nach oben

Translational Stroke Research

Erschienen in:

01.12.2015 | Review

A Systematic Research Review Assessing the Effectiveness of Pursuit Interventions in Spatial Neglect Following Stroke

verfasst von: Deborah Hill, Rachel O Coats, Aimee Halstead, Melanie Rose Burke

Erschienen in: Translational Stroke Research | Ausgabe 6/2015

Einloggen, um Zugang zu erhalten

Abstract

Rehabilitation after stroke is imperative for patients with spatial neglect as it can help improve behavioural, social and cognitive outcomes in these patients, and therefore reduce the financial burden on public health services. The main aim of this review is to investigate the effectiveness of active pursuit eye movements for rehabilitation interventions in patients with spatial neglect following stroke. Potential papers for inclusion were gathered by searching key terms in four main databases (AMED, Global Health, PubMed/Medline and PsychInfo) in addition to screening relevant reference lists. Two reviewers independently selected papers for inclusion based on agreed inclusion criteria (n = 9 with 147 participants). Risk of bias was assessed using the QUADAS-2 tool. All papers reported a statistically significant result in patients who received an intervention which used pursuit eye movements, and this was reported both as a short-term (immediate) effect and as a sustained effect up to 8 weeks after treatment. These effects were also reported in comparison with interventions using saccadic eye movements. One study also reported increased neural activity in a number of brain regions following pursuit-based intervention. Overall, there is good evidence in support of pursuit intervention used in the rehabilitation of stroke and spatial neglect over and above traditional interventions based on saccadic eye movements. Future research should aim to increase sample sizes, provide information on statistical power, record accurate eye movement responses and use randomised designs to reduce selection bias.

Nur mit Berechtigung zugänglich

Abbott A. Dementia: a problem for our age. Nature. 2011;475(7355):S2–4.CrossRefPubMed

Andersen RA, Snyder LH, Bradley DC, Xing J. Multimodal representation of space in the posterior parietal cortex and its use in planning movements. Annu Rev Neurosci. 1997;20(1):303–30.CrossRefPubMed

Appelros P, Karlsson GM, Seiger A, Nydevik I. Neglect and anosognosia after first-ever stroke: incidence and relationship to disability. J Rehabil Med. 2002;34(5):215–20.CrossRefPubMed

Barnes GR, Asselman PT. The mechanism of prediction in human smooth pursuit eye movements. J Physiol. 1991;439:439–61.PubMedCentralCrossRefPubMed

Baumann O, Ziemus B, Luerding R, Schuierer G, Bogdahn U, Greenlee MW. Differences in cortical activation during smooth pursuit and saccadic eye movements following cerebellar lesions. Exp Brain Res. 2007;181:237–47.CrossRefPubMed

Button KS, Ioannidis JP, Mokrysz C, Nosek BA, Flint J, Robinson ES, et al. Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 2013;14(5):365–76.CrossRefPubMed

Buxbaum LJ, Ferraro MK, Veramonti T, Farne A, Whyte J, Ladavas E, et al. Hemispatial neglect Subtypes, neuroanatomy, and disability. Neurology. 2004;62(5):749–56.CrossRefPubMed

Dieterich M, Bucher SF, Seelos KC, Brandt T. Cerebellar activation during optokinetic stimulation and saccades. Neurology. 2000;54(1):148.CrossRefPubMed

Di Monaco M, Schintu S, Dotta M, Barba S, Tappero R, Gindri P. Severity of unilateral spatial neglect is an independent predictor of functional outcome after acute inpatient rehabilitation in individuals with right hemispheric stroke. Arch Phys Med Rehabil. 2011;92(8):1250–6.CrossRefPubMed

10.

Dong W, Yan B, Johnson BP, Millist L, Davis S, Fielding J, et al. Ischaemic stroke: the ocular motor system as a sensitive marker for motor and cognitive recovery. J Neurol Neurosurg Psychiatry. 2013;84(3):337–41.PubMedCentralCrossRefPubMed

11.

Doricchi F, Thiebaut de Schotten M, Tomaiuolo F, Bartolomeo P. White matter(dis)connections and gray matter (dys)functions in visual neglect: gaining insights into the brain networks of spatial awareness. Cortex. 2008;44:983–95.CrossRefPubMed

12.

Farne A, Buxbaum LJ, Ferraro M, Frassinetti F, Whyte J, Veramonti T, et al. Patterns of spontaneous recovery of neglect and associated disorders in acute right brain-damaged patients. J Neurol Neurosurg Psychiatry. 2004;75(10):1401–10.PubMedCentralCrossRefPubMed

13.

Halligan PW, Cockburn J, Wilson BA. The behavioural assessment of visual neglect. Neuropsychol Rehabil. 1991;1(1):5–32.CrossRef

14.

Heide W, Kurzidim K, Kömpf D. Deficits of smooth pursuit eye movements after frontal and parietal lesions. Brain. 1996;119(6):1951–69.CrossRefPubMed

15.

Jehkonen M, Ahonen JP, Dastidar P, Koivisto AM, Laippala P, Vilkki J, et al. Visual neglect as a predictor of functional outcome one year after stroke. Acta Neurol Scand. 2000;101(3):195–201.CrossRefPubMed

16.

Karnath HO, Fruhmann BM, Kuker W, Rorden C. The anatomy of spatial neglect based on voxelwise statistical analysis: a study of 140 patients. Cereb Cortex. 2004;14:1164–72.CrossRefPubMed

17.

Keller I, Lefin-Rank G, Lösch J, Kerkhoff G. Combination of pursuit eye movement training with prism adaptation and arm movements in neglect therapy: a pilot study. Neurorehabil Neural Repair. 2009;23(1):58–66.CrossRefPubMed

18.

Kerkhoff G. Hemispatial neglect in man. Prog Neurobiol. 2001;63:1–27.CrossRefPubMed

19.

Kerkhoff G, Bucher L, Brasse M, Leonhart E, Holzgraefe M, Völzke V, et al. Smooth Pursuit “Bedside” Training Reduces Disability and Unawareness During the Activities of Daily Living in Neglect A Randomized Controlled Trial. Neurorehabil Neural Repair. 2014;28:554–63.CrossRefPubMed

20.

Kerkhoff G, Keller I, Artinger F, Hildebrandt H, Marquardt C, Reinhart S, et al. Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements-Transient modulation and enduring treatment effects. Neuropsychologia. 2012;50(6):1164–77.CrossRefPubMed

21.

Kerkhoff G, Keller I, Ritter V, Marquardt C. Repetitive optokinetic stimulation induces lasting recovery from visual neglect. Restor Neurol Neurosci. 2006;24(4):357–69.PubMed

22.

Kerkhoff G, Reinhart S, Ziegler W, Artinger F, Marquardt C, Keller I. Smooth pursuit eye movement training promotes recovery from auditory and visual neglect: a randomized controlled study. Neurorehabil Neural Repair. 2013;27(9):789–98.CrossRefPubMed

23.

Kinchla RA, Wolfe JM. The order of visual processing: “Top-down”, “bottom-up”, or “middle-out”. Percept Psychophys. 1979;25(3):225–31.CrossRefPubMed

24.

Krauzlis RJ. Recasting the smooth pursuit eye movement system. J Neurophysiol. 2004;91(2):591–603.CrossRefPubMed

25.

Lisa LP, Jughters A, Kerckhofs E. The effectiveness of different treatment modalities for the rehabilitation of unilateral neglect in stroke patients: A systematic review. NeuroRehabilitation. 2013;33(4):611–20.PubMed

26.

Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713–21.PubMed

27.

Martinez-Conde S, Macknik SL, Hubel DH. The role of fixational eye movements in visual perception. Nat Rev Neurosci. 2004;5(3):229–40.CrossRefPubMed

28.

Mort DJ, Malhotra P, Mannan SK, Rorden C, Pambakian A, Kennard C, et al. The anatomy of visual neglect. Brain. 2003;126:1986–97.CrossRefPubMed

29.

de Morton NA. The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother. 2009;55(2):129–33.CrossRefPubMed

30.

Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet. 1997;349(9061):1269–76.CrossRefPubMed

31.

Nijboer TC, Olthoff L, Van der Stigchel S, Visser-Meily JM. Prism adaptation improves postural imbalance in neglect patients. NeuroReport. 2014;25(5):307–11.PubMed

32.

Odgaard-Jensen J, Vist GE, Timmer A, Kunz R, Akl EA, Schünemann H, et al. Randomisation to protect against selection bias in healthcare trials. Cochrane Database System Review. 2011;4:MR000012.

33.

Paolucci S, Antonucci G, Grasso MG, Pizzamiglio L. The role of unilateral spatial neglect in rehabilitation of right brain -damaged ischemic stroke patients: A matched comparison. Arch Phys Med Rehabil. 2001;82(6):743–9.CrossRefPubMed

34.

Petit L, Haxby JV. Functional anatomy of pursuit eye movements in humans as revealed by fMRI. J Neurophysiol. 1999;82(1):463–71.PubMed

35.

Pitteri M, Kerkhoff G, Keller I, Meneghello F, Priftis K. Extra-powerful on the visuo-perceptual space, but variable on the number space: different effects of optokinetic stimulation in neglect patients. J Neuropsychol. 2014. doi:10.1111/jnp.12051.PubMed

36.

Pitzalis S, Spinelli D, Vallar G, Di Russo F. Transcutaneous electrical nerve stimulation effects on neglect: a visual-evoked potential study. Front Hum Neurosci. 2013;7(111):1–9.

37.

Priftis K, Pitteri M, Meneghello F, Umiltà C, Zorzi M. Optokinetic stimulation modulates neglect for the number space: evidence from mental number interval bisection. Front Hum Neurosci. 2012;6:23.PubMedCentralCrossRefPubMed

38.

Reinhart S, Schindler I, Kerkhoff G. Optokinetic stimulation affects word omissions but not stimulus-centered reading errors in paragraph reading in neglect dyslexia. Neuropsychologia. 2011;49(9):2728–35.CrossRefPubMed

39.

Rengachary J, He BJ, Shulman GL, Corbetta M. A behavioral analysis of spatial neglect and its recovery after stroke. Front Hum Neurosci. 2011;5:29.PubMedCentralCrossRefPubMed

40.

Schindler I, Kerkhoff G, Karnath HO, Keller I, Goldenberg G. Neck muscle vibration induces lasting recovery in spatial neglect. J Neurol Neurosurg Psychiatry. 2002;73(4):412–9.PubMedCentralCrossRefPubMed

41.

Schröder A, Wist ER, Hömberg V. TENS and optokinetic stimulation in neglect therapy after cerebrovascular accident: a randomized controlled study. Eur J Neurol. 2008;15(9):922–7.CrossRefPubMed

42.

Sherrington C, Herbert RD, Maher CG, Moseley AM. PEDro. A database of randomized trials and systematic reviews in physiotherapy. Man Ther. 2000;5(4):223–6.CrossRefPubMed

43.

Thimm M, Fink GR, Küst J, Karbe H, Willmes K, Sturm W. Recovery from hemineglect: differential neurobiological effects of optokinetic stimulation and alertness training. Cortex. 2009;45(7):850–62.CrossRefPubMed

44.

Vernet M, Quentin R, Chanes L, Mitsumasu A, Valero-Cabré A. Frontal eye field, where art thou? Anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations. Front Integr Neurosci. 2014;8.

45.

Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529–36.CrossRefPubMed

46.

Wilson B, Cockburn J, Halligan P. Development of a behavioral test of visuospatial neglect. Arch Phys Med Rehabil. 1987;68(2):98–102.PubMed

47.

Wright KW, Spiegel PH, Thompson LS, editors. Handbook of Pediatric Strabismus and Amblyopia (Vol. 5). New York: Springer; 2006.

Titel: A Systematic Research Review Assessing the Effectiveness of Pursuit Interventions in Spatial Neglect Following Stroke
verfasst von: Deborah Hill
Rachel O Coats
Aimee Halstead
Melanie Rose Burke
Publikationsdatum: 01.12.2015
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 6/2015
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-015-0420-z

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2015

Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126

Characteristics of Cerebrovascular Injury in the Hyperacute Phase After Induced Severe Subarachnoid Hemorrhage

Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke

An Outcome Model for Intravenous rt-PA in Acute Ischemic Stroke

Effect of APOE Gene Polymorphism on Early Cerebral Perfusion After Aneurysmal Subarachnoid Hemorrhage