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Cancer Causes & Control

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01.02.2009 | Original Paper

A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian Indigenous women

verfasst von: John R. Condon, Alice R. Rumbold, Jane C. Thorn, Margaret M. O’Brien, Margaret J. Davy, Ibrahim Zardawi

Erschienen in: Cancer Causes & Control | Ausgabe 1/2009

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Abstract

Objective

To describe the epidemiological features of a possible disease cluster of vulvar cancer and pre-cancers in Australian Indigenous women living in the Northern Territory (NT) of Australia.

Methods

We identified NT-resident women with a confirmed histological diagnosis of vulvar cancer or high-grade vulvar intraepithelial neoplasia (VIN) between 1 January 1996 and 31 December 2005.

Results

Seventy-one women were identified; 32 diagnosed with vulvar cancer and 39 with high-grade VIN. Most women diagnosed were Indigenous, aged less than 50 years and living in remote communities in the East Arnhem (EA) district, on the north-east coast of the NT. The age-adjusted incidence rate of vulvar cancer in EA Indigenous women aged 0–49 years was 31.1 per 100,000 (95% CI 13.1–49.1), over 50 times higher than the national Australian rate (0.4 per 100,000, 95% CI 0.4–0.5) for the same age-group. In the age-group of 0–49 years, the age-adjusted incidence rate of VIN for EA Indigenous women was 34.7 per 100,000 (95% CI 15.2–54.3), compared with 6.7 per 100,000 (95% CI 2.0–11.4) for Indigenous women living elsewhere in the Top End of the NT.

Conclusion

These data provide evidence of a geographic cluster of vulvar cancer in remote Indigenous communities in northern Australia.

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Titel: A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian Indigenous women
verfasst von: John R. Condon
Alice R. Rumbold
Jane C. Thorn
Margaret M. O’Brien
Margaret J. Davy
Ibrahim Zardawi
Publikationsdatum: 01.02.2009
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 1/2009
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-008-9218-6

Springer Medizin

A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian Indigenous women