Erschienen in:
01.09.2006 | LETTER TO THE EDITORS
A 45-year history of acquired autoimmune neuromyotonia
verfasst von:
Aisling Ryan, Gerard Mullins, Jacqui Scott, Sean Connolly, Orla Hardiman, Emrullah Yilmaz, Angela Vincent, Tim Lynch
Erschienen in:
Journal of Neurology
|
Ausgabe 9/2006
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Excerpt
Sirs: The syndrome of acquired peripheral nerve hyperexcitability (PNH), or neuromyotonia, is characterised by spontaneous and persistent muscle fibre activity. This results in continuous muscle twitching and rippling (myokymic) movements of the muscles that can be regular or irregular [
4,
5]. Autoimmune PNH is associated with antibodies to voltage-gated potassium channels (VGKC) and evidence exists that the antibodies are pathogenic [
6,
8]. Autoimmune PNH may occur in isolation, be associated with other autoimmune conditions or be a paraneoplastic phenomenon. Treatment consists of symptomatic relief with anti-spasticity agents and the use of sodium channel blockers such as phenytoin and carbamazepine. Plasma exchange and intravenous immunoglobulin (IVIg) have been used on the basis that the disease has an autoimmune aetiology [
3,
9]. …