¹⁸F-Fluorocholine PET/CT as a complementary tool in the follow-up of low-grade glioma

Excerpt

The management of low-grade glioma (LGG) is still challenging because malignant transformation to a high-grade tumor and/or recurrence after primary therapy may result in an unfavorable outcome. Since CT and MRI have limited capability to detect subtle changes indicative of recurrence, metabolic imaging markers were tested. In earlier studies, increased choline signal in proton magnetic resonance spectroscopy (MRS) was reported in patients with low- to high-grade malignant transformation and posttreatment recurrence in LGG [1]. Positron emission tomography (PET) with ¹⁸F-fluorodeoxyglucose (FDG) was also utilized to detect malignant transformation/posttreatment recurrence [2]. However, these are not widely utilized in the present clinical setting. …