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Journal of Natural Medicines

Erschienen in:

10.12.2022 | Note

A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins

verfasst von: Teruhisa Manome, Yasumasa Hara, Masami Ishibashi

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2023

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Abstract

A new 1,2-diketone physalin, physalin XII (1), and 13 known compounds were isolated from the methanol extract of Physalis minima whole plant collected in Thailand. Among them, five physalins (2–6) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activity, and physalin F (3) was the most active with an IC₅₀ value of 0.39 µM against human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL). An investigation of the TRAIL-resistance overcoming activity of physalins using western blot analysis showed that 3 promoted TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.

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Titel: A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins
verfasst von: Teruhisa Manome
Yasumasa Hara
Masami Ishibashi
Publikationsdatum: 10.12.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2023
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-022-01670-x

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins

Abstract

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

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