Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Current Pain and Headache Reports
Erschienen in: Current Pain and Headache Reports 4/2010

01.08.2010

Migraine and Epilepsy: A Focus on Overlapping Clinical, Pathophysiological, Molecular, and Therapeutic Aspects

verfasst von: Marino Muxfeldt Bianchin, Renata Gomes Londero, José Eduardo Lima, Marcelo Eduardo Bigal

Erschienen in: Current Pain and Headache Reports | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

The association of epilepsy and migraine has been long recognized. Migraine and epilepsy are both chronic disorders with episodic attacks. Furthermore, headache may be a premonitory or postdromic symptom of seizures, and migraine headaches may cause seizures per se (migralepsy). Migraine and epilepsy are comorbid, sharing pathophysiological mechanisms and common clinical features. Several recent studies identified common genetic and molecular substrates for migraine and epilepsy, including phenotypic-genotypic correlations with mutations in the CACNA1A, ATP1A2, and SCN1A genes, as well as in syndromes due to mutations in the SLC1A3, POLG, and C10orF2 genes. Herein, we review the relationship between migraine and epilepsy, focusing on clinical aspects and some recent pathophysiological and molecular studies.
Literatur
1.
•• Stovner LJ, Hagen K, Jensen R, et al.: The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 2007, 27:193–210. This article is a comprehensive review about the global impact of headache disorders according to headache type. CrossRefPubMed
2.
Lipton RB, Bigal ME: Migraine: epidemiology, impact, and risk factors for progression. Headache 2005, 45(Suppl 1):S3–S13.CrossRefPubMed
3.
Sander JW, Shorvon SD: Epidemiology of the epilepsies. J Neurol Neurosurg Psychiatry 1996, 61:433–443. (Published erratum appears in J Neurol Neurosurg Psychiatry 1997, 62:679.)CrossRefPubMed
4.
de Boer HM, Mula M, Sander JW: The global burden and stigma of epilepsy. Epilepsy Behav 2008, 12:540–546.CrossRefPubMed
5.
Pace BP, Sullivan-Fowler M: JAMA 100 years ago: A slander on the medical profession. JAMA 1996, 276:1222b.CrossRefPubMed
6.
•• Haut SR, Bigal ME, Lipton RB: Chronic disorders with episodic manifestations: focus on epilepsy and migraine. Lancet Neurol 2006, 5:148–157. This excellent review examines similarities and contrasts between migraine and epilepsy. CrossRefPubMed
7.
Andermann F, Andermann E: Migraine and epilepsy, with special reference to the benign epilepsies of childhood. Epilepsy Res Suppl 1992, 6:207–214.PubMed
8.
Ottman R, Lipton RB: Comorbidity of migraine and epilepsy. Neurology 1994, 44:2105–2110.PubMed
9.
Ottman R, Lipton RB: Is the comorbidity of epilepsy and migraine due to a shared genetic susceptibility? Neurology 1996, 47:918–924.PubMed
10.
Di Clemente L, Coppola G, Magis D, et al.: Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine? Brain 2007, 130:765–770.CrossRefPubMed
11.
Leniger T, von den Driesch S, Isbruch K, et al.: Clinical characteristics of patients with comorbidity of migraine and epilepsy. Headache 2003, 43:672–677.CrossRefPubMed
12.
Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004, 24 (Suppl 1):9–160.
13.
Bernasconi A, Andermann F, Bernasconi N, et al.: Lateralizing value of peri-ictal headache: A study of 100 patients with partial epilepsy. Neurology 2001, 56:130–132.PubMed
14.
Yankovsky AE, Andermann F, Bernasconi A: Characteristics of headache associated with intractable partial epilepsy. Epilepsia 2005, 46:1241–1245.CrossRefPubMed
15.
Cai S, Hamiwka LD, Wirrell EC: Peri-ictal headache in children: prevalence and character. Pediatr Neurol 2008, 39:91–96.CrossRefPubMed
16.
Yankovsky AE, Andermann F, Mercho S, et al.: Preictal headache in partial epilepsy. Neurology 2005, 65:1979–1981.CrossRefPubMed
17.
Laplante P, Saint-Hilaire JM, Bouvier G: Headache as an epileptic manifestation. Neurology 1983, 33:1493–1495.PubMed
18.
Moskowitz MA: Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Funct Neurol 2007, 22:133–136.PubMed
19.
Marks DA, Ehrenberg BL: Migraine-related seizures in adults with epilepsy, with EEG correlation. Neurology 1993, 43:2476–2483.PubMed
20.
Leniger T, Isbruch K, von den Driesch S, et al.: Seizure-associated headache in epilepsy. Epilepsia 2001, 42:1176–1179.CrossRefPubMed
21.
Piccioli M, Parisi P, Tisei P, et al.: Ictal headache and visual sensitivity. Cephalalgia 2009, 29:194–203.CrossRefPubMed
22.
Isler H, Wirsen ML, Elli N: Hemicrania epileptica: synchronous ipsilateral ictal headache with migraine features. In Migraine and Epilepsy. Edited by Andermann F, Lugaresi E. Boston: Butterworths; 1987:246–263.
23.
Guerrini R, Genton P: Epileptic syndromes and visually induced seizures. Epilepsia 2004, 45(Suppl 1):14–18.CrossRefPubMed
24.
Ito M, Adachi N, Nakamura F, et al.: Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia 2004, 24:23–28.CrossRefPubMed
25.
Ogunyemi A, Adams D: Migraine-like symptoms triggered by occipital lobe seizures: response to sumatriptan. Can J Neurol Sci 1998, 25:151–153.PubMed
26.
Caraballo RH, Cersósimo RO, Fejerman N: Childhood occipital epilepsy of Gastaut: a study of 33 patients. Epilepsia 2008, 49:288–297.CrossRefPubMed
27.
• Taylor I, Berkovic SF, Kivity S, Scheffer IE: Benign occipital epilepsies of childhood: clinical features and genetics. Brain 2008, 131:2287–2294. The authors examine early and late benign occipital epilepsies of childhood as two discrete electroclinical syndromes, exploring clinical features and clinical genetics of these two syndromes.CrossRefPubMed
28.
Panayiotopoulos CP, Michael M, Sanders S, et al.: Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 2008, 131:2264–2286.CrossRefPubMed
29.
Caraballo R, Koutroumanidis M, Panayiotopoulos CP, Fejerman N: Idiopathic childhood occipital epilepsy of Gastaut: a review and differentiation from migraine and other epilepsies. J Child Neurol 2009, 24:1536–1542.CrossRefPubMed
30.
Wirrell EC, Hamiwka LD: Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls? Epilepsia 2006, 47:1674–1681.CrossRefPubMed
31.
Clarke T, Baskurt Z, Strug LJ, Pal DK: Evidence of shared genetic risk factors for migraine and rolandic epilepsy. Epilepsia 2009, 50:2428–2433.CrossRefPubMed
32.
Deprez L, Peeters K, Van Paesschen W, et al.: Familial occipitotemporal lobe epilepsy and migraine with visual aura: linkage to chromosome 9q. Neurology 2007, 68:1995–2002.CrossRefPubMed
33.
Deprez L, Weckhuysen S, Peeters K, et al.: Epilepsy as part of the phenotype associated with ATP1A2 mutations. Epilepsia 2008, 49:500–508.CrossRefPubMed
34.
• Barrett CF, van den Maagdenberg AM, Frants RR, Ferrari MD: Familial hemiplegic migraine. Adv Genet 2008, 63:57–83. The authors review clinical features of migraine and discuss the continuing highway of migraine gene discovery.CrossRefPubMed
35.
Lipton RB, Stewart WF, Diamond S, et al.: Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001, 41:646–657.CrossRefPubMed
36.
Engel J Jr; International League Against Epilepsy (ILAE): A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001, 42:796–803.CrossRefPubMed
37.
• Crompton DE, Berkovic SF: The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. Lancet Neurol 2009, 8:370–381. The authors present an interesting discussion about clinical and molecular similarities and differences of epileptic seizures from other paroxysmal disorders.CrossRefPubMed
38.
Wild E: Deja vu in neurology. J Neurol 2005, 252:1–7.
39.
Gaitatzis A, Sander JW: The mortality of epilepsy revisited. Epileptic Disord 2004, 6:3–13.PubMed
40.
Goadsby PJ, Hoskin KL: Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine? Pain 1996, 67:355–359.CrossRefPubMed
41.
42.
•• de Vries B, Frants RR, Ferrari MD, van den Maagdenberg AM: Molecular genetics of migraine. Hum Genet 2009, 126:115–132. This is an excellent and comprehensive review about molecular aspects of migraine.CrossRefPubMed
43.
Bahra A, Matharu MS, Buchel C, et al.: Brainstem activation specific to migraine headache. Lancet 2001, 357:1016–1017.CrossRefPubMed
44.
Goadsby PJ: Neurovascular headache and a midbrain vascular malformation: evidence for a role of the brainstem in chronic migraine. Cephalalgia 2002, 22:107–111.CrossRefPubMed
45.
Lauritzen M: Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994, 117:199–210.
46.
Bolay H, Reuter U, Dunn AK, et al.: Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002, 8:136–142.CrossRefPubMed
47.
Ayata C, Jin H, Kudo C, et al.: Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 2006, 59:652–661.CrossRefPubMed
48.
Aurora SK: Is chronic migraine one end of a spectrum of migraine or a separate entity? Cephalalgia 2009, 29:597–605.CrossRefPubMed
49.
Ophoff RA, Terwindt GM, Vergouwe MN, et al.: Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996, 87:543–552.CrossRefPubMed
50.
Tottene A, Conti R, Fabbro A, et al.: Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron 2009, 61:762–773.CrossRefPubMed
51.
Gargus JJ: Genetic calcium signaling abnormalities in the central nervous system: seizures, migraine, and autism. Ann N Y Acad Sci 2009, 1151:133–156.CrossRefPubMed
52.
De Fusco M, Marconi R, Silvestri L, et al.: Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 2003, 33:192–196.CrossRefPubMed
53.
Castro MJ, Stam AH, Lemos C, et al.: Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. J Hum Genet 2007, 52:990–998.CrossRefPubMed
54.
Dichgans M, Freilinger T, Eckstein G, et al.: Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 2005, 366:371–377.CrossRefPubMed
55.
Gambardella A, Marini C: Clinical spectrum of SCN1A mutations. Epilepsia 2009, 50(Suppl 5):20–23.CrossRefPubMed
56.
Fujiwara T: Clinical spectrum of mutations in SCN1A gene: severe myoclonic epilepsy in infancy and related epilepsies. Epilepsy Res 2006, 70(Suppl 1):S223–S230.CrossRefPubMed
57.
• Harkin LA, McMahon JM, Iona X, et al.: The spectrum of SCN1A-related infantile epileptic encephalopathies. Brain 2007, 130:843–852. The authors present an expanded spectrum of epileptic encephalopathies associated with SCN1A mutations.CrossRefPubMed
58.
Claes LR, Deprez L, Suls A, et al.: The SCN1A variant database: a novel research and diagnostic tool. Hum Mutat 2009, 30:E904–E920.CrossRefPubMed
59.
Jen JC, Wan J, Palos TP, et al.: Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures. Neurology 2005, 65:529–534.CrossRefPubMed
60.
Tzoulis C, Engelsen BA, Telstad W, et al.: The spectrum of clinical disease caused by the A467T and W748S POLG mutations: a study of 26 cases. Brain 2006, 129:1685–1692.CrossRefPubMed
61.
Lönnqvist T, Paetau A, Valanne L, Pihko H: Recessive twinkle mutations cause severe epileptic encephalopathy. Brain 2009, 132:1553–1562.CrossRefPubMed
62.
63.
Silberstein SD: Topiramate in migraine prevention: evidence-based medicine from clinical trials. Neurol Sci 2004, 25(Suppl 3):S244–S245.CrossRefPubMed
64.
Rapoport AM, Bigal ME: Migraine preventive therapy: current and emerging treatment options. Neurol Sci 2005, 26(Suppl 2):s111–s120.CrossRefPubMed
Metadaten
Titel
Migraine and Epilepsy: A Focus on Overlapping Clinical, Pathophysiological, Molecular, and Therapeutic Aspects
verfasst von
Marino Muxfeldt Bianchin
Renata Gomes Londero
José Eduardo Lima
Marcelo Eduardo Bigal
Publikationsdatum
01.08.2010
Verlag
Current Science Inc.
Erschienen in
Current Pain and Headache Reports / Ausgabe 4/2010
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-010-0121-y

Weitere Artikel der Ausgabe 4/2010

Current Pain and Headache Reports 4/2010 Zur Ausgabe

ReviewPaper

Headache in Multiple Sclerosis

ReviewPaper

Posttraumatic Headache: A Review

ReviewPaper

Substance Abuse in Cancer Pain

ReviewPaper

Musculoskeletal Pain Associated With Corticosteroid Therapy in Cancer

ReviewPaper

The Role of Chemical Neurolysis in Cancer Pain

ReviewPaper

Headaches Due to External Compression

Neu im Fachgebiet AINS

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren
Bildnachweise