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Clinical Epileptology

Erschienen in:

16.11.2018 | Epilepsie | Übersichten

Lebensqualität bei Epilepsie: Ein Überblick zum Forschungsstand – Teil 3: Korrelate und Determinanten von Lebensqualität

verfasst von: Dr. Michael Endermann

Erschienen in: Clinical Epileptology | Ausgabe 4/2019

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Zusammenfassung

Hintergrund

Seit den 1990er-Jahren ist in der Epileptologie Lebensqualität (Quality of Life [QOL]) bzw. gesundheitsbezogene Lebensqualität Gegenstand der klinischen Forschung. Dabei wird in einzelnen Studien meist nicht explizit erläutert, von welchem QOL-Konzept bzw. -Verständnis ausgegangen wird.

Ziele der Arbeit

In einem Überblick sollen die wichtigsten Ergebnisse der Forschung zur QOL bei Epilepsie aufgezeigt werden. In diesem 3. Teil geht es abschließend um den Forschungsschwerpunkt „QOL-Korrelate und Determinanten“, also um Studien, die analysierten, welche Variablen mit QOL assoziiert sind bzw. QOL beeinflussen.

Material und Methoden

Die Archive der einschlägigen Fachzeitschriften Epilepsia, Epilepsy & Behavior sowie Seizure seit Beginn der 1990er-Jahre wurden daraufhin untersucht, ob in Publikationen QOL thematisiert oder QOL-Daten erhoben worden waren. Auf repräsentative Studien wird verwiesen.

Ergebnisse

Bezüglich der QOL-Korrelate und Determinanten ist festzuhalten: Anfallskontrolle und Depressivität haben sich regelhaft als wichtige Determinanten von epilepsiespezifischer QOL erwiesen, wobei klinische Variablen wie Anfallskontrolle weniger QOL-Varianz aufklären als psychosoziale Variablen wie Depressivität.

Schlussfolgerung

Das QOL-Konzept ist nicht als bloßes, auf subjektiver Patienteneinschätzung basierendes Surrogat für das Behandlungsziel Anfallskontrolle zu verstehen. Es verweist vielmehr auf die Notwendigkeit, sich damit zu beschäftigen, ob weitere Krankheitsaspekte bzw. Komorbidität eine Belastung für den Patienten darstellen und ggf. therapeutischer Interventionen bedürfen.

Agrawal N, Bird JS, von Oertzen TJ et al (2016) Depression correlates with quality of life in people with epilepsy independent of the measures used. Epilepsy Behav 62:246–250PubMed

Alsaadi T, Kassie S, El Hammasi K et al (2017) Potential factors impacting health-related quality of life among patients with epilepsy: results from the United Arab Emirates. Seizure 53:13–17PubMed

Amiri M, Hansen CP (2015) The interictal dysphoric disorder in patients with epilepsy: a doubtful disorder lacking diagnostic tools. Seizure 24:70–76PubMed

Au A, Li P, Chan J et al (2002) Predicting the quality of life in Hong Kong Chinese adults with epilepsy. Epilepsy Behav 3:350–357PubMed

Auriel E, Landov H, Blatt I et al (2009) Quality of life in seizure-free patients with epilepsy on monotherapy. Epilepsy Behav 14:130–133PubMed

Azuma H, Akechi T (2014) Effects of psychosocial functioning, depression, seizure frequency, and employment on quality of life in patients with epilepsy. Epilepsy Behav 41:18–20PubMed

Baca CB, Vickrey BG, Vassar SD, Berg AT (2012) Seizure recency and quality of life in adolescents with childhood-onset epilepsy. Epilepsy Behav 23:47–51PubMed

Baker GA, Gagnon D, McNulty P (1998) The relationship between seizure frequency, seizure type and quality of life: findings from three European countries. Epilepsy Res 30:231–240PubMed

Baker GA, Jacoby A, Chadwick DW (1996) The association of psychopathology in epilepsy: a community study. Epilepsy Res 25:29–39PubMed

10.

Baker GA, Jacoby A, Buck D et al (1997) Quality of life of people with epilepsy: a European study. Epilepsia 38:353–362PubMed

11.

Bala A, Szantroch M, Gleinert A et al (2016) Differences in quality of life of women and men with drug-resistant epilepsy in Poland. Epilepsy Behav 60:94–98PubMed

12.

Bautista RED, Glen ET (2009) Seizure severity is associated with quality of life independent of seizure frequency. Epilepsy Behav 16:325–329PubMed

13.

Boylan LS, Flint LA, Labovitz DL et al (2004) Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology 62:258–261PubMed

14.

Brandt C, Mula M (2016) Anxiety disorders in people with epilepsy. Epilepsy Behav 59:87–91PubMed

15.

Cañizares S, Torres X, Boget T et al (2000) Does neuroticism influence cognitive self-assessment after epilepsy surgery? Epilepsia 41:1303–1309PubMed

16.

Canuet L, Ishii R, Iwase M et al (2009) Factors associated with impaired quality of life in younger and older adults with epilepsy. Epilepsy Res 8:58–65

17.

Carreño M, Becerra JL, Castillo J et al (2011) Seizure frequency and social outcome in drug resistant epilepsy patients who do not undergo epilepsy surgery. Seizure 20:580–582PubMed

18.

Chen H‑F, Tsai Y‑F, Hsi M‑S, Chen J‑C (2016) Factors affecting quality of life in adults with epilepsy in Taiwan: a cross-sectional, correlational study. Epilepsy Behav 58:26–32PubMed

19.

Clarke AL, Critchley C (2016) Impact of choice of coping strategies and family functioning on psychosocial function of young people with epilepsy. Epilepsy Behav 59:50–56PubMed

20.

Conway L, Smith ML, Ferro MA et al (2016) Correlates of health-related quality of life in children with drug resistant epilepsy. Epilepsia 57:1256–1264PubMed

21.

Cramer JA, Brandenburg N, Xu X (2005) Differentiating anxiety and depression symptoms in patients with partial epilepsy. Epilepsy Behav 6:563–569PubMed

22.

Cramer JA, Blum D, Reed M et al (2003) The influence of comorbid depression on quality of life for people with epilepsy. Epilepsy Behav 4:515–521PubMed

23.

De la Loge C, Dimova S, Mueller K et al (2016) PatientsLikeMe® Online Epilepsy Community: patients characteristics and predictors of poor health-related quality of life. Epilepsy Behav 63:20–28PubMed

24.

Demirci K, Demirci S, Taşkiran E, Kutluhan S (2017) The effect of temperament and character traits on perceived social support and quality of life in patients with epilepsy. Epilepsy Behav 74:22–26PubMed

25.

Djibuti M, Shakarishvili R (2003) Influence of clinical, demographic, and socioeconomic variables on quality of life in patients with epilepsy: findings from Georgian study. J Neurol Neurosurg Psychiatr 74:570–573

26.

Duncan S, Talbot A, Sheldrick R, Caswell H (2009) Erectile function, sexual desire, and psychological well-being in men with epilepsy. Epilepsy Behav 15:351–357PubMed

27.

Ekinci O, Isik U, Gunes S, Ekinci N (2016) Understanding sleep problems in children with epilepsy: associations with quality of life, Attention-Deficit Hyperactivity Disorder and maternal emotional symptoms. Seizure 40:108–113PubMed

28.

Elliott JO, Richardson VE (2014) The biopsychosocial model and quality of life in persons with active epilepsy. Epilepsy Behav 41:55–65PubMed

29.

Elliott JO, Charyton C, Sprangers P et al (2011) The impact of marriage and social support on persons with active epilepsy. Epilepsy Behav 20:533–538PubMed

30.

Elsharkawy AE, Thorbecke R, Ebner A, May TW (2012) Determinants of quality of life in patients with refractory focal epilepsy who were not eligible for surgery or who rejected surgery. Epilepsy Behav 24:249–255PubMed

31.

Endermann M (2006) Quality of life among people with epilepsy and mild intellectual disabilities in residential care. Epilepsy Behav 8:703–712PubMed

32.

Endermann M (2013) Predictors of health-related and global quality of life among young adults with difficult-to-treat epilepsy and mild intellectual disability. Epilepsy Behav 26:188–195PubMed

33.

Endermann M, Zimmermann F (2009) Factors associated with health-related quality of life, anxiety and depression among young adults with epilepsy and mild cognitive impairments in short-term residential care. Seizure 18:167–175PubMed

34.

Ettinger AB, Good MB, Manjunath R et al (2014) The relationship of depression to antiepileptic drug adherence and quality of life in epilepsy. Epilepsy Behav 36:138–143PubMed

35.

Ettinger AB, Weisbrot DM, Krupp LB et al (1998) Fatigue and depression in epilepsy. J Epilepsy 11:105–109

36.

Fawale MB, Owolabi MO, Ogunniyi A (2014) Effects of seizure severity and seizure freedom on the health-related quality of life of an African population of people with epilepsy. Epilepsy Behav 32:9–14PubMed

37.

Ferro M (2014) Risk factors for health-related quality of life in children with epilepsy: a meta-analysis. Epilepsia 55:1722–1731PubMed

38.

Ferro MA, Avery L, Fayed N et al (2017) Child- and parent-reported quality of life trajectories in children with epilepsy: a prospective cohort study. Epilepsia 58:1277–1286PubMed

39.

Fraser RT, Johnson EK, Miller JW et al (2011) Managing epilepsy well: self-management needs assessment. Epilepsy Behav 20:291–298PubMed

40.

Friedman DE, Islam S, Ettinger AB (2013) Health-related quality of life among people with epilepsy with mild seizure-related head injuries. Epilepsy Behav 27:492–496PubMed

41.

Garcia ME, Garcia-Morales I, Gil-Nagel A (2015) Prevalence of depressive symptoms and their impact on quality of life in patients with drug-resistant focal epilepsy (IMDYVA study). Epilepsy Res 110:157–165PubMed

42.

Gilliam F, Hecimovic H, Sheline Y (2003) Psychiatric comorbidity, health, and function in epilepsy. Epilepsy Behav 4(Suppl 4):S26–S30PubMed

43.

Giovagnoli AR, Avanzini G (2000) Quality of life and memory performance in patients with temporal lobe epilepsy. Acta Neurol Scand 101:295–300PubMed

44.

Giovagnoli AR, Parente A, Tarallo A et al (2014) Self-rated and assessed cognitive functions in epilepsy: impact on quality of life. Epilepsy Res 108:1461–1468PubMed

45.

Gois J, Valente K, Vicentiis S et al (2011) Assessment of psychosocial adjustment in patients with temporal lobe epilepsy using a standard measure. Epilepsy Behav 20:89–94PubMed

46.

Goodwin SW, Wilk P, Campbell MK, Speechley KN (2017) Emotional well-being in children with epilepsy: family factors as mediators and moderators. Epilepsia 58:1912–1919PubMed

47.

Gordon-Perue G, Gayle F, Fraser R, Ali A (2011) Quality of life of patients with epilepsy living in Kingston, Jamaica. Epilepsy Behav 21:23–26PubMed

48.

Gramstad A, Iversen E, Engelsen BA (2001) The impact of affectivity dispositions, self-efficacy and locus of control on psychosocial adjustment in patients with epilepsy. Epilepsy Res 46:53–61PubMed

49.

Grant AC, Prus N, Nakhutina L (2013) Factors affecting quality of life in epilepsy in a multi-ethnic urban population. Epilepsy Behav 27:283–285PubMed

50.

Guekht AB, Mitrokhina TV, Lebedeva AV et al (2007) Factors influencing on quality of life in people with epilepsy. Seizure 16:128–133PubMed

51.

Gupta S, Kwan P, Faught E et al (2016) Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: an analysis from the National Health and Wellness Survey. Epilepsy Behav 55:146–156PubMed

52.

Gur-Ozmen S, Leibetseder A, Cock HR et al (2017) Screening of anxiety and quality of life in people with epilepsy. Seizure 45:107–113PubMed

53.

Hessen E, Lossius MI, Gjerstad L (2009) Health concerns predicts poor quality of life in well-controlled epilepsy. Seizure 18:487–491PubMed

54.

Iqbal M, Amirsalari S, Radfar S, Haidari MR (2016) Effects of parental gender and level of education on the quality of life and general health of pediatric patients with epilepsy: an outpatient cross-sectional study. Epilepsy Behav 60:118–123PubMed

55.

Jacoby A, Baker GA (2008) Quality-of-life trajectories in epilepsy: a review of the literature. Epilepsy Behav 12:557–571PubMed

56.

Jacoby A, Baker GA, Steen N et al (1996) The clinical course of epilepsy and its psychosocial correlates: findings from a U.K. community study. Epilepsia 37:148–161PubMed

57.

Jacoby A, Lane S, Marson A et al (2011) Relationship of clinical and quality of life trajectories following the onset of seizures: findings from the UK MESS Study. Epilepsia 52:965–974PubMed

58.

Jadhav PM, Bodke NK, Sanap DA, Gogtay NJ (2013) Assessment and comparison of health-related quality of life (HRQOL) in patients with epilepsy in India. Epilepsy Behav 27:165–168PubMed

59.

Jehi L, Tesar G, Obuchowski N et al (2011) Quality of life in 1931 adult patients with epilepsy: seizures do not tell the whole story. Epilepsy Behav 22:723–727PubMed

60.

Johnson EK, Jones JE, Seidenberg M, Hermann BP (2004) The relative impact of anxiety, depression, and clinical features on health-related quality of life in epilepsy. Epilepsia 45:544–550PubMed

61.

Jovel CAE, Salazar SR, Rodríguez CR, Mejía FES (2016) Factors associated with quality of life in a low-income population with epilepsy. Epilepsy Res 127:168–174

62.

Kanner AM (2003) Depression in epilepsy: a frequently neglected multifaceted disorder. Epilepsy Behav 4(Suppl 4):S11–S19

63.

Kanner AM (2017) Psychiatric comorbidities in new onset epilepsy: should they be always investigated? Seizure 49:79–82PubMed

64.

Kanner AM, Berry JJ (2003) The impact of mood disorders in neurological diseases: should neurologists be concerned? Epilepsy Behav 4(Suppl 3):S3–S13PubMed

65.

Kanner AM, Barry JJ, Gilliam F et al (2010) Anxiety disorders, subsyndromic depressive episodes, and major depressive episodes: do they differ on their impact on the quality of life of patients with epilepsy? Epilepsia 51:1152–1158PubMed

66.

Kotwas I, McGonigal A, Bastien-Toniazzo M et al (2017) Stress-regulation in drug resistant epilepsy. Epilepsy Behav 71:39–50PubMed

67.

Kováts D, Császár N, Haller J et al (2017) Factors affecting quality of life in Hungarian adults with epilepsy: a comparison of four psychiatric instruments. Epilepsy Behav 74:45–58PubMed

68.

Kubota H, Awaya Y (2010) Assessment of health-related quality of life and influencing factors using QOLIE-31 in Japanese patients with epilepsy. Epilepsy Behav 18:381–387PubMed

69.

Kwan P, Yu E, Leung H et al (2009) Association of subjective anxiety, depression, and sleep disturbance with quality-of-life ratings in adults with epilepsy. Epilepsia 50:1059–1066PubMed

70.

Kwon O‑Y, Park S‑P (2011) What is the role of depressive symptoms among other predictors of quality of life in people with well-controlled epilepsy on monotherapy? Epilepsy Behav 20:528–532PubMed

71.

Lee S‑A, Ryu HU, Choi E‑J et al (2017) Associations between religiosity and anxiety, depressive symptoms, and well-being in Korean adults living with epilepsy. Epilepsy Behav 75:246–251PubMed

72.

Lee S‑J, Kim J‑E, Seo J‑G et al (2014) Predictors of quality of life and their interrelations in Korean people with epilepsy: a MEPSY study. Seizure 23:762–768PubMed

73.

Lehrner J, Kalchmayr R, Serles W et al (1999) Health-related quality of life (HRQOL), activity of daily living (ADL) and depressive mood disorder in temporal lobe epilepsy patients. Seizure 8:88–92PubMed

74.

Leidy NK, Elixhauser A, Vickrey B (1999) Seizure frequency and the health-related quality of life of adults with epilepsy. Neurology 53:162–166PubMed

75.

Lin C‑Y, Chen H, Pakpour AH (2016) Correlation between adherence to antiepileptic drugs and quality of life in patients with epilepsy: a longitudinal study. Epilepsy Behav 63:103–108PubMed

76.

Loring DW, Meador KJ, Lee GP (2004) Determinants of quality of life in epilepsy. Epilepsy Behav 5:976–980PubMed

77.

Love CE, Webbe F, Kim G et al (2016) The role of executive functioning in pediatric intractable epilepsy. Epilepsy Behav 64:37–43PubMed

78.

Luoni C, Bisulli F, Canevini MP et al (2011) Determinants of health-related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments. Epilepsia 52:2181–2191PubMed

79.

Mameniškiene R, Karmonaite I, Zagorskis R (2016) The burden of headache in people with epilepsy. Seizure 41:120–126PubMed

80.

Mameniškienė R, Guk J, Jatužis D (2017) Family and sexual life in people with epilepsy. Epilepsy Behav 66:39–44PubMed

81.

Manor L, Streiner DL, Yam WKL et al (2013) Age-related variables in childhood epilepsy: how do they relate to each other and to quality of life? Epilepsy Behav 26:71–74PubMed

82.

McLaughlin DP, Pachana NA, Mcfarland K (2010) The impact of depression, seizure variables and locus of control on health related quality of life in a community dwelling sample of older adults. Seizure 19:232–236PubMed

83.

Melikyan E, Guekht A, Milchakova L et al (2012) Health-related quality of life in Russian adults with epilepsy: the effect of socio-demographic and clinical factors. Epilepsy Behav 25:670–675PubMed

84.

Mendes TP, Crespo CA, Austin JK (2017) The psychological costs of comparisons: parents’ social comparison moderates the links between family management of epilepsy and children’s outcomes. Epilepsy Behav 75:42–49PubMed

85.

Micoulaud-Franchi J‑A, Bartolomei F, Duncan R, McGonigal A (2017) Evaluating quality of life in epilepsy: the role of screening for adverse drug effects, depression, and anxiety. Epilepsy Behav 75:18–24PubMed

86.

Milovanović M, Martinović Ž, Toşković O (2014) Determinants of quality of life in people with epilepsy in Serbia. Epilepsy Behav 31:160–166PubMed

87.

Moran NF, Poole K, Bell G et al (2004) Epilepsy in the United Kingdom: seizure frequency and severity, anti-epileptic drug utilization and impact on life in 1652 people with epilepsy. Seizure 13:425–433PubMed

88.

Naess S, Eriksen J, Tambs K (2007) Psychological well-being of people with epilepsy in Norway. Epilepsy Behav 11:310–315PubMed

89.

Park S‑P, Song H‑S, Hwang Y‑H et al (2010) Differential effects of seizure control and affective symptoms on quality of life in people with epilepsy. Epilepsy Behav 18:455–459PubMed

90.

Pauli C, de Oliveira Thais ME, Claudino LC et al (2012) Predictors of quality of life in patients with refractory mesial temporal lobe epilepsy. Epilepsy Behav 25:208–213PubMed

91.

Perrine K, Hermann BP, Meador KJ et al (1995) The relationship of neuropsychological functioning to quality of life in epilepsy. Arch Neurol 52:997–1003PubMed

92.

Perucca P, Gilliam FG, Schmitz B (2009) Epilepsy treatment as a predeterminant of psychosocial ill health. Epilepsy Behav 15:S46–S50PubMed

93.

Petruzzi A, Rigamonti A, Finocchiaro CY et al (2017) Psychological features and quality of life in 50 adult patients with epilepsy and their caregivers from the Lecco epilepsy center, Italy. Epilepsy Behav 71:13–16PubMed

94.

Pham T, Sauro KM, Patten SB et al (2017) The prevalence of anxiety and associated factors in persons with epilepsy. Epilepsia 58:e107–e110PubMed

95.

Quintas R, Cerniauskaite M, Giovannetti AM et al (2016) PARADISE 24 instrument: an observational study on psychosocial difficulties, quality of life, and disability levels in patients with epilepsy. Epilepsy Behav 64:160–165PubMed

96.

Radović NI, Božić K, Ɖurić AP et al (2017) Health-related quality of life in adolescents with epilepsy in Montenegro. Epilepsy Behav 76:105–109PubMed

97.

Ramsey RR, Loiselle K, Rausch JR et al (2016) Predictors of trajectories of epilepsy-specific quality of life among children newly diagnosed with epilepsy. Epilepsy Behav 57:202–210PubMedPubMedCentral

98.

Räty L, Hamrin E, Söderfeldt B (1999) Quality of life in newly-debuted epilepsy. Acta Neurol Scand 100:221–226PubMed

99.

Rawlings GH, Brown I, Reuber M (2017) Predictors of health-related quality of life in patients with epilepsy and psychogenic nonepileptic seizures. Epilepsy Behav 68:153–158PubMed

100.

Ring A, Jacoby A, Baker GA et al (2016) Does the concept of resilience contribute to understanding good quality of life in the context of epilepsy? Epilepsy Behav 56:153–164PubMed

101.

Ronen GM, Streiner DL, Verhey LH et al (2010) Disease characteristics and psychosocial factors: explaining the expression of quality of life in childhood epilepsy. Epilepsy Behav 17:88–93

102.

Saadi A, Patenaude B, Nirola DK et al (2016) Quality of life in epilepsy in Bhutan. Seizure 39:44–48PubMed

103.

Sajatovic M, Tatsuoka C, Welter E et al (2017) Correlates of quality of life among individuals with epilepsy enrolled in self-management research. Epilepsy Behav 69:177–180PubMedPubMedCentral

104.

Sajobi TT, Wang M, Ferro MA et al (2017) Multivariate trajectories across multiple domains of health-related quality of life in children with new-onset epilepsy. Epilepsy Behav 75:72–78PubMed

105.

Salter KA, Prior KN, Bond MJ (2017) Predicting well-being among people with epilepsy using illness cognitions. Epilepsy Behav 71:1–6PubMed

106.

Sandstrom SA, Bowman ES, Johnson CS, Salanova V (2010) Interictal mood disorder and quality of life in active epilepsy. Epilepsy Behav 17:199–204PubMed

107.

Scévola L, Sarudiansky M, Lanzillotti A et al (2017) To what extent does depression influence quality of life of people with pharmacoresistant epilepsy in Argentina? Epilepsy Behav 69:133–138PubMed

108.

Schraegle WA, Titus JB (2016) Executive function and health-related quality of life in pediatric epilepsy. Epilepsy Behav 62:20–26PubMed

109.

Schraegle WA, Titus JB (2017) The relationship of seizure focus with depression, anxiety, and health-related quality of life in children and adolescents with epilepsy. Epilepsy Behav 68:115–122PubMed

110.

Şenol V, Soyuer F, Arman F, Öztürk A (2007) Influence of fatigue, depression, and demographic variables on quality of life of patients with epilepsy. Epilepsy Behav 10:96–104PubMed

111.

Shi Y, Wang S, Ying J et al (2017) Correlates of perceived stigma for people living with epilepsy: a meta-analysis. Epilepsy Behav 70:198–203PubMed

112.

Shinnar RC, Shinnar S, Hesdorffer DC et al (2017) Parental stress, pediatric quality of life, and behavior at baseline and one-year follow-up: results from the FEBSTAT study. Epilepsy Behav 69:95–99PubMedPubMedCentral

113.

Smith DF, Baker GA, Dewey M et al (1991) Seizure frequency, patient-perceived seizure severity and the psychosocial consequences of intractable epilepsy. Epilepsy Res 9:231–241PubMed

114.

Stevanovic D, Jancic J, Lakic A (2011) The impact of depression and anxiety disorder symptoms on the health-related quality of life of children and adolescents with epilepsy. Epilepsia 52:e75–e78PubMed

115.

Suda T, Tatsuzawa Y, Mogi T, Yoshino A (2016) Interictal dsyphoric disorder in patients with localization-related epilepsy: diagnostic relationships with DSM-IV psychiatric disorders and the impact of psychosocial burden. Epilepsy Behav 54:142–147PubMed

116.

Suurmeijer TPBM, Reuvekamp MF, Aldenkamp BP (2001) Social functioning, psychological functioning, and quality of life in epilepsy. Epilepsia 42:1160–1168PubMed

117.

Szaflarski M, Hansen B, Bebin EM, Szaflarski JP (2017) Social correlates of health status, quality of life, and mood states in patients treated with cannabidiol for epilepsy. Epilepsy Behav 70:364–369PubMed

118.

Tang V, Kwan P, Poon WS (2013) Neurocognitive and psychological profiles of adult patients with epilepsy in Hong Kong. Epilepsy Behav 29:337–343PubMed

119.

Taylor RS, Sander JW, Taylor RJ, Baker GA (2011) Predictors of health-related quality of life and costs in adults with epilepsy: a systematic review. Epilepsia 52:2168–2180PubMed

120.

Tedrus GMAS, Fonseca LC, Pereira RB (2015) Marital status of patients with epilepsy: factors and quality of life. Seizure 27:66–70PubMed

121.

Tedrus GMAS, Sterca GS, Pereira RB (2017) Physical activity, stigma, and quality of life in patients with epilepsy. Epilepsy Behav 77:96–98PubMed

122.

Titze K, Koch S, Lehmkuhl U, Rauh H (2001) Soziofamiliäre und epilepsiespezifische Belastungen von Frauen mit Epilepsie. Nervenarzt 72:529–534PubMed

123.

Tlusta E, Zarubova J, Simko J et al (2009) Clinical and demographic characteristics predicting QOL in patients with epilepsy in the Czech Republic: how this can influence practice. Seizure 18:895–898

124.

Tracy JI, Dechant V, Sperling MR et al (2007) The association of mood with quality of life ratings in epilepsy. Neurology 68:1101–1107PubMed

125.

Turky A, Beavis JM, Thapar AK, Kerr MP (2008) Psychopathology in children and adolescents with epilepsy: an investigation of predictive variables. Epilepsy Behav 12:136–144PubMed

126.

Van Hout B, Gagnon D, Souetre E et al (1997) Relationship between seizure frequency and costs and quality of life of outpatients with partial epilepsy in France, Germany, and the United Kingdom. Epilepsia 38:1221–1226PubMed

127.

Vickrey BG, Berg AT, Sperling MR et al (2000) Relationships between seizure severity and health-related quality of life in refractory localization-related epilepsy. Epilepsia 41:760–764PubMed

128.

Wiegartz P, Seidenberg M, Woodard A et al (1999) Co-morbid psychiatric disorder in chronic epilepsy: recognition and etiology of depression. Neurology 53(Suppl 2):S3–S8PubMed

129.

Williams J, Steel C, Sharp GB et al (2003) Parental anxiety and quality of life of children with epilepsy. Epilepsy Behav 4:483–486PubMed

130.

Yue L, Yu PM, Zhao DH et al (2011) Determinants of quality of life in people with epilepsy and their gender differences. Epilepsy Behav 22:692–696PubMed

131.

Zamani G, Shiva S, Mohammadi M et al (2014) A survey of quality of life in adolescents with epilepsy in Iran. Epilepsy Behav 33:69–72PubMed

132.

Zeber JE, Copeland LA, Amuan M et al (2007) The role of comorbid psychiatric conditions in health status in epilepsy. Epilepsy Behav 10:539–546PubMed

133.

Zimmermann F, Endermann M (2008) Self-proxy agreement and correlates of health-related quality of life in young adults with epilepsy and mild intellectual disabilities. Epilepsy Behav 13:202–211PubMed

134.

Zou X, Hong Z, Chen J, Zhou D (2014) Is antiepileptic drug withdrawal status related to quality of life in seizure-free adult patients with epilepsy? Epilepsy Behav 31:129–135PubMed

Titel: Lebensqualität bei Epilepsie: Ein Überblick zum Forschungsstand – Teil 3: Korrelate und Determinanten von Lebensqualität
verfasst von: Dr. Michael Endermann
Publikationsdatum: 16.11.2018
Verlag: Springer Medizin
Schlagwörter: Epilepsie
Affektive Störungen
Affektive Störungen
Erschienen in: Clinical Epileptology / Ausgabe 4/2019
Print ISSN: 2948-104X
Elektronische ISSN: 2948-1058
DOI: https://doi.org/10.1007/s10309-018-0222-x

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Depression behandeln. Natürlich.

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Aktuelle Ergebnisse aus in-vitro- und in-vivo-Untersuchungen liefern detaillierte Erklärungen zum Wirkmechanismus von hochdosiertem Johanniskraut-Extrakt: Neu ist die Erkenntnis, dass der Johanniskraut-Extrakt bei chronischem Stress die deregulierte Stressantwort der überaktiven HPA-Achse sowie die Expression des Stressgens FKBP5 normalisieren kann. Mehr zum aktuellen Stand der Wissenschaft bei der Therapie von Depressionen erfahren Sie hier.

Springer Medizin

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Depression behandeln. Natürlich.