Background
Methods
Patient eligibility requirements
Treatment plan
Treatment efficacy
Flow cytometry
Immunocytochemistry
Analysis of ALDH immunohistochemical staining
Statistical analysis
Results
Patient characteristics
Patient | Age | Gender | Diagnosis | Status | Evaluable? | Prior Doxo |
---|---|---|---|---|---|---|
1 | 19 | M | Mesenchymal Chondrosarcoma | RR 1 | N | Y |
2 | 43 | F | MFH | RR 1 | Y | Y |
3 | 39 | F | Leiomyosarcoma | Relapse 2 | Y | Y |
4 | 18 | M | Rhabdomyosarcoma | Relapse 1 | Y | N |
5 | 9 | F | Rhabdomyosarcoma | RR 2 | Y | N |
6 | 20 | F | Rhabdomyosarcoma | Relapse 1 | N | Y |
7 | 63 | F | Leiomyosarcoma | Relapse 2 | Y | Y |
8 | 21 | M | Rhabdomyosarcoma | RR 1 | Y | Y |
9 | 70 | M | Spindle Cell Sarcoma | Relapse 2 | Y | N |
10
|
59
|
F
|
Leiomyosarcoma
|
RR 1
|
Y
|
Y
|
11
|
57
|
F
|
Chondrosarcoma
|
Mult Relapse
|
Y
|
N
|
12
|
10
|
M
|
Osteosarcoma
|
RR 1
|
Y
|
Y
|
13 | 43 | F | Clear Cell Sarcoma | Relapse 2 | Y | N |
14 | 16 | M | Ewing Sarcoma | RR 1 | Y | Y |
15 | 68 | F | Leiomyosarcoma | RR 1 | N | N |
16 | 57 | F | Synovial Sarcoma | RR 2 | Y | Y |
17 | 22 | F | Mesenchymal Chondrosarcoma | Relapse 2 | Y | Y |
18 | 32 | M | MPNST | Relapse 2 | Y | Y |
19 | 20 | F | HGUPS | RR 1 | Y | Y |
20 | 21 | F | Epithelioid Sarcoma | Relapse 1 | Y | Y |
21 | 42 | M | Rhabdomyosarcoma | Refractory | Y | N |
Response to treatment
Toxicities
Group | Toxicity | Grade 3 | Grade 4 | Total | Dose level |
---|---|---|---|---|---|
Hematologic | Thrombocytopenia | 3 | 3 | 6 | 4 |
Neutropenia | 5 | – | 5 | 4 | |
Lymphocyte count decreased | 1 | – | 1 | 4 | |
White blood cell decreased | 1 | – | 1 | 4 | |
Gastrointestinal | Lipase increased | – | 3 | 3 | 4 |
ALT increased | 3 | – | 3 | 4 | |
Vomiting | 3 | – | 3 | 4, 5 | |
Serum Amylase increased | 2 | – | 2 | 4 | |
Abdominal pain | 1 | – | 1 | 5 | |
Anorexia | – | 1 | 1 | 5 | |
AST increased | 1 | – | 1 | 4 | |
Stomatitis | 1 | – | 1 | 4 | |
Weight loss | 1 | – | 1 | 4 | |
Metabolic | Hypophosphatemia | 6 | – | 6 | 4, 5 |
Hypokalemia | 2 | – | 2 | 4, 5 | |
Hypocalcemia | 1 | – | 1 | 4 | |
Hyponatremia | 1 | – | 1 | 4 | |
Other | Bone infection | 1 | – | 1 | 4 |