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Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie 11/2015

01.11.2015 | Editorials

Optimizing depth of sedation for colonoscopy

verfasst von: Matthew T. V. Chan, MBBS, PhD, William K. K. Wu, PhD, Raymond S. Y. Tang, MD

Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Ausgabe 11/2015

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Excerpt

Colonoscopy is one of the most common investigative procedures performed in contemporary medicine. With the promulgation of national guidelines for the early detection of colorectal cancer,1 it is estimated that millions of colonoscopies are performed worldwide and the demand is likely to grow further each year. Despite the introduction of smaller and more flexible endoscopes, colonoscopy is still associated with significant pain and discomfort. Sedation is therefore generally required for the procedure. Given the large volume of service required, healthcare providers are constantly looking for ways to improve efficiency. In some countries, nurses are trained to administer sedation,2 others have used computer feedback systems to provide sedation during colonoscopy.3,4 Typically, these techniques are limited to provide light sedation that may minimize hemodynamic changes, allow faster emergence, and expedite patient turnover. Nevertheless, patients may become agitated and awake during the procedure, resulting in serious complications. There has yet to be a consensus among endoscopists, anesthesiologists, and patients as to whether deep or light sedation should be provided for colonoscopy.
Table
Airway and hemodynamic adverse events during sedation for gastrointestinal endoscopy
Author, year
Country
Study design
Sedation techniques
Endoscopic procedures
No. of patients
Sedation-related adverse events n (%)
Airway*
Hemodynamic†
Clarke et al., 200210
Australia
Database review
Non-anesthesiologists using combination of propofol, fentanyl and midazolam
All GI endoscopy
28,472
107 (0.38%)
77 (0.27%)
Rex, et al., 200211
USA
Prospective data collection
Nurse administered propofol sedation
All GI endoscopy
2,222
5 (0.23%)
1 (0.05%)
Walker et al., 200312
USA
Prospective data collection
Nurse administered propofol sedation
All GI endoscopy
9,152
7 (0.08%)
 
Rex et al., 200513
USA
Prospective data collection
Nurse administered propofol sedation
Colonoscopy
17,527
7 (0.04%)
 
Tohda et al., 200614
Japan
Prospective data collection
Nurse administered propofol sedation
All GI endoscopy
27,500
1,842 (6.70%)
511 (1.86%)
       
Colonoscopy alone
7,900
567 (7.18%)
276 (3.49%)
Vargo et al., 200620
USA
Physician survey
Endoscopist or anesthesiologist administered propofol sedation
Colonoscopy
11,683
77 (0.66%)
81 (0.69%)
Külling et al., 200716
Switzerland
Prospective data collection
Nurse administered propofol sedation
All GI endoscopy
27,061
629 (2.32%)
 
Sharma et al., 200717
USA
Prospective data collection
General anesthesia or “conscious sedation”, unspecified regimen
All GI endoscopy
324,737
1,049 (0.32%)
2,244 (0.69%)
       
Colonoscopy alone
179,521
565 (0.31%)
1,805 (1.01%)
Jensen et al., 201118
Denmark
Prospective data collection
Nurse administered propofol sedation
All GI endoscopy
1,822
78 (4.28%)
 
       
Colonoscopy alone
707
16 (2.26%)
 
Cooper et al., 20137
USA
Database review
Sedation provided with and without anesthesia assistance (unspecified regimen)
Colonoscopy
165,527
125 (0.10%)
48 (0.14%)
Sieg et al., 201419
Germany
Prospective data collection
Endoscopist administered propofol sedation
All GI endoscopy
24,441
97 (0.40%)
12 (0.05%)
Jensen et al., 20159
Denmark
Database review
Nurse administered propofol sedation
All GI endoscopy
6,840
214 (3.13%)
204 (2.98%)
       
Colonoscopy alone
4,347
130 (2.99%)
154 (3.54%)
GI = gastrointestinal; *Airway events include partial or complete obstruction of airway, apnea, and hypoxia. †Hemodynamic changes include hypotension, arrhythmia, tachy- or bradycardia
Tableau
Évènements indésirables des voies aériennes et hémodynamiques au cours de la sédation pour endoscopie digestive
Auteur, année
Pays
Schéma de l’étude
Techniques de sédation
Procédures endoscopiques
Nombre de patients
Évènements indésirables liés à la sédation n (%)
Voies aériennes*
Hémodynamique†
Clarke et coll., 200210
Australie
Analyse d’une base de données
Non-anesthésiologistes utilisant une combinaison de propofol, fentanyl et midazolam
Toutes endoscopies digestives
28 472
107 (0,38 %)
77 (0,27 %)
Rex, et coll., 200211
États-Unis
Collecte prospective de données
Sédation par propofol administré par infirmier/ère
Toutes endoscopies digestives
2 222
5 (0,23 %)
1 (0,05 %)
Walker et coll., 200312
États-Unis
Collecte prospective de données
Sédation par propofol administré par infirmier/ère
Toutes endoscopies digestives
9 152
7 (0,08 %)
 
Rex et coll., 200513
États-Unis
Collecte prospective de données
Sédation par propofol administré par infirmier/ère
Colonoscopie
17 527
7 (0,04 %)
 
Tohda et coll., 200614
Japon
Collecte prospective de données
Sédation par propofol administré par infirmier/ère
Toutes endoscopies digestives
27 500
1 842 (6,70 %)
511 (1,86 %)
       
Colonoscopie uniquement
7 900
567 (7,18 %)
276 (3,49 %)
Vargo et coll., 200620
États-Unis
Enquête auprès des médecins
Un endoscopiste ou un anesthésiologiste a administré une sédation par propofol
Colonoscopie
11 683
77 (0,66 %)
81 (0,69 %)
Külling et coll., 200716
Suisse
Collecte prospective de données
Sédation par propofol administré par infirmier/ère
Toutes endoscopies digestives
27 061
629 (2,32 %)
 
Sharma et coll., 200717
États-Unis
Collecte prospective de données
Anesthésie générale ou « sédation consciente », protocole non précisé
Toutes endoscopies digestives
324 737
1 049 (0,32 %)
2 244 (0,69 %)
       
Colonoscopie uniquement
179 521
565 (0,31 %)
1 805 (1,01 %)
Jensen et coll., 201118
Danemark
Collecte prospective de données
Sédation par propofol administré par infirmier/ère
Toutes endoscopies digestives
1 822
78 (4,28 %)
 
       
Colonoscopie uniquement
707
16 (2,26 %)
 
Cooper et coll., 20137
États-Unis
Analyse d’une base de données
Sédation fournie avec ou sans assistance anesthésique (protocole non précisé)
Colonoscopie
165 527
125 (0,10 %)
48 (0,14 %)
Sieg et coll., 201419
Allemagne
Collecte prospective de données
Sédation par propofol administré par endoscopiste
Toutes endoscopies digestives
24 441
97 (0,40 %)
12 (0,05 %)
Jensen et coll., 20159
Danemark
Analyse d’une base de données
Sédation par propofol administré par infirmier/ère
Toutes endoscopies digestives
6 840
214 (3,13 %)
204 (2,98 %)
       
Colonoscopie uniquement
4 347
130 (2,99 %)
154 (3,54 %)
* les évènements des voies aériennes incluent: obstruction partielle ou complète de la voie aérienne, apnée et hypoxie. † Les modifications hémodynamiques incluent: hypotension, arythmie, tachy- ou bradycardie
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Metadaten
Titel
Optimizing depth of sedation for colonoscopy
verfasst von
Matthew T. V. Chan, MBBS, PhD
William K. K. Wu, PhD
Raymond S. Y. Tang, MD
Publikationsdatum
01.11.2015
Verlag
Springer US
Erschienen in
Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Ausgabe 11/2015
Print ISSN: 0832-610X
Elektronische ISSN: 1496-8975
DOI
https://doi.org/10.1007/s12630-015-0462-4

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