Background
Methods
Study subjects
Complete HBV genome sequencing
Molecular evolutionary analyses
Statistical comparisons
GenBank accession number
Results
Demographic information
City | No. of cases | Age, yr (mean ± sd) | M/F ratio | ALT (U/L) | AST (U/L) |
---|---|---|---|---|---|
Lanzhou
|
67
|
29.63 ± 13.78
|
42/25
|
42.65 ± 36.37
|
34.27 ± 25.70
|
Urumuqi
|
27
|
28.74 ± 13.75
|
10/17
|
48.79 ± 56.16
|
43.21 ± 59.04
|
Xi’an
|
78
|
28.52 ± 12.88
|
40/38
|
43.81 ± 41.12
|
39.33 ± 40.91
|
Xining
|
56
|
30.05 ± 14.59
|
29/27
|
42.77 ± 33.34
|
38.63 ± 21.74
|
Yinchuan
|
14
|
32.29 ± 15.79
|
8/6
|
29.00 ± 19.29
|
24.15 ± 12.22
|
Total
|
242
|
28.74 ± 13.14
|
132/110
|
43.89 ± 46.93
|
39.36 ± 45.42
|
HBV genotypes and serotypes
City | No. of sequences | Genotype B | Genotype C | Genotype D |
---|---|---|---|---|
Xi’an
|
78
|
23
|
52
|
3
|
Lanzhou
|
67
|
6
|
47
|
14
|
Yinchuan
|
14
|
0
|
12
|
2
|
Urumuqi
|
27
|
10
|
16
|
1
|
Xining
|
56
|
4
|
18
|
34
|
Total
|
242
|
43
|
145
|
54
|
Genotype | adr | adw | ayr | ayw | Total | ||||
---|---|---|---|---|---|---|---|---|---|
adrq- | adrq+ | adw2 | adw4 | ayr | ayw1 | ayw2 | ayw3 | ||
B
|
0
|
28
|
3
|
1
|
0
|
1
|
10
|
0
|
43
|
C
|
0
|
84
|
25
|
0
|
1
|
1
|
33
|
1
|
145
|
D
|
1
|
25
|
11
|
1
|
1
|
0
|
15
|
0
|
54
|
Total
|
1
|
137
|
39
|
2
|
2
|
2
|
58
|
1
|
242
|
Genotype consensus sequences
Clinically relevant mutations
Genotype B | Genotype C | Genotype D | Total number | |
---|---|---|---|---|
No of sequences
|
43
|
145
|
54
|
242
|
preS1 deletion mutation**
|
0
|
5
|
11
|
16
|
preS2 deletion mutation
|
1
|
4
|
0
|
5
|
G129H/R
|
1
|
5
|
2
|
8
|
G145R
|
1
|
4
|
0
|
5
|
T126A/S
|
1
|
1
|
1
|
3
|
P127T
|
0
|
4
|
2
|
6
|
G130R
|
1
|
2
|
0
|
3
|
T131P
|
2
|
5
|
2
|
9
|
M134Y
|
11
|
31
|
14
|
56
|
S143T/L
|
8
|
20
|
11
|
39
|