nach oben

Cancer Causes & Control

Erschienen in:

01.10.2015 | Original paper

A case–control study of breast cancer risk in nurses from Northeastern Ontario, Canada

verfasst von: Stacey A. Santi, Margaret L. Meigs, Yantao Zhao, Mary A. Bewick, Robert M. Lafrenie, Michael S. Conlon

Erschienen in: Cancer Causes & Control | Ausgabe 10/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Previously published findings have documented increased breast cancer risks associated with the nursing profession. The aim of the present study was to assess whether an increased risk of breast cancer was associated with nursing in a population-based case–control breast cancer study of women in Northeastern Ontario, Canada.

Methods

A total of 1519 women (1380 never-nurses: 716 controls and 664 cases; 139 ever-nurses: 59 controls and 80 cases) were included in the present study. Study participants filled out a detailed questionnaire which included a history of smoking, general health information, breast cancer risk factors, and a detailed occupational history.

Results

Ever-nurses were at higher, but nonsignificant risk of breast cancer compared to never-nurses (adjusted OR 1.39, 95 % CI 0.93–2.07). Ever-nurses who worked for longer than 10 years were at a significantly increased risk of breast cancer compared to never-nurses (adjusted OR 1.70, 95 % CI 1.04–2.79). A nonsignificant, but increased risk of breast cancer was observed in ever-nurses who worked full-time compared to never-nurses (OR 1.52, 95 % CI 0.92–2.52), while nurses who worked part-time, or both part-time and full-time were not at increased risk. Ever-nurses who worked in a hospital setting had a significantly increased risk of breast cancer (OR 1.65, 95 % CI 1.04–2.62) compared to never-nurses.

Conclusions

The results indicate that the nurses in the present study population are at increased risk of breast cancer. A prolonged duration of nursing years and prolonged intensity (being a full-time nurse) are factors associated with this increased risk.

Sankila R, Karjalainen S, Laara E, Pukkala E, Teppo L (1990) Cancer risk among health care personnel in Finland, 1971–1980. Scand J Work Environ Health 16(4):252–257CrossRefPubMed

Gunnarsdottir H, Rafnsson V (1995) Cancer incidence among Icelandic nurses. J Occup Environ Med 37(3):307–312CrossRefPubMed

Andersen A, Barlow L, Engeland A, Kjaerheim K, Lynge E, Pukkala E (1999) Work-related cancer in the Nordic countries. Scand J Work Environ Health 25(Suppl 2):1–116PubMed

Lie JA, Andersen A, Kjaerheim K (2007) Cancer risk among 43000 Norwegian nurses. Scand J Work Environ Health 33(1):66–73CrossRefPubMed

Petralia SA, Vena JE, Freudenheim JL et al (1999) Risk of premenopausal breast cancer and patterns of established breast cancer risk factors among teachers and nurses. Am J Ind Med 35(2):137–141CrossRefPubMed

Calle EE, Murphy TK, Rodriguez C, Thun MJ, Heath CW Jr (1998) Occupation and breast cancer mortality in a prospective cohort of US women. Am J Epidemiol 148(2):191–197CrossRefPubMed

Gunnarsdottir H, Rafnsson V (1995) Mortality among Icelandic nurses. Scand J Work Environ Health 21(1):24–29CrossRefPubMed

Davis S, Mirick DK, Stevens RG (2001) Night shift work, light at night, and risk of breast cancer. J Natl Cancer Inst 93(20):1557–1562CrossRefPubMed

Schernhammer ES, Laden F, Speizer FE et al (2001) Rotating night shifts and risk of breast cancer in women participating in the nurses’ health study. J Natl Cancer Inst 93(20):1563–1568CrossRefPubMed

10.

Kjaer TK, Hansen J (2009) Cancer incidence among large cohort of female Danish registered nurses. Scand J Work Environ Health 35(6):446–453CrossRefPubMed

11.

Lie JA, Roessink J, Kjaerheim K (2006) Breast cancer and night work among Norwegian nurses. Cancer Causes Control 17(1):39–44CrossRefPubMed

12.

Lie JA, Kjuus H, Zienolddiny S, Haugen A, Stevens RG, Kjaerheim K (2011) Night work and breast cancer risk among Norwegian nurses: assessment by different exposure metrics. Am J Epidemiol 173(11):1272–1279CrossRefPubMed

13.

Lie JA, Kjuus H, Zienolddiny S, Haugen A, Kjaerheim K (2013) Breast cancer among nurses: is the intensity of night work related to hormone receptor status? Am J Epidemiol 178(1):110–117CrossRefPubMed

14.

Pijpe A, Slottje P, van PC et al (2014) The Nightingale study: rationale, study design and baseline characteristics of a prospective cohort study on shift work and breast cancer risk among nurses. BMC Cancer 14:47CrossRefPubMedCentralPubMed

15.

Schernhammer ES, Kroenke CH, Laden F, Hankinson SE (2006) Night work and risk of breast cancer. Epidemiology 17(1):108–111CrossRefPubMed

16.

Hansen J, Stevens RG (2012) Case-control study of shift-work and breast cancer risk in Danish nurses: impact of shift systems. Eur J Cancer 48(11):1722–1729CrossRefPubMed

17.

Stevens RG, Hansen J, Costa G et al (2011) Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report. Occup Environ Med 68(2):154–162CrossRefPubMed

18.

Straif K, Baan R, Grosse Y et al (2007) Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol 8(12):1065–1066CrossRefPubMed

19.

Stevens RG, Brainard GC, Blask DE, Lockley SW, Motta ME (2014) Breast cancer and circadian disruption from electric lighting in the modern world. CA Cancer J Clin 64(3):207–218CrossRefPubMedCentralPubMed

20.

Conlon MS, Johnson KC, Bewick MA, Lafrenie RM, Donner A (2010) Smoking (active and passive), N-acetyltransferase 2, and risk of breast cancer. Cancer Epidemiol 34(2):142–149CrossRefPubMed

21.

Conlon MS, Bewick MA (2011) Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada. Nicotine Tob Res 13(11):1076–1083CrossRefPubMed

22.

Statististics Canada and Human Resources and Skills Development Canada (2011) National Occupation Classification (NOC) Catalogue 12-583-X. http://www5.hrsdc.gc.ca/NOC/English/NOC/2011/SearchIndex.aspx, and http://www5.hrsdc.gc.ca/NOC/English/NOC/2011/pdf/PrintableVersionNOC2011.pdf

23.

Grundy A, Richardson H, Burstyn I et al (2013) Increased risk of breast cancer associated with long-term shift work in Canada. Occup Environ Med 70(12):831–838CrossRefPubMed

24.

Gunnarsdottir HK, Aspelund T, Karlsson T, Rafnsson VV (1997) Occupational risk factors for breast cancer among nurses. Int J Occup Environ Health 3(4):254–258CrossRefPubMed

25.

Bracci M, Manzella N, Copertaro A et al (2014) Rotating-shift nurses after a day off: peripheral clock gene expression, urinary melatonin, and serum 17-beta-estradiol levels. Scand J Work Environ Health 40(3):295–304CrossRefPubMed

26.

Gamble KL, Motsinger-Reif AA, Hida A et al (2011) Shift work in nurses: contribution of phenotypes and genotypes to adaptation. PLoS ONE 6(4):e18395CrossRefPubMedCentralPubMed

27.

Reszka E, Peplonska B, Wieczorek E et al (2013) Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm. Scand J Work Environ Health 39(2):178–186CrossRefPubMed

28.

Zienolddiny S, Haugen A, Lie JA, Kjuus H, Anmarkrud KH, Kjaerheim K (2013) Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts. Breast Cancer Res 15(4):R53CrossRefPubMedCentralPubMed

29.

Lie JA, Kjaerheim K (2003) Cancer risk among female nurses: a literature review. Eur J Cancer Prev 12(6):517–526CrossRefPubMed

Titel: A case–control study of breast cancer risk in nurses from Northeastern Ontario, Canada
verfasst von: Stacey A. Santi
Margaret L. Meigs
Yantao Zhao
Mary A. Bewick
Robert M. Lafrenie
Michael S. Conlon
Publikationsdatum: 01.10.2015
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 10/2015
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-015-0633-1

Neu im Fachgebiet Onkologie

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Springer Medizin

A case–control study of breast cancer risk in nurses from Northeastern Ontario, Canada