Background
Methods
A time-course microarray data
Screening of differentially expressed genes
Functional enrichment analysis of the differentially expressed genes
Construction of regulatory network between microRNAs and differentially expressed genes
Results
Identification of DEGs
Gene | Log2FC_3d | Log2FC_7d | Log2FC_12d | Log2FC_18d |
---|---|---|---|---|
AF251705
| 1.305238 | 1.457843 | 1.423637 | 1.534935 |
Adam8
| 1.397521 | 1.545198 | 1.64087 | 1.397731 |
Arg1
| 3.216408 | 3.470759 | 3.253301 | 3.500893 |
Basp1
| 1.183961 | 1.402966 | 1.330427 | 1.417313 |
Ccl2
| 3.136399 | 2.754264 | 2.608425 | 2.605791 |
Ccl7
| 2.379615 | 1.747449 | 1.676018 | 1.364921 |
Ccl9
| 1.592837 | 1.25133 | 1.348077 | 1.222959 |
Ccr2
| 1.395741 | 1.265384 | 1.07037 | 1.021065 |
Clec4a2
| 1.344762 | 1.371277 | 1.486593 | 1.286852 |
Clec4d
| 2.328534 | 3.102078 | 3.12611 | 3.014611 |
Cxcl1
| 1.152963 | 2.378911 | 2.050006 | 2.15751 |
Ephx1
| − 1.12827 | − 1.5318 | − 1.36148 | − 1.05361 |
Fabp5
| 1.300109 | 1.492187 | 1.360936 | 1.174031 |
Fcgr1
| 1.565833 | 1.337319 | 1.266228 | 1.255231 |
Gp49a
| 1.08629 | 1.48513 | 1.472467 | 1.684876 |
Il1rn
| 2.356432 | 2.933974 | 2.905693 | 3.029609 |
Saa3
| 2.536273 | 3.692907 | 3.451593 | 4.212274 |
Functional enrichment analysis results
Term | Number |
P value | Gene lists |
---|---|---|---|
GO term | |||
GO_BP: immune response | 11 | 5.86E−12 |
Cxcl1, Ccl2, Gp49a, Ccr2, Il1rn, Ccl9, Clec4a2, AF251705, Clec4d, Fcgr1, Ccl7
|
GO_BP: response to wounding | 7 | 1.09E−06 |
Cxcl1, Arg1, Ccl2, Ccr2, Saa3, Fcgr1, Ccl7
|
GO_BP: inflammatory response | 6 | 3.12E−06 |
Cxcl1, Ccl2, Ccr2, Saa3, Fcgr1, Ccl7
|
GO_MF: chemokine activity | 4 | 4.66E−06 |
Cxcl1, Ccl2, Ccl9, Ccl7
|
GO_MF: chemokine receptor binding | 4 | 5.05E−06 |
Cxcl1, Ccl2, Ccl9, Ccl7
|
GO_CC: extracellular space | 7 | 1.65E−05 |
Cxcl1, Arg1, Ccl2, Il1rn, Saa3, Ccl9, Ccl7
|
GO_BP: defense response | 6 | 8.70E−05 |
Cxcl1, Ccl2, Ccr2, Saa3, Fcgr1, Ccl7
|
GO_CC: extracellular region part | 7 | 1.70E−04 |
Cxcl1, Arg1, Ccl2, Il1rn, Saa3, Ccl9, Ccl7
|
GO_MF: cytokine activity | 4 | 4.92E−04 |
Cxcl1, Ccl2, Ccl9, Ccl7
|
GO_BP: chemotaxis | 3 | 6.25E−03 |
Ccl2, Ccl9, Ccl7
|
GO_BP: taxis | 3 | 6.25E−03 |
Ccl2, Ccl9, Ccl7
|
GO_CC: extracellular region | 7 | 9.88E−03 |
Cxcl1, Arg1, Ccl2, Il1rn, Saa3, Ccl9, Ccl7
|
GO_BP: locomotory behavior | 3 | 2.78E−02 |
Ccl2, Ccl9, Ccl7
|
GO_MF: carbohydrate binding | 3 | 3.20E−02 |
Clec4a2, Clec4d, Ccl7
|
KEGG pathway | |||
mmu04062:chemokine signaling pathway | 5 | 6.21E−05 |
Cxcl1, Ccl2, Ccr2, Ccl9, Ccl7
|
mmu04060:cytokine-cytokine receptor interaction | 5 | 1.95E−04 |
Cxcl1, Ccl2, Ccr2, Ccl9, Ccl7
|
mmu04621:NOD-like receptor signaling pathway | 3 | 3.08E−03 |
Cxcl1, Ccl2, Ccl7
|