Background
Methods
Eligibility criteria
Study selection and data collection
Data collection process & data items
Assessment of study quality and risk of bias in individual studies
Statistics
Results
Studies included
Study | Sample size | Presentation of tendinopathy | Additional factors associated with inflammationa | Site | QA | Method (cells) | Inflammatory cell + b | Cell types | Method (markers) | Inflammatory markers |
---|---|---|---|---|---|---|---|---|---|---|
Campbell 2014 [13] | 18 | Partial tear | Mean number of steroid injections 1.5 | RC | 8/11 | IHC | 100% | MP | qPCR | IL-21 receptor protein and mRNA |
Cetti 2003 [14] | 60 | Rupture | High activity level | AT | 8/11 | IHC | 100% | NP | n/a | n/a |
Dakin 2015 [15] | 32 | Pain or partial tear | n/a | RC | 9/11 | IHC | 100% | MP | n/a | n/a |
Dakin 2017 [16] | 17 | Pain or rupture | n/a | AT | 7/11 | IHC | 100% | MP | qPCR, IF | IL-8 mRNA, protein |
Hackett 2016 [17] | 39 | Calcific | n/a | RC | 9/11 | IHC | 100% | MP, TC, MC | n/a | n/a |
Klatte-schulz 2018 [18] | 26 | Pain or ruptures | High activity level | AT | 8/11 | IHC | 88% | MP, NS | qPCR | IL-6, IL-10, IL-33. IL1B, TNFa, TGFB1, COX-2 |
Kragsnaes 2014 [19] | 50 | Pain | 44% received steroid injection | AT | 9/11 | IHC | 96% | MP, TC, MC, NKC | n/a | n/a |
Matthews 2006 [20] | 38 | Rupture | Mean number of steroid injections 1.8 | RC | 8/11 | IHC | 100% | MP, TC, MC | n/a | n/a |
Millar 2010 [21] | 20 | Pain or partial tear | High activity level with mean number of 1.5 steroid injections | RC | 8/11 | IHC | 100% | MP, TC, MC | n/a | n/a |
Millar 2012 [22] | 15 | Pain or partial tear | High activity level with mean number of 1.6 steroid injections | RC | 8/11 | IHC | 100% | MP, TC, MC | IHC, qPCR | IL-6, IL-8 protein and mRNA |
Millar 2016 [23] | 10 | Pain or partial tear | High activity level with mean number of 1.7 steroid injections | RC | 7/11 | IHC | 100% | MP, TC, MC | qPCR | IL-17A mRNA |
Mosca 2017 [24] | 13 | Pain | n/a | RC | 9/11 | IHC | 100% | MP | qPCR | IL-33 protein |
Pecina 2010 [25] | 34 | Pain | n/a | PT | 8/11 | IHC | 100% | NS | n/a | n/a |
Schubert 2005 [26] | 10 | Pain or rupture | 40% received steroid injection | AT | 6/11 | IHC | 80% | MP, TC, GC | n/a | n/a |
Scott 2008 [27] | 22 | Pain | n/a | PT | 7/11 | IHC | 23% | MC | n/a | n/a |
Thankam 2017 [28] | 15 | Pain or partial tear | Glenohumeral arthritis observed | LHBT | 7/11 | IHC | 27% | MP, NP | n/a | n/a |
Åström 1995 [29] | 145 | Pain or partial tear | n/a | AT | 6/11 | H&E | 9% | NS | n/a | n/a |
Gaida 2012 [30] | 23 | Pain | n/a | AT | 8/11 | H&E | 0% | / | ELISA | TNFa protein |
Gumina 2006 [31] | 38 | Partial tear | n/a | RC | 10/11 | H&E | 100% | MP, LC | n/a | n/a |
Kannus 1991 [32] | 891 | Rupture | n/a | Various | 9/11 | H&E | 0% | / | n/a | n/a |
Khan 1996 [33] | 28 | Pain | n/a | PT | 9/11 | H&E | 0% | / | n/a | n/a |
Lian 2007 [34] | 23 | Pain | n/a | PT | 7/11 | H&E | 0% | / | n/a | n/a |
Ljung 1999 [35] | 6 | Pain | n/a | ECRB | 6/11 | H&E | 0% | / | n/a | n/a |
Longo 2008 [36] | 88 | Rupture | n/a | RC | 8/11 | H&E | 0% | / | n/a | n/a |
Longo 2009 [37] | 51 | Rupture | n/a | LHBT | 8/11 | H&E | 0% | / | n/a | n/a |
Popp 1997 [38] | 11 | Pain | n/a | PT | 5/11 | H&E | 0% | / | n/a | n/a |
Potter 1995 [39] | 20 | Pain | n/a | ECRB | 7/11 | H&E | 0% | / | n/a | n/a |
Rolf 1997 [40] | 60 | Pain | 72% received NSAIDs and 27% received steroid injection | AT | 8/11 | H&E | 0% | / | n/a | n/a |
Rolf 2017 [41] | 20 | Rupture | Sign of infection in 40% (bacteria), 5% received steroid injection 7/20 high activity level | AT | 9/11 | H&E | 50% | MP, TC, MC | n/a | n/a |
Shalabi 2002 [42] | 15 | Pain | n/a | AT | 8/11. | H&E | 0% | / | n/a | n/a |
Singaraju 2008 [43] | 6 | Pain | n/a | LHBT | 6/11 | H&E | 100% | NS | n/a | n/a |
Tillander 2002 [44] | 23 | Pain, partial tear or rupture | n/a | RC | 6/11. | H&E | 0% | / | n/a | n/a |
Zabrzynski 2017 [45] | 35 | Pain | n/a | LHBT | 9/11 | H&E | 9% | NS | n/a | n/a |
Ackermann 2013 [46] | 18 | Rupture | n/a | AT | 7/11 | n/a | n/a | / | MD | IL-12, IL-17, IL-1B, IL-6, IL-8, IL-10 protein |
Alfredson 2000 [47] | 4 | Pain | n/a | ECRB | 6/11 | n/a | n/a | / | MD | PGE2 |
Alfredson 2003 [48] | 10 | Pain | n/a | AT | 7/11 | n/a | n/a | / | MA | IL 1–6, 10–15 mRNA |
Alfredson 2001 [49] | 10 | Pain | n/a | PT | 7/11 | H&E | n/a | NS | MD | PGE2 |
Alfredsson 1999 [50] | 5 | Pain | n/a | AT | 6/11 | n/a | n/a | / | MD | PGE2 |
Chaudhury 2016 [51] | 16 | Pain | n/a | RC | 8/11 | n/a | n/a | / | qPCR | IL-8 mRNA |
Dean 2015 [52] | 9 | Pain | 100% received steroid injection | RC | 7/11 | n/a | n/a | / | qPCR | TNF-a, IL-1b mRNA |
Fabis 2014 [53] | 9 | Rupture | n/a | RC | 7/11 | n/a | n/a | / | qPCR | TNF-a, IL-10 mRNA |
Fu 2002 [54] | 11 | Pain | n/a | PT | 7/11 | n/a | 0% | / | IHC, WB | COX-2, TGF-b protein, PGE2 |
Gilmer 2015 [55] | 62 | Pain or partial tear | n/a | LHBT | 9/11 | H&E | n/a | NS | n/a | n/a |
Jelinsky 2011 [56] | 23 | Pain, tear, or rupture | 52% received steroid injection | Various | 8/11 | n/a | 0% | / | qPCR | IL13A2, FGFR1, FGFR2, IL-17D mRNA |
Jozsa 1980 [57] | 120 | Rupture or calcific | n/a | Various | 8/11 | H&E | n/a | NS | n/a | n/a |
Legerlotz 2012 [58] | 20 | Pain or rupture | n/a | AT PT | 7/11 | n/a | n/a | / | qPCR | COX-2, IL6, IL6R mRNA |
Millar 2015 [59] | 17 | Pain or partial tear | n/a | RC | 8/11 | n/a | n/a | / | qPCR | IL-33 mRNA |
Pingel 2012 [60] | 14 | Pain | 100% received steroid injection | AT | 8/11 | n/a | n/a | / | qPCR | COX-1, IL-1R, TGF-B1, bFGF mRNA |
Pingel 2013 [61] | 27 | Pain | 100% received steroid injection | AT | 8/11 | n/a | n/a | / | qPCR | IL-1b, IL-6, IL-10, COX-2, TGF-b, TNF-a mRNA |
Robertson 2012 [62] | 35 | Partial tear or rupture | n/a | RC | 8/11 | n/a | n/a | / | qPCR | IL-1b, IL-6, TNF-a, COX-2 mRNA |
Shindle 2011 [63] | 24 | Partial tear or Rupture | Joint inflammation | RC | 8/11 | n/a | n/a | / | qPCR | IL-1b, IL-6, COX-2, TNF-a mRNA |
Takeuchi 2001 [64] | 7 | Calcific | n/a | RC | 5/11 | IHC | n/a | MP | n/a | n/a |
Waugh 2015 [65] | 10 | Pain | n/a | AT PT | 7/11 | n/a | n/a | / | MD | IL-1b, IL-2, IL-6,IL-8, IL-10 protein |