Erschienen in:
19.11.2015 | Review
Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer
verfasst von:
Ci Zhao, Guanyu Wang, Yuanyuan Zhu, Xiaobo Li, Feihu Yan, Chunhui Zhang, Xiaoyi Huang, Yanqiao Zhang
Erschienen in:
Tumor Biology
|
Ausgabe 1/2016
Einloggen, um Zugang zu erhalten
Abstract
MicroRNAs encoded by the miR-15b/16-2 cluster act as tumor suppressors. Aberrant regulation of miR-15b in human malignant tumors is reportedly involved in cancer development, contributing to cell death, reduced proliferation, angiogenesis and metastasis resistance, metabolism reprogramming, genome instability, and tumor-associated inflammation. In this review, we summarize the mechanisms involved in regulating miR-15b expression in mammalian tumors and discuss the effects of miR-15b dysregulation on the hallmarks of cancer and highlight its role as a potentially valuable target for future cancer therapeutic strategies.