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01.01.2013 | Original paper

A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis

verfasst von: Rodolphe Thuret, Maxine Sun, Lars Budaus, Firas Abdollah, Daniel Liberman, Shahrokh F. Shariat, François Iborra, Jacques Guiter, Jean-Jacques Patard, Paul Perrotte, Pierre I. Karakiewicz

Erschienen in: Cancer Causes & Control | Ausgabe 1/2013

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Abstract

Purpose

The association between marital status and tumor stage and grade, as well as overall mortality (OM) and cancer-specific mortality (CSM) received little attention in patients with squamous cell carcinoma of the penis (SCCP).

Methods

We relied on the surveillance, epidemiology, and end results (SEER) 17 database to identify patients diagnosed with primary SCCP. Logistic and Cox regression models, respectively, addressed the effect of marital status on the rate of locally advanced disease and its effect on OM and CSM. Covariates consisted of age, race, socioeconomic status, year of surgery, and SEER registries.

Results

Between 1988 and 2006, 1,884 patients with SCCP were identified. At surgery, 1,192 (63.3 %) were married and 966 (51.3 %) had locally advanced disease. In multivariable logistic regression models predicting locally advanced disease at surgery, unmarried men had a 1.5-fold higher (p < 0.001) risk than others. In multivariable Cox models predicting CSM, marital status had no effect [hazard ratio (HR) = 1.3, p = 0.1]. Finally, in multivariable Cox models predicting OM, unmarried men had a 1.3-fold higher (p = 0.001) risk than others.

Conclusion

Unmarried men tend to present with less favorable disease stage at SCCP. Moreover, unmarried men tend to live less long than their married counterparts. However, marital status has no effect on CSM.

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Titel: A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis
verfasst von: Rodolphe Thuret
Maxine Sun
Lars Budaus
Firas Abdollah
Daniel Liberman
Shahrokh F. Shariat
François Iborra
Jacques Guiter
Jean-Jacques Patard
Paul Perrotte
Pierre I. Karakiewicz
Publikationsdatum: 01.01.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 1/2013
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-0091-y

Springer Medizin

A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis