997) Neurologie. Thieme, Stuttgart, S 341
112.
113.
Richer O, Lagarde M, Lerouge-Bailhache M, Pillet P (2015) Douleur abdominale aiguë: quand penser à une maladie rare? Arch Pediatr 22(5 Suppl 1):145–146PubMedCrossRef
114.
115.
Adams RD, Victor M (1985) Nonviral infections oft the nervous system. In: Adams RD, Victor M (Hrsg) Principles of neurology. McGraw-Hill, New York, S 510–544
116.
Mumenthaler M, Mattle H (1997) Neurologie. Thieme, Stuttgart, S 203–206
117.
Kułakowska A, Pogorzelski R, Borowik H, Drozdowski W (2003) Wearing off phenomenon presenting with features of paroxysmal abdominal pain. Neurol Neurochir Pol 37(Suppl 5):197–202PubMed
118.
Vrabec-Matković D, Šklebar D, ŠklebarI I, Klobučić M, Jancović RI (2012) Acute paroxysmal precordial pain as a somatosensory elementary partial onset of epileptic seizure. Med Glas 9:125–128
119.
Bianchin MM, Londero RG, Lima JE, Bigal ME (2010) Migraine and epilepsy: a focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects. Curr Pain Headache Rep 14:276–283PubMedCrossRef
120.
Çilliler AE, Güven H, Çomoğlu SS (2017) Epilepsy and headaches: further evidence of a link. Epilepsy Behav 70:161–165PubMedCrossRef
121.
Ito M, Adachi N, Nakamura F, Koyama T, Okamura T, Kato M, Kanemoto K, Nakano T, Matsuura M, Hara S (2004) Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia 24:23–28PubMedCrossRef
122.
Leniger T, Isbruch K, von den Driesch S, Diener HC, Hufnagel A (2001) Seizure-associated headache in epilepsy. Epilepsia 42:1176–1179PubMedCrossRef
123.
Yankovsky AE, Andermann F, Mercho S, Dubeau F, Bernasconi A (2005) Preictal headache in partial epilepsy. Neurology 65:1979–1981PubMedCrossRef
124.
Schon F, Blau JN (1987) Post-epileptic headache and migraine. J Neurol Neurosurg Psychiatr 50:1148–1152CrossRef
125.
Ito M, Adachi N, Nakamura F, Koyama T, Okamura T, Kato M, Kanemoto K, Nakano T, Matsuura M, Hara S (2002) Multi-center study on post-ictal headache in patients with localization-related epilepsy. Psychiatry Clin Neurosci 57:385–389CrossRef
126.
Bernasconi A, Andermann F, Bernasconi N, Reutens DC, Dubeau F (2001) Lateralizing value of peri-ictal headache: a study of 100 patients with partial epilepsy. Neurology 56:130–132PubMedCrossRef
127.
Lennox WG, Lennox MA (1960) Epilepsy and related disorders Bd. 1. Little Brown, Boston, S 451
128.
129.
Verrotti A, Coppola G, Di Fonzo A, Tozzi E, Spalice A, Aloisi P, Bruschi R, Iannetti P, Villa MP, Parisi P (2011) Should “migralepsy” be considered an obsolete concept? Amulticenter retrospective clinical study and review of the literature. Epilepsy Behav 21:52–59PubMedCrossRef
130.
Verrotti A, Striano P, Belcastro V, Matricardi S, Villa MP, Parisi P (2011) Migralepsy and related conditions: advances in pathophysiology and classification. Seizure 20:271–275PubMedCrossRef
131.
Sances G, Guaschino E, Perucca P, Allena M, Ghiotto N, Manni R (2009) Migralepsy: a call for revision of the definition. Epilepsia 50:2487–2496PubMedCrossRef
132.
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005–2009. Epilepsia 51:676–685PubMedCrossRef
133.
134.
135.
136.
137.
Toldo I, Perissinotto E, Menegazzo F, Bonvier C, Sartori S, Salviati L, Clementi M, Montagna P, Battistella PA (2010) comorbidity between headache and epilepsy in a pediatric headache center. J Headache Pain 11:235–240PubMedPubMedCentralCrossRef
138.
Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N (2017) Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies. Neurology 88:296–303PubMedPubMedCentralCrossRef
139.
Rogawski MA (2012) Migraine and epilepsy – shared mechanisms within the family of episodic disorders. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV (Hrsg) Jasper’s basic mechanisms of the epilepsies. National Center for Biotechnology Information, Bethesda (https://​www.​ncbi.​nlm.​nih.​gov/​books/​NBK98193/​)
140.
de Vries B, Frants RR, Ferrari MD, van den Maagdenberg AM (2009) Molecular genetics of migraine. Hum Genet 126:115–132PubMedCrossRef
141.
Janssen W, Quaegebeur A, Van Goethem G, Ann L, Smets K, Vandenberghe R, Van Paesschen W (2016) The spectrum of epilepsy caused by POLG mutations. Acta Neurol Belg 116:17–25PubMedCrossRef
142.
De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, Ballabio A, Aridon P, Casari G (2003) Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 33:192–196PubMedCrossRef
143.
144.
Riant F, Ducros A, Ploton C, Barbance C, Depienne C, Tournier-Lasserve E (2010) De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. Neurology 75:967–972PubMedCrossRef
145.
Dreier JP (2011) The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 17:439–447PubMedCrossRef
146.
Noseda R, Burstein R (2013) Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain 154(Suppl 1):S44–S53PubMedCrossRef
147.
Bagnato F, Good J (2016) The use of antiepileptics in migraine prophylaxis. Headache 56:603–615PubMedCrossRef
148.
149.
VanderPluym J, Evans RW, Starlin AJ (2016) Long-term use and safety of migraine preventive medications. Headache 56:1335–1343PubMedCrossRef
150.
Begnato F, Good J (2016) The use of antiepileptics in migraine prophylaxis. Headache 56:603–615CrossRef
151.
Parisi P (2016) “Ictal epileptic headache” is certainly a seizure which manifests itself only as headache. Seizure 38:77PubMedCrossRef
152.
Parisi P, Verrotti A, Costa P, Striano P, Zanus C, Carrozzi M, Raucci U, Villa MP, Belcastro V (2015) diagnostic criteria currently proposed for “ictal epileptic headache”: perspectives and strengths, weaknesses and pitfalls. Seizure 31:56–63PubMedCrossRef
153.
Parisi P, Striano P, Verrotti A, Villa MP, Belcasto V (2013) What have we learned about ictal epileptic headache? A review of well-documented cases. Seizure 22:253–258PubMedCrossRef
154.
Belcastro V, Striano P, Trenité K‑N, Villa MP, Parisi P (2011) Migralepsy, hemicranias epileptic, post-ictal headache and “ictal epileptic Headache”: a proposal for terminology and classification revision. J Headache Pain 12:289–294PubMedPubMedCentralCrossRef
155.
Fanella M, Fattouch J, Casciato S, Lapenta L, Morano A, Egeo G, Manfredi M, Prencipe M, Giallonardo AT, Di Bonaventura C (2012) Ictal epileptic headache as “subtle” symptom in generalized idiopathic epilepsy. Epilepsia 53:e67–70PubMedCrossRef
156.
Laplante P, Saint-Hilaire JM, Bouvier G (1983) Headache as an epileptic manifestation. Neurology 33:1493–1495PubMedCrossRef
157.
Isler H, Wieser HG, Egli M (1987) Hemicrnaia epileptic: synchronous ipsilateral ictal headache with migraine features. In: Andermann F, Lugaresi E (Hrsg) Migraine and epilepsy. Butterworth, Boston, S 249–263
158.
Cianchetti C, Dainese F, Ledda MG, Avanzini G (2017) Epileptic headache: a rare form of painful seizure. Seizure 52:169–175PubMedCrossRef
159.
Cianchetti C, Avanzini G, Dainese F, Guidetti V (2017) The complex interrelations between two paroxysmal disorders: headache and epilepsy. Neurol Sci 38:941–948PubMedCrossRef
160.
Andermann F, Zifkin B (1998) The benign occipital epilepsies of childhood: an overview of the idiopathic syndromes and of the relationship to migraine. Epilepsia 39(Suppl 4):S9–23PubMedCrossRef
161.
Gastaut H (1982) A new type of epilepsy: benign partial epilepsy of childhood with occipital spikes-waves. Clin Electroencephalogr 13:13–22PubMedCrossRef
162.
Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M (2008) Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 131:2264–2286PubMedCrossRef
163.
Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M (2016) Idiopathic focal epilepsies: the “lost tribe”. Epileptic Disord 18:252–288PubMed
164.
Guerrini R, Genton P (2004) Epileptic syndromes and visually induced seizures. Epilepsia 45(Suppl. 1):14–18PubMedCrossRef
165.
Guerrini R, Dravet C, Genton P, Bureau M, Bonanni P, Ferrari AR, Roger J (1995) Idiopathic photosensitive occipital lobe epilepsy. Epilepsia 36:883–891PubMedCrossRef
166.
Koutroumanidis M, Tsirka V, Panayiotopoulos C (2015) Adult-onset photosensitivity: clinical significance and epilepsy syndromes including idiopathic (possibly genetic) photosensitive occipital epilepsy. Epileptic Disord 17:275–286PubMed
167.
Politi-Elishkevich K, Kivity S, Shuper A, Levine H, Goldberg-Stern H (2014) Idiopathic photosensitive occipital epilepsy: clinical and electroencephalographic (EEG) features. J Child Neurol 29:307–311PubMedCrossRef
168.
Martin P (2017) Pain in Rett syndrome: peculiarities in pain processing and expression, liability to pain causing disorders and diseases, and specific aspects of pain assessment. Adv Autism 3:163–182CrossRef
169.
Brennan SA, O’Neill CJ, Tarazi M, Moran R (2013) Bilateral neck of femur fractures secondary to seizure. Pract Neurol 13:420–421PubMedCrossRef
170.
Dussault PM, Lazzari AA (2017) Epilepsy and osteoporosis risk. Curr Opin Endocrinol Diabetes Obes 24:395–401PubMedCrossRef
171.
172.
Mimata Y, Sato K, Oikawa R, Doita M (2016) Non-traumatic thoracic vertebral compression fractures occurred in a young epileptic patient: a case report. J Orthop Case Rep 6:85–87PubMedPubMedCentral
173.
Petty SJ, Wilding H, Wark JD (2016) Osteoporosis associated with epilepsy and the use of anti-epileptics-a review. Curr Osteoporos Rep 14:54–65PubMedCrossRef
174.
175.
Liu J, Meng F, Liu Z (2012) Seizure-related adverse events during video-electroencephalography monitoring. Epileptic Disord 14:51–56PubMed
176.
Nonato ER, Borges MA (2011) Oral and maxillofacial trauma in patients with epilepsy: prospective study based on an outpatient population. Arq Neuropsiquiatr 69:491–495PubMedCrossRef
177.
Faurie MP, Allorto NL, Aldous C, Clarke DL (2015) A closer look at burn injuries and epilepsy in a developing world burn service. S Afr J Surg 53:48–50PubMed
178.
Zwimpfer TJ, Brown J, Sullivan I, Moulton RJ (1997) Head injuries due to falls caused by seizures: a group at high risk for traumatic intracranial hematomas. J Neurosurg 86:433–437PubMedCrossRef
179.
Martin P, Rombach A, Staack A (2015) Schädigung des zervikalen Rückenmarks. Resultat leichter Traumen bei Personen mit Entwicklungsstörungen/Epilepsie und zervikaler Spondylose. Z Epileptol 28:40–48CrossRef
Metadaten
Titel
Schmerz und Epilepsie
Eine klinisch-neuroanatomisch-pathophysiologische Übersicht
verfasst von
Prof. Dr. med. P. Martin
Publikationsdatum
23.05.2018
Verlag
Springer Medizin
Erschienen in
Der Schmerz / Ausgabe 4/2018
Print ISSN: 0932-433X
Elektronische ISSN: 1432-2129
DOI
https://doi.org/10.1007/s00482-018-0298-2

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