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14.12.2018 | Original Article

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life

verfasst von: Wen-Chi Chou, Jen-Shi Chen, Chia-Yen Hung, Chang-Hsien Lu, Yu-Yun Shao, Tzeon-Jye Chiou, Yung-Chuan Sung, Kun-Ming Rau, Chia-Jui Yen, Su-Peng Yeh, Ta-Chih Liu, Ming-Fang Wu, Ming-Yang Lee, Ming-Sun Yu, Wen-Li Hwang, Pang-Yu Lai, Cheng-Shyong Chang, Ruey-Kuen Hsieh

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2019

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Abstract

Purpose

Poor adherence to analgesic drugs is one of the most common barriers to adequate pain management. This prospective, cross-sectional, patient-oriented observational study aimed to explore the adherence rate, clinical factors, and impact of adherence to analgesic drugs on the quality of life (QoL) among cancer outpatients in Taiwan.

Methods

Eight hundred ninety-seven consecutive adult outpatients with cancer who had reported tumor pain and received regular analgesic drug treatment were enrolled from 16 medical centers across Taiwan. The Brief Pain Inventory was used to assess pain intensity and QoL. Morisky’s four-item medication adherence scale was used to assess adherence to analgesic drugs. Clinical factors possibly associated with good adherence to analgesic drugs were analyzed using multivariate logistic regression analyses.

Results

Of the 897 patients, 26.9% met criteria for the good, 35.5% for the moderate, and 37.6% for the poor adherence groups. The good adherence group had significantly better QoL outcomes than the moderate and poor adherence groups (all p < 0.05). Age ≥ 50 years, head and neck or hematological malignancies, cancer-related pain, patients who agreed or strongly agreed that the side effects of analgesic drugs were tolerable, and patients who disagreed or strongly disagreed that the dosing schedule could be flexibly self-adjusted to deal with the actual pain were predictors of good adherence to analgesic drugs.

Conclusions

Awareness of the clinical factors associated with adherence to analgesic drugs may help clinicians to identify cancer patients at a greater risk of non-adherence, reinforce optimal pain management, and improve the QoL by enhancing adherence to pain medications.

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Titel: A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life
verfasst von: Wen-Chi Chou
Jen-Shi Chen
Chia-Yen Hung
Chang-Hsien Lu
Yu-Yun Shao
Tzeon-Jye Chiou
Yung-Chuan Sung
Kun-Ming Rau
Chia-Jui Yen
Su-Peng Yeh
Ta-Chih Liu
Ming-Fang Wu
Ming-Yang Lee
Ming-Sun Yu
Wen-Li Hwang
Pang-Yu Lai
Cheng-Shyong Chang
Ruey-Kuen Hsieh
Publikationsdatum: 14.12.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 8/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4599-x

Springer Medizin

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life