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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

13.12.2021 | Original Article

¹³ N-ammonia PET-derived right ventricular longitudinal strain and myocardial flow reserve in right coronary artery disease

verfasst von: Masateru Kawakubo, Michinobu Nagao, Atsushi Yamamoto, Risako Nakao, Yuka Matsuo, Koichiro Kaneko, Eri Watanabe, Akiko Sakai, Masayuki Sasaki, Shuji Sakai

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2022

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Abstract

Purpose

We developed a feature-tracking algorithm for use with electrocardiography-gated high-resolution ¹³ N-ammonia positron emission tomography (PET) imaging, and we hypothesized it could be used to clarify the association between right ventricular (RV) longitudinal strain (LS) and right coronary artery (RCA) ischemia. The aim of this study was to investigate the association between the reduction of regional myocardial flow reserve (MFR) in RCA territories and PET-derived LS of the RV free wall.

Methods

Ninety-three patients with coronary artery stenosis > 50%, diagnosed by coronary computed tomography angiography, and 10 controls were retrospectively analyzed. RV-LS in the free wall was measured by a feature-tracking technique on the resting and stressed ¹³ N-ammonia PET images of horizontal long axis slices. The patients were sub-grouped according to regional MFR values at the territories of RCA, left anterior descending artery (LAD), and left circumflex coronary artery (LCx): RCA-MFR < 2.0 [n = 34], RCA-MFR ≥ 2.0 but MFR < 2.0 at LAD or LCx territories [n = 11], and MFR ≥ 2.0 for all territories [n = 48]. Stress and resting RV-LS were compared in each of the four groups. Multiple comparisons of RV-LS among the four groups were performed in the stress and resting state.

Results

Decreased stress RV-LS in patients with an RCA-MFR < 2.0 was observed. In the patients with MFR ≥ 2.0 for all territories, the stressed RV-LS was significantly increased compared to that in the resting state. Significantly decreased RV free wall LS during adenosine stress in patients with RCA-MFR < 2.0 was observed in the other three groups.

Conclusions

We measured RV myocardial LS using feature tracking in cine imaging of ¹³ N-ammonia PET. The results of this study suggest that PET-derived stressed RV-LS is useful for detecting reduced RV myocardial motion due to ischemia in the RCA territory.

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Titel: 13 N-ammonia PET-derived right ventricular longitudinal strain and myocardial flow reserve in right coronary artery disease
verfasst von: Masateru Kawakubo
Michinobu Nagao
Atsushi Yamamoto
Risako Nakao
Yuka Matsuo
Koichiro Kaneko
Eri Watanabe
Akiko Sakai
Masayuki Sasaki
Shuji Sakai
Publikationsdatum: 13.12.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2022
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05647-y

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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